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Vulva verrucous carcinoma

MedGen UID:
234482
•Concept ID:
C1336983
•
Neoplastic Process
Synonyms: mammalian vulva verrucous carcinoma; Verrucous Carcinoma of the Vulva; verrucous carcinoma of the vulva; Verrucous Carcinoma of Vulva; verrucous carcinoma of vulva; vulva verrucous carcinoma; Vulvar Verrucous Carcinoma; vulvar verrucous carcinoma
 
Monarch Initiative: MONDO:0002758

Definition

A highly differentiated squamous cell carcinoma that arises from the vulva. It is characterized by the presence of a warty and hyperkeratinized surface, malignant cells with abundant eosinophilic cytoplasm, minimal cytologic atypia, and absence or rarity of mitotic figures. The tumor infiltrates the underlying stroma with a pushing border. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulva verrucous carcinoma

Professional guidelines

PubMed

Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
Combination of oral acitretin, antiretroviral therapy, human papillomavirus vaccine, and carbon dioxide laser ablation for the treatment of giant condyloma acuminatum of the vulva in a patient with AIDS.
Namuduri RP, Lee LY, Aan Koh MJ
Dermatol Ther 2020 Nov;33(6):e14253. Epub 2020 Sep 11 doi: 10.1111/dth.14253. PMID: 32862466
Vulvar cancer. ACOG Technical Bulletin Number 186--November 1993.
Int J Gynaecol Obstet 1994 Jan;44(1):79-85. PMID: 7907068

Recent clinical studies

Etiology

Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
Recent advances in cutaneous HPV infection.
Shimizu A, Yamaguchi R, Kuriyama Y
J Dermatol 2023 Mar;50(3):290-298. Epub 2023 Jan 5 doi: 10.1111/1346-8138.16697. PMID: 36601717
HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva.
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Major p53 immunohistochemical patterns in in situ and invasive squamous cell carcinomas of the vulva and correlation with TP53 mutation status.
Tessier-Cloutier B, Kortekaas KE, Thompson E, Pors J, Chen J, Ho J, Prentice LM, McConechy MK, Chow C, Proctor L, McAlpine JN, Huntsman DG, Gilks CB, Bosse T, Hoang LN
Mod Pathol 2020 Aug;33(8):1595-1605. Epub 2020 Mar 20 doi: 10.1038/s41379-020-0524-1. PMID: 32203095
Human Papillomavirus-Independent Squamous Lesions of the Vulva.
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103

Diagnosis

Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva.
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Verrucous carcinoma of the vulva: Patterns of care and treatment outcomes.
Dryden SM, Reshko LB, Gaskins JT, Silva SR
Cancer Rep (Hoboken) 2022 Oct;5(10):e21591. Epub 2022 Jan 24 doi: 10.1002/cnr2.1591. PMID: 35075817Free PMC Article
Vulvar malignancies: an interdisciplinary perspective.
Wohlmuth C, Wohlmuth-Wieser I
J Dtsch Dermatol Ges 2019 Dec;17(12):1257-1276. Epub 2019 Dec 12 doi: 10.1111/ddg.13995. PMID: 31829526Free PMC Article
Human Papillomavirus-Independent Squamous Lesions of the Vulva.
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103

Therapy

Malignancy-associated acquired vulvar lymphangioma circumscriptum: A clinicopathologic study of 71 cases.
Luu YT, Kimmis BD, Bodine JS, Gloyeske NC, Dai H
J Cutan Pathol 2022 May;49(5):426-433. Epub 2021 Dec 21 doi: 10.1111/cup.14181. PMID: 34877687
Vulvar and perineal verrucous changes complicating hidradenitis suppurativa after wide excision: a case and literature review.
Ward RA, Udechukwu NS, Selim MA, Jaleel T
Dermatol Online J 2020 Jun 15;26(7) PMID: 32898403
Successful management of giant condyloma acuminatum of vulva with the combination of surgery and photodynamic therapy: Report of two cases.
Chen X, Zhou Y, Tan Y, Duan G, Li Z, Zou P, Xiao R, Zhan Y
Photodiagnosis Photodyn Ther 2020 Sep;31:101847. Epub 2020 May 30 doi: 10.1016/j.pdpdt.2020.101847. PMID: 32479901
Verrucous carcinoma of the renal pelvis with a focus of conventional squamous cell carcinoma.
Baseskioğlu B, Yenilmez A, Acıkalın M, Can C, Dönmez T
Urol Int 2012;88(1):115-7. Epub 2011 Sep 28 doi: 10.1159/000330906. PMID: 21968520
Treatment of verrucous carcinoma of vulva with acitretin.
Mehta RK, Rytina E, Sterling JC
Br J Dermatol 2000 Jun;142(6):1195-8. doi: 10.1046/j.1365-2133.2000.03548.x. PMID: 10848746

