U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chronic lymphocytic leukemia/small lymphocytic lymphoma

MedGen UID:
224906
•Concept ID:
C1302547
•
Neoplastic Process
Synonyms: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma; chronic lymphocytic leukemia/small lymphocytic lymphoma; chronic lymphocytic leukemia/small lymphocytic lymphoma (morphologic abnormality); CLL/SLL
 
Monarch Initiative: MONDO:0003864

Definition

An indolent, mature B-cell neoplasm composed of small, round B-lymphocytes. When the bone marrow and peripheral blood are involved, the term chronic lymphocytic leukemia is used. The term small lymphocytic lymphoma is restricted to cases which do not show leukemic involvement of the bone marrow and peripheral blood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic lymphocytic leukemia/small lymphocytic lymphoma

Professional guidelines

PubMed

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Cortese M, Cripe L, Davis RS, Eradat H, Fakhri B, Fletcher CD, Gaballa S, Hamid MS, Hill B, Kaesberg P, Kahl B, Kamdar M, Kipps TJ, Ma S, Mosse C, Nakhoda S, Parikh S, Schorr A, Schuster S, Seshadri M, Siddiqi T, Stephens DM, Thompson M, Ujjani C, Valdez R, Wagner-Johnston N, Woyach JA, Sundar H, Dwyer M
J Natl Compr Canc Netw 2024 Apr;22(3):175-204. doi: 10.6004/jnccn.2024.0018. PMID: 38626800
Differential diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma and other indolent lymphomas, including mantle cell lymphoma.
Yoshino T, Tanaka T, Sato Y
J Clin Exp Hematop 2020 Dec 15;60(4):124-129. Epub 2020 Apr 3 doi: 10.3960/jslrt.19041. PMID: 32249238Free PMC Article
Management of chronic lymphocytic leukemia.
Stilgenbauer S, Furman RR, Zent CS
Am Soc Clin Oncol Educ Book 2015:164-75. doi: 10.14694/EdBook_AM.2015.35.164. PMID: 25993154

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Chronic Lymphocytic Leukemia/ Small Lymphocytic Lymphoma, 2023

Recent clinical studies

Etiology

MAJIC: a phase III trial of acalabrutinib + venetoclax versus venetoclax + obinutuzumab in previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma.
Ryan CE, Davids MS, Hermann R, Shahkarami M, Biondo J, Abhyankar S, Alhasani H, Sharman JP, Mato AR, Roeker LE
Future Oncol 2022 Oct;18(33):3689-3699. Epub 2022 Sep 14 doi: 10.2217/fon-2022-0456. PMID: 36102212
Ibrutinib Treatment for First-Line and Relapsed/Refractory Chronic Lymphocytic Leukemia: Final Analysis of the Pivotal Phase Ib/II PCYC-1102 Study.
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Ibrutinib for the treatment of chronic lymphocytic leukemia.
Deodato M, Frustaci AM, Zamprogna G, Cairoli R, Montillo M, Tedeschi A
Expert Rev Hematol 2019 May;12(5):273-284. Epub 2019 Apr 11 doi: 10.1080/17474086.2019.1597703. PMID: 30916599
Histologic transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma.
Agbay RL, Jain N, Loghavi S, Medeiros LJ, Khoury JD
Am J Hematol 2016 Oct;91(10):1036-43. Epub 2016 Aug 4 doi: 10.1002/ajh.24473. PMID: 27414262
Transformation in Low-grade B-cell Neoplasms.
Montgomery ND, Mathews SP
Surg Pathol Clin 2016 Mar;9(1):79-92. doi: 10.1016/j.path.2015.09.004. PMID: 26940269

