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Metastatic Chondrosarcoma

MedGen UID:
208940
•Concept ID:
C0855012
•
Neoplastic Process
Synonym: Chondrosarcoma, Metastatic

Definition

A chondrosarcoma that has spread to a secondary anatomical site. [from NCI]

Professional guidelines

PubMed

Molecular oncogenesis of chondrosarcoma: impact for targeted treatment.
Speetjens FM, de Jong Y, Gelderblom H, Bovée JV
Curr Opin Oncol 2016 Jul;28(4):314-22. doi: 10.1097/CCO.0000000000000300. PMID: 27166664
NYESO-1/LAGE-1s and PRAME are targets for antigen specific T cells in chondrosarcoma following treatment with 5-Aza-2-deoxycitabine.
Pollack SM, Li Y, Blaisdell MJ, Farrar EA, Chou J, Hoch BL, Loggers ET, Rodler E, Eary JF, Conrad EU 3rd, Jones RL, Yee C
PLoS One 2012;7(2):e32165. Epub 2012 Feb 27 doi: 10.1371/journal.pone.0032165. PMID: 22384167Free PMC Article
Total femur replacement procedures in tumor treatment.
Mankin HJ, Hornicek FJ, Harris M
Clin Orthop Relat Res 2005 Sep;438:60-4. doi: 10.1097/00003086-200509000-00012. PMID: 16131870

Recent clinical studies

Etiology

IMP3, CDK4, MDM2 and β-catenin expression in Enchondroma and Central Chondrosarcoma: Diagnostic and prognostic utility.
Losada DM, Etchebehere M, Cintra FF, Amstalden EMI
Clinics (Sao Paulo) 2024;79:100483. Epub 2024 Oct 4 doi: 10.1016/j.clinsp.2024.100483. PMID: 39368400Free PMC Article
Prognostic Factors and Surgical Impact of Non-metastatic Conventional Chondrosarcoma of the Extremities.
Wang W, Zhen J
Orthop Surg 2023 Dec;15(12):3288-3299. Epub 2023 Oct 24 doi: 10.1111/os.13916. PMID: 37875420Free PMC Article
Does primary tumor resection improve survival for patients with sarcomas of pelvic bones, sacrum, and coccyx who have metastasis at diagnosis ?
Hu X, Fujiwara T, Sun Y, Huang W, Yan W
Eur Spine J 2023 Dec;32(12):4362-4376. Epub 2023 Oct 23 doi: 10.1007/s00586-023-07985-x. PMID: 37870700
Multicentric chondrosarcomas.
Damron TA, Sim FH, Unni KK
Clin Orthop Relat Res 1996 Jul;(328):211-9. doi: 10.1097/00003086-199607000-00033. PMID: 8653959
Pulmonary metastatic chondrosarcoma with intracardiac extension.
Gardner MA, Bett JH, Stafford EG, Matar K
Ann Thorac Surg 1979 Mar;27(3):238-41. doi: 10.1016/s0003-4975(10)63282-1. PMID: 453987

Diagnosis

Electropermeabilization of metastatic chondrosarcoma cells from primary cell culture.
Michel O, Błasiak P, Saczko J, Kulbacka J, Drąg-Zalesińska M, Rzechonek A
Biotechnol Appl Biochem 2019 Nov;66(6):945-954. Epub 2019 Sep 18 doi: 10.1002/bab.1809. PMID: 31476023
Metastatic nasal chondrosarcoma.
Sathappan S, Razak HA, Loo CP
Med J Malaysia 2007 Oct;62(4):347-8. PMID: 18551946
Multicentric chondrosarcomas.
Damron TA, Sim FH, Unni KK
Clin Orthop Relat Res 1996 Jul;(328):211-9. doi: 10.1097/00003086-199607000-00033. PMID: 8653959
Metastatic chondrosarcoma of the gingiva mimicking a reactive exophytic lesion: a case report.
Taicher S, Mazar A, Hirshberg A, Dayan D
J Periodontol 1991 Mar;62(3):223-6. doi: 10.1902/jop.1991.62.3.223. PMID: 2027076
An unusual cutaneous metastasis of a chondrosarcoma.
Leal-Khouri SM, Barnhill RL, Baden HP
J Cutan Pathol 1990 Oct;17(5):274-7. doi: 10.1111/j.1600-0560.1990.tb00102.x. PMID: 2258476

