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Abnormal circulating hepatic transaminase concentration

MedGen UID:
1863669
•Concept ID:
C5936882
•
Finding
Synonym: Abnormal circulating hepatic transaminase activity
 
HPO: HP:0430135

Definition

Any deviation from the normal concentration in the blood circulation of alanine aminotransferase or aspartate aminotransferase. [from HPO]

Recent clinical studies

Etiology

Metabolic dysfunction-associated fatty liver disease and liver function markers are associated with Crohn's disease but not Ulcerative Colitis: a prospective cohort study.
Chen J, Dan L, Tu X, Sun Y, Deng M, Chen X, Hesketh T, Li R, Wang X, Li X
Hepatol Int 2023 Feb;17(1):202-214. Epub 2022 Oct 4 doi: 10.1007/s12072-022-10424-6. PMID: 36194337Free PMC Article
Changes Over Time in Hepatic Markers Predict Changes in Insulin Sensitivity, β-Cell Function, and Glycemia.
Pinnaduwage L, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, Retnakaran R
J Clin Endocrinol Metab 2018 Jul 1;103(7):2651-2659. doi: 10.1210/jc.2018-00306. PMID: 29897453
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level.
Sookoian S, Castaño GO, Scian R, Fernández Gianotti T, Dopazo H, Rohr C, Gaj G, San Martino J, Sevic I, Flichman D, Pirola CJ
Am J Clin Nutr 2016 Feb;103(2):422-34. Epub 2016 Jan 20 doi: 10.3945/ajcn.115.118695. PMID: 26791191
Correlation of circulating endoglin with clinical outcome in biliary atresia.
Preativatanyou K, Honsawek S, Chongsrisawat V, Vejchapipat P, Theamboonlers A, Poovorawan Y
Eur J Pediatr Surg 2010 Jul;20(4):237-41. Epub 2010 Apr 9 doi: 10.1055/s-0030-1249695. PMID: 20383820

Diagnosis

Changes Over Time in Hepatic Markers Predict Changes in Insulin Sensitivity, β-Cell Function, and Glycemia.
Pinnaduwage L, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, Retnakaran R
J Clin Endocrinol Metab 2018 Jul 1;103(7):2651-2659. doi: 10.1210/jc.2018-00306. PMID: 29897453
Correlation of circulating endoglin with clinical outcome in biliary atresia.
Preativatanyou K, Honsawek S, Chongsrisawat V, Vejchapipat P, Theamboonlers A, Poovorawan Y
Eur J Pediatr Surg 2010 Jul;20(4):237-41. Epub 2010 Apr 9 doi: 10.1055/s-0030-1249695. PMID: 20383820

Therapy

Organokines and liver enzymes in adolescent girls with polycystic ovary syndrome during randomized treatments.
Garcia-Beltran C, Peyrou M, Navarro-Gascon A, López-Bermejo A, de Zegher F, Villarroya F, Ibáñez L
Front Endocrinol (Lausanne) 2024;15:1325230. Epub 2024 May 16 doi: 10.3389/fendo.2024.1325230. PMID: 38818508Free PMC Article
Assessment of the pharmacokinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers.
Abel S, van der Ryst E, Rosario MC, Ridgway CE, Medhurst CG, Taylor-Worth RJ, Muirhead GJ
Br J Clin Pharmacol 2008 Apr;65 Suppl 1(Suppl 1):5-18. doi: 10.1111/j.1365-2125.2008.03130.x. PMID: 18333861Free PMC Article
Non-transferrin-bound iron and hepatic dysfunction in African dietary iron overload.
McNamara L, MacPhail AP, Mandishona E, Bloom P, Paterson AC, Rouault TA, Gordeuk VR
J Gastroenterol Hepatol 1999 Feb;14(2):126-32. doi: 10.1046/j.1440-1746.1999.01830.x. PMID: 10029292

Prognosis

Changes Over Time in Hepatic Markers Predict Changes in Insulin Sensitivity, β-Cell Function, and Glycemia.
Pinnaduwage L, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, Retnakaran R
J Clin Endocrinol Metab 2018 Jul 1;103(7):2651-2659. doi: 10.1210/jc.2018-00306. PMID: 29897453
Correlation of circulating endoglin with clinical outcome in biliary atresia.
Preativatanyou K, Honsawek S, Chongsrisawat V, Vejchapipat P, Theamboonlers A, Poovorawan Y
Eur J Pediatr Surg 2010 Jul;20(4):237-41. Epub 2010 Apr 9 doi: 10.1055/s-0030-1249695. PMID: 20383820

Clinical prediction guides

Organokines and liver enzymes in adolescent girls with polycystic ovary syndrome during randomized treatments.
Garcia-Beltran C, Peyrou M, Navarro-Gascon A, López-Bermejo A, de Zegher F, Villarroya F, Ibáñez L
Front Endocrinol (Lausanne) 2024;15:1325230. Epub 2024 May 16 doi: 10.3389/fendo.2024.1325230. PMID: 38818508Free PMC Article
Metabolic dysfunction-associated fatty liver disease and liver function markers are associated with Crohn's disease but not Ulcerative Colitis: a prospective cohort study.
Chen J, Dan L, Tu X, Sun Y, Deng M, Chen X, Hesketh T, Li R, Wang X, Li X
Hepatol Int 2023 Feb;17(1):202-214. Epub 2022 Oct 4 doi: 10.1007/s12072-022-10424-6. PMID: 36194337Free PMC Article
Changes Over Time in Hepatic Markers Predict Changes in Insulin Sensitivity, β-Cell Function, and Glycemia.
Pinnaduwage L, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, Retnakaran R
J Clin Endocrinol Metab 2018 Jul 1;103(7):2651-2659. doi: 10.1210/jc.2018-00306. PMID: 29897453
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level.
Sookoian S, Castaño GO, Scian R, Fernández Gianotti T, Dopazo H, Rohr C, Gaj G, San Martino J, Sevic I, Flichman D, Pirola CJ
Am J Clin Nutr 2016 Feb;103(2):422-34. Epub 2016 Jan 20 doi: 10.3945/ajcn.115.118695. PMID: 26791191
Assessment of the pharmacokinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers.
Abel S, van der Ryst E, Rosario MC, Ridgway CE, Medhurst CG, Taylor-Worth RJ, Muirhead GJ
Br J Clin Pharmacol 2008 Apr;65 Suppl 1(Suppl 1):5-18. doi: 10.1111/j.1365-2125.2008.03130.x. PMID: 18333861Free PMC Article

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