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Poorly Differentiated Malignant Neoplasm

MedGen UID:
233331
•Concept ID:
C1335444
•
Neoplastic Process

Definition

A neoplasm whose histologic characteristics have regressed and are more similar to stem cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPoorly Differentiated Malignant Neoplasm

Professional guidelines

PubMed

Diagnosis and treatment of primary aldosteronism.
Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA
Lancet Diabetes Endocrinol 2021 Dec;9(12):876-892. doi: 10.1016/S2213-8587(21)00210-2. PMID: 34798068
Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Shah MH, Goldner WS, Benson AB, Bergsland E, Blaszkowsky LS, Brock P, Chan J, Das S, Dickson PV, Fanta P, Giordano T, Halfdanarson TR, Halperin D, He J, Heaney A, Heslin MJ, Kandeel F, Kardan A, Khan SA, Kuvshinoff BW, Lieu C, Miller K, Pillarisetty VG, Reidy D, Salgado SA, Shaheen S, Soares HP, Soulen MC, Strosberg JR, Sussman CR, Trikalinos NA, Uboha NA, Vijayvergia N, Wong T, Lynn B, Hochstetler C
J Natl Compr Canc Netw 2021 Jul 28;19(7):839-868. doi: 10.6004/jnccn.2021.0032. PMID: 34340212
Diffuse large B-cell lymphoma: 2019 update on diagnosis, risk stratification, and treatment.
Liu Y, Barta SK
Am J Hematol 2019 May;94(5):604-616. doi: 10.1002/ajh.25460. PMID: 30859597

Recent clinical studies

Etiology

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
Pancreatic Neuroendocrine Neoplasms: Landscape and Horizon.
Tang LH
Arch Pathol Lab Med 2020 Jul 1;144(7):816-828. doi: 10.5858/arpa.2019-0654-RA. PMID: 32298138
Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas.
Patel N, Barbieri A, Gibson J
Surg Pathol Clin 2019 Dec;12(4):1021-1044. doi: 10.1016/j.path.2019.08.007. PMID: 31672292
Pulmonary Sarcomatoid Carcinomas: A Review.
Weissferdt A
Adv Anat Pathol 2018 Sep;25(5):304-313. doi: 10.1097/PAP.0000000000000202. PMID: 29912718
Epigenetic modifications in poorly differentiated and anaplastic thyroid cancer.
Sasanakietkul T, Murtha TD, Javid M, Korah R, Carling T
Mol Cell Endocrinol 2018 Jul 5;469:23-37. Epub 2017 May 25 doi: 10.1016/j.mce.2017.05.022. PMID: 28552796

Diagnosis

Chordoma.
Ulici V, Hart J
Arch Pathol Lab Med 2022 Mar 1;146(3):386-395. doi: 10.5858/arpa.2020-0258-RA. PMID: 34319396
Notochordal Tumors.
Tirabosco R, O'Donnell P, Flanagan AM
Surg Pathol Clin 2021 Dec;14(4):619-643. Epub 2021 Jul 28 doi: 10.1016/j.path.2021.06.006. PMID: 34742484
Pathologic Considerations in Gastroenteropancreatic Neuroendocrine Tumors.
Bellizzi AM
Surg Oncol Clin N Am 2020 Apr;29(2):185-208. doi: 10.1016/j.soc.2019.11.003. PMID: 32151355Free PMC Article
Neuroendocrine Tumors of the Breast.
Rosen LE, Gattuso P
Arch Pathol Lab Med 2017 Nov;141(11):1577-1581. doi: 10.5858/arpa.2016-0364-RS. PMID: 29072945
Poorly Differentiated and Undifferentiated Thyroid Carcinomas.
Eloy C, Ferreira L, Salgado C, Soares P, Sobrinho-Simões M
Turk Patoloji Derg 2015;31 Suppl 1:48-59. doi: 10.5146/tjpath.2015.01314. PMID: 26177317

Therapy

Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
Kar SP, Quiros PM, Gu M, Jiang T, Mitchell J, Langdon R, Iyer V, Barcena C, Vijayabaskar MS, Fabre MA, Carter P, Petrovski S, Burgess S, Vassiliou GS
Nat Genet 2022 Aug;54(8):1155-1166. Epub 2022 Jul 14 doi: 10.1038/s41588-022-01121-z. PMID: 35835912Free PMC Article
Phase I trial of the DLL3/CD3 bispecific T-cell engager BI 764532 in DLL3-positive small-cell lung cancer and neuroendocrine carcinomas.
Wermke M, Felip E, Gambardella V, Kuboki Y, Morgensztern D, Hamed ZO, Liu M, Studeny M, Owonikoko TK
Future Oncol 2022 Aug;18(24):2639-2649. Epub 2022 Jul 11 doi: 10.2217/fon-2022-0196. PMID: 35815644
Carboplatin in Combination with Oral or Intravenous Etoposide for Extra-Pulmonary, Poorly-Differentiated Neuroendocrine Carcinomas.
Frizziero M, Spada F, Lamarca A, Kordatou Z, Barriuso J, Nuttall C, McNamara MG, Hubner RA, Mansoor W, Manoharan P, Fazio N, Valle JW
Neuroendocrinology 2019;109(2):100-112. Epub 2019 Jan 21 doi: 10.1159/000497336. PMID: 30703770
Fighting Resilient Cancers with Iron.
Chen JJ, Galluzzi L
Trends Cell Biol 2018 Feb;28(2):77-78. Epub 2017 Dec 7 doi: 10.1016/j.tcb.2017.11.007. PMID: 29223642
A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.
Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD
Cell Metab 2015 Jul 7;22(1):86-99. Epub 2015 Jun 18 doi: 10.1016/j.cmet.2015.05.012. PMID: 26094889Free PMC Article