Therapy

Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma.
Subbiah V, Chawla SP, Conley AP, Wilky BA, Tolcher A, Lakhani NJ, Berz D, Andrianov V, Crago W, Holcomb M, Hussain A, Veldstra C, Kalabus J, O'Neill B, Senne L, Rowell E, Heidt AB, Willis KM, Eckelman BP
Clin Cancer Res 2023 Aug 15;29(16):2988-3003. doi: 10.1158/1078-0432.CCR-23-0974. PMID: 37265425Free PMC Article
Efficacy and safety of regorafenib in patients with metastatic or locally advanced chondrosarcoma: Results of a non-comparative, randomised, double-blind, placebo controlled, multicentre phase II study.
Duffaud F, Italiano A, Bompas E, Rios M, Penel N, Mir O, Piperno-Neumann S, Chevreau C, Delcambre C, Bertucci F, Boudou-Rouquette P, Cancel M, Perrin C, Saada-Bouzid E, Monard L, Schiffler C, Chaigneau L, Hervieu A, Collard O, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Eur J Cancer 2021 Jun;150:108-118. Epub 2021 Apr 22 doi: 10.1016/j.ejca.2021.03.039. PMID: 33895682
Clinical benefit of antiangiogenic therapy in advanced and metastatic chondrosarcoma.
Jones RL, Katz D, Loggers ET, Davidson D, Rodler ET, Pollack SM
Med Oncol 2017 Aug 29;34(10):167. doi: 10.1007/s12032-017-1030-2. PMID: 28852958Free PMC Article
Molecular oncogenesis of chondrosarcoma: impact for targeted treatment.
Speetjens FM, de Jong Y, Gelderblom H, Bovée JV
Curr Opin Oncol 2016 Jul;28(4):314-22. doi: 10.1097/CCO.0000000000000300. PMID: 27166664
Biochemical and autoradiographic studies in a case of fulminant, metastatic chondrosarcoma unsuccessfully treated with 35S-sulfate.
Boström H, Friberg U, Larsson KS, Lohmander S, Nilsonne U, Wengle B
Acta Orthop Scand 1970;41(1):57-73. doi: 10.3109/17453677008991978. PMID: 4247715

Prognosis

Prognostic Factors and Surgical Impact of Non-metastatic Conventional Chondrosarcoma of the Extremities.
Wang W, Zhen J
Orthop Surg 2023 Dec;15(12):3288-3299. Epub 2023 Oct 24 doi: 10.1111/os.13916. PMID: 37875420Free PMC Article
Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma.
Subbiah V, Chawla SP, Conley AP, Wilky BA, Tolcher A, Lakhani NJ, Berz D, Andrianov V, Crago W, Holcomb M, Hussain A, Veldstra C, Kalabus J, O'Neill B, Senne L, Rowell E, Heidt AB, Willis KM, Eckelman BP
Clin Cancer Res 2023 Aug 15;29(16):2988-3003. doi: 10.1158/1078-0432.CCR-23-0974. PMID: 37265425Free PMC Article
Molecular oncogenesis of chondrosarcoma: impact for targeted treatment.
Speetjens FM, de Jong Y, Gelderblom H, Bovée JV
Curr Opin Oncol 2016 Jul;28(4):314-22. doi: 10.1097/CCO.0000000000000300. PMID: 27166664
Chondrosarcoma presenting as a saddle tumor pulmonary embolism.
Morgan JA, Paone G
J Card Surg 2013 Jul;28(4):436-8. Epub 2013 May 15 doi: 10.1111/jocs.12115. PMID: 23675701
Multicentric chondrosarcomas.
Damron TA, Sim FH, Unni KK
Clin Orthop Relat Res 1996 Jul;(328):211-9. doi: 10.1097/00003086-199607000-00033. PMID: 8653959

Clinical prediction guides

IMP3, CDK4, MDM2 and β-catenin expression in Enchondroma and Central Chondrosarcoma: Diagnostic and prognostic utility.
Losada DM, Etchebehere M, Cintra FF, Amstalden EMI
Clinics (Sao Paulo) 2024;79:100483. Epub 2024 Oct 4 doi: 10.1016/j.clinsp.2024.100483. PMID: 39368400Free PMC Article
Prognostic Factors and Surgical Impact of Non-metastatic Conventional Chondrosarcoma of the Extremities.
Wang W, Zhen J
Orthop Surg 2023 Dec;15(12):3288-3299. Epub 2023 Oct 24 doi: 10.1111/os.13916. PMID: 37875420Free PMC Article
Identifying the Prognosis Factors and Predicting the Survival Probability in Patients with Non-Metastatic Chondrosarcoma from the SEER Database.
Huang R, Sun Z, Zheng H, Yan P, Hu P, Yin H, Zhang J, Meng T, Huang Z
Orthop Surg 2019 Oct;11(5):801-810. doi: 10.1111/os.12521. PMID: 31663279Free PMC Article
Postoperative local morbidity and the use of vacuum-assisted closure after complex chest wall reconstructions with new and conventional materials.
Rocco G, Martucci N, La Rocca A, La Manna C, De Luca G, Fazioli F, Mori S
Ann Thorac Surg 2014 Jul;98(1):291-6. Epub 2014 May 21 doi: 10.1016/j.athoracsur.2014.04.022. PMID: 24857855
Multicentric chondrosarcomas.
Damron TA, Sim FH, Unni KK
Clin Orthop Relat Res 1996 Jul;(328):211-9. doi: 10.1097/00003086-199607000-00033. PMID: 8653959

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