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Orbital inflammation

MedGen UID:
1863893
Concept ID:
C5937369
Pathologic Function
HPO: HP:6000614

Definition

An inflammatory condition localized to the orbit, presenting capillary dilatation, leukocytic infiltration, redness, heat, and pain. CT or MIR Imaging demonstrates enlargement of the muscle belly of one (or more) extraocular muscles typically with the involvement of tendinous insertions. Inflammation can also be observed in surrounding tissues, including the orbital fat, lacrimal gland, and optic nerve sheath. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrbital inflammation

Professional guidelines

PubMed

O'Donnell B
Br J Ophthalmol 2011 Aug;95(8):1043. Epub 2011 Jun 13 doi: 10.1136/bjo.2011.203513. PMID: 21670070
Harris GJ
Ophthalmic Plast Reconstr Surg 2006 Mar-Apr;22(2):79-86. doi: 10.1097/01.iop.0000203734.52333.93. PMID: 16550048
Rubin PA, Foster CS
Am J Ophthalmol 2004 Dec;138(6):1041-3. doi: 10.1016/j.ajo.2004.09.032. PMID: 15629299

Recent clinical studies

Etiology

Wilde C, Vahdani K, Thaung C, Rose GE
Orbit 2023 Aug;42(4):434-436. Epub 2022 Jan 19 doi: 10.1080/01676830.2022.2025855. PMID: 35043740
Costan VV, Bogdănici CM, Gheorghe L, Obadă O, Budacu C, Grigoraș C, Andronic DG, Niagu IA
Rom J Ophthalmol 2020 Apr-Jun;64(2):116-121. PMID: 32685776Free PMC Article
Dammacco R
Clin Exp Med 2018 May;18(2):135-149. Epub 2017 Dec 14 doi: 10.1007/s10238-017-0479-9. PMID: 29243035
Kerstetter J, Wang J
Dermatol Clin 2015 Jul;33(3):457-63. Epub 2015 May 8 doi: 10.1016/j.det.2015.03.010. PMID: 26143425
Chen JJ, Costello F, Kardon RH
Curr Eye Res 2015 Feb;40(2):247-65. Epub 2014 Jun 9 doi: 10.3109/02713683.2014.922195. PMID: 24911098

Diagnosis

Rachwani-Anil R, Zamorano-Martín F, Rocha-de-Lossada C, García-Lorente M, Pérez-Casaseca C, Hernando-Ayala C, Ortiz-Pérez S
Arch Soc Esp Oftalmol (Engl Ed) 2022 Feb;97(2):89-99. Epub 2022 Feb 3 doi: 10.1016/j.oftale.2021.05.001. PMID: 35152954
Lee JY, Gallo RA, Vu DM, Anagnostopoulos AG, Rong AJ
Orbit 2022 Jun;41(3):346-349. Epub 2020 Nov 26 doi: 10.1080/01676830.2020.1852263. PMID: 33243070
Saitakis G, Chwalisz BK
J Neurol Sci 2021 May 15;424:117420. Epub 2021 Mar 27 doi: 10.1016/j.jns.2021.117420. PMID: 33845982
Yeşiltaş YS, Gündüz AK
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):71-80. doi: 10.4103/meajo.MEAJO_44_18. PMID: 30122852Free PMC Article
Dammacco R
Clin Exp Med 2018 May;18(2):135-149. Epub 2017 Dec 14 doi: 10.1007/s10238-017-0479-9. PMID: 29243035

Therapy

Chartrand NA, Lau CK, Parsons MT, Handlon JJ, Ronquillo YC, Hoopes PC, Moshirfar M
J Ocul Pharmacol Ther 2023 Jan-Feb;39(1):3-16. Epub 2022 Nov 21 doi: 10.1089/jop.2022.0094. PMID: 36409537
Rachwani-Anil R, Zamorano-Martín F, Rocha-de-Lossada C, García-Lorente M, Pérez-Casaseca C, Hernando-Ayala C, Ortiz-Pérez S
Arch Soc Esp Oftalmol (Engl Ed) 2022 Feb;97(2):89-99. Epub 2022 Feb 3 doi: 10.1016/j.oftale.2021.05.001. PMID: 35152954
Lee JY, Gallo RA, Vu DM, Anagnostopoulos AG, Rong AJ
Orbit 2022 Jun;41(3):346-349. Epub 2020 Nov 26 doi: 10.1080/01676830.2020.1852263. PMID: 33243070
Khalid MF, Micieli J
BMJ Case Rep 2021 Aug 19;14(8) doi: 10.1136/bcr-2021-245359. PMID: 34413050Free PMC Article
Yamamoto M, Hashimoto M, Takahashi H, Shinomura Y
J Neuroophthalmol 2014 Dec;34(4):393-9. doi: 10.1097/WNO.0000000000000172. PMID: 25405661

