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Aspirin-induced asthma

MedGen UID:
230819
•Concept ID:
C1319853
•
Disease or Syndrome; Finding
Synonyms: Aspirin Induced Asthma; Aspirin Induced Asthma Syndrome; Aspirin Induced Asthmas; Aspirin-Induced Asthma; Aspirin-Induced Asthma Syndrome; Aspirin-Induced Asthma Syndromes; Aspirin-Induced Asthmas; Asthma Syndrome, Aspirin-Induced; Asthma Syndromes, Aspirin-Induced; Asthma, Aspirin Induced; Asthma, Aspirin-Induced; Asthma, NSAID induced; Asthma, NSAID-induced; Asthmas, Aspirin Induced; Asthmas, Aspirin-Induced; Asthmas, NSAID-induced; Induced Asthma, Aspirin; Induced Asthmas, Aspirin; NSAID-induced Asthma; NSAID-induced Asthmas; Syndrome, Aspirin-Induced Asthma; Syndromes, Aspirin-Induced Asthma
SNOMED CT: Aspirin-induced asthma (407674008)
 
HPO: HP:0012042

Definition

A type of asthma in which aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygen-ase 1 (COX-1) exacerbate bronchoconstriction. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAspirin-induced asthma

Conditions with this feature

Asthma, nasal polyps, and aspirin intolerance
MedGen UID:
347198
•Concept ID:
C1859648
•
Disease or Syndrome
See: Condition Record
Asthma, nasal polyps, and aspirin intolerance

Professional guidelines

PubMed

Current complications and treatment of aspirin-exacerbated respiratory disease.
Cook KA, Stevenson DD
Expert Rev Respir Med 2016 Dec;10(12):1305-1316. Epub 2016 Nov 17 doi: 10.1080/17476348.2016.1258306. PMID: 27817219
The mechanisms of aspirin-intolerant asthma and its management.
McGeehan M, Bush RK
Curr Allergy Asthma Rep 2002 Mar;2(2):117-25. doi: 10.1007/s11882-002-0006-1. PMID: 11892091
Aspirin-induced asthma: advances in pathogenesis and management.
Szczeklik A, Stevenson DD
J Allergy Clin Immunol 1999 Jul;104(1):5-13. doi: 10.1016/s0091-6749(99)70106-5. PMID: 10400832

Recent clinical studies

Etiology

Recent Updates in Understanding NSAID Hypersensitivity.
Minaldi E, Cahill K
Curr Allergy Asthma Rep 2023 Mar;23(3):181-188. Epub 2023 Feb 9 doi: 10.1007/s11882-023-01064-3. PMID: 36757490
Mepolizumab for chronic rhinosinusitis with nasal polyps: Treatment efficacy by comorbidity and blood eosinophil count.
Bachert C, Sousa AR, Han JK, Schlosser RJ, Sowerby LJ, Hopkins C, Maspero JF, Smith SG, Kante O, Karidi-Andrioti DE, Mayer B, Chan RH, Yancey SW, Chaker AM
J Allergy Clin Immunol 2022 May;149(5):1711-1721.e6. Epub 2022 Jan 7 doi: 10.1016/j.jaci.2021.10.040. PMID: 35007624
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease.
Buchheit KM, Lewis E, Gakpo D, Hacker J, Sohail A, Taliaferro F, Berreondo Giron E, Asare C, Vukovic M, Bensko JC, Dwyer DF, Shalek AK, Ordovas-Montanes J, Laidlaw TM
J Allergy Clin Immunol 2021 Aug;148(2):574-584. Epub 2021 Jun 16 doi: 10.1016/j.jaci.2021.05.043. PMID: 34144111Free PMC Article
The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspirin-exacerbated respiratory disease: A Work Group Report from the Rhinitis, Rhinosinusitis and Ocular Allergy Committee of the American Academy of Allergy, Asthma & Immunology.
Stevens WW, Jerschow E, Baptist AP, Borish L, Bosso JV, Buchheit KM, Cahill KN, Campo P, Cho SH, Keswani A, Levy JM, Nanda A, Laidlaw TM, White AA
J Allergy Clin Immunol 2021 Mar;147(3):827-844. Epub 2020 Dec 9 doi: 10.1016/j.jaci.2020.10.043. PMID: 33307116Free PMC Article
Analgesics.
Szczeklik A
Chem Immunol Allergy 2010;95:170-179. Epub 2010 Jun 1 doi: 10.1159/000315950. PMID: 20519889

