U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Recurrent respiratory papillomatosis(RRP)

MedGen UID:
216998
•Concept ID:
C1168198
•
Neoplastic Process
Synonyms: Adult-onset recurrent respiratory papillomatosis (type); AORRP (type); JORRP (type); Juvenile laryngeal papilloma; Juvenile-onset recurrent respiratory papillomatosis (type); Laryngeal papilloma, recurrent; RRP
SNOMED CT: Recurrent respiratory papillomatosis (472827002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018955
Orphanet: ORPHA60032

Definition

Recurrent respiratory papillomatosis is a rare respiratory disease characterized by the development of exophytic papillomas, affecting the mucosa of the upper aero-digestive tract (with a strong predilection for the larynx), caused by an infection with human papilloma virus. Symptoms at presentation may include hoarseness, chronic cough, dyspnea, recurrent upper respiratory tract infections, pneumonia, dysphagia, stridor, and/or failure to thrive. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent respiratory papillomatosis
Follow this link to review classifications for Recurrent respiratory papillomatosis in Orphanet.

Professional guidelines

PubMed

CO(2) laser "Ablation Suction" technique for treatment of laryngeal recurrent respiratory papillomatosis.
Bowles PF, Liu A, Harries ML
Clin Otolaryngol 2019 Sep;44(5):884-885. Epub 2019 Jan 28 doi: 10.1111/coa.13278. PMID: 30615261
Diagnosis and management of recurrent respiratory papillomatosis.
Wilcox LJ, Hull BP, Baldassari CM, Derkay CS
Pediatr Infect Dis J 2014 Dec;33(12):1283-4. doi: 10.1097/INF.0000000000000551. PMID: 25229272
Treatment of recurrent respiratory papillomatosis.
Kavuru MS, Mehta AC
N Engl J Med 1992 Jan 16;326(3):204-5. PMID: 1727560

Recent clinical studies

Etiology

HPV-related diseases in male patients: an underestimated conundrum.
Garolla A, Graziani A, Grande G, Ortolani C, Ferlin A
J Endocrinol Invest 2024 Feb;47(2):261-274. Epub 2023 Sep 28 doi: 10.1007/s40618-023-02192-3. PMID: 37770654Free PMC Article
Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Manifestations of Human Papillomavirus in the Head and Neck.
Dable C, Nicolli E
Med Clin North Am 2021 Sep;105(5):849-858. doi: 10.1016/j.mcna.2021.05.007. PMID: 34391538
Biologics for the Treatment of Recurrent Respiratory Papillomatosis.
Allen CT
Otolaryngol Clin North Am 2021 Aug;54(4):769-777. Epub 2021 Jun 5 doi: 10.1016/j.otc.2021.05.002. PMID: 34099306Free PMC Article
Epidemiology and burden of HPV-related disease.
Serrano B, Brotons M, Bosch FX, Bruni L
Best Pract Res Clin Obstet Gynaecol 2018 Feb;47:14-26. Epub 2017 Sep 2 doi: 10.1016/j.bpobgyn.2017.08.006. PMID: 29037457

Diagnosis

Recurrent Respiratory Papillomatosis.
Frazier AA
Radiographics 2018 Nov-Dec;38(7):2150. doi: 10.1148/rg.2018184010. PMID: 30422770
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Diagnosis and management of recurrent respiratory papillomatosis.
Wilcox LJ, Hull BP, Baldassari CM, Derkay CS
Pediatr Infect Dis J 2014 Dec;33(12):1283-4. doi: 10.1097/INF.0000000000000551. PMID: 25229272
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Recurrent respiratory papillomatosis.
Tasca RA, Clarke RW
Arch Dis Child 2006 Aug;91(8):689-91. doi: 10.1136/adc.2005.090514. PMID: 16861486Free PMC Article