Prognosis

Major p53 immunohistochemical patterns in in situ and invasive squamous cell carcinomas of the vulva and correlation with TP53 mutation status.
Tessier-Cloutier B, Kortekaas KE, Thompson E, Pors J, Chen J, Ho J, Prentice LM, McConechy MK, Chow C, Proctor L, McAlpine JN, Huntsman DG, Gilks CB, Bosse T, Hoang LN
Mod Pathol 2020 Aug;33(8):1595-1605. Epub 2020 Mar 20 doi: 10.1038/s41379-020-0524-1. PMID: 32203095
Vulvar malignancies: an interdisciplinary perspective.
Wohlmuth C, Wohlmuth-Wieser I
J Dtsch Dermatol Ges 2019 Dec;17(12):1257-1276. Epub 2019 Dec 12 doi: 10.1111/ddg.13995. PMID: 31829526Free PMC Article
Human Papillomavirus-Independent Squamous Lesions of the Vulva.
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103
Verrucous Carcinoma of the Vulva: A Case Report and Literature Review.
Zhang W, Wang Y, Chen W, Du J, Xiang L, Ye S, Yang H
Am J Case Rep 2019 Apr 19;20:551-556. doi: 10.12659/AJCR.914367. PMID: 31002657Free PMC Article
Verrucous Carcinoma of the Vulva: A 20 Year Retrospective Study and Literature Review.
Liu G, Li Q, Shang X, Qi Z, Han C, Wang Y, Xue F
J Low Genit Tract Dis 2016 Jan;20(1):114-8. doi: 10.1097/LGT.0000000000000164. PMID: 26704335

Clinical prediction guides

MTA1 as negative prognostic marker in vulvar carcinoma.
Wanka G, Jueckstock J, Wild CM, Vattai A, Fürst S, Heidegger HH, Kuhn C, Schmoeckel E, Jeschke U, Dannecker C
J Cancer Res Clin Oncol 2023 Aug;149(9):6191-6201. Epub 2023 Jan 23 doi: 10.1007/s00432-023-04579-4. PMID: 36689059Free PMC Article
Verrucous carcinoma of the vulva: Patterns of care and treatment outcomes.
Dryden SM, Reshko LB, Gaskins JT, Silva SR
Cancer Rep (Hoboken) 2022 Oct;5(10):e21591. Epub 2022 Jan 24 doi: 10.1002/cnr2.1591. PMID: 35075817Free PMC Article
Vulvar and perineal verrucous changes complicating hidradenitis suppurativa after wide excision: a case and literature review.
Ward RA, Udechukwu NS, Selim MA, Jaleel T
Dermatol Online J 2020 Jun 15;26(7) PMID: 32898403
Major p53 immunohistochemical patterns in in situ and invasive squamous cell carcinomas of the vulva and correlation with TP53 mutation status.
Tessier-Cloutier B, Kortekaas KE, Thompson E, Pors J, Chen J, Ho J, Prentice LM, McConechy MK, Chow C, Proctor L, McAlpine JN, Huntsman DG, Gilks CB, Bosse T, Hoang LN
Mod Pathol 2020 Aug;33(8):1595-1605. Epub 2020 Mar 20 doi: 10.1038/s41379-020-0524-1. PMID: 32203095
The pathology of vulvar squamous cell carcinoma and verrucous carcinoma.
Dvoretsky PM, Bonfiglio TA
Pathol Annu 1986;21 Pt 2:23-45. PMID: 3748617

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