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Desmoplastic melanoma

MedGen UID:
232127
•Concept ID:
C1333280
•
Neoplastic Process
Synonyms: desmoplastic cutaneous (skin) melanoma; Desmoplastic Melanoma; desmoplastic melanoma
 
Monarch Initiative: MONDO:0044785

Definition

A melanoma of the skin characterized by a proliferation of atypical spindled melanocytes in the dermis, in a background of abundant collagen. It usually presents as an amelanotic raised nodular lesion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDesmoplastic melanoma

Professional guidelines

PubMed

Single-Agent PD-1 Blockade Is "Treatment of Choice" for Desmoplastic Melanoma.
Cancer Discov 2023 Jun 2;13(6):OF7. doi: 10.1158/2159-8290.CD-NB2023-0033. PMID: 37071762
Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
The changing landscape in management of desmoplastic melanoma.
Dunne JA, Adigbli G
J Surg Oncol 2022 Feb;125(2):227-228. Epub 2021 Sep 17 doi: 10.1002/jso.26677. PMID: 34535908

Recent clinical studies

Etiology

Variation in second cancer risk by melanoma subtype among survivors.
Luu YT, Goldstein AM, Sargen MR
J Am Acad Dermatol 2023 Feb;88(2):433-434. Epub 2022 May 16 doi: 10.1016/j.jaad.2022.05.022. PMID: 35588927Free PMC Article
Desmoplastic melanoma: a brief review and the efficacy of immunotherapy.
Ochoa CE, Joseph RW
Expert Rev Anticancer Ther 2019 Mar;19(3):205-207. Epub 2019 Feb 4 doi: 10.1080/14737140.2019.1574573. PMID: 30686076
Malignant Melanoma: Beyond the Basics.
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194
Desmoplastic melanoma of the hand: case reports and review of the literature.
Chung KC, Calkins ER, Crawford R, Rees RS
J Hand Surg Am 1995 Sep;20(5):873-6. doi: 10.1016/S0363-5023(05)80447-2. PMID: 8522760
Neurotropic Melanoma. A variant of desmoplastic melanoma.
Kossard S, Doherty E, Murray E
Arch Dermatol 1987 Jul;123(7):907-12. PMID: 3606170

Diagnosis

Dermatoscopy of melanoma according to type, anatomic site and stage.
Lallas A, Paschou E, Manoli SM, Papageorgiou C, Spyridis I, Liopyris K, Bobos M, Moutsoudis A, Lazaridou E, Apalla Z
Ital J Dermatol Venerol 2021 Jun;156(3):274-288. Epub 2020 Dec 14 doi: 10.23736/S2784-8671.20.06784-X. PMID: 33314891
Amelanotic melanoma.
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Malignant Melanoma: Beyond the Basics.
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194
Desmoplastic melanoma.
Schleich C, Ferringer T
Cutis 2015 Nov;96(5):306;313;314;335. PMID: 26682559
Immunohistochemical characteristics of melanoma.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807

Therapy

Dramatic response of face desmoplastic melanoma after two doses of immunotherapy.
Rubatto M, Gelato F, Broganelli P, Fava P, Senetta R, Avallone G, Mastorino L, Grandinetti D, Ribero S, Quaglino P
Ital J Dermatol Venerol 2023 Apr;158(2):153-154. doi: 10.23736/S2784-8671.22.07329-7. PMID: 37153950
The changing landscape in management of desmoplastic melanoma.
Dunne JA, Adigbli G
J Surg Oncol 2022 Feb;125(2):227-228. Epub 2021 Sep 17 doi: 10.1002/jso.26677. PMID: 34535908
SOX10 commonly stains scar in Mohs sections.
Donaldson MR, Weber LA
Dermatol Online J 2020 Jan 15;26(1) PMID: 32155034
Neurotrophin Receptors and Perineural Invasion: Analyses in Select Lineage-Unrelated Cutaneous Malignancies With a Propensity for Perineural Invasion.
Frydenlund NF, Mahalingam M
Vitam Horm 2017;104:497-531. Epub 2016 Dec 13 doi: 10.1016/bs.vh.2016.11.003. PMID: 28215306
Cutaneous desmoplastic melanoma.
Busam KJ
Adv Anat Pathol 2005 Mar;12(2):92-102. doi: 10.1097/01.pap.0000155071.86944.a6. PMID: 15731577

