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Nodular lymphocyte predominant Hodgkin lymphoma

MedGen UID:
233758
Concept ID:
C1334968
Neoplastic Process
Synonyms: Nodular Lymphocyte Predominant Hodgkin's Lymphoma; Nodular Lymphocyte-Predominant Hodgkin's Lymphoma; Nodular Sclerosing Hodgkin's Lymphoma
SNOMED CT: Hodgkin's disease, lymphocytic predominance, nodular (70600005); Hodgkin lymphoma, lymphocyte predominance, nodular (70600005); Hodgkin lymphoma, nodular lymphocyte predominance (70600005); Hodgkin lymphoma, nodular lymphocyte predominance (clinical) (118605002); Hodgkin lymphoma, nodular lymphocyte predominance (118605002)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
Monarch Initiative: MONDO:0044778
Orphanet: ORPHA86893

Definition

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma (HL; see this term) characterized histologically by malignant lymphocyte predominant (LP) cells and the absence of typical Hodgkin and Reed-Sternberg (HRS) cells. [from ORDO]

Professional guidelines

PubMed

Sereda S, Shankar A, Weber L, Ramsay AD, Hall GW, Hayward J, Wallace WHB, Landman-Parker J, Braeuninger A, Hasenclever D, Schneider A, Mauz-Koerholz C, Koerholz D, Gattenloehner S
Blood Adv 2023 Oct 24;7(20):6285-6289. doi: 10.1182/bloodadvances.2023010652. PMID: 37611165Free PMC Article
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251
Eichenauer DA, Engert A
Hematol Oncol 2013 Jun;31 Suppl 1:47-50. doi: 10.1002/hon.2067. PMID: 23775649

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Hodgkin Lymphoma, 2024

Recent clinical studies

Etiology

Binkley MS, Flerlage JE, Savage KJ, Akhtar S, Steiner R, Zhang XY, Dickinson M, Prica A, Major A, Hendrickson PG, Hopkins D, Ng A, Casulo C, Baron J, Roberts KB, Al Kendi J, Balogh A, Ricardi U, Torka P, Specht L, De Silva R, Pickard K, Blazin LJ, Henry M, Smith CM, Halperin D, Brady J, Brennan B, Senchenko MA, Reeves M, Hoppe BS, Terezakis S, Talaulikar D, Picardi M, Kirova Y, Fergusson P, Hawkes EA, Lee D, Doo NW, Barraclough A, Cheah CY, Ku M, Hamad N, Mutsando H, Gilbertson M, Marconi T, Viiala N, Maurer MJ, Eichenauer DA, Hoppe RT; GLOW Consortium
J Clin Oncol 2024 Jul 1;42(19):2271-2280. Epub 2024 Mar 26 doi: 10.1200/JCO.23.01655. PMID: 38531001
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Savage KJ, Mottok A, Fanale M
Semin Hematol 2016 Jul;53(3):190-202. Epub 2016 May 13 doi: 10.1053/j.seminhematol.2016.05.009. PMID: 27496311
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Diagnosis

Sereda S, Shankar A, Weber L, Ramsay AD, Hall GW, Hayward J, Wallace WHB, Landman-Parker J, Braeuninger A, Hasenclever D, Schneider A, Mauz-Koerholz C, Koerholz D, Gattenloehner S
Blood Adv 2023 Oct 24;7(20):6285-6289. doi: 10.1182/bloodadvances.2023010652. PMID: 37611165Free PMC Article
Weniger MA, Küppers R
Leukemia 2021 Apr;35(4):968-981. Epub 2021 Mar 8 doi: 10.1038/s41375-021-01204-6. PMID: 33686198Free PMC Article
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Wang HW, Balakrishna JP, Pittaluga S, Jaffe ES
Br J Haematol 2019 Jan;184(1):45-59. Epub 2018 Nov 8 doi: 10.1111/bjh.15614. PMID: 30407610Free PMC Article
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251

