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Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome

MedGen UID:
231352
•Concept ID:
C1332153
•
Neoplastic Process
Synonyms: Acute Myeloid Leukemia with Multilineage Dysplasia following Myelodysplastic Syndrome; AML/MDS

Definition

An acute myeloid leukemia developing in patients with a prior history of myelodysplastic syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome

Professional guidelines

PubMed

Therapy-related myeloid neoplasms after treatment for ovarian cancer: A retrospective single-center case series.
Matsuoka A, Tate S, Nishikimi K, Otsuka S, Usui H, Tajima S, Habu Y, Nakamura N, Okuya R, Katayama E, Shozu M, Inaba Y, Koga K
J Obstet Gynaecol Res 2024 Jul;50(7):1148-1154. Epub 2024 Apr 17 doi: 10.1111/jog.15954. PMID: 38634254
Practical considerations for diagnosis and management of patients and carriers.
Niemeyer CM, Mecucci C
Semin Hematol 2017 Apr;54(2):69-74. Epub 2017 Apr 6 doi: 10.1053/j.seminhematol.2017.04.002. PMID: 28637619

Recent clinical studies

Etiology

Practical considerations for diagnosis and management of patients and carriers.
Niemeyer CM, Mecucci C
Semin Hematol 2017 Apr;54(2):69-74. Epub 2017 Apr 6 doi: 10.1053/j.seminhematol.2017.04.002. PMID: 28637619
Cytogenetics in benzene-associated myelodysplastic syndromes and acute myeloid leukemia: new insights into a disease continuum.
Irons RD, Kerzic PJ
Ann N Y Acad Sci 2014 Mar;1310:84-8. Epub 2014 Feb 12 doi: 10.1111/nyas.12336. PMID: 24611724
Myelodysplastic syndromes arising in patients with germline TP53 mutation and Li-Fraumeni syndrome.
Talwalkar SS, Yin CC, Naeem RC, Hicks MJ, Strong LC, Abruzzo LV
Arch Pathol Lab Med 2010 Jul;134(7):1010-5. doi: 10.5858/2009-0015-OA.1. PMID: 20586629
Secondary acute myeloid leukemia - a single center experience.
Szotkowski T, Rohon P, Zapletalova L, Sicova K, Hubacek J, Indrak K
Neoplasma 2010;57(2):170-8. doi: 10.4149/neo_2010_02_170. PMID: 20099982
Is secondary leukemia an independent poor prognostic factor in acute myeloid leukemia?
Larson RA
Best Pract Res Clin Haematol 2007 Mar;20(1):29-37. doi: 10.1016/j.beha.2006.10.006. PMID: 17336252

Diagnosis

Bone marrow morphological features and therapy in patients with Philadelphia-negative neoplasms.
Pich A, Beggiato E, Godio L, Riera L, Francia di Celle P, Lanzarone G, Benevolo G
Expert Rev Hematol 2021 Sep;14(9):841-850. Epub 2021 Aug 20 doi: 10.1080/17474086.2021.1967138. PMID: 34384330
Practical considerations for diagnosis and management of patients and carriers.
Niemeyer CM, Mecucci C
Semin Hematol 2017 Apr;54(2):69-74. Epub 2017 Apr 6 doi: 10.1053/j.seminhematol.2017.04.002. PMID: 28637619
Myelodysplastic syndromes arising in patients with germline TP53 mutation and Li-Fraumeni syndrome.
Talwalkar SS, Yin CC, Naeem RC, Hicks MJ, Strong LC, Abruzzo LV
Arch Pathol Lab Med 2010 Jul;134(7):1010-5. doi: 10.5858/2009-0015-OA.1. PMID: 20586629
Secondary acute myeloid leukemia - a single center experience.
Szotkowski T, Rohon P, Zapletalova L, Sicova K, Hubacek J, Indrak K
Neoplasma 2010;57(2):170-8. doi: 10.4149/neo_2010_02_170. PMID: 20099982
Is secondary leukemia an independent poor prognostic factor in acute myeloid leukemia?
Larson RA
Best Pract Res Clin Haematol 2007 Mar;20(1):29-37. doi: 10.1016/j.beha.2006.10.006. PMID: 17336252

