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T2 hyperintense cerebellar lesion

MedGen UID:
1864276
•Concept ID:
C5937199
•
Finding
Synonym: T2 hyperintensities in cerebellum
 
HPO: HP:6000416

Definition

A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the cerebellum. This term refers to a localized hyperintensity affecting a particular region of the cerebellum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT2 hyperintense cerebellar lesion

Professional guidelines

PubMed

Bilateral middle cerebellar peduncle lesions: Neuroimaging features and differential diagnoses.
Jiang J, Wang J, Lin M, Wang X, Zhao J, Shang X
Brain Behav 2020 Oct;10(10):e01778. Epub 2020 Aug 5 doi: 10.1002/brb3.1778. PMID: 32755074Free PMC Article
Intracranial lesions with high signal intensity on T1-weighted MR images: differential diagnosis.
Ginat DT, Meyers SP
Radiographics 2012 Mar-Apr;32(2):499-516. doi: 10.1148/rg.322105761. PMID: 22411945
The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours.
O'Brien DF, Farrell M, Delanty N, Traunecker H, Perrin R, Smyth MD, Park TS; Children's Cancer and Leukaemia Group
Br J Neurosurg 2007 Dec;21(6):539-49. doi: 10.1080/02688690701594817. PMID: 18071981

Recent clinical studies

Etiology

Clinical characteristics of myelin-oligodendrocyte glycoprotein antibody-positive pediatric autoimmune encephalitis without demyelination: A case series.
Song X, Ma J
Front Immunol 2022;13:1050688. Epub 2022 Dec 1 doi: 10.3389/fimmu.2022.1050688. PMID: 36532000Free PMC Article
Glial Fibrillary Acidic Protein Autoimmunity: A French Cohort Study.
Gravier-Dumonceau A, Ameli R, Rogemond V, Ruiz A, Joubert B, Muñiz-Castrillo S, Vogrig A, Picard G, Ambati A, Benaiteau M, Rulquin F, Ciron J, Deiva K, de Broucker T, Kremer L, Kerschen P, Sellal F, Bouldoires B, Genet R, Biberon J, Bigot A, Duval F, Issa N, Rusu EC, Goudot M, Dutray A, Devoize JL, Hopes L, Kaminsky AL, Philbert M, Chanson E, Leblanc A, Morvan E, Andriuta D, Diraison P, Mirebeau G, Derollez C, Bourg V, Bodard Q, Fort C, Grigorashvili-Coin I, Rieul G, Molinier-Tiganas D, Bonnan M, Tchoumi T, Honnorat J, Marignier R
Neurology 2022 Feb 8;98(6):e653-e668. Epub 2021 Nov 19 doi: 10.1212/WNL.0000000000013087. PMID: 34799461Free PMC Article
Imaging Patterns Characterizing Mitochondrial Leukodystrophies.
Roosendaal SD, van de Brug T, Alves CAPF, Blaser S, Vanderver A, Wolf NI, van der Knaap MS
AJNR Am J Neuroradiol 2021 Jul;42(7):1334-1340. Epub 2021 Apr 1 doi: 10.3174/ajnr.A7097. PMID: 34255734Free PMC Article
Neuro-Behçet disease. A review.
Borhani Haghighi A, Pourmand R, Nikseresht AR
Neurologist 2005 Mar;11(2):80-9. doi: 10.1097/01.nrl.0000156343.16797.c4. PMID: 15733330
MR imaging of the central nervous system in diving-related decompression illness.
Reuter M, Tetzlaff K, Hutzelmann A, Fritsch G, Steffens JC, Bettinghausen E, Heller M
Acta Radiol 1997 Nov;38(6):940-4. doi: 10.1080/02841859709172107. PMID: 9394646

