U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Alpha granule disease

MedGen UID:
1842309
•Concept ID:
C5681720
•
Disease or Syndrome
Synonym: alpha granule disease
 
Monarch Initiative: MONDO:0020117
Orphanet: ORPHA98455

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlpha granule disease

Professional guidelines

PubMed

Ovarian cancer treatment and natural killer cell-based immunotherapy.
Fan Z, Han D, Fan X, Zhao L
Front Immunol 2023;14:1308143. Epub 2023 Dec 21 doi: 10.3389/fimmu.2023.1308143. PMID: 38187402Free PMC Article
Current trends in epigenetic, cellular and molecular pathways in management of rheumatoid arthritis.
Makkar R, Sehgal A, Singh S, Sharma N, Rawat R, Rashid S, Vargas-De-La-Cruz C, Yadav S, Bungau SG, Behl T
Inflammopharmacology 2023 Aug;31(4):1577-1588. Epub 2023 Jun 19 doi: 10.1007/s10787-023-01262-5. PMID: 37335368
Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation.
Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG
Am J Surg Pathol 1998 Jul;22(7):779-94. doi: 10.1097/00000478-199807000-00001. PMID: 9669341

Recent clinical studies

Etiology

Natural history study of patients with familial platelet disorder with associated myeloid malignancy.
Cunningham L, Merguerian M, Calvo KR, Davis J, Deuitch NT, Dulau-Florea A, Patel N, Yu K, Sacco K, Bhattacharya S, Passi M, Ozkaya N, De Leon S, Chong S, Craft K, Diemer J, Bresciani E, O'Brien K, Andrews EJ, Park N, Hathaway L, Cowen EW, Heller T, Ryan K, Barochia A, Nghiem K, Niemela J, Rosenzweig S, Young DJ, Frischmeyer-Guerrerio PA, Braylan R, Liu PP
Blood 2023 Dec 21;142(25):2146-2158. doi: 10.1182/blood.2023019746. PMID: 37738626Free PMC Article
Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease.
Zhang X, Chao P, Zhang L, Xu L, Cui X, Wang S, Wusiman M, Jiang H, Lu C
Front Immunol 2023;14:1030198. Epub 2023 Mar 29 doi: 10.3389/fimmu.2023.1030198. PMID: 37063851Free PMC Article
Human mast cell tryptase in biology and medicine.
Vitte J
Mol Immunol 2015 Jan;63(1):18-24. Epub 2014 May 3 doi: 10.1016/j.molimm.2014.04.001. PMID: 24793463
Platelet-cancer interactions.
Goubran HA, Stakiw J, Radosevic M, Burnouf T
Semin Thromb Hemost 2014 Apr;40(3):296-305. Epub 2014 Mar 3 doi: 10.1055/s-0034-1370767. PMID: 24590421
Hepatobiliary pathology.
Lefkowitch JH
Curr Opin Gastroenterol 2006 May;22(3):198-208. doi: 10.1097/01.mog.0000218955.55688.af. PMID: 16550033

Diagnosis

Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease.
Zhang X, Chao P, Zhang L, Xu L, Cui X, Wang S, Wusiman M, Jiang H, Lu C
Front Immunol 2023;14:1030198. Epub 2023 Mar 29 doi: 10.3389/fimmu.2023.1030198. PMID: 37063851Free PMC Article
Human mast cell tryptase in biology and medicine.
Vitte J
Mol Immunol 2015 Jan;63(1):18-24. Epub 2014 May 3 doi: 10.1016/j.molimm.2014.04.001. PMID: 24793463
Quebec platelet disorder.
Hayward CP, Rivard GE
Expert Rev Hematol 2011 Apr;4(2):137-41. doi: 10.1586/ehm.11.5. PMID: 21495923
Hepatobiliary pathology.
Lefkowitch JH
Curr Opin Gastroenterol 2006 May;22(3):198-208. doi: 10.1097/01.mog.0000218955.55688.af. PMID: 16550033
Fabry's disease.
Kato H, Sato K, Hattori S, Ikemoto S, Shimizu M, Isogai Y
Intern Med 1992 May;31(5):682-5. doi: 10.2169/internalmedicine.31.682. PMID: 1324036

Therapy

The Possible Roles of IL-4/IL-13 in the Development of Eosinophil-Predominant Severe Asthma.
Nakagome K, Nagata M
Biomolecules 2024 May 2;14(5) doi: 10.3390/biom14050546. PMID: 38785953Free PMC Article
Natural history study of patients with familial platelet disorder with associated myeloid malignancy.
Cunningham L, Merguerian M, Calvo KR, Davis J, Deuitch NT, Dulau-Florea A, Patel N, Yu K, Sacco K, Bhattacharya S, Passi M, Ozkaya N, De Leon S, Chong S, Craft K, Diemer J, Bresciani E, O'Brien K, Andrews EJ, Park N, Hathaway L, Cowen EW, Heller T, Ryan K, Barochia A, Nghiem K, Niemela J, Rosenzweig S, Young DJ, Frischmeyer-Guerrerio PA, Braylan R, Liu PP
Blood 2023 Dec 21;142(25):2146-2158. doi: 10.1182/blood.2023019746. PMID: 37738626Free PMC Article
PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36.
Qi Z, Hu L, Zhang J, Yang W, Liu X, Jia D, Yao Z, Chang L, Pan G, Zhong H, Luo X, Yao K, Sun A, Qian J, Ding Z, Ge J
Circulation 2021 Jan 5;143(1):45-61. Epub 2020 Sep 29 doi: 10.1161/CIRCULATIONAHA.120.046290. PMID: 32988222
Regulation of PCSK9 by nutraceuticals.
Momtazi AA, Banach M, Pirro M, Katsiki N, Sahebkar A
Pharmacol Res 2017 Jun;120:157-169. Epub 2017 Mar 29 doi: 10.1016/j.phrs.2017.03.023. PMID: 28363723
Progress in pathogenesis and therapy of vasculitis syndrome.
Origuchi T, Ichinose K, Tamai M, Nakamura H, Kawakami A, Eguchi K
Nihon Rinsho Meneki Gakkai Kaishi 2007 Dec;30(6):432-43. doi: 10.2177/jsci.30.432. PMID: 18174672

