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Stage IIIB Breast Inflammatory Carcinoma

MedGen UID:
208889
•Concept ID:
C0853971
•
Neoplastic Process
Synonyms: Stage IIIB Inflammatory Breast Cancer; Stage IIIB Inflammatory Breast Carcinoma

Definition

Inflammatory breast carcinoma is classified as AJCC Stage IIIB (T4d) unless other criteria indicate more advanced staging. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage IIIB Breast Inflammatory Carcinoma

Professional guidelines

PubMed

Characteristics and treatment modalities for African American women diagnosed with stage III breast cancer.
Rizzo M, Lund MJ, Mosunjac M, Bumpers H, Holmes L, O'Regan R, Brawley OW, Gabram S
Cancer 2009 Jul 1;115(13):3009-15. doi: 10.1002/cncr.24334. PMID: 19466698
Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer.
Shenkier T, Weir L, Levine M, Olivotto I, Whelan T, Reyno L; Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer
CMAJ 2004 Mar 16;170(6):983-94. doi: 10.1503/cmaj.1030944. PMID: 15023926Free PMC Article
Management of stage III breast cancer.
Honkoop AH, Wagstaff J, Pinedo HM
Oncology 1998 May-Jun;55(3):218-27. doi: 10.1159/000011861. PMID: 9560054

Recent clinical studies

Etiology

Locally advanced breast cancer.
Aebi S, Karlsson P, Wapnir IL
Breast 2022 Mar;62 Suppl 1(Suppl 1):S58-S62. Epub 2021 Dec 15 doi: 10.1016/j.breast.2021.12.011. PMID: 34930650Free PMC Article
Delayed breast reconstruction with tram-flap and various modifications after radical mastectomy.
Smolanka II, Bagmut IY, Sheremet MI, Lyashenko AO, Movchan OV, Smolanka II Jr, Loboda AD, Kolisnyk IL, Sydorchuk LP, Lazaruk OV
J Med Life 2021 Nov-Dec;14(6):847-852. doi: 10.25122/jml-2021-0354. PMID: 35126757Free PMC Article
Characteristics and treatment modalities for African American women diagnosed with stage III breast cancer.
Rizzo M, Lund MJ, Mosunjac M, Bumpers H, Holmes L, O'Regan R, Brawley OW, Gabram S
Cancer 2009 Jul 1;115(13):3009-15. doi: 10.1002/cncr.24334. PMID: 19466698
Scope and significance of non-uniform classification practices in breast cancer with non-inflammatory skin involvement: a clinicopathologic study and an international survey.
Güth U, Singer G, Schötzau A, Langer I, Dieterich H, Rochlitz C, Herberich L, Holzgreve W, Wight E
Ann Oncol 2005 Oct;16(10):1618-23. Epub 2005 Jul 20 doi: 10.1093/annonc/mdi319. PMID: 16033873
Management of stage III breast cancer.
Honkoop AH, Wagstaff J, Pinedo HM
Oncology 1998 May-Jun;55(3):218-27. doi: 10.1159/000011861. PMID: 9560054

Diagnosis

Delayed breast reconstruction with tram-flap and various modifications after radical mastectomy.
Smolanka II, Bagmut IY, Sheremet MI, Lyashenko AO, Movchan OV, Smolanka II Jr, Loboda AD, Kolisnyk IL, Sydorchuk LP, Lazaruk OV
J Med Life 2021 Nov-Dec;14(6):847-852. doi: 10.25122/jml-2021-0354. PMID: 35126757Free PMC Article
Characteristics and treatment modalities for African American women diagnosed with stage III breast cancer.
Rizzo M, Lund MJ, Mosunjac M, Bumpers H, Holmes L, O'Regan R, Brawley OW, Gabram S
Cancer 2009 Jul 1;115(13):3009-15. doi: 10.1002/cncr.24334. PMID: 19466698
Scope and significance of non-uniform classification practices in breast cancer with non-inflammatory skin involvement: a clinicopathologic study and an international survey.
Güth U, Singer G, Schötzau A, Langer I, Dieterich H, Rochlitz C, Herberich L, Holzgreve W, Wight E
Ann Oncol 2005 Oct;16(10):1618-23. Epub 2005 Jul 20 doi: 10.1093/annonc/mdi319. PMID: 16033873
Preoperative therapy in breast cancer: lessons from the treatment of locally advanced disease.
Wolff AC, Davidson NE
Oncologist 2002;7(3):239-45. doi: 10.1634/theoncologist.7-3-239. PMID: 12065797
Locally advanced breast cancer.
Sikov WM
Curr Treat Options Oncol 2000 Aug;1(3):228-38. doi: 10.1007/s11864-000-0034-9. PMID: 12057165

