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Thyroid Gland Oncocytic Neoplasm

MedGen UID:
215387
•Concept ID:
C0949541
•
Neoplastic Process
Synonyms: Huerthle Cell Tumor; Hurthle Cell Tumor
SNOMED CT: Hurthle cell adenoma (89439007); Hurthle cell tumor (89439007); Hurthle cell neoplasm (363639001)

Definition

An adenoma or carcinoma arising from the follicular cells of the thyroid gland. It is composed of large oncocytic cells with abundant granular eosinophilic cytoplasm. [from NCI]

Professional guidelines

PubMed

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms.
McFadden DG, Sadow PM
Front Endocrinol (Lausanne) 2021;12:696386. Epub 2021 Jun 10 doi: 10.3389/fendo.2021.696386. PMID: 34177816Free PMC Article
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Recent clinical studies

Etiology

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Do we need an updated classification of oncocytic renal tumors? : Emergence of low-grade oncocytic tumor (LOT) and eosinophilic vacuolated tumor (EVT) as novel renal entities.
Hes O, Trpkov K
Mod Pathol 2022 Sep;35(9):1140-1150. Epub 2022 Mar 10 doi: 10.1038/s41379-022-01057-z. PMID: 35273336
The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland.
Lubin D, Song S, Zafar HM, Baloch Z
Diagn Cytopathol 2019 Jun;47(6):617-636. Epub 2019 Mar 26 doi: 10.1002/dc.24175. PMID: 30912629
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Oncocytic tumours.
Tallini G
Virchows Arch 1998 Jul;433(1):5-12. doi: 10.1007/s004280050209. PMID: 9692819

Diagnosis

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms.
McFadden DG, Sadow PM
Front Endocrinol (Lausanne) 2021;12:696386. Epub 2021 Jun 10 doi: 10.3389/fendo.2021.696386. PMID: 34177816Free PMC Article
Renal Oncocytoma: An Algorithm for Diagnosis and Management.
Abdessater M, Kanbar A, Comperat E, Dupont-Athenor A, Alechinsky L, Mouton M, Sebe P
Urology 2020 Sep;143:173-180. Epub 2020 Jun 5 doi: 10.1016/j.urology.2020.05.047. PMID: 32512107
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Follicular thyroid cancer and Hürthle cell carcinoma: challenges in diagnosis, treatment, and clinical management.
Grani G, Lamartina L, Durante C, Filetti S, Cooper DS
Lancet Diabetes Endocrinol 2018 Jun;6(6):500-514. Epub 2017 Nov 5 doi: 10.1016/S2213-8587(17)30325-X. PMID: 29102432

Therapy

Clinical and Histopathological Risk Factors for Radioactive Iodine-Refractory Follicular and Oncocytic Thyroid Carcinoma.
Stegenga MT, van Velsen EFS, Oudijk L, Verburg FA, van Ginhoven TM, Peeters RP, Medici M, Visser WE, van Kemenade FJ
J Clin Endocrinol Metab 2024 Nov 18;109(12):e2334-e2341. doi: 10.1210/clinem/dgae084. PMID: 38349206Free PMC Article
Hürthle Cell Carcinoma of the Thyroid Gland: Systematic Review and Meta-analysis.
Coca-Pelaz A, Rodrigo JP, Shah JP, Sanabria A, Al Ghuzlan A, Silver CE, Shaha AR, Angelos P, Hartl DM, Mäkitie AA, Olsen KD, Owen RP, Randolph GW, Simó R, Tufano RP, Kowalski LP, Zafereo ME, Rinaldo A, Ferlito A
Adv Ther 2021 Oct;38(10):5144-5164. Epub 2021 Aug 22 doi: 10.1007/s12325-021-01876-7. PMID: 34423400
Optimizing therapy for radioactive iodine-refractory differentiated thyroid cancer: current state of the art and future directions.
Dadu R, Cabanillas ME
Minerva Endocrinol 2012 Dec;37(4):335-56. PMID: 23235190Free PMC Article
Poorly differentiated oncocytic thyroid carcinoma--diagnostic implications and outcome.
Dettmer M, Schmitt A, Steinert H, Moch H, Komminoth P, Perren A
Histopathology 2012 Jun;60(7):1045-51. Epub 2012 Feb 20 doi: 10.1111/j.1365-2559.2012.04188.x. PMID: 22348590
Hürthle cell carcinoma.
Yutan E, Clark OH
Curr Treat Options Oncol 2001 Aug;2(4):331-5. doi: 10.1007/s11864-001-0026-4. PMID: 12057113

Prognosis

Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Follicular thyroid cancer and Hürthle cell carcinoma: challenges in diagnosis, treatment, and clinical management.
Grani G, Lamartina L, Durante C, Filetti S, Cooper DS
Lancet Diabetes Endocrinol 2018 Jun;6(6):500-514. Epub 2017 Nov 5 doi: 10.1016/S2213-8587(17)30325-X. PMID: 29102432
Intraductal Oncocytic Papillary Neoplasms of the Pancreas.
Kallen ME, Naini BV
Arch Pathol Lab Med 2016 Sep;140(9):992-6. doi: 10.5858/arpa.2014-0595-RS. PMID: 27575268
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Clinical prediction guides

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Oncocytic lesions of the thyroid, kidney, salivary glands, adrenal cortex, and parathyroid glands.
Máximo V, Rios E, Sobrinho-Simões M
Int J Surg Pathol 2014 Feb;22(1):33-6. Epub 2014 Jan 9 doi: 10.1177/1066896913517938. PMID: 24406625
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Recent systematic reviews

Salivary Gland Oncocytomas. A Systematic Review.
Alberto PL, Ashim S, Megan K, Wei Z, Nestor G, Matthew Z, Dayana M, Marcelo V, John W
Head Neck Pathol 2024 Nov 30;18(1):126. doi: 10.1007/s12105-024-01730-6. PMID: 39614964Free PMC Article
Hürthle Cell Carcinoma of the Thyroid Gland: Systematic Review and Meta-analysis.
Coca-Pelaz A, Rodrigo JP, Shah JP, Sanabria A, Al Ghuzlan A, Silver CE, Shaha AR, Angelos P, Hartl DM, Mäkitie AA, Olsen KD, Owen RP, Randolph GW, Simó R, Tufano RP, Kowalski LP, Zafereo ME, Rinaldo A, Ferlito A
Adv Ther 2021 Oct;38(10):5144-5164. Epub 2021 Aug 22 doi: 10.1007/s12325-021-01876-7. PMID: 34423400
A systematic review of sinonasal oncocytomas and oncocytic carcinomas: Diagnosis, management, and technical considerations.
Hodzic Z, Rowan NR, Kashiwazaki R, Willson TJ, Wang EW, Lee SE
Int Forum Allergy Rhinol 2017 May;7(5):514-524. Epub 2017 Jan 16 doi: 10.1002/alr.21902. PMID: 28092140
Rare metastases of well-differentiated thyroid cancers: a systematic review.
Madani A, Jozaghi Y, Tabah R, How J, Mitmaker E
Ann Surg Oncol 2015 Feb;22(2):460-6. Epub 2014 Sep 6 doi: 10.1245/s10434-014-4058-y. PMID: 25192681
Adrenal oncocytic neoplasm: a systematic review.
Mearini L, Del Sordo R, Costantini E, Nunzi E, Porena M
Urol Int 2013;91(2):125-33. Epub 2012 Nov 8 doi: 10.1159/000345141. PMID: 23147196

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