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monoclonal gammopathy

MedGen UID:
210153
Concept ID:
C1136085
Neoplastic Process
Synonyms: Gammapathy, Monoclonal; Gammopathy, Monoclonal; Monoclonal Gammapathies; Monoclonal Gammapathy; Monoclonal Gammopathies; Monoclonal Gammopathy
SNOMED CT: Monoclonal gammopathy (clinical) (109983007); Monoclonal gammopathy (109983007); Monoclonal paraproteinemia (109983007); Monoclonal gammopathy (35601003)
 
Monarch Initiative: MONDO:0004960

Definition

An abnormal laboratory test result indicating the presence of monoclonal immunoglobulins in the blood or urine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVmonoclonal gammopathy

Professional guidelines

PubMed

Khwaja J, D'Sa S, Minnema MC, Kersten MJ, Wechalekar A, Vos JM
Haematologica 2022 Sep 1;107(9):2037-2050. doi: 10.3324/haematol.2022.280953. PMID: 35770530Free PMC Article
Padala SA, Barsouk A, Barsouk A, Rawla P, Vakiti A, Kolhe R, Kota V, Ajebo GH
Med Sci (Basel) 2021 Jan 20;9(1) doi: 10.3390/medsci9010003. PMID: 33498356Free PMC Article
Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D'Agati VD, Dispenzieri A, Fervenza FC, Fermand JP, Gibbs S, Gillmore JD, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle RA, Lachmann HJ, Larsen CP, Ludwig H, Markowitz GS, Merlini G, Mollee P, Picken MM, Rajkumar VS, Royal V, Sanders PW, Sethi S, Venner CP, Voorhees PM, Wechalekar AD, Weiss BM, Nasr SH
Nat Rev Nephrol 2019 Jan;15(1):45-59. doi: 10.1038/s41581-018-0077-4. PMID: 30510265Free PMC Article

Recent clinical studies

Etiology

Kaur J, Valisekka SS, Hameed M, Bandi PS, Varma S, Onwughalu CJ, Ibrahim H, Mongia H
Clin Lymphoma Myeloma Leuk 2023 May;23(5):e195-e212. Epub 2023 Feb 23 doi: 10.1016/j.clml.2023.02.004. PMID: 36966041
Gonsalves WI, Rajkumar SV
Ann Intern Med 2022 Dec;175(12):ITC177-ITC192. Epub 2022 Dec 13 doi: 10.7326/AITC202212200. PMID: 36508741
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Amaador K, Peeters H, Minnema MC, Nguyen TQ, Dendooven A, Vos JMI, Croockewit AJ, van de Donk NWCJ, Jacobs JFM, Wetzels JFM, Sprangers B, Abrahams AC
Neth J Med 2019 Sep;77(7):243-254. PMID: 31582582
Mouhieddine TH, Weeks LD, Ghobrial IM
Blood 2019 Jun 6;133(23):2484-2494. Epub 2019 Apr 22 doi: 10.1182/blood.2019846782. PMID: 31010848

Diagnosis

Kaur J, Valisekka SS, Hameed M, Bandi PS, Varma S, Onwughalu CJ, Ibrahim H, Mongia H
Clin Lymphoma Myeloma Leuk 2023 May;23(5):e195-e212. Epub 2023 Feb 23 doi: 10.1016/j.clml.2023.02.004. PMID: 36966041
Gonsalves WI, Rajkumar SV
Ann Intern Med 2022 Dec;175(12):ITC177-ITC192. Epub 2022 Dec 13 doi: 10.7326/AITC202212200. PMID: 36508741
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Amaador K, Peeters H, Minnema MC, Nguyen TQ, Dendooven A, Vos JMI, Croockewit AJ, van de Donk NWCJ, Jacobs JFM, Wetzels JFM, Sprangers B, Abrahams AC
Neth J Med 2019 Sep;77(7):243-254. PMID: 31582582
O'Connell TX, Horita TJ, Kasravi B
Am Fam Physician 2005 Jan 1;71(1):105-12. PMID: 15663032