Therapy

Eichenauer DA, Engert A
Curr Opin Oncol 2021 Sep 1;33(5):395-399. doi: 10.1097/CCO.0000000000000774. PMID: 34224482
McKay P, Fielding P, Gallop-Evans E, Hall GW, Lambert J, Leach M, Marafioti T, McNamara C; British Committee for Standards in Haematology
Br J Haematol 2016 Jan;172(1):32-43. Epub 2015 Nov 5 doi: 10.1111/bjh.13842. PMID: 26538004
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251
Bartlett NL
Clin Adv Hematol Oncol 2013 Jun;11(6):385-7. PMID: 24472810
Eichenauer DA, Engert A
Hematol Oncol 2013 Jun;31 Suppl 1:47-50. doi: 10.1002/hon.2067. PMID: 23775649

Prognosis

Binkley MS, Flerlage JE, Savage KJ, Akhtar S, Steiner R, Zhang XY, Dickinson M, Prica A, Major A, Hendrickson PG, Hopkins D, Ng A, Casulo C, Baron J, Roberts KB, Al Kendi J, Balogh A, Ricardi U, Torka P, Specht L, De Silva R, Pickard K, Blazin LJ, Henry M, Smith CM, Halperin D, Brady J, Brennan B, Senchenko MA, Reeves M, Hoppe BS, Terezakis S, Talaulikar D, Picardi M, Kirova Y, Fergusson P, Hawkes EA, Lee D, Doo NW, Barraclough A, Cheah CY, Ku M, Hamad N, Mutsando H, Gilbertson M, Marconi T, Viiala N, Maurer MJ, Eichenauer DA, Hoppe RT; GLOW Consortium
J Clin Oncol 2024 Jul 1;42(19):2271-2280. Epub 2024 Mar 26 doi: 10.1200/JCO.23.01655. PMID: 38531001
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Wang HW, Balakrishna JP, Pittaluga S, Jaffe ES
Br J Haematol 2019 Jan;184(1):45-59. Epub 2018 Nov 8 doi: 10.1111/bjh.15614. PMID: 30407610Free PMC Article
Ansell SM
Mayo Clin Proc 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID: 26541251
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Clinical prediction guides

Salvaris RT, Allanson BM, Collins G, Cheah C
Haematologica 2024 Nov 1;109(11):3476-3487. doi: 10.3324/haematol.2024.285903. PMID: 39234861Free PMC Article
Binkley MS, Flerlage JE, Savage KJ, Akhtar S, Steiner R, Zhang XY, Dickinson M, Prica A, Major A, Hendrickson PG, Hopkins D, Ng A, Casulo C, Baron J, Roberts KB, Al Kendi J, Balogh A, Ricardi U, Torka P, Specht L, De Silva R, Pickard K, Blazin LJ, Henry M, Smith CM, Halperin D, Brady J, Brennan B, Senchenko MA, Reeves M, Hoppe BS, Terezakis S, Talaulikar D, Picardi M, Kirova Y, Fergusson P, Hawkes EA, Lee D, Doo NW, Barraclough A, Cheah CY, Ku M, Hamad N, Mutsando H, Gilbertson M, Marconi T, Viiala N, Maurer MJ, Eichenauer DA, Hoppe RT; GLOW Consortium
J Clin Oncol 2024 Jul 1;42(19):2271-2280. Epub 2024 Mar 26 doi: 10.1200/JCO.23.01655. PMID: 38531001
Borchmann S
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):717-722. doi: 10.1182/hematology.2022000364. PMID: 36485084Free PMC Article
Aldrink JH, Appel B, Kaplan JA, Hutchison RE, Schwartz CL, Kelly KM, McCarten K, Ehrlich PF
J Pediatr Hematol Oncol 2018 Apr;40(3):246-247. doi: 10.1097/MPH.0000000000001107. PMID: 29401099Free PMC Article
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Hodgkin Lymphoma, 2024

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