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Oral Cavity Granular Cell Tumor

MedGen UID:
233795
Concept ID:
C1335118
Neoplastic Process
Synonyms: Granular Cell Neoplasm of Mouth; Granular Cell Neoplasm of Oral Cavity; Granular Cell Neoplasm of the Mouth; Granular Cell Neoplasm of the Oral Cavity; Granular Cell Tumor of Mouth; Granular Cell Tumor of Oral Cavity; Granular Cell Tumor of the Mouth; Granular Cell Tumor of the Oral Cavity; Mouth Granular Cell Neoplasm; Mouth Granular Cell Tumor; Oral Cavity Granular Cell Neoplasm

Definition

A rare neoplasm that arises from the oral cavity, usually the tongue. It is characterized by the presence of plump eosinophilic cells with abundant granular cytoplasm. The neoplastic cells extend into the surrounding tissues, usually skeletal muscle. The vast majority of cases follow a benign clinical course. Recurrences are rare after removal of the tumor. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Szlachetka K, Lemcke-Berno EM, Ozcan T
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Recent clinical studies

Etiology

Schafer DR, Glass SH
Head Neck Pathol 2019 Mar;13(1):33-46. Epub 2019 Jan 31 doi: 10.1007/s12105-018-0977-4. PMID: 30693453Free PMC Article
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Head Face Med 2018 Jan 3;14(1):1. doi: 10.1186/s13005-017-0158-9. PMID: 29329562Free PMC Article
van de Loo S, Thunnissen E, Postmus P, van der Waal I
Med Oral Patol Oral Cir Bucal 2015 Jan 1;20(1):e30-3. doi: 10.4317/medoral.19867. PMID: 24880452Free PMC Article
Ritter JH, Nappi O
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Baden E, Doyle JL, Lederman DA
Eur J Cancer B Oral Oncol 1994 Jan;30B(1):1-7. doi: 10.1016/0964-1955(94)90043-4. PMID: 9135966

Diagnosis

Chapman MC, Soares BP, Li Y, Shum DJ, Glenn OA, Glastonbury CM, Courtier JL
Radiographics 2019 Jul-Aug;39(4):1143-1160. doi: 10.1148/rg.2019180128. PMID: 31283464
Schafer DR, Glass SH
Head Neck Pathol 2019 Mar;13(1):33-46. Epub 2019 Jan 31 doi: 10.1007/s12105-018-0977-4. PMID: 30693453Free PMC Article
Tobouti PL, Pigatti FM, Martins-Mussi MC, Sedassari BT, Orsini-Machado de Sousa SC
Med Oral Patol Oral Cir Bucal 2017 Jan 1;22(1):e31-e35. doi: 10.4317/medoral.21401. PMID: 27918739Free PMC Article
Serpa MS, Costa-Neto H, de Oliveira PT, da Silveira ÉJ, de Medeiros AM
Eur Arch Otorhinolaryngol 2016 Oct;273(10):3439-41. Epub 2016 Mar 23 doi: 10.1007/s00405-016-4006-5. PMID: 27007285
Noonan V, Lerman MA, Woo SB, Kabani S
J Mass Dent Soc 2014 Spring;63(1):45. PMID: 24941552

Therapy

Papamichael K, Archavlis E, Lariou C, Tsigka A, Mantzaris GJ
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Med Oral Patol Oral Cir Bucal 2005 Mar-Apr;10(2):123-7. PMID: 15735544
Kaplan I, Vered M, Moskona D, Buchner A, Dayan D
Oral Dis 1998 Sep;4(3):194-9. doi: 10.1111/j.1601-0825.1998.tb00278.x. PMID: 9972170
Dabelsteen E, Graem N, Hakomori S, Young WW Jr
Bull Cancer 1983;70(2):127-31. PMID: 6871487

Prognosis

Aragão HHR, Lima LBR, Cavalcante IL, da Silva Neto SS, Turatti E, Cavalcante RB, Gilligan G, Panico R, de Mendonça EF, de Albuquerque-Júnior RLC, Nonaka CFW, Alves PM, de Andrade BAB, Cunha JLS
Oral Maxillofac Surg 2024 Sep;28(3):1383-1397. Epub 2024 Jun 21 doi: 10.1007/s10006-024-01272-9. PMID: 38904898
Roesch S, Dejaco M, Hauser-Kronberger C, Rasp G
Laryngoscope 2013 Oct;123(10):2459-62. Epub 2013 Aug 5 doi: 10.1002/lary.23919. PMID: 23917999
Lapid O, Shaco-Levy R, Krieger Y, Kachko L, Sagi A
Pediatrics 2001 Feb;107(2):E22. doi: 10.1542/peds.107.2.e22. PMID: 11158496
te Boekhorst DS, Gerhards MF, van Gulik TM, Gouma DJ
Dig Surg 2000;17(3):299-303. doi: 10.1159/000018858. PMID: 10867472
Baden E, Doyle JL, Lederman DA
Eur J Cancer B Oral Oncol 1994 Jan;30B(1):1-7. doi: 10.1016/0964-1955(94)90043-4. PMID: 9135966

Clinical prediction guides

Lafuente Ibáñez de Mendoza I, López Ortega K, Trierveiler M, Oliveira Alves MG, Dias Almeida J, Gándara Vila P, Aguirre Urízar JM, Pérez Sayans M
Oral Dis 2020 Apr;26(3):573-589. Epub 2020 Jan 28 doi: 10.1111/odi.13273. PMID: 31898368
Omar L, Pfeifer CM, Kulkarni S, Sharma P, Sengupta A, Kwon JK
Clin Imaging 2018 Nov-Dec;52:334-336. Epub 2018 Sep 9 doi: 10.1016/j.clinimag.2018.09.003. PMID: 30241035
Tobouti PL, Pigatti FM, Martins-Mussi MC, Sedassari BT, Orsini-Machado de Sousa SC
Med Oral Patol Oral Cir Bucal 2017 Jan 1;22(1):e31-e35. doi: 10.4317/medoral.21401. PMID: 27918739Free PMC Article
Serpa MS, Costa-Neto H, de Oliveira PT, da Silveira ÉJ, de Medeiros AM
Eur Arch Otorhinolaryngol 2016 Oct;273(10):3439-41. Epub 2016 Mar 23 doi: 10.1007/s00405-016-4006-5. PMID: 27007285
van de Loo S, Thunnissen E, Postmus P, van der Waal I
Med Oral Patol Oral Cir Bucal 2015 Jan 1;20(1):e30-3. doi: 10.4317/medoral.19867. PMID: 24880452Free PMC Article

Recent systematic reviews

Lafuente Ibáñez de Mendoza I, López Ortega K, Trierveiler M, Oliveira Alves MG, Dias Almeida J, Gándara Vila P, Aguirre Urízar JM, Pérez Sayans M
Oral Dis 2020 Apr;26(3):573-589. Epub 2020 Jan 28 doi: 10.1111/odi.13273. PMID: 31898368

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