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Arteriolosclerosis

MedGen UID:: 209223
•Concept ID:: C0878486
•: Disease or Syndrome

Synonym:	Arterioloscleroses
SNOMED CT:	Arteriolosclerosis (17941002)

Monarch Initiative:	MONDO:0006658

Definition

The thickening of the wall of the small arteries and arterioles. It is caused by deposition of hyaline material in the wall or concentric smooth muscle wall hypertrophy. It results in lumen narrowing and tissue ischemia. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVArteriolosclerosis

Abnormality of the cardiovascular system
- Abnormal cardiovascular system morphology
  - Abnormal vascular morphology
    - Abnormal blood vessel morphology
      - Abnormal systemic arterial morphology
        Arteriosclerosis disorder
        Arteriolosclerosis
        Hyaline Arteriolosclerosis
        Efferent Arteriolar Hyalinosis

Professional guidelines

PubMed

Cardiovascular Management in Asymptomatic (Silent) Cerebral Microbleeds and Suspected Cerebral Amyloid Angiopathy.

Charidimou A, Smith EE
Stroke 2024 Apr;55(4):1101-1112. Epub 2024 Mar 11 doi: 10.1161/STROKEAHA.123.044167. PMID: 38465605

The contribution of MRI in the differential diagnosis of posterior fossa damage.

Gass A, Filippi M, Grossman RI
J Neurol Sci 2000 Jan 15;172 Suppl 1:S43-9. doi: 10.1016/s0022-510x(99)00278-6. PMID: 10606806

The diagnosis and treatment of chronic occlusive disease of the peripheral arteries.

BARKER NW
Wis Med J 1950 Jun;49(6):470-4. PMID: 15431648

See all (9)

Recent clinical studies

Etiology

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease.

Inoue Y, Shue F, Bu G, Kanekiyo T
Mol Neurodegener 2023 Jul 11;18(1):46. doi: 10.1186/s13024-023-00640-5. PMID: 37434208 Free PMC Article

Cerebral small vessel disease: Recent advances and future directions.

Markus HS, de Leeuw FE
Int J Stroke 2023 Jan;18(1):4-14. doi: 10.1177/17474930221144911. PMID: 36575578 Free PMC Article

Vascular Cognitive Impairment and Dementia.

Chang Wong E, Chang Chui H
Continuum (Minneap Minn) 2022 Jun 1;28(3):750-780. doi: 10.1212/CON.0000000000001124. PMID: 35678401 Free PMC Article

Structural and Functional Changes in Human Kidneys with Healthy Aging.

Hommos MS, Glassock RJ, Rule AD
J Am Soc Nephrol 2017 Oct;28(10):2838-2844. Epub 2017 Aug 8 doi: 10.1681/ASN.2017040421. PMID: 28790143 Free PMC Article

Impact of multiple pathologies on the threshold for clinically overt dementia.

Kapasi A, DeCarli C, Schneider JA
Acta Neuropathol 2017 Aug;134(2):171-186. Epub 2017 May 9 doi: 10.1007/s00401-017-1717-7. PMID: 28488154 Free PMC Article

See all (263)

Diagnosis

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease.

Inoue Y, Shue F, Bu G, Kanekiyo T
Mol Neurodegener 2023 Jul 11;18(1):46. doi: 10.1186/s13024-023-00640-5. PMID: 37434208 Free PMC Article

Cerebral small vessel disease: Recent advances and future directions.

Markus HS, de Leeuw FE
Int J Stroke 2023 Jan;18(1):4-14. doi: 10.1177/17474930221144911. PMID: 36575578 Free PMC Article

Vascular Cognitive Impairment and Dementia.

Chang Wong E, Chang Chui H
Continuum (Minneap Minn) 2022 Jun 1;28(3):750-780. doi: 10.1212/CON.0000000000001124. PMID: 35678401 Free PMC Article

The pathology and pathophysiology of vascular dementia.

Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521

Impact of multiple pathologies on the threshold for clinically overt dementia.

Kapasi A, DeCarli C, Schneider JA
Acta Neuropathol 2017 Aug;134(2):171-186. Epub 2017 May 9 doi: 10.1007/s00401-017-1717-7. PMID: 28488154 Free PMC Article

See all (175)

Therapy

Cardiovascular Management in Asymptomatic (Silent) Cerebral Microbleeds and Suspected Cerebral Amyloid Angiopathy.

Charidimou A, Smith EE
Stroke 2024 Apr;55(4):1101-1112. Epub 2024 Mar 11 doi: 10.1161/STROKEAHA.123.044167. PMID: 38465605

Cerebral small vessel disease: Recent advances and future directions.