Diagnosis

Recent Updates in Understanding NSAID Hypersensitivity.
Minaldi E, Cahill K
Curr Allergy Asthma Rep 2023 Mar;23(3):181-188. Epub 2023 Feb 9 doi: 10.1007/s11882-023-01064-3. PMID: 36757490
The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspirin-exacerbated respiratory disease: A Work Group Report from the Rhinitis, Rhinosinusitis and Ocular Allergy Committee of the American Academy of Allergy, Asthma & Immunology.
Stevens WW, Jerschow E, Baptist AP, Borish L, Bosso JV, Buchheit KM, Cahill KN, Campo P, Cho SH, Keswani A, Levy JM, Nanda A, Laidlaw TM, White AA
J Allergy Clin Immunol 2021 Mar;147(3):827-844. Epub 2020 Dec 9 doi: 10.1016/j.jaci.2020.10.043. PMID: 33307116Free PMC Article
Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes.
Gans MD, Gavrilova T
Paediatr Respir Rev 2020 Nov;36:118-127. Epub 2019 Oct 9 doi: 10.1016/j.prrv.2019.08.002. PMID: 31678040
Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper.
Kowalski ML, Agache I, Bavbek S, Bakirtas A, Blanca M, Bochenek G, Bonini M, Heffler E, Klimek L, Laidlaw TM, Mullol J, Niżankowska-Mogilnicka E, Park HS, Sanak M, Sanchez-Borges M, Sanchez-Garcia S, Scadding G, Taniguchi M, Torres MJ, White AA, Wardzyńska A
Allergy 2019 Jan;74(1):28-39. Epub 2018 Oct 2 doi: 10.1111/all.13599. PMID: 30216468
Aspirin-Exacerbated Respiratory Disease.
Walgama ES, Hwang PH
Otolaryngol Clin North Am 2017 Feb;50(1):83-94. doi: 10.1016/j.otc.2016.08.007. PMID: 27888917

Therapy

Mepolizumab for chronic rhinosinusitis with nasal polyps: Treatment efficacy by comorbidity and blood eosinophil count.
Bachert C, Sousa AR, Han JK, Schlosser RJ, Sowerby LJ, Hopkins C, Maspero JF, Smith SG, Kante O, Karidi-Andrioti DE, Mayer B, Chan RH, Yancey SW, Chaker AM
J Allergy Clin Immunol 2022 May;149(5):1711-1721.e6. Epub 2022 Jan 7 doi: 10.1016/j.jaci.2021.10.040. PMID: 35007624
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease.
Buchheit KM, Lewis E, Gakpo D, Hacker J, Sohail A, Taliaferro F, Berreondo Giron E, Asare C, Vukovic M, Bensko JC, Dwyer DF, Shalek AK, Ordovas-Montanes J, Laidlaw TM
J Allergy Clin Immunol 2021 Aug;148(2):574-584. Epub 2021 Jun 16 doi: 10.1016/j.jaci.2021.05.043. PMID: 34144111Free PMC Article
The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspirin-exacerbated respiratory disease: A Work Group Report from the Rhinitis, Rhinosinusitis and Ocular Allergy Committee of the American Academy of Allergy, Asthma & Immunology.
Stevens WW, Jerschow E, Baptist AP, Borish L, Bosso JV, Buchheit KM, Cahill KN, Campo P, Cho SH, Keswani A, Levy JM, Nanda A, Laidlaw TM, White AA
J Allergy Clin Immunol 2021 Mar;147(3):827-844. Epub 2020 Dec 9 doi: 10.1016/j.jaci.2020.10.043. PMID: 33307116Free PMC Article
Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper.
Kowalski ML, Agache I, Bavbek S, Bakirtas A, Blanca M, Bochenek G, Bonini M, Heffler E, Klimek L, Laidlaw TM, Mullol J, Niżankowska-Mogilnicka E, Park HS, Sanak M, Sanchez-Borges M, Sanchez-Garcia S, Scadding G, Taniguchi M, Torres MJ, White AA, Wardzyńska A
Allergy 2019 Jan;74(1):28-39. Epub 2018 Oct 2 doi: 10.1111/all.13599. PMID: 30216468
Aspirin-Exacerbated Respiratory Disease.
Walgama ES, Hwang PH
Otolaryngol Clin North Am 2017 Feb;50(1):83-94. doi: 10.1016/j.otc.2016.08.007. PMID: 27888917

