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Sarcoma, Experimental

MedGen UID:
20652
•Concept ID:
C0036216
•
Experimental Model of Disease; Neoplastic Process
Synonyms: Experimental Sarcoma; Experimental Sarcomas; Sarcomas, Experimental

Definition

Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSarcoma, Experimental

Professional guidelines

PubMed

4-amino-2-phenyl-6-(p-fluorophenyl)-5-carbonitrile-pyrimidine-bis-substituted-loaded liposomes as promising system for cancer treatment.
Oliveira JV, Almeida GC, Nogueira MCBL, Aguiar Júnior FCA, Melo AO, Silva TDS, Santos NPS, Magalhães NSS, Melo SJ, Falcão EPS
An Acad Bras Cienc 2023;95(suppl 1):e20211078. Epub 2023 Jul 10 doi: 10.1590/0001-3765202320211078. PMID: 37436228
Survival impact of centralization and clinical guidelines for soft tissue sarcoma (A prospective and exhaustive population-based cohort).
Derbel O, Heudel PE, Cropet C, Meeus P, Vaz G, Biron P, Cassier P, Decouvelaere AV, Ranchere-Vince D, Collard O, De Laroche E, Thiesse P, Farsi F, Cellier D, Gilly FN, Blay JY, Ray-Coquard I
PLoS One 2017;12(2):e0158406. Epub 2017 Feb 3 doi: 10.1371/journal.pone.0158406. PMID: 28158190Free PMC Article

Recent clinical studies

Etiology

The anticancer peptide RT53 induces immunogenic cell death.
Pasquereau-Kotula E, Habault J, Kroemer G, Poyet JL
PLoS One 2018;13(8):e0201220. Epub 2018 Aug 6 doi: 10.1371/journal.pone.0201220. PMID: 30080874Free PMC Article
The high mobility group protein, HMGI-C.
Goodwin G
Int J Biochem Cell Biol 1998 Jul;30(7):761-6. doi: 10.1016/s1357-2725(98)00016-8. PMID: 9722980
Tumour pH in human mammary carcinoma.
van den Berg AP, Wike-Hooley JL, van den Berg-Blok AE, van der Zee J, Reinhold HS
Eur J Cancer Clin Oncol 1982 May;18(5):457-62. doi: 10.1016/0277-5379(82)90114-6. PMID: 6889524
Cancer and ageing in mice and men.
Peto R, Roe FJ, Lee PN, Levy L, Clack J
Br J Cancer 1975 Oct;32(4):411-26. doi: 10.1038/bjc.1975.242. PMID: 1212409Free PMC Article
Microwave absorption by normal and tumor cells.
Webb SJ, Booth AD
Science 1971 Oct 1;174(4004):72-4. doi: 10.1126/science.174.4004.72. PMID: 5120873

Diagnosis

Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response.
Vienne M, Etiennot M, Escalière B, Galluso J, Spinelli L, Guia S, Fenis A, Vivier E, Kerdiles YM
Front Immunol 2021;12:768989. Epub 2021 Nov 16 doi: 10.3389/fimmu.2021.768989. PMID: 34868026Free PMC Article
Circulating MicroRNA-92b-3p as a Novel Biomarker for Monitoring of Synovial Sarcoma.
Uotani K, Fujiwara T, Yoshida A, Iwata S, Morita T, Kiyono M, Yokoo S, Kunisada T, Takeda K, Hasei J, Numoto K, Nezu Y, Yonemoto T, Ishii T, Kawai A, Ochiya T, Ozaki T
Sci Rep 2017 Nov 7;7(1):14634. doi: 10.1038/s41598-017-12660-5. PMID: 29116117Free PMC Article
Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.
Moding EJ, Lee CL, Castle KD, Oh P, Mao L, Zha S, Min HD, Ma Y, Das S, Kirsch DG
J Clin Invest 2014 Aug;124(8):3325-38. Epub 2014 Jul 18 doi: 10.1172/JCI73932. PMID: 25036710Free PMC Article
The selective nature of metastasis.
Talmadge JE
Cancer Metastasis Rev 1983;2(1):25-40. doi: 10.1007/BF00046904. PMID: 6616441
Nature and expression of tumour antigens associated with experimental animal and human tumours.
Baldwin RW, Price MR
Ann Clin Biochem 1976 Sep;13(5):488-94. doi: 10.1177/000456327601300146. PMID: 63261

