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Acute myeloid leukemia with t(8;21)(q22;q22) translocation

MedGen UID:
224862
•Concept ID:
C1292774
•
Neoplastic Process
Synonyms: Acute myeloid leukemia with RUNX1::RUNX1T1 fusion; Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1-RUNX1T1; Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1-RUNX1T1 Fusion; Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1::RUNX1T1; Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1::RUNX1T1 Fusion; Acute Myeloid Leukemia with t(8;21)(q22;q22); Acute myeloid leukemia with t(8;21)(q22;q22) RUNX1-RUNX1T1; acute myeloid leukemia with t(8;21)(q22;q22) translocation; Acute Myeloid Leukemia with t(8;21)(q22;q22)(AML1(CBFa)/ETO); Acute Myeloid Leukemia with t(8;21)(q22;q22); RUNX1-RUNX1T1; Acute myeloid leukemia, t(8;21) (q22;q22.1); Acute Myeloid Leukemia, t(8;21)(q22;q22); AML with t(8;21)(q22;q22) translocation
SNOMED CT: Acute myeloid leukemia with t(8;21)(q22;q22) RUNX1-RUNX1T1 (1148906001); Acute myeloid leukemia with RUNX1::RUNX1T1 fusion (128828000); Acute myeloid leukemia, t(8;21) (q22;q22.1) (128828000)
 
Monarch Initiative: MONDO:0015166

Definition

An acute myeloid leukemia with t(8;21)(q22; q22.1) giving rise to RUNX1/RUNX1T1 fusion transcript and showing maturation in the neutrophil lineage. The bone marrow and the peripheral blood show large myeloblasts with abundant basophilic cytoplasm, often containing azurophilic granules. This type of AML is associated with good response to chemotherapy and high complete remission rate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute myeloid leukemia with t(8;21)(q22;q22) translocation

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