Prognosis

Asthma pharmacotherapy: an update on leukotriene treatments.
Trinh HKT, Lee SH, Cao TBT, Park HS
Expert Rev Respir Med 2019 Dec;13(12):1169-1178. Epub 2019 Sep 26 doi: 10.1080/17476348.2019.1670640. PMID: 31544544
Heterogeneity of NSAID-Exacerbated Respiratory Disease: has the time come for subphenotyping?
Kowalski ML
Curr Opin Pulm Med 2019 Jan;25(1):64-70. doi: 10.1097/MCP.0000000000000530. PMID: 30489335
Potential Biomarkers for NSAID-Exacerbated Respiratory Disease.
Park H, Choi Y, Jung CG, Park HS
Mediators Inflamm 2017;2017:8160148. Epub 2017 Aug 9 doi: 10.1155/2017/8160148. PMID: 28852271Free PMC Article
Aspirin desensitization in patients with aspirin-induced and aspirin-tolerant asthma: a double-blind study.
Świerczyńska-Krępa M, Sanak M, Bochenek G, Stręk P, Ćmiel A, Gielicz A, Plutecka H, Szczeklik A, Niżankowska-Mogilnicka E
J Allergy Clin Immunol 2014 Oct;134(4):883-90. Epub 2014 Apr 24 doi: 10.1016/j.jaci.2014.02.041. PMID: 24767875
Aspirin-intolerant asthma (AIA) assessment using the urinary biomarkers, leukotriene E4 (LTE4) and prostaglandin D2 (PGD2) metabolites.
Higashi N, Taniguchi M, Mita H, Yamaguchi H, Ono E, Akiyama K
Allergol Int 2012 Sep;61(3):393-403. Epub 2012 May 25 doi: 10.2332/allergolint.11-RA-0403. PMID: 22627848

Clinical prediction guides

Mepolizumab for chronic rhinosinusitis with nasal polyps: Treatment efficacy by comorbidity and blood eosinophil count.
Bachert C, Sousa AR, Han JK, Schlosser RJ, Sowerby LJ, Hopkins C, Maspero JF, Smith SG, Kante O, Karidi-Andrioti DE, Mayer B, Chan RH, Yancey SW, Chaker AM
J Allergy Clin Immunol 2022 May;149(5):1711-1721.e6. Epub 2022 Jan 7 doi: 10.1016/j.jaci.2021.10.040. PMID: 35007624
Asthma pharmacotherapy: an update on leukotriene treatments.
Trinh HKT, Lee SH, Cao TBT, Park HS
Expert Rev Respir Med 2019 Dec;13(12):1169-1178. Epub 2019 Sep 26 doi: 10.1080/17476348.2019.1670640. PMID: 31544544
Woakes' syndrome.
El Fakiri MM, Lakhdar Y, Raji A
BMJ Case Rep 2019 Mar 31;12(3) doi: 10.1136/bcr-2018-229021. PMID: 30936362Free PMC Article
Current complications and treatment of aspirin-exacerbated respiratory disease.
Cook KA, Stevenson DD
Expert Rev Respir Med 2016 Dec;10(12):1305-1316. Epub 2016 Nov 17 doi: 10.1080/17476348.2016.1258306. PMID: 27817219
Aspirin-sensitive asthma and upper airway diseases.
Chang JE, Chin W, Simon R
Am J Rhinol Allergy 2012 Jan-Feb;26(1):27-30. doi: 10.2500/ajra.2012.26.3721. PMID: 22391075Free PMC Article

Recent systematic reviews

Relationship Between Alcohol Intolerance and Aspirin-Exacerbated Respiratory Disease (AERD): Systematic Review.
Candelo E, McCalla M, Valderrama OA, Avila-Castano K, Chelf C, Olomu O, Donaldson AM
Otolaryngol Head Neck Surg 2023 Jul;169(1):12-20. Epub 2023 Jan 29 doi: 10.1002/ohn.248. PMID: 36939486
Management of United Airway Disease Focused on Patients With Asthma and Chronic Rhinosinusitis With Nasal Polyps: A Systematic Review.
Mullol J, Maldonado M, Castillo JA, Miguel-Blanco C, Dávila I, Domínguez-Ortega J, Blanco-Aparicio M
J Allergy Clin Immunol Pract 2022 Sep;10(9):2438-2447.e9. Epub 2022 May 12 doi: 10.1016/j.jaip.2022.04.039. PMID: 35568331
Meta-analysis Exploring Sinopulmonary Outcomes of Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease.
Chaaban MR, Moffatt D, Wright AE, Cowthran JA, Hsu ES, Kuo YF
Otolaryngol Head Neck Surg 2021 Jan;164(1):11-18. Epub 2020 Jun 23 doi: 10.1177/0194599820932137. PMID: 32571140
Aspirin desensitization therapy in aspirin-exacerbated respiratory disease: a systematic review.
Larivée N, Chin CJ
Int Forum Allergy Rhinol 2020 Apr;10(4):450-464. Epub 2020 Jan 16 doi: 10.1002/alr.22520. PMID: 31951112
Benefits and harms of aspirin desensitization for aspirin-exacerbated respiratory disease: a systematic review and meta-analysis.
Chu DK, Lee DJ, Lee KM, Schünemann HJ, Szczeklik W, Lee JM
Int Forum Allergy Rhinol 2019 Dec;9(12):1409-1419. Epub 2019 Sep 13 doi: 10.1002/alr.22428. PMID: 31518069

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