Therapy

HPV-related diseases in male patients: an underestimated conundrum.
Garolla A, Graziani A, Grande G, Ortolani C, Ferlin A
J Endocrinol Invest 2024 Feb;47(2):261-274. Epub 2023 Sep 28 doi: 10.1007/s40618-023-02192-3. PMID: 37770654Free PMC Article
Diagnosis and management of recurrent respiratory papillomatosis.
Wilcox LJ, Hull BP, Baldassari CM, Derkay CS
Pediatr Infect Dis J 2014 Dec;33(12):1283-4. doi: 10.1097/INF.0000000000000551. PMID: 25229272
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Recurrent respiratory papillomatosis.
Tasca RA, Clarke RW
Arch Dis Child 2006 Aug;91(8):689-91. doi: 10.1136/adc.2005.090514. PMID: 16861486Free PMC Article
Recurrent respiratory papillomatosis.
Derkay CS, Rimell FL, Thompson JW
Head Neck 1998 Aug;20(5):418-24. doi: 10.1002/(sici)1097-0347(199808)20:5<418::aid-hed10>3.0.co;2-c. PMID: 9663670

Prognosis

Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Systemic Bevacizumab Treatment for Recurrent Respiratory Papillomatosis: Long-Term Follow-Up.
Ruiz R, Balamuth N, Javia LR, Zur KB
Laryngoscope 2022 Oct;132(10):2071-2075. Epub 2022 Jan 19 doi: 10.1002/lary.30021. PMID: 35043981
Epidemiology and burden of HPV-related disease.
Serrano B, Brotons M, Bosch FX, Bruni L
Best Pract Res Clin Obstet Gynaecol 2018 Feb;47:14-26. Epub 2017 Sep 2 doi: 10.1016/j.bpobgyn.2017.08.006. PMID: 29037457
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article

Clinical prediction guides

HPV-related diseases in male patients: an underestimated conundrum.
Garolla A, Graziani A, Grande G, Ortolani C, Ferlin A
J Endocrinol Invest 2024 Feb;47(2):261-274. Epub 2023 Sep 28 doi: 10.1007/s40618-023-02192-3. PMID: 37770654Free PMC Article
Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Evone(®) Flow controlled ventilation: a new device for laryngotracheal surgery.
Filauro M, Mora F, Vallin A, Della Casa P, Arceri C, Gratarola A, Peretti G
Acta Otorhinolaryngol Ital 2022 Apr;42(2):189-193. doi: 10.14639/0392-100X-N1834. PMID: 35612512Free PMC Article
Prevalence of Epstein-Barr virus infection in recurrent respiratory papillomatosis and the influence on disease severity.
Chantre-Justino M, Figueiredo MC, Alves G, Ornellas MHF
Diagn Microbiol Infect Dis 2022 May;103(1):115655. Epub 2022 Feb 3 doi: 10.1016/j.diagmicrobio.2022.115655. PMID: 35228131
A Systematic Review.
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562

Recent systematic reviews

Intralesional cidofovir vs. bevacizumab for recurrent respiratory papillomatosis: a systematic review and indirect meta-analysis.
Zagzoog FH, Mogharbel AM, Alqutub A, Bukhari M, Almohizea MI
Eur Arch Otorhinolaryngol 2024 Feb;281(2):601-627. Epub 2023 Oct 13 doi: 10.1007/s00405-023-08279-0. PMID: 37831132
Recurrent Respiratory Papillomatosis Office versus Operating Room: Systematic Review and Meta-Analysis.
Chen S, Connors J, Zhang Y, Wang B, Vieira D, Shapira-Galitz Y, Garber D, Amin MR
Ann Otol Rhinol Laryngol 2021 Mar;130(3):234-244. Epub 2020 Aug 12 doi: 10.1177/0003489420949586. PMID: 32781827
A Systematic Review.
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562
The association between gastroesophageal reflux disease and recurrent respiratory papillomatosis: A systematic review.
San Giorgi MR, Helder HM, Lindeman RJ, de Bock GH, Dikkers FG
Laryngoscope 2016 Oct;126(10):2330-9. Epub 2016 Apr 26 doi: 10.1002/lary.25898. PMID: 27113025
Photodynamic therapy for recurrent respiratory papillomatosis.
Lieder A, Khan MK, Lippert BM
Cochrane Database Syst Rev 2014 Jun 5;2014(6):CD009810. doi: 10.1002/14651858.CD009810.pub2. PMID: 24898010Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...