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Extraskeletal Cartilaginous and Osseous Neoplasm

MedGen UID:
232171
•Concept ID:
C1333515
•
Neoplastic Process
Synonym: Extraskeletal Cartilaginous and Osseous Tumor

Definition

A benign or malignant mesenchymal neoplasm with cartilaginous or osseous differentiation arising from the soft tissues exclusively. Representative examples include chondroma, osteoma, and osteosarcoma. [from NCI]

Professional guidelines

PubMed

Keratin subsets and monoclonal antibody HBME-1 in chordoma: immunohistochemical differential diagnosis between tumors simulating chordoma.
O'Hara BJ, Paetau A, Miettinen M
Hum Pathol 1998 Feb;29(2):119-26. doi: 10.1016/s0046-8177(98)90220-9. PMID: 9490269

Recent clinical studies

Etiology

Falcine and parasagittal chondrosarcomas.
Safaee M, Clark AJ, Tihan T, Parsa AT, Bloch O
J Clin Neurosci 2013 Sep;20(9):1232-6. Epub 2013 Jun 10 doi: 10.1016/j.jocn.2013.01.004. PMID: 23759737
Update on chondrosarcomas.
Chow WA
Curr Opin Oncol 2007 Jul;19(4):371-6. doi: 10.1097/CCO.0b013e32812143d9. PMID: 17545802
Genetics of chondrosarcoma and related tumors.
Sandberg AA
Curr Opin Oncol 2004 Jul;16(4):342-54. doi: 10.1097/01.cco.0000129678.72521.e5. PMID: 15187889
Extraskeletal chondromas.
Marcial-Seoane RA, Marcial-Seoane MA, Ramos E, Marcial-Rojas RA
Bol Asoc Med P R 1990 Sep;82(9):394-402. PMID: 2076144
Extraskeletal osteosarcoma.
Chung EB, Enzinger FM
Cancer 1987 Sep 1;60(5):1132-42. doi: 10.1002/1097-0142(19870901)60:5<1132::aid-cncr2820600536>3.0.co;2-l. PMID: 3475157

Diagnosis

Extraskeletal cartilaginous, osseous, and chordoid tumors in children and adolescents.
Cates JM, Coffin CM
Pediatr Dev Pathol 2012;15(1 Suppl):255-66. doi: 10.2350/10-07-0875-PB.1. PMID: 22420731
Genetics of chondrosarcoma and related tumors.
Sandberg AA
Curr Opin Oncol 2004 Jul;16(4):342-54. doi: 10.1097/01.cco.0000129678.72521.e5. PMID: 15187889
From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation.
Murphey MD, Walker EA, Wilson AJ, Kransdorf MJ, Temple HT, Gannon FH
Radiographics 2003 Sep-Oct;23(5):1245-78. doi: 10.1148/rg.235035134. PMID: 12975513
From the archives of the AFIP. Extraskeletal osseous and cartilaginous tumors of the extremities.
Kransdorf MJ, Meis JM
Radiographics 1993 Jul;13(4):853-84. doi: 10.1148/radiographics.13.4.8356273. PMID: 8356273
Extraskeletal chondromas.
Marcial-Seoane RA, Marcial-Seoane MA, Ramos E, Marcial-Rojas RA
Bol Asoc Med P R 1990 Sep;82(9):394-402. PMID: 2076144

Therapy

Extraskeletal osteosarcoma of the pleura:report of a case.
Shiota H, Yasukawa T, Hirai A, Chiyo M, Yusa T, Hiroshima K
Ann Thorac Cardiovasc Surg 2013;19(4):297-301. Epub 2012 Nov 17 doi: 10.5761/atcs.cr.12.01964. PMID: 23232263
Quiz. Correct answer to the quiz. Check your diagnosis. Mesenchymal chondrosarcoma of the orbit: two cases and a brief review of the literature.
Szumera-Ciećkiewicz A, Ptaszyński K, Grabowski P, Krajewski R, Tacikowska M
Pol J Pathol 2012 Mar;63(1):80-4. PMID: 22535612
Mesenchymal chondrosarcoma of the orbit: a report of two cases and review of the literature.
Kaur A, Kishore P, Agrawal A, Gupta A
Orbit 2008;27(1):63-7. doi: 10.1080/01676830601169007. PMID: 18307151

Prognosis

Bone Tumors Occurring in the Soft Tissues: A Review of the Clinical, Imaging, and Histopathologic Findings.
Veselis CA, Awan O, Thomas A, Ling S, Jonnalagadda P, Aneja A, Ali S
Curr Probl Diagn Radiol 2021 May-Jun;50(3):419-429. Epub 2020 Jun 26 doi: 10.1067/j.cpradiol.2020.06.004. PMID: 32665061
Falcine and parasagittal chondrosarcomas.
Safaee M, Clark AJ, Tihan T, Parsa AT, Bloch O
J Clin Neurosci 2013 Sep;20(9):1232-6. Epub 2013 Jun 10 doi: 10.1016/j.jocn.2013.01.004. PMID: 23759737
Extraskeletal osteosarcoma of the pleura:report of a case.
Shiota H, Yasukawa T, Hirai A, Chiyo M, Yusa T, Hiroshima K
Ann Thorac Cardiovasc Surg 2013;19(4):297-301. Epub 2012 Nov 17 doi: 10.5761/atcs.cr.12.01964. PMID: 23232263
Update on chondrosarcomas.
Chow WA
Curr Opin Oncol 2007 Jul;19(4):371-6. doi: 10.1097/CCO.0b013e32812143d9. PMID: 17545802
From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation.
Murphey MD, Walker EA, Wilson AJ, Kransdorf MJ, Temple HT, Gannon FH
Radiographics 2003 Sep-Oct;23(5):1245-78. doi: 10.1148/rg.235035134. PMID: 12975513

Clinical prediction guides

Target-like chondrocytes with thick perichondrocytic rings in cartilage-forming tumours. Preliminary report.
Povysil C, Kana M
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Jun;165(2):203-208. Epub 2021 Apr 30 doi: 10.5507/bp.2021.024. PMID: 33928945
NKX3.1 immunoreactivity is not identified in mesenchymal chondrosarcoma: a 25-case cohort study.
Chen W, Hornick JL, Fletcher CDM
Histopathology 2021 Jan;78(2):334-337. Epub 2020 Oct 19 doi: 10.1111/his.14231. PMID: 32779239
Extraskeletal osteosarcoma of the pleura:report of a case.
Shiota H, Yasukawa T, Hirai A, Chiyo M, Yusa T, Hiroshima K
Ann Thorac Cardiovasc Surg 2013;19(4):297-301. Epub 2012 Nov 17 doi: 10.5761/atcs.cr.12.01964. PMID: 23232263
A low-grade extraskeletal osteosarcoma.
Okada K, Ito H, Miyakoshi N, Sageshima M, Nishida J, Itoi E
Skeletal Radiol 2003 Mar;32(3):165-9. Epub 2002 Nov 21 doi: 10.1007/s00256-002-0589-6. PMID: 12605283
From the archives of the AFIP. Extraskeletal osseous and cartilaginous tumors of the extremities.
Kransdorf MJ, Meis JM
Radiographics 1993 Jul;13(4):853-84. doi: 10.1148/radiographics.13.4.8356273. PMID: 8356273

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