Diagnosis

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Cortese M, Cripe L, Davis RS, Eradat H, Fakhri B, Fletcher CD, Gaballa S, Hamid MS, Hill B, Kaesberg P, Kahl B, Kamdar M, Kipps TJ, Ma S, Mosse C, Nakhoda S, Parikh S, Schorr A, Schuster S, Seshadri M, Siddiqi T, Stephens DM, Thompson M, Ujjani C, Valdez R, Wagner-Johnston N, Woyach JA, Sundar H, Dwyer M
J Natl Compr Canc Netw 2024 Apr;22(3):175-204. doi: 10.6004/jnccn.2024.0018. PMID: 38626800
NCCN Guidelines® Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 3.2022.
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Chanan-Khan AA, Coutre SE, Davis RS, Eradat H, Fletcher CD, Gaballa S, Ghobadi A, Hamid MS, Hernandez-Ilizaliturri F, Hill B, Kaesberg P, Kamdar M, Kaplan LD, Khan N, Kipps TJ, Ma S, Mato A, Mosse C, Schuster S, Siddiqi T, Stephens DM, Ujjani C, Wagner-Johnston N, Woyach JA, Ye JC, Dwyer MA, Sundar H
J Natl Compr Canc Netw 2022 Jun;20(6):622-634. doi: 10.6004/jnccn.2022.0031. PMID: 35714675
Differential diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma and other indolent lymphomas, including mantle cell lymphoma.
Yoshino T, Tanaka T, Sato Y
J Clin Exp Hematop 2020 Dec 15;60(4):124-129. Epub 2020 Apr 3 doi: 10.3960/jslrt.19041. PMID: 32249238Free PMC Article
Hepatic Lymphoma Diagnosis.
Choi WT, Gill RM
Surg Pathol Clin 2018 Jun;11(2):389-402. Epub 2018 Mar 21 doi: 10.1016/j.path.2018.02.003. PMID: 29751882
Transformation in Low-grade B-cell Neoplasms.
Montgomery ND, Mathews SP
Surg Pathol Clin 2016 Mar;9(1):79-92. doi: 10.1016/j.path.2015.09.004. PMID: 26940269

Therapy

MAJIC: a phase III trial of acalabrutinib + venetoclax versus venetoclax + obinutuzumab in previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma.
Ryan CE, Davids MS, Hermann R, Shahkarami M, Biondo J, Abhyankar S, Alhasani H, Sharman JP, Mato AR, Roeker LE
Future Oncol 2022 Oct;18(33):3689-3699. Epub 2022 Sep 14 doi: 10.2217/fon-2022-0456. PMID: 36102212
NCCN Guidelines® Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 3.2022.
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Chanan-Khan AA, Coutre SE, Davis RS, Eradat H, Fletcher CD, Gaballa S, Ghobadi A, Hamid MS, Hernandez-Ilizaliturri F, Hill B, Kaesberg P, Kamdar M, Kaplan LD, Khan N, Kipps TJ, Ma S, Mato A, Mosse C, Schuster S, Siddiqi T, Stephens DM, Ujjani C, Wagner-Johnston N, Woyach JA, Ye JC, Dwyer MA, Sundar H
J Natl Compr Canc Netw 2022 Jun;20(6):622-634. doi: 10.6004/jnccn.2022.0031. PMID: 35714675
Richter Syndrome.
Condoluci A, Rossi D
Curr Oncol Rep 2021 Feb 12;23(3):26. doi: 10.1007/s11912-020-01001-x. PMID: 33580422Free PMC Article
Ibrutinib Treatment for First-Line and Relapsed/Refractory Chronic Lymphocytic Leukemia: Final Analysis of the Pivotal Phase Ib/II PCYC-1102 Study.
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
ALPINE: zanubrutinib versus ibrutinib in relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma.
Hillmen P, Brown JR, Eichhorst BF, Lamanna N, O'Brien SM, Qiu L, Salmi T, Hilger J, Wu K, Cohen A, Huang J, Tam CS
Future Oncol 2020 Apr;16(10):517-523. Epub 2020 Mar 24 doi: 10.2217/fon-2019-0844. PMID: 32207333

Prognosis

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Cortese M, Cripe L, Davis RS, Eradat H, Fakhri B, Fletcher CD, Gaballa S, Hamid MS, Hill B, Kaesberg P, Kahl B, Kamdar M, Kipps TJ, Ma S, Mosse C, Nakhoda S, Parikh S, Schorr A, Schuster S, Seshadri M, Siddiqi T, Stephens DM, Thompson M, Ujjani C, Valdez R, Wagner-Johnston N, Woyach JA, Sundar H, Dwyer M
J Natl Compr Canc Netw 2024 Apr;22(3):175-204. doi: 10.6004/jnccn.2024.0018. PMID: 38626800
NCCN Guidelines® Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 3.2022.
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Chanan-Khan AA, Coutre SE, Davis RS, Eradat H, Fletcher CD, Gaballa S, Ghobadi A, Hamid MS, Hernandez-Ilizaliturri F, Hill B, Kaesberg P, Kamdar M, Kaplan LD, Khan N, Kipps TJ, Ma S, Mato A, Mosse C, Schuster S, Siddiqi T, Stephens DM, Ujjani C, Wagner-Johnston N, Woyach JA, Ye JC, Dwyer MA, Sundar H
J Natl Compr Canc Netw 2022 Jun;20(6):622-634. doi: 10.6004/jnccn.2022.0031. PMID: 35714675
Richter Syndrome.
Condoluci A, Rossi D
Curr Oncol Rep 2021 Feb 12;23(3):26. doi: 10.1007/s11912-020-01001-x. PMID: 33580422Free PMC Article
Ibrutinib Treatment for First-Line and Relapsed/Refractory Chronic Lymphocytic Leukemia: Final Analysis of the Pivotal Phase Ib/II PCYC-1102 Study.
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Histologic transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma.
Agbay RL, Jain N, Loghavi S, Medeiros LJ, Khoury JD
Am J Hematol 2016 Oct;91(10):1036-43. Epub 2016 Aug 4 doi: 10.1002/ajh.24473. PMID: 27414262

