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Metastatic carcinoma in the bone

MedGen UID:
195970
•Concept ID:
C0700110
•
Neoplastic Process
Synonyms: Metastatic Carcinoma in the Bone; metastatic carcinoma in the bone; Metastatic Carcinoma to the Bone; metastatic carcinoma to the bone
 
Monarch Initiative: MONDO:0024884

Definition

A carcinoma that has spread to the bone from another, primary anatomic site. Bone is one of the most frequent sites of metastatic carcinoma. Common sites of origin include lung, breast, and prostate. [from NCI]

Professional guidelines

PubMed

Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline.
Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
The Role of Targeted Therapy in the Management of Sinonasal Malignancies.
Kashat L, Le CH, Chiu AG
Otolaryngol Clin North Am 2017 Apr;50(2):443-455. doi: 10.1016/j.otc.2016.12.016. PMID: 28314406
Nanoparticles-Based Treatment for Bone Metastasis.
Saracino R, Luciano R, Battafarano G, Perrotta A, Muraca M, Del Fattore A
Curr Drug Targets 2016;17(3):303-10. doi: 10.2174/1389450116666150427154706. PMID: 25915486

Recent clinical studies

Etiology

Clinical features and outcomes of metastatic bone tumors of the pelvis.
Yang Q, Chen N, Fu W
J Int Med Res 2021 Jun;49(6):3000605211013152. doi: 10.1177/03000605211013152. PMID: 34154434Free PMC Article
The Role of the Microenvironment in Prostate Cancer-Associated Bone Disease.
Turner CJ, Edwards CM
Curr Osteoporos Rep 2016 Oct;14(5):170-7. doi: 10.1007/s11914-016-0323-2. PMID: 27566487
Implications of bone metastases and the benefits of bone-targeted therapy.
Lipton A
Semin Oncol 2010 Oct;37 Suppl 2:S15-29. doi: 10.1053/j.seminoncol.2010.10.002. PMID: 21111244
Metastatic carcinoma of the long bones.
Riccio AI, Wodajo FM, Malawer M
Am Fam Physician 2007 Nov 15;76(10):1489-94. PMID: 18052014
Tumors of unknown origin.
Greco FA, Hainsworth JD
CA Cancer J Clin 1992 Mar-Apr;42(2):96-115. doi: 10.3322/canjclin.42.2.96. PMID: 1540854

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Nasal Cavity, Paranasal Sinuses and Skull Base.
Thompson LDR, Bishop JA
Head Neck Pathol 2022 Mar;16(1):1-18. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01406-5. PMID: 35312976Free PMC Article
Acrometastases.
Mavrogenis AF, Mimidis G, Kokkalis ZT, Karampi ES, Karampela I, Papagelopoulos PJ, Armaganidis A
Eur J Orthop Surg Traumatol 2014 Apr;24(3):279-83. Epub 2013 Sep 8 doi: 10.1007/s00590-013-1311-1. PMID: 24013815
Primary bone lymphoma.
Bhagavathi S, Fu K
Arch Pathol Lab Med 2009 Nov;133(11):1868-71. doi: 10.5858/133.11.1868. PMID: 19886726
Metastatic carcinoma of the long bones.
Riccio AI, Wodajo FM, Malawer M
Am Fam Physician 2007 Nov 15;76(10):1489-94. PMID: 18052014
Acrometastases.
Bricout PB
J Natl Med Assoc 1981 Apr;73(4):325-9. PMID: 7218364Free PMC Article

Therapy

Treatment and trials in non-metastatic castration-resistant prostate cancer.
Lokeshwar SD, Klaassen Z, Saad F
Nat Rev Urol 2021 Jul;18(7):433-442. Epub 2021 May 17 doi: 10.1038/s41585-021-00470-4. PMID: 34002069
The Role of the Microenvironment in Prostate Cancer-Associated Bone Disease.
Turner CJ, Edwards CM
Curr Osteoporos Rep 2016 Oct;14(5):170-7. doi: 10.1007/s11914-016-0323-2. PMID: 27566487
Numb chin syndrome: a rare and often overlooked symptom.
Assaf AT, Jürgens TP, Benecke AW, Riecke B, Blessmann M, Zrnc TA, Much CC, Heiland M, Friedrich RE
J Oral Facial Pain Headache 2014 Winter;28(1):80-90. doi: 10.11607/jop.994. PMID: 24482791
Carcinoid tumors.
Boushey RP, Dackiw AP
Curr Treat Options Oncol 2002 Aug;3(4):319-26. doi: 10.1007/s11864-002-0031-2. PMID: 12074768
Medullary thyroid cancer.
Kebebew E, Clark OH
Curr Treat Options Oncol 2000 Oct;1(4):359-67. doi: 10.1007/s11864-000-0052-7. PMID: 12057161