Prognosis

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
Notochordal Tumors.
Tirabosco R, O'Donnell P, Flanagan AM
Surg Pathol Clin 2021 Dec;14(4):619-643. Epub 2021 Jul 28 doi: 10.1016/j.path.2021.06.006. PMID: 34742484
Epigenetic modifications in poorly differentiated and anaplastic thyroid cancer.
Sasanakietkul T, Murtha TD, Javid M, Korah R, Carling T
Mol Cell Endocrinol 2018 Jul 5;469:23-37. Epub 2017 May 25 doi: 10.1016/j.mce.2017.05.022. PMID: 28552796
Neuroendocrine Tumors of the Breast.
Rosen LE, Gattuso P
Arch Pathol Lab Med 2017 Nov;141(11):1577-1581. doi: 10.5858/arpa.2016-0364-RS. PMID: 29072945
Poorly Differentiated and Undifferentiated Thyroid Carcinomas.
Eloy C, Ferreira L, Salgado C, Soares P, Sobrinho-Simões M
Turk Patoloji Derg 2015;31 Suppl 1:48-59. doi: 10.5146/tjpath.2015.01314. PMID: 26177317

Clinical prediction guides

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Pulmonary Sarcomatoid Carcinomas: A Review.
Weissferdt A
Adv Anat Pathol 2018 Sep;25(5):304-313. doi: 10.1097/PAP.0000000000000202. PMID: 29912718
Epigenetic modifications in poorly differentiated and anaplastic thyroid cancer.
Sasanakietkul T, Murtha TD, Javid M, Korah R, Carling T
Mol Cell Endocrinol 2018 Jul 5;469:23-37. Epub 2017 May 25 doi: 10.1016/j.mce.2017.05.022. PMID: 28552796
Poorly Differentiated and Undifferentiated Thyroid Carcinomas.
Eloy C, Ferreira L, Salgado C, Soares P, Sobrinho-Simões M
Turk Patoloji Derg 2015;31 Suppl 1:48-59. doi: 10.5146/tjpath.2015.01314. PMID: 26177317

Recent systematic reviews

Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact.
Coca-Pelaz A, Rodrigo JP, Agaimy A, Williams MD, Saba NF, Nuyts S, Randolph GW, López F, Vander Poorten V, Kowalski LP, Civantos FJ, Zafereo ME, Mäkitie AA, Cohen O, Nixon IJ, Rinaldo A, Ferlito A
Virchows Arch 2024 May;484(5):733-742. Epub 2024 Feb 24 doi: 10.1007/s00428-024-03752-5. PMID: 38400843
Non-demyelinating disorders mimicking and misdiagnosed as NMOSD: a literature review.
Zara P, Dinoto A, Carta S, Floris V, Turilli D, Budhram A, Ferrari S, Milia S, Solla P, Mariotto S, Flanagan EP, Lopez Chiriboga AS, Sechi E
Eur J Neurol 2023 Oct;30(10):3367-3376. Epub 2023 Jul 19 doi: 10.1111/ene.15983. PMID: 37433584Free PMC Article
Thyrotoxicosis with concomitant thyroid cancer.
Fu H, Cheng L, Jin Y, Chen L
Endocr Relat Cancer 2019 Jul;26(7):R395-R413. doi: 10.1530/ERC-19-0129. PMID: 31026810
Unraveling molecular pathways of poorly differentiated neuroendocrine carcinomas of the gastroenteropancreatic system: A systematic review.
Girardi DM, Silva ACB, Rêgo JFM, Coudry RA, Riechelmann RP
Cancer Treat Rev 2017 May;56:28-35. Epub 2017 Apr 17 doi: 10.1016/j.ctrv.2017.04.002. PMID: 28456055
Liver transplantation for neuroendocrine tumour liver metastases.
Fan ST, Le Treut YP, Mazzaferro V, Burroughs AK, Olausson M, Breitenstein S, Frilling A
HPB (Oxford) 2015 Jan;17(1):23-8. Epub 2014 Jul 3 doi: 10.1111/hpb.12308. PMID: 24992381Free PMC Article

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