Therapy

Therapy-related myeloid neoplasms after treatment for ovarian cancer: A retrospective single-center case series.
Matsuoka A, Tate S, Nishikimi K, Otsuka S, Usui H, Tajima S, Habu Y, Nakamura N, Okuya R, Katayama E, Shozu M, Inaba Y, Koga K
J Obstet Gynaecol Res 2024 Jul;50(7):1148-1154. Epub 2024 Apr 17 doi: 10.1111/jog.15954. PMID: 38634254
Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial.
Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT
Lancet Haematol 2020 Feb;7(2):e122-e133. Epub 2019 Dec 11 doi: 10.1016/S2352-3026(19)30203-0. PMID: 31837959Free PMC Article
Phase II pilot study of oral dasatinib in patients with higher-risk myelodysplastic syndrome (MDS) who failed conventional therapy.
Duong VH, Jaglal MV, Zhang L, Kale V, Lancet JE, Komrokji RS, List AF
Leuk Res 2013 Mar;37(3):300-4. Epub 2012 Dec 27 doi: 10.1016/j.leukres.2012.11.001. PMID: 23273539
Secondary acute myeloid leukemia - a single center experience.
Szotkowski T, Rohon P, Zapletalova L, Sicova K, Hubacek J, Indrak K
Neoplasma 2010;57(2):170-8. doi: 10.4149/neo_2010_02_170. PMID: 20099982
Chemotherapy of secondary leukemias.
Visani G, Pagano L, Pulsoni A, Tosi P, Piccaluga PP, Pastano R, Grafone T, Malagola M, Isidori A, Tura S
Leuk Lymphoma 2000 May;37(5-6):543-9. doi: 10.3109/10428190009058506. PMID: 11042514

Prognosis

Myelodysplastic syndromes arising in patients with germline TP53 mutation and Li-Fraumeni syndrome.
Talwalkar SS, Yin CC, Naeem RC, Hicks MJ, Strong LC, Abruzzo LV
Arch Pathol Lab Med 2010 Jul;134(7):1010-5. doi: 10.5858/2009-0015-OA.1. PMID: 20586629
Secondary acute myeloid leukemia - a single center experience.
Szotkowski T, Rohon P, Zapletalova L, Sicova K, Hubacek J, Indrak K
Neoplasma 2010;57(2):170-8. doi: 10.4149/neo_2010_02_170. PMID: 20099982
Is secondary leukemia an independent poor prognostic factor in acute myeloid leukemia?
Larson RA
Best Pract Res Clin Haematol 2007 Mar;20(1):29-37. doi: 10.1016/j.beha.2006.10.006. PMID: 17336252
Implications of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome (MDS): future molecular therapeutic directions for MDS.
Harada H, Harada Y, Kimura A
Curr Cancer Drug Targets 2006 Sep;6(6):553-65. doi: 10.2174/156800906778194595. PMID: 17017876
Chemotherapy of secondary leukemias.
Visani G, Pagano L, Pulsoni A, Tosi P, Piccaluga PP, Pastano R, Grafone T, Malagola M, Isidori A, Tura S
Leuk Lymphoma 2000 May;37(5-6):543-9. doi: 10.3109/10428190009058506. PMID: 11042514

Clinical prediction guides

Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial.
Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT
Lancet Haematol 2020 Feb;7(2):e122-e133. Epub 2019 Dec 11 doi: 10.1016/S2352-3026(19)30203-0. PMID: 31837959Free PMC Article
Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis.
Campos L, Guyotat D, Archimbaud E, Calmard-Oriol P, Tsuruo T, Troncy J, Treille D, Fiere D
Blood 1992 Jan 15;79(2):473-6. PMID: 1370388

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