Prognosis

The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review).
Jimi E, Shin M, Furuta H, Tada Y, Kusukawa J
Int J Oncol 2013 Mar;42(3):803-9. Epub 2013 Jan 23 doi: 10.3892/ijo.2013.1794. PMID: 23354319
Muscle metastasis of carcinoma.
Molina-Garrido MJ, Guillén-Ponce C
Clin Transl Oncol 2011 Feb;13(2):98-101. doi: 10.1007/s12094-011-0625-x. PMID: 21324797
Primary bone lymphoma.
Bhagavathi S, Fu K
Arch Pathol Lab Med 2009 Nov;133(11):1868-71. doi: 10.5858/133.11.1868. PMID: 19886726
Sarcoma and metastatic carcinoma.
Wolf RE
J Surg Oncol 2000 Jan;73(1):39-46. doi: 10.1002/(sici)1096-9098(200001)73:1<39::aid-jso11>3.0.co;2-q. PMID: 10649279
Metastatic orbital tumors.
Günalp I, Gündüz K
Jpn J Ophthalmol 1995;39(1):65-70. PMID: 7643486

Clinical prediction guides

Non-bone metastatic cancers promote osteocyte-induced bone destruction.
Pin F, Prideaux M, Huot JR, Essex AL, Plotkin LI, Bonetto A, Bonewald LF
Cancer Lett 2021 Nov 1;520:80-90. Epub 2021 Jul 4 doi: 10.1016/j.canlet.2021.06.030. PMID: 34233150Free PMC Article
Surgical treatment in bone metastases in the appendicular skeleton.
Clara-Altamirano MA, Garcia-Ortega DY, Martinez-Said H, Caro-Sánchez CHS, Herrera-Gomez A, Cuellar-Hubbe M
Rev Esp Cir Ortop Traumatol (Engl Ed) 2018 May-Jun;62(3):185-189. Epub 2018 Mar 21 doi: 10.1016/j.recot.2017.12.001. PMID: 29574162
Metastatic bone disease: A review of survival, prognostic factors and outcomes following surgical treatment of the appendicular skeleton.
Kirkinis MN, Lyne CJ, Wilson MD, Choong PF
Eur J Surg Oncol 2016 Dec;42(12):1787-1797. Epub 2016 Apr 19 doi: 10.1016/j.ejso.2016.03.036. PMID: 27499111
Long-Term Follow-up in Medullary Thyroid Carcinoma.
Raue F, Frank-Raue K
Recent Results Cancer Res 2015;204:207-25. doi: 10.1007/978-3-319-22542-5_10. PMID: 26494391
The role of metastasectomy in renal cell carcinoma in the era of targeted therapy.
Ljungberg B
Curr Urol Rep 2013 Feb;14(1):19-25. doi: 10.1007/s11934-012-0293-6. PMID: 23212738

Recent systematic reviews

Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline.
Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
Acrometastases to the Hand: A Systematic Review.
Umana GE, Scalia G, Palmisciano P, Passanisi M, Da Ros V, Pompili G, Barone F, Amico P, Tomasi SO, Graziano F, Patti IV, Mele S, Maugeri R, Raffa G, Giammalva GR, Iacopino GD, Germanò A, Nicoletti GF, Ippolito M, Sabini MG, Cicero S, Strigari L, Cuttone G
Medicina (Kaunas) 2021 Sep 9;57(9) doi: 10.3390/medicina57090950. PMID: 34577873Free PMC Article
Systematic review of site distribution of bone metastases in differentiated thyroid cancer.
Osorio M, Moubayed SP, Su H, Urken ML
Head Neck 2017 Apr;39(4):812-818. Epub 2017 Jan 11 doi: 10.1002/hed.24655. PMID: 28079945
Metastasis therapies for renal cancer.
Dabestani S, Marconi L, Bex A
Curr Opin Urol 2016 Nov;26(6):566-72. doi: 10.1097/MOU.0000000000000330. PMID: 27471993
Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.
Zhang WB, Peng X
Head Neck 2016 Apr;38 Suppl 1:E2335-42. Epub 2016 Feb 18 doi: 10.1002/hed.24274. PMID: 26890607

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