Prognosis

Natural history study of patients with familial platelet disorder with associated myeloid malignancy.
Cunningham L, Merguerian M, Calvo KR, Davis J, Deuitch NT, Dulau-Florea A, Patel N, Yu K, Sacco K, Bhattacharya S, Passi M, Ozkaya N, De Leon S, Chong S, Craft K, Diemer J, Bresciani E, O'Brien K, Andrews EJ, Park N, Hathaway L, Cowen EW, Heller T, Ryan K, Barochia A, Nghiem K, Niemela J, Rosenzweig S, Young DJ, Frischmeyer-Guerrerio PA, Braylan R, Liu PP
Blood 2023 Dec 21;142(25):2146-2158. doi: 10.1182/blood.2023019746. PMID: 37738626Free PMC Article
Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease.
Zhang X, Chao P, Zhang L, Xu L, Cui X, Wang S, Wusiman M, Jiang H, Lu C
Front Immunol 2023;14:1030198. Epub 2023 Mar 29 doi: 10.3389/fimmu.2023.1030198. PMID: 37063851Free PMC Article
Human mast cell tryptase in biology and medicine.
Vitte J
Mol Immunol 2015 Jan;63(1):18-24. Epub 2014 May 3 doi: 10.1016/j.molimm.2014.04.001. PMID: 24793463
Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation.
Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG
Am J Surg Pathol 1998 Jul;22(7):779-94. doi: 10.1097/00000478-199807000-00001. PMID: 9669341
Liver pathology in alpha1-antitrypsin deficiency. A review.
Cohen C
S Afr Med J 1975 May 17;49(21):849-52. PMID: 166455

Clinical prediction guides

Natural history study of patients with familial platelet disorder with associated myeloid malignancy.
Cunningham L, Merguerian M, Calvo KR, Davis J, Deuitch NT, Dulau-Florea A, Patel N, Yu K, Sacco K, Bhattacharya S, Passi M, Ozkaya N, De Leon S, Chong S, Craft K, Diemer J, Bresciani E, O'Brien K, Andrews EJ, Park N, Hathaway L, Cowen EW, Heller T, Ryan K, Barochia A, Nghiem K, Niemela J, Rosenzweig S, Young DJ, Frischmeyer-Guerrerio PA, Braylan R, Liu PP
Blood 2023 Dec 21;142(25):2146-2158. doi: 10.1182/blood.2023019746. PMID: 37738626Free PMC Article
Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease.
Zhang X, Chao P, Zhang L, Xu L, Cui X, Wang S, Wusiman M, Jiang H, Lu C
Front Immunol 2023;14:1030198. Epub 2023 Mar 29 doi: 10.3389/fimmu.2023.1030198. PMID: 37063851Free PMC Article
Human mast cell tryptase in biology and medicine.
Vitte J
Mol Immunol 2015 Jan;63(1):18-24. Epub 2014 May 3 doi: 10.1016/j.molimm.2014.04.001. PMID: 24793463
Peroxisomes in human health and disease: metabolic pathways, metabolite transport, interplay with other organelles and signal transduction.
Wanders RJ
Subcell Biochem 2013;69:23-44. doi: 10.1007/978-94-007-6889-5_2. PMID: 23821141
Fabry's disease.
Kato H, Sato K, Hattori S, Ikemoto S, Shimizu M, Isogai Y
Intern Med 1992 May;31(5):682-5. doi: 10.2169/internalmedicine.31.682. PMID: 1324036

Recent systematic reviews

Uterine wound healing after caesarean section: A systematic review.
Debras E, Capmas P, Maudot C, Chavatte-Palmer P
Eur J Obstet Gynecol Reprod Biol 2024 May;296:83-90. Epub 2024 Feb 27 doi: 10.1016/j.ejogrb.2024.02.045. PMID: 38417279
Adverse reactions of Niaoduqing granules: A systematic review and meta-analysis.
Fu B, Shang Z, Song S, Xu Y, Wei L, Li G, Yang H
Phytomedicine 2023 Jan;109:154535. Epub 2022 Nov 9 doi: 10.1016/j.phymed.2022.154535. PMID: 36610168
Effects of Uremic Clearance Granules in Uremic Pruritus: A Meta-Analysis.
Lu PH, Wang JY, Chuo HE, Lu PH
Toxins (Basel) 2021 Oct 4;13(10) doi: 10.3390/toxins13100702. PMID: 34678995Free PMC Article
What Is the Impact of Depletion of Immunoregulatory Genes on Wound Healing? A Systematic Review of Preclinical Evidence.
Nogueira BCF, Campos AK, Alves RS, Sarandy MM, Novaes RD, Esposito D, Gonçalves RV
Oxid Med Cell Longev 2020;2020:8862953. Epub 2020 Dec 7 doi: 10.1155/2020/8862953. PMID: 33488938Free PMC Article
Platelet rich plasma: a valid augmentation for cartilage scaffolds? A systematic review.
Perdisa F, Filardo G, Di Matteo B, Marcacci M, Kon E
Histol Histopathol 2014 Jul;29(7):805-14. Epub 2014 Jan 24 doi: 10.14670/HH-29.805. PMID: 24458849

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...