Therapy

Kapoor P, Rajkumar SV
Blood Rev 2023 Nov;62:101129. Epub 2023 Aug 26 doi: 10.1016/j.blre.2023.101129. PMID: 37659912Free PMC Article
Gertz MA
Hematol Oncol Clin North Am 2022 Apr;36(2):341-352. Epub 2022 Mar 11 doi: 10.1016/j.hoc.2021.11.001. PMID: 35282954Free PMC Article
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article
Kazandjian D
Semin Oncol 2016 Dec;43(6):676-681. Epub 2016 Nov 10 doi: 10.1053/j.seminoncol.2016.11.004. PMID: 28061985Free PMC Article

Prognosis

Gozzetti A, Guarnieri A, Zamagni E, Zakharova E, Coriu D, Bittrich M, Pika T, Tovar N, Schutz N, Ciofini S, Peña C, Rocchi S, Rassner M, Avivi I, Waszczuk-Gajda A, Chhabra S, Usnarska-Zubkiewicz L, González-Calle V, Mateos MV, Bocchia M, Bigi F, Füllgraf H, Bhasin-Chhabra B, Gentile M, Davila J, Vesole DH, Cavo M, Thapa B, Crusoe E, Einsele H, Legiec W, Charliński G, Jurczyszyn A
Am J Hematol 2022 Jul;97(7):877-884. Epub 2022 Apr 20 doi: 10.1002/ajh.26566. PMID: 35389534Free PMC Article
Gertz MA
Blood Cancer J 2018 May 1;8(4):40. doi: 10.1038/s41408-018-0076-5. PMID: 29712895Free PMC Article
Jachiet M, Harel S, Saussine A, Battistella M, Rybojad M, Asli B, Bengoufa D, Mahevas T, Bessis D, Galicier L, Schmutz JL, Hadj-Rabia S, Boutboul D, Lebbé C, Bagot M, Malphettes M, Lipsker D, Fermand JP, Bouaziz JD, Arnulf B; Study Group of Systemic Diseases in Dermatology (Étude des Maladies Systémiques en Dermatologie); Groupe d'Etude des Dermatoses Associées à une Immunoglobuline Monoclonale
J Am Acad Dermatol 2018 Nov;79(5):945-947. Epub 2018 Apr 3 doi: 10.1016/j.jaad.2018.03.039. PMID: 29621555
Kyle RA, Larson DR, Therneau TM, Dispenzieri A, Kumar S, Cerhan JR, Rajkumar SV
N Engl J Med 2018 Jan 18;378(3):241-249. doi: 10.1056/NEJMoa1709974. PMID: 29342381Free PMC Article
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797

Clinical prediction guides

Rajkumar SV, Kumar S, Lonial S, Mateos MV
Blood Cancer J 2022 Sep 5;12(9):129. doi: 10.1038/s41408-022-00719-0. PMID: 36064707Free PMC Article
Fermand JP, Bridoux F, Dispenzieri A, Jaccard A, Kyle RA, Leung N, Merlini G
Blood 2018 Oct 4;132(14):1478-1485. Epub 2018 Jul 16 doi: 10.1182/blood-2018-04-839480. PMID: 30012636
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
O'Connell TX, Horita TJ, Kasravi B
Am Fam Physician 2005 Jan 1;71(1):105-12. PMID: 15663032

Recent systematic reviews

Du J, Hu Z
BMC Nephrol 2024 Jan 16;25(1):22. doi: 10.1186/s12882-024-03458-5. PMID: 38229028Free PMC Article
Cárdenas MC, García-Sanz R, Puig N, Pérez-Surribas D, Flores-Montero J, Ortiz-Espejo M, de la Rubia J, Cruz-Iglesias E
Clin Chem Lab Med 2023 Nov 27;61(12):2115-2130. Epub 2023 Jul 24 doi: 10.1515/cclm-2023-0326. PMID: 37477188
Gertz MA, Dispenzieri A
JAMA 2020 Jul 7;324(1):79-89. doi: 10.1001/jama.2020.5493. PMID: 32633805
Karmacharya P, Shahukhal R, Ogdie A
Rheum Dis Clin North Am 2020 Aug;46(3):463-511. Epub 2020 Jun 11 doi: 10.1016/j.rdc.2020.04.001. PMID: 32631600
Veronese N, Luchini C, Solmi M, Sergi G, Manzato E, Stubbs B
J Bone Miner Metab 2018 Jan;36(1):128-132. Epub 2017 Feb 27 doi: 10.1007/s00774-017-0817-8. PMID: 28243796

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