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Inflammatory leiomyosarcoma

MedGen UID:
233554
•Concept ID:
C1334179
•
Neoplastic Process
Synonyms: Inflammatory Leiomyosarcoma; inflammatory leiomyosarcoma
 
Monarch Initiative: MONDO:0003347

Definition

A morphologic variant of leiomyosarcoma characterized by the presence of an inflammatory infiltrate admixed with malignant spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInflammatory leiomyosarcoma

Professional guidelines

PubMed

The differential diagnoses of uterine leiomyomas and leiomyosarcomas using DNA and RNA sequencing.
Mas A, Alonso R, Garrido-Gómez T, Escorcia P, Montero B, Jiménez-Almazán J, Martín J, Pellicer N, Monleón J, Simón C
Am J Obstet Gynecol 2019 Oct;221(4):320.e1-320.e23. Epub 2019 May 20 doi: 10.1016/j.ajog.2019.05.018. PMID: 31121144
Myxoid Mesenchymal Tumors of the Uterus: An Update on Classification, Definitions, and Differential Diagnosis.
Busca A, Parra-Herran C
Adv Anat Pathol 2017 Nov;24(6):354-361. doi: 10.1097/PAP.0000000000000164. PMID: 28787279
EMAS position statement: management of uterine fibroids.
Pérez-López FR, Ornat L, Ceausu I, Depypere H, Erel CT, Lambrinoudaki I, Schenck-Gustafsson K, Simoncini T, Tremollieres F, Rees M; EMAS
Maturitas 2014 Sep;79(1):106-16. Epub 2014 Jun 9 doi: 10.1016/j.maturitas.2014.06.002. PMID: 24975954

Recent clinical studies

Etiology

Inflammatory Rhabdomyoblastic Tumor: Clinicopathologic and Molecular Analysis of 13 Cases.
Odate T, Satomi K, Kubo T, Matsushita Y, Ueno T, Kurose A, Shomori K, Nakai T, Watanabe R, Segawa K, Ohshika S, Miyake N, Kudo S, Shimoi T, Kobayashi E, Komiyama M, Yoshimoto S, Nakatani F, Kawai A, Yatabe Y, Kohsaka S, Ichimura K, Ichikawa H, Yoshida A
Mod Pathol 2024 Jan;37(1):100359. Epub 2023 Oct 21 doi: 10.1016/j.modpat.2023.100359. PMID: 37871654
Pulmonary "Inflammatory Leiomyosarcomas" Are Indolent Tumors With Diploid Genomes and No Convincing Rhabdomyoblastic Differentiation.
Kao YC, Kuo CT, Kuo PY, Huang HY, Lu TP, Hsieh TH, Fletcher CDM, Lee JC
Am J Surg Pathol 2022 Mar 1;46(3):424-433. doi: 10.1097/PAS.0000000000001804. PMID: 35175969
"Inflammatory Leiomyosarcoma" and "Histiocyte-rich Rhabdomyoblastic Tumor": a clinicopathological, immunohistochemical and genetic study of 13 cases, with a proposal for reclassification as "Inflammatory Rhabdomyoblastic Tumor".
Cloutier JM, Charville GW, Mertens F, Sukov W, Fritchie K, Perry KD, Edgar M, Rowsey RA, Folpe AL
Mod Pathol 2021 Apr;34(4):758-769. Epub 2020 Oct 22 doi: 10.1038/s41379-020-00703-8. PMID: 33318583
Leiomyosarcoma of soft tissue in children: clinicopathologic analysis of 20 cases.
de Saint Aubain Somerhausen N, Fletcher CD
Am J Surg Pathol 1999 Jul;23(7):755-63. doi: 10.1097/00000478-199907000-00002. PMID: 10403297
Inflammatory leiomyosarcoma may be characterized by specific near-haploid chromosome changes.
Dal Cin P, Sciot R, Fletcher CD, Samson I, De Vos R, Mandahl N, Willén H, Larsson O, Van den Berghe H
J Pathol 1998 May;185(1):112-5. doi: 10.1002/(SICI)1096-9896(199805)185:1<112::AID-PATH54>3.0.CO;2-U. PMID: 9713368

Diagnosis

Pulmonary "Inflammatory Leiomyosarcomas" Are Indolent Tumors With Diploid Genomes and No Convincing Rhabdomyoblastic Differentiation.
Kao YC, Kuo CT, Kuo PY, Huang HY, Lu TP, Hsieh TH, Fletcher CDM, Lee JC
Am J Surg Pathol 2022 Mar 1;46(3):424-433. doi: 10.1097/PAS.0000000000001804. PMID: 35175969
"Inflammatory Leiomyosarcoma" and "Histiocyte-rich Rhabdomyoblastic Tumor": a clinicopathological, immunohistochemical and genetic study of 13 cases, with a proposal for reclassification as "Inflammatory Rhabdomyoblastic Tumor".
Cloutier JM, Charville GW, Mertens F, Sukov W, Fritchie K, Perry KD, Edgar M, Rowsey RA, Folpe AL
Mod Pathol 2021 Apr;34(4):758-769. Epub 2020 Oct 22 doi: 10.1038/s41379-020-00703-8. PMID: 33318583
Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor.
Michal M, Rubin BP, Kazakov DV, Michalová K, Šteiner P, Grossmann P, Hájková V, Martínek P, Švajdler M, Agaimy A, Hadravský L, Kalmykova AV, Konishi E, Heidenreich F, Michal M
Virchows Arch 2020 Aug;477(2):219-230. Epub 2020 Feb 20 doi: 10.1007/s00428-020-02774-z. PMID: 32078043
Anaplastic Kaposi's Sarcoma of the Adrenal in an HIV-negative Patient With Literature Review.
Bisceglia M, Minenna E, Altobella A, Sanguedolce F, Panniello G, Bisceglia S, Ben-Dor DJ
Adv Anat Pathol 2019 Mar;26(2):133-149. doi: 10.1097/PAP.0000000000000213. PMID: 30212382
Inflammatory leiomyosarcoma of the retroperitoneum.
Morović A, Delcore R, Damjanov I
Pathol Res Pract 2003;199(1):41-3; discussion 45-6. doi: 10.1078/0344-0338-00351. PMID: 12650517