Therapy

Locally advanced breast cancer.
Aebi S, Karlsson P, Wapnir IL
Breast 2022 Mar;62 Suppl 1(Suppl 1):S58-S62. Epub 2021 Dec 15 doi: 10.1016/j.breast.2021.12.011. PMID: 34930650Free PMC Article
Locally advanced breast cancer.
Sikov WM
Curr Treat Options Oncol 2000 Aug;1(3):228-38. doi: 10.1007/s11864-000-0034-9. PMID: 12057165
Management of stage III breast cancer.
Honkoop AH, Wagstaff J, Pinedo HM
Oncology 1998 May-Jun;55(3):218-27. doi: 10.1159/000011861. PMID: 9560054
Primary chemotherapy for early and advanced breast cancer.
Hortobagyi GN, Buzdar AU, Strom EA, Ames FC, Singletary SE
Cancer Lett 1995 Mar 23;90(1):103-9. doi: 10.1016/0304-3835(94)03684-b. PMID: 7720036
Therapy for inflammatory breast cancer: impact of doxorubicin-based therapy.
Bauer RL, Busch E, Levine E, Edge SB
Ann Surg Oncol 1995 Jul;2(4):288-94. doi: 10.1007/BF02307059. PMID: 7552616

Prognosis

Features of VEGF and IL-6 expression in patients with inflammatory breast cancer considering molecular-biological characteristics.
Smolanka II, Bagmut IY, Movchan OV, Sheremet MI, Bilyi OM, Lyashenko AO, Dosenko IV, Loboda AD, Ivankova OM, Kolisnyk IL
J Med Life 2023 Jan;16(1):153-159. doi: 10.25122/jml-2022-0172. PMID: 36873124Free PMC Article
Scope and significance of non-uniform classification practices in breast cancer with non-inflammatory skin involvement: a clinicopathologic study and an international survey.
Güth U, Singer G, Schötzau A, Langer I, Dieterich H, Rochlitz C, Herberich L, Holzgreve W, Wight E
Ann Oncol 2005 Oct;16(10):1618-23. Epub 2005 Jul 20 doi: 10.1093/annonc/mdi319. PMID: 16033873
Locally advanced breast cancer.
Sikov WM
Curr Treat Options Oncol 2000 Aug;1(3):228-38. doi: 10.1007/s11864-000-0034-9. PMID: 12057165
Management of stage III breast cancer.
Honkoop AH, Wagstaff J, Pinedo HM
Oncology 1998 May-Jun;55(3):218-27. doi: 10.1159/000011861. PMID: 9560054
Primary chemotherapy for early and advanced breast cancer.
Hortobagyi GN, Buzdar AU, Strom EA, Ames FC, Singletary SE
Cancer Lett 1995 Mar 23;90(1):103-9. doi: 10.1016/0304-3835(94)03684-b. PMID: 7720036

Clinical prediction guides

Stress management, leukocyte transcriptional changes and breast cancer recurrence in a randomized trial: An exploratory analysis.
Antoni MH, Bouchard LC, Jacobs JM, Lechner SC, Jutagir DR, Gudenkauf LM, Carver CS, Lutgendorf S, Cole SW, Lippman M, Blomberg BB
Psychoneuroendocrinology 2016 Dec;74:269-277. Epub 2016 Sep 24 doi: 10.1016/j.psyneuen.2016.09.012. PMID: 27689900Free PMC Article
Differences in survival among women with stage III inflammatory and noninflammatory locally advanced breast cancer appear early: a large population-based study.
Dawood S, Ueno NT, Valero V, Woodward WA, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM, Cristofanilli M
Cancer 2011 May 1;117(9):1819-26. Epub 2010 Nov 29 doi: 10.1002/cncr.25682. PMID: 21509759
Phase III comparison of standard doxorubicin and cyclophosphamide versus weekly doxorubicin and daily oral cyclophosphamide plus granulocyte colony-stimulating factor as neoadjuvant therapy for inflammatory and locally advanced breast cancer: SWOG 0012.
Ellis GK, Barlow WE, Gralow JR, Hortobagyi GN, Russell CA, Royce ME, Perez EA, Lew D, Livingston RB
J Clin Oncol 2011 Mar 10;29(8):1014-21. Epub 2011 Jan 10 doi: 10.1200/JCO.2009.27.6543. PMID: 21220618Free PMC Article
Inflammatory breast cancer as a model disease to study tumor angiogenesis: results of a phase IB trial of combination SU5416 and doxorubicin.
Overmoyer B, Fu P, Hoppel C, Radivoyevitch T, Shenk R, Persons M, Silverman P, Robertson K, Ziats NP, Wasman JK, Abdul-Karim FW, Jesberger JA, Duerk J, Hartman P, Hanks S, Lewin J, Dowlati A, McCrae K, Ivy P, Remick SC
Clin Cancer Res 2007 Oct 1;13(19):5862-8. doi: 10.1158/1078-0432.CCR-07-0688. PMID: 17908980
Results of mastectomy and postoperative irradiation in the management of locoregionally advanced carcinoma of the breast.
Strom EA, McNeese MD, Fletcher GH, Romsdahl MA, Montague ED, Oswald MJ
Int J Radiat Oncol Biol Phys 1991 Jul;21(2):319-23. doi: 10.1016/0360-3016(91)90777-2. PMID: 2061108

Recent systematic reviews

Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer.
Shenkier T, Weir L, Levine M, Olivotto I, Whelan T, Reyno L; Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer
CMAJ 2004 Mar 16;170(6):983-94. doi: 10.1503/cmaj.1030944. PMID: 15023926Free PMC Article

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