Therapy

Dendritic cell immunotherapy in soft tissue sarcoma.
Indelicato DJ, Finkelstein SE
Immunotherapy 2012 Oct;4(10):1023-9. doi: 10.2217/imt.12.106. PMID: 23148754
Radiofrequency ablation of lung malignancies.
Nguyen CL, Scott WJ, Goldberg M
Ann Thorac Surg 2006 Jul;82(1):365-71. doi: 10.1016/j.athoracsur.2005.11.069. PMID: 16798261
A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes.
Rosenberg SA, Spiess P, Lafreniere R
Science 1986 Sep 19;233(4770):1318-21. doi: 10.1126/science.3489291. PMID: 3489291
Radiation sensitizers.
Cancer 1976 Apr;37(4 Suppl):2062-70. PMID: 130967
Implications of cancer immunity.
Burnet FM
Aust N Z J Med 1973 Feb;3(1):71-7. doi: 10.1111/j.1445-5994.1973.tb03959.x. PMID: 4573195

Prognosis

Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.
Hattinger CM, Patrizio MP, Luppi S, Serra M
Int J Mol Sci 2020 Jun 30;21(13) doi: 10.3390/ijms21134659. PMID: 32629971Free PMC Article
Chemical sympathectomy suppresses fibrosarcoma development and improves survival of tumor-bearing rats.
Lackovicova L, Banovska L, Bundzikova J, Janega P, Bizik J, Kiss A, Mravec B
Neoplasma 2011;58(5):424-9. doi: 10.4149/neo_2011_05_424. PMID: 21744996
Phosphorus MR spectroscopy in the treatment of human extremity sarcomas.
Sijens PE
NMR Biomed 1998 Nov;11(7):341-53. doi: 10.1002/(sici)1099-1492(1998110)11:7<341::aid-nbm516>3.0.co;2-u. PMID: 9859940
Perioperative blood transfusions and survival in osteosarcoma.
Chesi R, Borghi B, Lari S
Cancer Treat Res 1993;62:25-8. doi: 10.1007/978-1-4615-3518-8_4. PMID: 8096741
Past failures and future possibilities in Ewing's sarcoma. Experimental and preliminary clinical results.
Johnson R, Humphreys SR
Cancer 1969 Jan;23(1):161-6. doi: 10.1002/1097-0142(196901)23:1<161::aid-cncr2820230121>3.0.co;2-l. PMID: 5763249

Clinical prediction guides

Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.
Hattinger CM, Patrizio MP, Luppi S, Serra M
Int J Mol Sci 2020 Jun 30;21(13) doi: 10.3390/ijms21134659. PMID: 32629971Free PMC Article
The anticancer peptide RT53 induces immunogenic cell death.
Pasquereau-Kotula E, Habault J, Kroemer G, Poyet JL
PLoS One 2018;13(8):e0201220. Epub 2018 Aug 6 doi: 10.1371/journal.pone.0201220. PMID: 30080874Free PMC Article
The high mobility group protein, HMGI-C.
Goodwin G
Int J Biochem Cell Biol 1998 Jul;30(7):761-6. doi: 10.1016/s1357-2725(98)00016-8. PMID: 9722980
Antitumor 2-(aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines.
Shyam K, Penketh PG, Loomis RH, Rose WC, Sartorelli AC
J Med Chem 1996 Feb 2;39(3):796-801. doi: 10.1021/jm9505021. PMID: 8576923
The selective nature of metastasis.
Talmadge JE
Cancer Metastasis Rev 1983;2(1):25-40. doi: 10.1007/BF00046904. PMID: 6616441

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