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Metastatic Adult Malignant Neoplasm in the Brain

MedGen UID:
233184
Concept ID:
C1334723
Neoplastic Process
Synonyms: Brain Metastases, Adult; Metastasis to the Adult Brain; Metastatic Malignant Neoplasm to the Adult Brain; Metastatic Neoplasm to the Adult Brain; Metastatic Tumor to the Adult Brain; Secondary Malignant Neoplasm to the Adult Brain; Secondary Malignant Tumor to the Adult Brain

Definition

A malignant neoplasm that has spread from its original site of growth to the brain in an adult patient. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Adult Malignant Neoplasm in the Brain

Professional guidelines

PubMed

Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Perkins A, Liu G
Am Fam Physician 2016 Feb 1;93(3):211-7. PMID: 26926614
Lin NU, Lee EQ, Aoyama H, Barani IJ, Barboriak DP, Baumert BG, Bendszus M, Brown PD, Camidge DR, Chang SM, Dancey J, de Vries EG, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wen PY; Response Assessment in Neuro-Oncology (RANO) group
Lancet Oncol 2015 Jun;16(6):e270-8. Epub 2015 May 27 doi: 10.1016/S1470-2045(15)70057-4. PMID: 26065612

Recent clinical studies

Etiology

Chen TW, Dai MS, Tseng LM, Chen SC, Chao TY, Chao TC, Chang YC, Chiu CF, Liu CT, Lin CH, Liu CY, Chen YF, Chang DY, Yu JC, Rau KM, Hsieh YY, Shen SC, Huang SM, Cheng AL, Lu YS
JAMA Oncol 2024 Mar 1;10(3):325-334. doi: 10.1001/jamaoncol.2023.5456. PMID: 38127335Free PMC Article
Khalid MU, Shah MM, Bajwa MH, Zafar SN, Laghari AA, Anis SB, Raghib MF, Akhunzada NZ; Pakistan Brain Tumour Consortium, Siddiqi S, Enam SA; Pakistan Brain Tumour Consortium Group Names
J Pak Med Assoc 2022 Nov;72(Suppl 4)(11):S68-S73. doi: 10.47391/JPMA.11-S4-AKUB11. PMID: 36591631
Saadeh F, El Iskandarani S, Najjar M, Assi HI
Clin Neurol Neurosurg 2019 Jul;182:98-103. Epub 2019 May 14 doi: 10.1016/j.clineuro.2019.05.008. PMID: 31112812
Perkins A, Liu G
Am Fam Physician 2016 Feb 1;93(3):211-7. PMID: 26926614
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780

Diagnosis

Khalid MU, Shah MM, Bajwa MH, Zafar SN, Laghari AA, Anis SB, Raghib MF, Akhunzada NZ; Pakistan Brain Tumour Consortium, Siddiqi S, Enam SA; Pakistan Brain Tumour Consortium Group Names
J Pak Med Assoc 2022 Nov;72(Suppl 4)(11):S68-S73. doi: 10.47391/JPMA.11-S4-AKUB11. PMID: 36591631
Humbert C, Gérard D, Rech F, Gauchotte G, Broséus J, Lesesve JF
Cytopathology 2020 Mar;31(2):167-168. Epub 2019 Nov 20 doi: 10.1111/cyt.12775. PMID: 31563142
Barajas RF Jr, Cha S
Neuroimaging Clin N Am 2016 Nov;26(4):601-620. Epub 2016 Sep 2 doi: 10.1016/j.nic.2016.06.008. PMID: 27712796Free PMC Article
Perkins A, Liu G
Am Fam Physician 2016 Feb 1;93(3):211-7. PMID: 26926614
Spencer K, Hall A, Jain P
Clin Med (Lond) 2014 Oct;14(5):535-7. doi: 10.7861/clinmedicine.14-5-535. PMID: 25301918Free PMC Article

Therapy

Palmer JD, Klamer BG, Ballman KV, Brown PD, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, Laack NNI, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D
JAMA Oncol 2022 Dec 1;8(12):1809-1815. doi: 10.1001/jamaoncol.2022.5049. PMID: 36264568Free PMC Article
Campbell KL, Zadravec K, Bland KA, Chesley E, Wolf F, Janelsins MC
Phys Ther 2020 Mar 10;100(3):523-542. doi: 10.1093/ptj/pzz090. PMID: 32065236Free PMC Article
Brown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, Laack NNI, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D
Lancet Oncol 2017 Aug;18(8):1049-1060. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30441-2. PMID: 28687377Free PMC Article
Lin NU, Lee EQ, Aoyama H, Barani IJ, Barboriak DP, Baumert BG, Bendszus M, Brown PD, Camidge DR, Chang SM, Dancey J, de Vries EG, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wen PY; Response Assessment in Neuro-Oncology (RANO) group
Lancet Oncol 2015 Jun;16(6):e270-8. Epub 2015 May 27 doi: 10.1016/S1470-2045(15)70057-4. PMID: 26065612
Patchell RA, Tibbs PA, Walsh JW, Dempsey RJ, Maruyama Y, Kryscio RJ, Markesbery WR, Macdonald JS, Young B
N Engl J Med 1990 Feb 22;322(8):494-500. doi: 10.1056/NEJM199002223220802. PMID: 2405271