Diagnosis

MRI findings in autoimmune encephalitis.
Hartung TJ, Bartels F, Kuchling J, Krohn S, Leidel J, Mantwill M, Wurdack K, Yogeshwar S, Scheel M, Finke C
Rev Neurol (Paris) 2024 Nov;180(9):895-907. Epub 2024 Oct 2 doi: 10.1016/j.neurol.2024.08.006. PMID: 39358087
Encephalomyeloradiculitis after COVID-19 infection.
Hoshina Y, Takeuchi T
BMJ Case Rep 2023 Nov 27;16(11) doi: 10.1136/bcr-2023-257672. PMID: 38011956Free PMC Article
MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders.
Shahriari M, Sotirchos ES, Newsome SD, Yousem DM
AJR Am J Roentgenol 2021 Apr;216(4):1031-1039. Epub 2021 Feb 17 doi: 10.2214/AJR.20.24061. PMID: 32755221
Posterior leukoencephalopathy syndrome.
Garg RK
Postgrad Med J 2001 Jan;77(903):24-8. doi: 10.1136/pmj.77.903.24. PMID: 11123390Free PMC Article
MR imaging of the central nervous system in diving-related decompression illness.
Reuter M, Tetzlaff K, Hutzelmann A, Fritsch G, Steffens JC, Bettinghausen E, Heller M
Acta Radiol 1997 Nov;38(6):940-4. doi: 10.1080/02841859709172107. PMID: 9394646

Therapy

Intracranial giant tuberculoma: A 7-year institutional experience and literature review.
Swamy SBG, Jaikumar V, Nagaraj NM, Khandelwal S
Clin Neurol Neurosurg 2023 Feb;225:107593. Epub 2023 Jan 16 doi: 10.1016/j.clineuro.2023.107593. PMID: 36701938
Leukoencephalopathy due to oral methotrexate.
González-Suárez I, Aguilar-Amat MJ, Trigueros M, Borobia AM, Cruz A, Arpa J
Cerebellum 2014 Feb;13(1):178-83. doi: 10.1007/s12311-013-0528-1. PMID: 24068485
Diffusion weighted imaging of cerebellar lesions in Wernicke's encephalopathy.
Lapergue B, Klein I, Olivot JM, Amarenco P
J Neuroradiol 2006 Apr;33(2):126-8. doi: 10.1016/s0150-9861(06)77243-1. PMID: 16733427
Hypertensive brainstem encephalopathy without parieto-occipital lesion--two case reports.
Doi Y, Kimura F, Fujiyama T, Fujimura C, Nishina T, Sato T, Hosokawa T, Uehara H, Ishida S, Hanafusa T
Neurol Med Chir (Tokyo) 2006 Feb;46(2):75-9. doi: 10.2176/nmc.46.75. PMID: 16498216
MR findings of Minamata disease--organic mercury poisoning.
Korogi Y, Takahashi M, Okajima T, Eto K
J Magn Reson Imaging 1998 Mar-Apr;8(2):308-16. doi: 10.1002/jmri.1880080210. PMID: 9562057

