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Lipid-laden bone-marrow macrophages

MedGen UID:
1863684
•Concept ID:
C5937390
•
Finding
HPO: HP:6000640

Definition

Bone marrow with increased numbers of macrophages heavily laden with lipids. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLipid-laden bone-marrow macrophages

Recent clinical studies

Etiology

Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease.
Lefebvre T, Reihani N, Daher R, de Villemeur TB, Belmatoug N, Rose C, Colin-Aronovicz Y, Puy H, Le Van Kim C, Franco M, Karim Z
Haematologica 2018 Apr;103(4):587-596. Epub 2018 Jan 5 doi: 10.3324/haematol.2017.177816. PMID: 29305416Free PMC Article
Atypical cytomorphology of Gaucher cells is frequently seen in bone marrow smears from untreated patients with Gaucher disease type 1.
Markuszewska-Kuczynska A, Klimkowska M, Regenthal S, Bulanda A, Kämpe Björkvall C, Machaczka M
Folia Histochem Cytobiol 2015;53(1):62-9. Epub 2015 Mar 4 doi: 10.5603/FHC.a2015.0003. PMID: 25736845
Gaucher iPSC-derived macrophages produce elevated levels of inflammatory mediators and serve as a new platform for therapeutic development.
Panicker LM, Miller D, Awad O, Bose V, Lun Y, Park TS, Zambidis ET, Sgambato JA, Feldman RA
Stem Cells 2014 Sep;32(9):2338-49. doi: 10.1002/stem.1732. PMID: 24801745Free PMC Article
Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition.
Ghesquiere SA, Gijbels MJ, Anthonsen M, van Gorp PJ, van der Made I, Johansen B, Hofker MH, de Winther MP
J Lipid Res 2005 Feb;46(2):201-10. Epub 2004 Dec 1 doi: 10.1194/jlr.M400253-JLR200. PMID: 15576846

Diagnosis

Platelets induce endoplasmic reticulum stress in macrophages in vitro.
Derler M, Teubenbacher T, Carapuig A, Nieswandt B, Fessler J, Kolb D, Mussbacher M
J Thromb Haemost 2024 May;22(5):1475-1488. Epub 2024 Jan 24 doi: 10.1016/j.jtha.2024.01.009. PMID: 38278417
Atypical cytomorphology of Gaucher cells is frequently seen in bone marrow smears from untreated patients with Gaucher disease type 1.
Markuszewska-Kuczynska A, Klimkowska M, Regenthal S, Bulanda A, Kämpe Björkvall C, Machaczka M
Folia Histochem Cytobiol 2015;53(1):62-9. Epub 2015 Mar 4 doi: 10.5603/FHC.a2015.0003. PMID: 25736845
Oral aspects of Gaucher's disease: a literature review and case report.
Horwitz J, Hirsh I, Machtei EE
J Periodontol 2007 Apr;78(4):783-8. doi: 10.1902/jop.2007.060341. PMID: 17397330
Gaucher disease: from fundamental research to effective therapeutic interventions.
de Fost M, Aerts JM, Hollak CE
Neth J Med 2003 Jan;61(1):3-8. PMID: 12688562
Sea-blue histiocyte syndrome in bone marrow secondary to total parenteral nutrition including fat-emulsion sources: a clinicopathologic study of seven cases.
Bigorgne C, Le Tourneau A, Messing B, Rio B, Giraud V, Molina T, Audouin J, Diebold J
Br J Haematol 1996 Nov;95(2):258-62. doi: 10.1046/j.1365-2141.1996.d01-1907.x. PMID: 8904878