Prognosis

Siegel RL, Miller KD, Jemal A
CA Cancer J Clin 2020 Jan;70(1):7-30. Epub 2020 Jan 8 doi: 10.3322/caac.21590. PMID: 31912902
Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G
Lancet Oncol 2017 Aug;18(8):1040-1048. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30414-X. PMID: 28687375Free PMC Article
Vivekananda U, Howard RS, Matar W, Phadke R
J Neurol Neurosurg Psychiatry 2011 Mar;82(3):347-8. Epub 2010 Sep 30 doi: 10.1136/jnnp.2010.220012. PMID: 20884676
Grau JJ, Verger E
Eur J Cancer 2000 Mar;36(4):443-7. doi: 10.1016/s0959-8049(99)00321-4. PMID: 10717518
Colon G, Quint DJ, Blaivas M, McGillicuddy J
AJNR Am J Neuroradiol 1995 Sep;16(8):1739-41. PMID: 7502986Free PMC Article

Clinical prediction guides

Khalid MU, Shah MM, Bajwa MH, Zafar SN, Laghari AA, Anis SB, Raghib MF, Akhunzada NZ; Pakistan Brain Tumour Consortium, Siddiqi S, Enam SA; Pakistan Brain Tumour Consortium Group Names
J Pak Med Assoc 2022 Nov;72(Suppl 4)(11):S68-S73. doi: 10.47391/JPMA.11-S4-AKUB11. PMID: 36591631
Biganzoli L, Battisti NML, Wildiers H, McCartney A, Colloca G, Kunkler IH, Cardoso MJ, Cheung KL, de Glas NA, Trimboli RM, Korc-Grodzicki B, Soto-Perez-de-Celis E, Ponti A, Tsang J, Marotti L, Benn K, Aapro MS, Brain EGC
Lancet Oncol 2021 Jul;22(7):e327-e340. Epub 2021 May 14 doi: 10.1016/S1470-2045(20)30741-5. PMID: 34000244
Minniti G, Scaringi C, Paolini S, Lanzetta G, Romano A, Cicone F, Osti M, Enrici RM, Esposito V
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1142-8. Epub 2016 Mar 19 doi: 10.1016/j.ijrobp.2016.03.013. PMID: 27209508
Blecharz KG, Colla R, Rohde V, Vajkoczy P
Biol Cell 2015 Oct;107(10):342-71. Epub 2015 Jun 25 doi: 10.1111/boc.201500011. PMID: 26032862
Moffie D, Ongerboer de Visser BW, Stefanko SZ
J Neurol Sci 1983 Feb;58(2):175-83. doi: 10.1016/0022-510x(83)90215-0. PMID: 6834076

Recent systematic reviews

Brain E, Chen C, Simon S, Pasupuleti V, Pfitzer KV, Gelmon KA
Target Oncol 2024 May;19(3):303-320. Epub 2024 Mar 28 doi: 10.1007/s11523-024-01046-z. PMID: 38546943Free PMC Article
Himič V, Burman RJ, Fountain DM, Hofer M, Livermore LJ, Jeyaretna DS
Acta Neurochir (Wien) 2023 Oct;165(10):2873-2883. Epub 2023 Jul 26 doi: 10.1007/s00701-023-05687-3. PMID: 37491650Free PMC Article
Yang R, Isaacs AM, Cadieux M, Hirmer TJ, CreveCoeur TS, Lapointe AP, Opoku-Darko M, Premji Z, Riva-Cambrin J, Gallagher CN
Childs Nerv Syst 2021 Jun;37(6):1849-1858. Epub 2021 Mar 6 doi: 10.1007/s00381-021-05098-8. PMID: 33675391
Campbell KL, Zadravec K, Bland KA, Chesley E, Wolf F, Janelsins MC
Phys Ther 2020 Mar 10;100(3):523-542. doi: 10.1093/ptj/pzz090. PMID: 32065236Free PMC Article
Tsao MN, Xu W, Wong RK, Lloyd N, Laperriere N, Sahgal A, Rakovitch E, Chow E
Cochrane Database Syst Rev 2018 Jan 25;1(1):CD003869. doi: 10.1002/14651858.CD003869.pub4. PMID: 29365347Free PMC Article

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