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REM parasomnia

MedGen UID:
1853234
•Concept ID:
C5872993
•
Finding
Synonyms: Disturbance in REM; Rapid eye movement parasomnia
 
HPO: HP:5200299

Definition

Parasomnia occurs during REM sleep. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVREM parasomnia

Professional guidelines

PubMed

NREM parasomnias: a treatment approach based upon a retrospective case series of 512 patients.
Drakatos P, Marples L, Muza R, Higgins S, Gildeh N, Macavei R, Dongol EM, Nesbitt A, Rosenzweig I, Lyons E, d'Ancona G, Steier J, Williams AJ, Kent BD, Leschziner G
Sleep Med 2019 Jan;53:181-188. Epub 2018 Apr 10 doi: 10.1016/j.sleep.2018.03.021. PMID: 29753639Free PMC Article
Neuropathological criteria of anti-IgLON5-related tauopathy.
Gelpi E, Höftberger R, Graus F, Ling H, Holton JL, Dawson T, Popovic M, Pretnar-Oblak J, Högl B, Schmutzhard E, Poewe W, Ricken G, Santamaria J, Dalmau J, Budka H, Revesz T, Kovacs GG
Acta Neuropathol 2016 Oct;132(4):531-43. Epub 2016 Jun 29 doi: 10.1007/s00401-016-1591-8. PMID: 27358064Free PMC Article
Clinical assessment and management of sleep disorders in multiple sclerosis: a literature review.
Lunde HM, Bjorvatn B, Myhr KM, Bø L
Acta Neurol Scand Suppl 2013;(196):24-30. doi: 10.1111/ane.12046. PMID: 23190288

Recent clinical studies

Etiology

Non-REM Sleep Parasomnias.
Spector AR
Continuum (Minneap Minn) 2023 Aug 1;29(4):1117-1129. doi: 10.1212/CON.0000000000001261. PMID: 37590825
Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.
Gelegen C, Cash D, Ilic K, Sander M, Kim E, Simmons C, Bernanos M, Lama J, Randall K, Brown JT, Kalanj-Bognar S, Cooke S, Ray Chaudhuri K, Ballard C, Francis P, Rosenzweig I
Sci Rep 2022 May 13;12(1):7973. doi: 10.1038/s41598-022-11516-x. PMID: 35562385Free PMC Article
Sleep-wake misperception. A comprehensive analysis of a large sleep lab cohort.
Valko PO, Hunziker S, Graf K, Werth E, Baumann CR
Sleep Med 2021 Dec;88:96-103. Epub 2021 Oct 22 doi: 10.1016/j.sleep.2021.10.023. PMID: 34742039
Non-REM Parasomnia: The Promise of Precision Medicine.
Erickson J, Vaughn BV
Sleep Med Clin 2019 Sep;14(3):363-370. Epub 2019 Jul 1 doi: 10.1016/j.jsmc.2019.05.002. PMID: 31375204
Apathy in Parkinson's disease with REM sleep behavior disorder.
Bargiotas P, Ntafouli M, Lachenmayer ML, Krack P, Schüpbach WMM, Bassetti CLA
J Neurol Sci 2019 Apr 15;399:194-198. Epub 2019 Feb 20 doi: 10.1016/j.jns.2019.02.028. PMID: 30826716

Diagnosis

Sleep-Related Dissociative Disorders.
Eiser AS
Sleep Med Clin 2024 Mar;19(1):159-167. Epub 2023 Nov 22 doi: 10.1016/j.jsmc.2023.10.003. PMID: 38368062
Non-REM Sleep Parasomnias.
Spector AR
Continuum (Minneap Minn) 2023 Aug 1;29(4):1117-1129. doi: 10.1212/CON.0000000000001261. PMID: 37590825
REM sleep, REM parasomnias, REM sleep behaviour disorder.
Szûcs A, Mutti C, Papp A, Halász P, Parrino L
Ideggyogy Sz 2022 May 30;75(5-06):171-182. doi: 10.18071/isz.75.0171. PMID: 35819343
Rapid eye movement sleep behaviour disorder: Past, present, and future.
Högl B, Arnulf I, Bergmann M, Cesari M, Gan-Or Z, Heidbreder A, Iranzo A, Krohn L, Luppi PH, Mollenhauer B, Provini F, Santamaria J, Trenkwalder C, Videnovic A, Stefani A
J Sleep Res 2022 Aug;31(4):e13612. Epub 2022 Apr 25 doi: 10.1111/jsr.13612. PMID: 35470494Free PMC Article
A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study.
Sabater L, Gaig C, Gelpi E, Bataller L, Lewerenz J, Torres-Vega E, Contreras A, Giometto B, Compta Y, Embid C, Vilaseca I, Iranzo A, Santamaría J, Dalmau J, Graus F
Lancet Neurol 2014 Jun;13(6):575-86. Epub 2014 Apr 3 doi: 10.1016/S1474-4422(14)70051-1. PMID: 24703753Free PMC Article