Therapy

Pulmonary injury in patients undergoing complex spine surgery.
Urban MK, Jules-Elysee KM, Beckman JB, Sivjee K, King T, Kelsey W, Boachie-Adjei O
Spine J 2005 May-Jun;5(3):269-76. doi: 10.1016/j.spinee.2004.10.049. PMID: 15863083
Sea-blue histiocytosis and pancytopaenia associated with chronic total parenteral nutrition administration.
Meiklejohn DJ, Baden H, Greaves M
Clin Lab Haematol 1997 Sep;19(3):219-21. PMID: 9352150
Elevated levels of M-CSF, sCD14 and IL8 in type 1 Gaucher disease.
Hollak CE, Evers L, Aerts JM, van Oers MH
Blood Cells Mol Dis 1997 Aug;23(2):201-12. doi: 10.1006/bcmd.1997.0137. PMID: 9236158
Lipid-laden macrophage infiltration of human adenocarcinoma in vivo associated with taxol and GCSF treatment.
Abramson N, Castro S, Goldstein JD
Cancer Invest 1997;15(1):18-22. doi: 10.3109/07357909709018913. PMID: 9028386
Sea-blue histiocyte syndrome in bone marrow secondary to total parenteral nutrition including fat-emulsion sources: a clinicopathologic study of seven cases.
Bigorgne C, Le Tourneau A, Messing B, Rio B, Giraud V, Molina T, Audouin J, Diebold J
Br J Haematol 1996 Nov;95(2):258-62. doi: 10.1046/j.1365-2141.1996.d01-1907.x. PMID: 8904878

Prognosis

Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease.
Brinkman J, Wijburg FA, Hollak CE, Groener JE, Verhoek M, Scheij S, Aten J, Boot RG, Aerts JM
J Inherit Metab Dis 2005;28(1):13-20. doi: 10.1007/s10545-005-4416-9. PMID: 15702402
The hematon, a morphogenetic functional complex in mammalian bone marrow, involves erythroblastic islands and granulocytic cobblestones.
Blazsek I, Liu XH, Anjo A, Quittet P, Comisso M, Kim-Triana B, Misset JL
Exp Hematol 1995 Apr;23(4):309-19. PMID: 7895780

Clinical prediction guides

Formation of Foamy Macrophages by Tuberculous Pleural Effusions Is Triggered by the Interleukin-10/Signal Transducer and Activator of Transcription 3 Axis through ACAT Upregulation.
Genoula M, Marín Franco JL, Dupont M, Kviatcovsky D, Milillo A, Schierloh P, Moraña EJ, Poggi S, Palmero D, Mata-Espinosa D, González-Domínguez E, León Contreras JC, Barrionuevo P, Rearte B, Córdoba Moreno MO, Fontanals A, Crotta Asis A, Gago G, Cougoule C, Neyrolles O, Maridonneau-Parini I, Sánchez-Torres C, Hernández-Pando R, Vérollet C, Lugo-Villarino G, Sasiain MDC, Balboa L
Front Immunol 2018;9:459. Epub 2018 Mar 9 doi: 10.3389/fimmu.2018.00459. PMID: 29593722Free PMC Article
Atypical cytomorphology of Gaucher cells is frequently seen in bone marrow smears from untreated patients with Gaucher disease type 1.
Markuszewska-Kuczynska A, Klimkowska M, Regenthal S, Bulanda A, Kämpe Björkvall C, Machaczka M
Folia Histochem Cytobiol 2015;53(1):62-9. Epub 2015 Mar 4 doi: 10.5603/FHC.a2015.0003. PMID: 25736845
Elevated levels of M-CSF, sCD14 and IL8 in type 1 Gaucher disease.
Hollak CE, Evers L, Aerts JM, van Oers MH
Blood Cells Mol Dis 1997 Aug;23(2):201-12. doi: 10.1006/bcmd.1997.0137. PMID: 9236158
Lipid-laden macrophages in bone marrow of leprosy patients.
Sen R, Sehgal PK, Dixit V, Singh U, Chaudhary SD, Sikka R, Jain VK
Lepr Rev 1991 Dec;62(4):374-80. doi: 10.5935/0305-7518.19910043. PMID: 1784152
Multifocal verruciform xanthoma of the upper aerodigestive tract in a child with a systemic lipid storage disease.
Travis WD, Davis GE, Tsokos M, Lebovics R, Merrick HF, Miller SP, Gregg RE, Di Bisceglie AM, Parker RI, Ishak KG
Am J Surg Pathol 1989 Apr;13(4):309-16. doi: 10.1097/00000478-198904000-00006. PMID: 2539022

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