Clinical prediction guides

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Cortese M, Cripe L, Davis RS, Eradat H, Fakhri B, Fletcher CD, Gaballa S, Hamid MS, Hill B, Kaesberg P, Kahl B, Kamdar M, Kipps TJ, Ma S, Mosse C, Nakhoda S, Parikh S, Schorr A, Schuster S, Seshadri M, Siddiqi T, Stephens DM, Thompson M, Ujjani C, Valdez R, Wagner-Johnston N, Woyach JA, Sundar H, Dwyer M
J Natl Compr Canc Netw 2024 Apr;22(3):175-204. doi: 10.6004/jnccn.2024.0018. PMID: 38626800
NCCN Guidelines® Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 3.2022.
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Chanan-Khan AA, Coutre SE, Davis RS, Eradat H, Fletcher CD, Gaballa S, Ghobadi A, Hamid MS, Hernandez-Ilizaliturri F, Hill B, Kaesberg P, Kamdar M, Kaplan LD, Khan N, Kipps TJ, Ma S, Mato A, Mosse C, Schuster S, Siddiqi T, Stephens DM, Ujjani C, Wagner-Johnston N, Woyach JA, Ye JC, Dwyer MA, Sundar H
J Natl Compr Canc Netw 2022 Jun;20(6):622-634. doi: 10.6004/jnccn.2022.0031. PMID: 35714675
Ibrutinib Treatment for First-Line and Relapsed/Refractory Chronic Lymphocytic Leukemia: Final Analysis of the Pivotal Phase Ib/II PCYC-1102 Study.
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Histologic transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma.
Agbay RL, Jain N, Loghavi S, Medeiros LJ, Khoury JD
Am J Hematol 2016 Oct;91(10):1036-43. Epub 2016 Aug 4 doi: 10.1002/ajh.24473. PMID: 27414262
Management of chronic lymphocytic leukemia.
Stilgenbauer S, Furman RR, Zent CS
Am Soc Clin Oncol Educ Book 2015:164-75. doi: 10.14694/EdBook_AM.2015.35.164. PMID: 25993154

Recent systematic reviews

Efficacy and safety of new-generation Bruton tyrosine kinase inhibitors in chronic lymphocytic leukemia/small lymphocytic lymphoma: a systematic review and meta-analysis.
Yin S, Zheng X, Zhang W, Zhao H, Zhang R, Li W, Chen F
Ann Hematol 2024 Jul;103(7):2231-2244. Epub 2023 Oct 16 doi: 10.1007/s00277-023-05486-x. PMID: 37843620Free PMC Article
The relationship between physical activity and lymphoma: a systematic review and meta analysis.
Davies GA, Strader C, Chibbar R, Papatheodorou S, Dmytriw AA
BMC Cancer 2020 Oct 6;20(1):962. doi: 10.1186/s12885-020-07431-x. PMID: 33023529Free PMC Article
Anthropometric factors and non-Hodgkin's lymphoma risk: systematic review and meta-analysis of prospective studies.
Hidayat K, Li HJ, Shi BM
Crit Rev Oncol Hematol 2018 Sep;129:113-123. Epub 2018 Jun 6 doi: 10.1016/j.critrevonc.2018.05.018. PMID: 30097229
Chlorambucil for the treatment of patients with chronic lymphocytic leukemia (CLL) - a systematic review and meta-analysis of randomized trials.
Vidal L, Gurion R, Ram R, Raanani P, Bairey O, Robak T, Gafter-Gvili A, Shpilberg O
Leuk Lymphoma 2016 Sep;57(9):2047-57. Epub 2016 Mar 16 doi: 10.3109/10428194.2016.1154956. PMID: 26980554
Use of non-steroidal anti-inflammatory drugs and risk of non-Hodgkin lymphoma: a systematic review and meta-analysis.
Ye X, Casaclang N, Mahmud SM
Hematol Oncol 2015 Dec;33(4):176-86. Epub 2014 Oct 23 doi: 10.1002/hon.2165. PMID: 25345915

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Chronic Lymphocytic Leukemia/ Small Lymphocytic Lymphoma, 2023

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...