Prognosis

Rachwani-Anil R, Zamorano-Martín F, Rocha-de-Lossada C, García-Lorente M, Pérez-Casaseca C, Hernando-Ayala C, Ortiz-Pérez S
Arch Soc Esp Oftalmol (Engl Ed) 2022 Feb;97(2):89-99. Epub 2022 Feb 3 doi: 10.1016/j.oftale.2021.05.001. PMID: 35152954
Costan VV, Bogdănici CM, Gheorghe L, Obadă O, Budacu C, Grigoraș C, Andronic DG, Niagu IA
Rom J Ophthalmol 2020 Apr-Jun;64(2):116-121. PMID: 32685776Free PMC Article
Galuska L, Barna SK, Varga J, Garai I, Nagy EV
Nucl Med Rev Cent East Eur 2018;21(1):54-58. Epub 2018 Jan 10 doi: 10.5603/NMR.a2018.0005. PMID: 29319139
Yamamoto M, Hashimoto M, Takahashi H, Shinomura Y
J Neuroophthalmol 2014 Dec;34(4):393-9. doi: 10.1097/WNO.0000000000000172. PMID: 25405661
Cockerham KP, Hong SH, Browne EE
Curr Neurol Neurosci Rep 2003 Sep;3(5):401-9. doi: 10.1007/s11910-003-0023-z. PMID: 12914683

Clinical prediction guides

Verma R, Chen AJ, Choi D, Wilson DJ, Grossniklaus HE, Dailey RA, Ng JD, Steele EA, Planck SR, Czyz CN, Korn BS, Kikkawa DO, Foster JA, Kazim M, Harris GJ, Edward DP, Al Maktabi A, Rosenbaum JT
Ophthalmic Plast Reconstr Surg 2023 Nov-Dec 01;39(6):588-593. Epub 2023 Jun 6 doi: 10.1097/IOP.0000000000002410. PMID: 37279012Free PMC Article
Flores Balverdi J, Baenas DF, Riscanevo NC, Sánchez AV, Figueroa Rosales R, Alvarellos A
Arch Soc Esp Oftalmol (Engl Ed) 2018 Oct;93(10):494-496. Epub 2018 Jun 1 doi: 10.1016/j.oftal.2018.04.003. PMID: 29866378
Mombaerts I, Rose GE, Garrity JA
Surv Ophthalmol 2016 Sep-Oct;61(5):664-9. Epub 2016 Mar 17 doi: 10.1016/j.survophthal.2016.03.002. PMID: 26994870
Bhatti MT
Semin Neurol 2007 Jul;27(3):269-87. doi: 10.1055/s-2007-979685. PMID: 17577868
Faktorich EG, Tucker N, O'Brien JM
Curr Opin Ophthalmol 1994 Oct;5(5):45-52. PMID: 10150816

Recent systematic reviews

Ang T, Chaggar V, Tong JY, Selva D
Surv Ophthalmol 2024 Jul-Aug;69(4):622-631. Epub 2024 Mar 13 doi: 10.1016/j.survophthal.2024.03.003. PMID: 38490453
Anwar MR, Mahant S, Agbaje-Ojo T, Mahood Q, Borkhoff CM, Parkin PC, Gill PJ
PLoS One 2023;18(7):e0288011. Epub 2023 Jul 6 doi: 10.1371/journal.pone.0288011. PMID: 37410730Free PMC Article
Gupta L, Peterson EL, Williams C, Altman E, Harpole R, Martin DJ, Escott EJ, Timoney PJ, Prendes MA
Ophthalmic Plast Reconstr Surg 2023 Sep-Oct 01;39(5):407-418. Epub 2023 Feb 9 doi: 10.1097/IOP.0000000000002325. PMID: 36757844
Sharifi A, Akbari Z, Shafie'ei M, Nasiri N, Sharifi M, Shafiei M, Zand A
Ophthalmic Plast Reconstr Surg 2022 Sep-Oct 01;38(5):425-432. Epub 2022 Aug 8 doi: 10.1097/IOP.0000000000002256. PMID: 35943425Free PMC Article
Fionda B, Pagliara MM, Lancellotta V, Sammarco MG, Casà C, Savino G, Deodato F, Morganti AG, Gambacorta MA, Tagliaferri L, Blasi MA
Ocul Immunol Inflamm 2022 Jul;30(5):1162-1167. Epub 2021 Feb 9 doi: 10.1080/09273948.2020.1871493. PMID: 33561371

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