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Spermatogonial maturation arrest

MedGen UID:
1853186
•Concept ID:
C5872938
•
Finding
Synonym: Spermatogonial arrest
 
HPO: HP:4000187

Definition

A type of spermatogenesis maturation arrest in which the block of developmental occurs in the spermatogonial stage. Testicular histology shows seminiferous tubules with Sertoli cells and spermatogonial cells but no further differentiated cells like spermatocytes or round spermatids. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpermatogonial maturation arrest

Professional guidelines

PubMed

Biotechnological approaches to the treatment of aspermatogenic men.
Aponte PM, Schlatt S, Franca LR
Clinics (Sao Paulo) 2013;68 Suppl 1(Suppl 1):157-67. doi: 10.6061/clinics/2013(sup01)18. PMID: 23503966Free PMC Article
Treatment options for impaired spermatogenesis: germ cell transplantation and stem-cell based therapy.
Neri QV, Takeuchi T, Rosenwaks Z, Palermo GD
Minerva Ginecol 2009 Aug;61(4):253-9. PMID: 19745793

Recent clinical studies

Etiology

X-linked RBBP7 mutation causes maturation arrest and testicular tumors.
Li J, Zheng H, Hou J, Chen J, Zhang F, Yang X, Jin F, Xi Y
J Clin Invest 2023 Oct 16;133(20) doi: 10.1172/JCI171541. PMID: 37843278Free PMC Article
Investigation of CD133 and CD24 as candidate azoospermia markers and their relationship with spermatogenesis defects.
Yukselten Y, Aydos OSE, Sunguroglu A, Aydos K
Gene 2019 Jul 20;706:211-221. Epub 2019 May 1 doi: 10.1016/j.gene.2019.04.028. PMID: 31054360
Correlation between testicular mast cell count and spermatogenic epithelium in non-obstructive azoospermia.
Abdel-Hamid AAM, Atef H, Zalata KR, Abdel-Latif A
Int J Exp Pathol 2018 Feb;99(1):22-28. Epub 2018 Feb 26 doi: 10.1111/iep.12261. PMID: 29479754Free PMC Article
Highly Conserved Testicular Localization of Claudin-11 in Normal and Impaired Spermatogenesis.
Stammler A, Lüftner BU, Kliesch S, Weidner W, Bergmann M, Middendorff R, Konrad L
PLoS One 2016;11(8):e0160349. Epub 2016 Aug 3 doi: 10.1371/journal.pone.0160349. PMID: 27486954Free PMC Article
Inhibin B levels in azoospermic subjects with cytologically characterized testicular pathology.
Foresta C, Bettella A, Petraglia F, Pistorello M, Luisi S, Rossato M
Clin Endocrinol (Oxf) 1999 Jun;50(6):695-701. doi: 10.1046/j.1365-2265.1999.00659.x. PMID: 10468940

Diagnosis

Seminiferous tubule molecular imaging for evaluation of male fertility: Seeing is believing.
Yao C, Zhao L, Tian R, Li P, Zhu Z, Xue Y, Chen H, Gong Y, Liu N, Yang C, He Z, Li Z
Tissue Cell 2019 Jun;58:24-32. Epub 2019 Apr 6 doi: 10.1016/j.tice.2019.04.003. PMID: 31133243
Treatment options for impaired spermatogenesis: germ cell transplantation and stem-cell based therapy.
Neri QV, Takeuchi T, Rosenwaks Z, Palermo GD
Minerva Ginecol 2009 Aug;61(4):253-9. PMID: 19745793
Inhibin B levels in azoospermic subjects with cytologically characterized testicular pathology.
Foresta C, Bettella A, Petraglia F, Pistorello M, Luisi S, Rossato M
Clin Endocrinol (Oxf) 1999 Jun;50(6):695-701. doi: 10.1046/j.1365-2265.1999.00659.x. PMID: 10468940
Physiopathology of spermatogenic arrest.
Martin-du Pan RC, Campana A
Fertil Steril 1993 Dec;60(6):937-46. doi: 10.1016/s0015-0282(16)56388-2. PMID: 8243695
Assessment of testicular cytology by fine needle aspiration as a diagnostic parameter in the evaluation of the oligospermic subject.
Foresta C, Varotto A
Fertil Steril 1992 Nov;58(5):1028-33. doi: 10.1016/s0015-0282(16)55455-7. PMID: 1426354

Therapy

Seminiferous tubule molecular imaging for evaluation of male fertility: Seeing is believing.
Yao C, Zhao L, Tian R, Li P, Zhu Z, Xue Y, Chen H, Gong Y, Liu N, Yang C, He Z, Li Z
Tissue Cell 2019 Jun;58:24-32. Epub 2019 Apr 6 doi: 10.1016/j.tice.2019.04.003. PMID: 31133243
FSH in the treatment of oligozoospermia.
Foresta C, Bettella A, Merico M, Garolla A, Plebani M, Ferlin A, Rossato M
Mol Cell Endocrinol 2000 Mar 30;161(1-2):89-97. doi: 10.1016/s0303-7207(99)00228-2. PMID: 10773396
Physiopathology of spermatogenic arrest.
Martin-du Pan RC, Campana A
Fertil Steril 1993 Dec;60(6):937-46. doi: 10.1016/s0015-0282(16)56388-2. PMID: 8243695
Effects of long term GnRH analogue treatment on hormone levels and spermatogenesis in patients with carcinoma of the prostate.
Lunglmayr G, Girsch E, Meixner EM, Viehberger G, Bieglmayer C
Urol Res 1988;16(4):315-9. doi: 10.1007/BF00263642. PMID: 2972102

Prognosis

Classification of several types of maturational arrest of spermatogonia according to Sertoli cell morphology: an approach to aetiology.
Nistal M, De Mora JC, Paniagua R
Int J Androl 1998 Dec;21(6):317-26. doi: 10.1046/j.1365-2605.1998.00122.x. PMID: 9972489

Clinical prediction guides

X-linked RBBP7 mutation causes maturation arrest and testicular tumors.
Li J, Zheng H, Hou J, Chen J, Zhang F, Yang X, Jin F, Xi Y
J Clin Invest 2023 Oct 16;133(20) doi: 10.1172/JCI171541. PMID: 37843278Free PMC Article
Seminiferous tubule molecular imaging for evaluation of male fertility: Seeing is believing.
Yao C, Zhao L, Tian R, Li P, Zhu Z, Xue Y, Chen H, Gong Y, Liu N, Yang C, He Z, Li Z
Tissue Cell 2019 Jun;58:24-32. Epub 2019 Apr 6 doi: 10.1016/j.tice.2019.04.003. PMID: 31133243
Correlation between testicular mast cell count and spermatogenic epithelium in non-obstructive azoospermia.
Abdel-Hamid AAM, Atef H, Zalata KR, Abdel-Latif A
Int J Exp Pathol 2018 Feb;99(1):22-28. Epub 2018 Feb 26 doi: 10.1111/iep.12261. PMID: 29479754Free PMC Article
Morphological and ultrastructural studies of human spermatogonial stem cells from patients with maturation arrest.
Mirzapour T, Tengku Ibrahim TAB, Movahedin M, Nowroozi MR
Andrologia 2017 Sep;49(7) Epub 2016 Sep 29 doi: 10.1111/and.12700. PMID: 27682317
Physiopathology of spermatogenic arrest.
Martin-du Pan RC, Campana A
Fertil Steril 1993 Dec;60(6):937-46. doi: 10.1016/s0015-0282(16)56388-2. PMID: 8243695

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