Prognosis

MRI findings in autoimmune encephalitis.
Hartung TJ, Bartels F, Kuchling J, Krohn S, Leidel J, Mantwill M, Wurdack K, Yogeshwar S, Scheel M, Finke C
Rev Neurol (Paris) 2024 Nov;180(9):895-907. Epub 2024 Oct 2 doi: 10.1016/j.neurol.2024.08.006. PMID: 39358087
Glial Fibrillary Acidic Protein Autoimmunity: A French Cohort Study.
Gravier-Dumonceau A, Ameli R, Rogemond V, Ruiz A, Joubert B, Muñiz-Castrillo S, Vogrig A, Picard G, Ambati A, Benaiteau M, Rulquin F, Ciron J, Deiva K, de Broucker T, Kremer L, Kerschen P, Sellal F, Bouldoires B, Genet R, Biberon J, Bigot A, Duval F, Issa N, Rusu EC, Goudot M, Dutray A, Devoize JL, Hopes L, Kaminsky AL, Philbert M, Chanson E, Leblanc A, Morvan E, Andriuta D, Diraison P, Mirebeau G, Derollez C, Bourg V, Bodard Q, Fort C, Grigorashvili-Coin I, Rieul G, Molinier-Tiganas D, Bonnan M, Tchoumi T, Honnorat J, Marignier R
Neurology 2022 Feb 8;98(6):e653-e668. Epub 2021 Nov 19 doi: 10.1212/WNL.0000000000013087. PMID: 34799461Free PMC Article
MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders.
Shahriari M, Sotirchos ES, Newsome SD, Yousem DM
AJR Am J Roentgenol 2021 Apr;216(4):1031-1039. Epub 2021 Feb 17 doi: 10.2214/AJR.20.24061. PMID: 32755221
Neuro-Behçet disease. A review.
Borhani Haghighi A, Pourmand R, Nikseresht AR
Neurologist 2005 Mar;11(2):80-9. doi: 10.1097/01.nrl.0000156343.16797.c4. PMID: 15733330
MR imaging of the central nervous system in diving-related decompression illness.
Reuter M, Tetzlaff K, Hutzelmann A, Fritsch G, Steffens JC, Bettinghausen E, Heller M
Acta Radiol 1997 Nov;38(6):940-4. doi: 10.1080/02841859709172107. PMID: 9394646

Clinical prediction guides

MRI findings in autoimmune encephalitis.
Hartung TJ, Bartels F, Kuchling J, Krohn S, Leidel J, Mantwill M, Wurdack K, Yogeshwar S, Scheel M, Finke C
Rev Neurol (Paris) 2024 Nov;180(9):895-907. Epub 2024 Oct 2 doi: 10.1016/j.neurol.2024.08.006. PMID: 39358087
Clinical characteristics of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy in children: A case series of 16 patients.
Li T, Li X, Hong S, Jiang L, Ma J
J Neuroimmunol 2023 Sep 15;382:578176. Epub 2023 Aug 7 doi: 10.1016/j.jneuroim.2023.578176. PMID: 37572437
Glial Fibrillary Acidic Protein Autoimmunity: A French Cohort Study.
Gravier-Dumonceau A, Ameli R, Rogemond V, Ruiz A, Joubert B, Muñiz-Castrillo S, Vogrig A, Picard G, Ambati A, Benaiteau M, Rulquin F, Ciron J, Deiva K, de Broucker T, Kremer L, Kerschen P, Sellal F, Bouldoires B, Genet R, Biberon J, Bigot A, Duval F, Issa N, Rusu EC, Goudot M, Dutray A, Devoize JL, Hopes L, Kaminsky AL, Philbert M, Chanson E, Leblanc A, Morvan E, Andriuta D, Diraison P, Mirebeau G, Derollez C, Bourg V, Bodard Q, Fort C, Grigorashvili-Coin I, Rieul G, Molinier-Tiganas D, Bonnan M, Tchoumi T, Honnorat J, Marignier R
Neurology 2022 Feb 8;98(6):e653-e668. Epub 2021 Nov 19 doi: 10.1212/WNL.0000000000013087. PMID: 34799461Free PMC Article
Central Nervous System Lymphoma Harboring the JAK2 V617F Mutation That Developed after a 20-year History of Polycythemia Vera.
Kajikawa N, Seki Y, Fujio T, Okoshi Y, Hori M, Saito H, Iijima T, Kojima H
Intern Med 2018 Nov 15;57(22):3293-3297. Epub 2018 Jul 6 doi: 10.2169/internalmedicine.1093-18. PMID: 29984752Free PMC Article
Hypertrophic Olivary Degeneration: Neurosurgical Perspective and Literature Review.
Onen MR, Moore K, Cikla U, Ucer M, Schmidt B, Field AS, Baskaya MK
World Neurosurg 2018 Apr;112:e763-e771. Epub 2018 Jan 31 doi: 10.1016/j.wneu.2018.01.150. PMID: 29382617

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