Markus HS, de Leeuw FE
Int J Stroke 2023 Jan;18(1):4-14. doi: 10.1177/17474930221144911. PMID: 36575578 Free PMC Article

Cerebral Small Vessel Disease.

Li Q, Yang Y, Reis C, Tao T, Li W, Li X, Zhang JH
Cell Transplant 2018 Dec;27(12):1711-1722. Epub 2018 Sep 25 doi: 10.1177/0963689718795148. PMID: 30251566 Free PMC Article

Asymptomatic Cerebrovascular Disease in Dialysis Patients.

Naganuma T, Takemoto Y
Contrib Nephrol 2018;196:22-26. Epub 2018 Jul 24 doi: 10.1159/000485692. PMID: 30041200

The immunological basis of degenerative diseases of the eye.

Nussenblatt RB, Liu B, Wei L, Sen HN
Int Rev Immunol 2013 Feb;32(1):97-112. doi: 10.3109/08830185.2012.740536. PMID: 23360161

See all (73)

Prognosis

Cerebral small vessel disease: neuroimaging markers and clinical implication.

Chen X, Wang J, Shan Y, Cai W, Liu S, Hu M, Liao S, Huang X, Zhang B, Wang Y, Lu Z
J Neurol 2019 Oct;266(10):2347-2362. Epub 2018 Oct 5 doi: 10.1007/s00415-018-9077-3. PMID: 30291424

Asymptomatic Cerebrovascular Disease in Dialysis Patients.

Naganuma T, Takemoto Y
Contrib Nephrol 2018;196:22-26. Epub 2018 Jul 24 doi: 10.1159/000485692. PMID: 30041200

The pathology and pathophysiology of vascular dementia.

Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521

Impact of multiple pathologies on the threshold for clinically overt dementia.

Kapasi A, DeCarli C, Schneider JA
Acta Neuropathol 2017 Aug;134(2):171-186. Epub 2017 May 9 doi: 10.1007/s00401-017-1717-7. PMID: 28488154 Free PMC Article

Arteriosclerosis: facts and fancy.

Fishbein MC, Fishbein GA
Cardiovasc Pathol 2015 Nov-Dec;24(6):335-42. Epub 2015 Aug 5 doi: 10.1016/j.carpath.2015.07.007. PMID: 26365806

See all (143)

Clinical prediction guides

Brain arteriolosclerosis.

Blevins BL, Vinters HV, Love S, Wilcock DM, Grinberg LT, Schneider JA, Kalaria RN, Katsumata Y, Gold BT, Wang DJJ, Ma SJ, Shade LMP, Fardo DW, Hartz AMS, Jicha GA, Nelson KB, Magaki SD, Schmitt FA, Teylan MA, Ighodaro ET, Phe P, Abner EL, Cykowski MD, Van Eldik LJ, Nelson PT
Acta Neuropathol 2021 Jan;141(1):1-24. Epub 2020 Oct 24 doi: 10.1007/s00401-020-02235-6. PMID: 33098484 Free PMC Article

Epidemiology of Vascular Dementia.

Wolters FJ, Ikram MA
Arterioscler Thromb Vasc Biol 2019 Aug;39(8):1542-1549. Epub 2019 Jul 11 doi: 10.1161/ATVBAHA.119.311908. PMID: 31294622

Cerebral small vessel disease: neuroimaging markers and clinical implication.

Chen X, Wang J, Shan Y, Cai W, Liu S, Hu M, Liao S, Huang X, Zhang B, Wang Y, Lu Z
J Neurol 2019 Oct;266(10):2347-2362. Epub 2018 Oct 5 doi: 10.1007/s00415-018-9077-3. PMID: 30291424

The pathology and pathophysiology of vascular dementia.

Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521

Arteriosclerosis: facts and fancy.

Fishbein MC, Fishbein GA
Cardiovasc Pathol 2015 Nov-Dec;24(6):335-42. Epub 2015 Aug 5 doi: 10.1016/j.carpath.2015.07.007. PMID: 26365806

See all (191)

Recent systematic reviews

Pathological Changes of Small Vessel Disease in Intracerebral Hemorrhage: a Systematic Review and Meta-analysis.

Xu M, Zhu Y, Song X, Zhong X, Yu X, Wang D, Cheng Y, Tao W, Wu B, Liu M
Transl Stroke Res 2024 Jun;15(3):533-544. Epub 2023 Jun 6 doi: 10.1007/s12975-023-01154-4. PMID: 37280502 Free PMC Article

See all (1)

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Arteriolosclerosis

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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