Therapy

A long-living case of carotid aneurysm caused by inflammatory leiomyosarcoma.
Morita I, Isoda R, Hirabayashi Y, Naomoto Y
Asian Cardiovasc Thorac Ann 2016 Oct;24(8):801-804. Epub 2016 Jul 26 doi: 10.1177/0218492316659975. PMID: 27461101

Prognosis

Pulmonary "Inflammatory Leiomyosarcomas" Are Indolent Tumors With Diploid Genomes and No Convincing Rhabdomyoblastic Differentiation.
Kao YC, Kuo CT, Kuo PY, Huang HY, Lu TP, Hsieh TH, Fletcher CDM, Lee JC
Am J Surg Pathol 2022 Mar 1;46(3):424-433. doi: 10.1097/PAS.0000000000001804. PMID: 35175969
"Inflammatory Leiomyosarcoma" and "Histiocyte-rich Rhabdomyoblastic Tumor": a clinicopathological, immunohistochemical and genetic study of 13 cases, with a proposal for reclassification as "Inflammatory Rhabdomyoblastic Tumor".
Cloutier JM, Charville GW, Mertens F, Sukov W, Fritchie K, Perry KD, Edgar M, Rowsey RA, Folpe AL
Mod Pathol 2021 Apr;34(4):758-769. Epub 2020 Oct 22 doi: 10.1038/s41379-020-00703-8. PMID: 33318583
Histiocyte-rich rhabdomyoblastic tumor: a report of two cases and a review of the differential diagnoses.
Bourgeau M, Martinez AP
Virchows Arch 2021 Feb;478(2):367-373. Epub 2020 Jun 9 doi: 10.1007/s00428-020-02857-x. PMID: 32514584
Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor.
Michal M, Rubin BP, Kazakov DV, Michalová K, Šteiner P, Grossmann P, Hájková V, Martínek P, Švajdler M, Agaimy A, Hadravský L, Kalmykova AV, Konishi E, Heidenreich F, Michal M
Virchows Arch 2020 Aug;477(2):219-230. Epub 2020 Feb 20 doi: 10.1007/s00428-020-02774-z. PMID: 32078043
Inflammatory leiomyosarcoma of the ankle: a case report and review of the literature.
Efstathopoulos N, Lazarettos J, Nikolaou V, Chronopoulos E
J Foot Ankle Surg 2006 Mar-Apr;45(2):127-30. doi: 10.1053/j.jfas.2005.12.010. PMID: 16513508

Clinical prediction guides

Pulmonary "Inflammatory Leiomyosarcomas" Are Indolent Tumors With Diploid Genomes and No Convincing Rhabdomyoblastic Differentiation.
Kao YC, Kuo CT, Kuo PY, Huang HY, Lu TP, Hsieh TH, Fletcher CDM, Lee JC
Am J Surg Pathol 2022 Mar 1;46(3):424-433. doi: 10.1097/PAS.0000000000001804. PMID: 35175969
"Inflammatory Leiomyosarcoma" and "Histiocyte-rich Rhabdomyoblastic Tumor": a clinicopathological, immunohistochemical and genetic study of 13 cases, with a proposal for reclassification as "Inflammatory Rhabdomyoblastic Tumor".
Cloutier JM, Charville GW, Mertens F, Sukov W, Fritchie K, Perry KD, Edgar M, Rowsey RA, Folpe AL
Mod Pathol 2021 Apr;34(4):758-769. Epub 2020 Oct 22 doi: 10.1038/s41379-020-00703-8. PMID: 33318583
Histiocyte-rich rhabdomyoblastic tumor: a report of two cases and a review of the differential diagnoses.
Bourgeau M, Martinez AP
Virchows Arch 2021 Feb;478(2):367-373. Epub 2020 Jun 9 doi: 10.1007/s00428-020-02857-x. PMID: 32514584
Anaplastic Kaposi's Sarcoma of the Adrenal in an HIV-negative Patient With Literature Review.
Bisceglia M, Minenna E, Altobella A, Sanguedolce F, Panniello G, Bisceglia S, Ben-Dor DJ
Adv Anat Pathol 2019 Mar;26(2):133-149. doi: 10.1097/PAP.0000000000000213. PMID: 30212382
Inflammatory leiomyosarcoma of the ankle: a case report and review of the literature.
Efstathopoulos N, Lazarettos J, Nikolaou V, Chronopoulos E
J Foot Ankle Surg 2006 Mar-Apr;45(2):127-30. doi: 10.1053/j.jfas.2005.12.010. PMID: 16513508

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