Therapy

Non-REM Parasomnia: The Promise of Precision Medicine.
Erickson J, Vaughn BV
Sleep Med Clin 2019 Sep;14(3):363-370. Epub 2019 Jul 1 doi: 10.1016/j.jsmc.2019.05.002. PMID: 31375204
NREM parasomnias: a treatment approach based upon a retrospective case series of 512 patients.
Drakatos P, Marples L, Muza R, Higgins S, Gildeh N, Macavei R, Dongol EM, Nesbitt A, Rosenzweig I, Lyons E, d'Ancona G, Steier J, Williams AJ, Kent BD, Leschziner G
Sleep Med 2019 Jan;53:181-188. Epub 2018 Apr 10 doi: 10.1016/j.sleep.2018.03.021. PMID: 29753639Free PMC Article
Two Cases of Sleep-Related Eating Disorder Responding Promptly to Low-Dose Sertraline Therapy.
Varghese R, Rey de Castro J, Liendo C, Schenck CH
J Clin Sleep Med 2018 Oct 15;14(10):1805-1808. doi: 10.5664/jcsm.7404. PMID: 30353815Free PMC Article
Complex dream-enacting behavior in sleepwalking.
Pillmann F
Psychosom Med 2009 Feb;71(2):231-4. Epub 2008 Dec 10 doi: 10.1097/PSY.0b013e318190772e. PMID: 19073753
Conversion disorder revisited: severe parasomnia discovered.
Bokey K
Aust N Z J Psychiatry 1993 Dec;27(4):694-8. doi: 10.3109/00048679309075833. PMID: 8135695

Prognosis

Sleep disorders and polysomnography findings in patients with autoimmune encephalitis.
Erkent I, Elibol B, Saka E, Saygi S, Tezer I
Neurol Sci 2023 Apr;44(4):1351-1360. Epub 2022 Dec 1 doi: 10.1007/s10072-022-06513-x. PMID: 36454441
Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.
Gelegen C, Cash D, Ilic K, Sander M, Kim E, Simmons C, Bernanos M, Lama J, Randall K, Brown JT, Kalanj-Bognar S, Cooke S, Ray Chaudhuri K, Ballard C, Francis P, Rosenzweig I
Sci Rep 2022 May 13;12(1):7973. doi: 10.1038/s41598-022-11516-x. PMID: 35562385Free PMC Article
REM sleep behavior disorder: Mimics and variants.
Antelmi E, Lippolis M, Biscarini F, Tinazzi M, Plazzi G
Sleep Med Rev 2021 Dec;60:101515. Epub 2021 Jun 10 doi: 10.1016/j.smrv.2021.101515. PMID: 34186416
Rapid Eye Movement Sleep Behavior Disorder and Other Rapid Eye Movement Sleep Parasomnias.
Högl B, Iranzo A
Continuum (Minneap Minn) 2017 Aug;23(4, Sleep Neurology):1017-1034. doi: 10.1212/CON.0000000000000489. PMID: 28777174

Clinical prediction guides

A population-based study exploring association of parasomnia symptoms with sleep onset delay among school-aged children.
Lu R, Li R, Chen Y, Zhang Y, Kang W, Zhao A, Lin X, Hu Y, Liu S, Xu Z, Lu Z, Li S
Sleep Med 2024 May;117:1-8. Epub 2024 Feb 2 doi: 10.1016/j.sleep.2024.02.010. PMID: 38460489
Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.
Gelegen C, Cash D, Ilic K, Sander M, Kim E, Simmons C, Bernanos M, Lama J, Randall K, Brown JT, Kalanj-Bognar S, Cooke S, Ray Chaudhuri K, Ballard C, Francis P, Rosenzweig I
Sci Rep 2022 May 13;12(1):7973. doi: 10.1038/s41598-022-11516-x. PMID: 35562385Free PMC Article
Sexsomnia: A Specialized Non-REM Parasomnia?
Dubessy AL, Leu-Semenescu S, Attali V, Maranci JB, Arnulf I
Sleep 2017 Feb 1;40(2) doi: 10.1093/sleep/zsw043. PMID: 28364495
A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study.
Sabater L, Gaig C, Gelpi E, Bataller L, Lewerenz J, Torres-Vega E, Contreras A, Giometto B, Compta Y, Embid C, Vilaseca I, Iranzo A, Santamaría J, Dalmau J, Graus F
Lancet Neurol 2014 Jun;13(6):575-86. Epub 2014 Apr 3 doi: 10.1016/S1474-4422(14)70051-1. PMID: 24703753Free PMC Article
Cyclic alternating pattern analysis in REM sleep behavior disorder.
Kutlu A, Işeri P, Selekler M, Benbir G, Karadeniz D
Sleep Breath 2013 Mar;17(1):209-15. Epub 2012 Feb 28 doi: 10.1007/s11325-012-0675-5. PMID: 22367462

Recent systematic reviews

The parasomnia defense in sleep-related homicide: A systematic review and a critical analysis of the medical literature.
Castelnovo A, Schraemli M, Schenck CH, Manconi M
Sleep Med Rev 2024 Apr;74:101898. Epub 2024 Jan 14 doi: 10.1016/j.smrv.2024.101898. PMID: 38364685

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