Prognosis

Amelanotic melanoma.
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Desmoplastic melanoma.
Nicolson NG, Han D
J Surg Oncol 2019 Jan;119(2):208-215. Epub 2018 Nov 27 doi: 10.1002/jso.25317. PMID: 30481377
Unusual Clinical Presentations of Malignant Melanoma: A Review of Clinical and Histologic Features with Special Emphasis on Dermatoscopic Findings.
Cabrera R, Recule F
Am J Clin Dermatol 2018 Nov;19(Suppl 1):15-23. doi: 10.1007/s40257-018-0373-6. PMID: 30374898Free PMC Article
Immunohistochemical characteristics of melanoma.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807
Neurotropic Melanoma. A variant of desmoplastic melanoma.
Kossard S, Doherty E, Murray E
Arch Dermatol 1987 Jul;123(7):907-12. PMID: 3606170

Clinical prediction guides

PRAME Expression Is a Useful Tool in the Diagnosis of Primary and Metastatic Dedifferentiated and Undifferentiated Melanoma.
Hornick JL, Plaza JA, Mentzel T, Gru AA, Brenn T
Am J Surg Pathol 2023 Dec 1;47(12):1390-1397. Epub 2023 Sep 19 doi: 10.1097/PAS.0000000000002125. PMID: 37727938
Comparison of Survival Outcomes With/Without Adjuvant Radiation Therapy in Desmoplastic Melanoma.
Lewis GD, Guzman AK, Haque W, McLellan BN, Teh BS
Dermatol Surg 2021 Oct 1;47(10):1333-1336. doi: 10.1097/DSS.0000000000003177. PMID: 34537788
Desmoplastic Melanomas Mimicking Neurofibromas.
Gerami P, Kim D, Zhang B, Compres EV, Khan AU, Yazdan P, Guitart J, Busam K
Am J Dermatopathol 2020 Dec;42(12):916-922. doi: 10.1097/DAD.0000000000001754. PMID: 32732692Free PMC Article
Desmoplastic Melanoma of the Head and Neck: Incidence and Survival, 1992-2013.
Khan F, Strohl A, Allen PD, Doerr TD
Otolaryngol Head Neck Surg 2017 Oct;157(4):648-656. Epub 2017 Aug 22 doi: 10.1177/0194599817725696. PMID: 28828926
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article

Recent systematic reviews

Local Recurrence Rates After Excision of Desmoplastic Melanoma: A Systematic Review and Meta-Analysis.
Ran NA, Veerabagu S, Miller CJ, Elenitsas R, Chu EY, Krausz AE
Dermatol Surg 2023 Apr 1;49(4):330-337. Epub 2023 Mar 1 doi: 10.1097/DSS.0000000000003699. PMID: 36857167
Sentinel lymph node biopsy in desmoplastic melanoma - the percent desmoplastic component matters: A systematic review.
Hodson M, Feustel P, Davis L
J Plast Reconstr Aesthet Surg 2022 Dec;75(12):4441-4449. Epub 2022 Aug 28 doi: 10.1016/j.bjps.2022.08.044. PMID: 36283925
Clinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma: A Systematic Review.
Pampena R, Lai M, Lombardi M, Mirra M, Raucci M, Lallas A, Apalla Z, Argenziano G, Pellacani G, Longo C
JAMA Dermatol 2020 Apr 1;156(4):430-439. doi: 10.1001/jamadermatol.2019.4912. PMID: 32101255
Is sentinel lymph node biopsy warranted for desmoplastic melanoma? A systematic review.
Dunne JA, Wormald JC, Steele J, Woods E, Odili J, Powell BW
J Plast Reconstr Aesthet Surg 2017 Feb;70(2):274-280. Epub 2016 Nov 16 doi: 10.1016/j.bjps.2016.11.003. PMID: 28017261
Rare presentations of primary melanoma and special populations: a systematic review.
Kottschade LA, Grotz TE, Dronca RS, Salomao DR, Pulido JS, Wasif N, Jakub JW, Bagaria SP, Kumar R, Kaur JS, Morita SY, Moran SL, Nguyen JT, Nguyen EC, Hand JL, Erickson LA, Brewer JD, Baum CL, Miller RC, Swanson DL, Lowe V, Markovic SN
Am J Clin Oncol 2014 Dec;37(6):635-41. doi: 10.1097/COC.0b013e3182868e82. PMID: 23563206Free PMC Article

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