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Elevated erythrocyte adenosine triphosphate concentration

MedGen UID:
1842068
•Concept ID:
C5826912
•
Finding
Synonym: Adenosine triphosphate (ATP) high in erythrocytes
 
HPO: HP:4000186

Definition

Concentration of adenosine triphosphate (ATP) in red blood cells (erythrocytes) above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated erythrocyte adenosine triphosphate concentration

Professional guidelines

PubMed

Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic.
Nieland TJ, Feng Y, Brown JX, Chuang TD, Buckett PD, Wang J, Xie XS, McGraw TE, Kirchhausen T, Wessling-Resnick M
Traffic 2004 Jul;5(7):478-92. doi: 10.1111/j.1398-9219.2004.00193.x. PMID: 15180825Free PMC Article

Recent clinical studies

Etiology

An In Vitro Comparative Study of the Effects of Tetrabromobisphenol A and Tetrabromobisphenol S on Human Erythrocyte Membranes-Changes in ATP Level, Perturbations in Membrane Fluidity, Alterations in Conformational State and Damage to Proteins.
Jarosiewicz M, Duchnowicz P, Jarosiewicz P, Huras B, Bukowska B
Int J Mol Sci 2021 Aug 31;22(17) doi: 10.3390/ijms22179443. PMID: 34502352Free PMC Article
Antioxidant status and energy state of erythrocytes in Alzheimer dementia: probing for markers.
Kosenko EA, Aliev G, Tikhonova LA, Li Y, Poghosyan AC, Kaminsky YG
CNS Neurol Disord Drug Targets 2012 Nov 1;11(7):926-32. doi: 10.2174/1871527311201070926. PMID: 22998137
Cellular toxicity of nicotinamide metabolites.
Rutkowski B, Rutkowski P, Słomińska E, Smolenski RT, Swierczyński J
J Ren Nutr 2012 Jan;22(1):95-7. doi: 10.1053/j.jrn.2011.10.033. PMID: 22200423
High plasma adenine concentration in chronic renal failure and its relation to erythrocyte ATP.
Slominska EM, Szolkiewicz M, Smolenski RT, Rutkowski B, Swierczynski J
Nephron 2002 Jun;91(2):286-91. doi: 10.1159/000058406. PMID: 12053067
Red cell 2,3-DPG, ATP, and mean cell volume in highly trained athletes. Effect of long-term submaximal exercise.
Brodthagen UA, Hansen KN, Knudsen JB, Jordal R, Kristensen O, Paulev PE
Eur J Appl Physiol Occup Physiol 1985;53(4):334-8. doi: 10.1007/BF00422849. PMID: 4039260

Diagnosis

A 9-yr evaluation of carrier erythrocyte encapsulated adenosine deaminase (ADA) therapy in a patient with adult-type ADA deficiency.
Bax BE, Bain MD, Fairbanks LD, Webster AD, Ind PW, Hershfield MS, Chalmers RA
Eur J Haematol 2007 Oct;79(4):338-48. Epub 2007 Aug 3 doi: 10.1111/j.1600-0609.2007.00927.x. PMID: 17680812
Postoperative blood salvage and reinfusion in spinal surgery: blood quality, effectiveness and impact on patient blood parameters.
Sebastián C, Romero R, Olalla E, Ferrer C, García-Vallejo JJ, Muñoz M
Eur Spine J 2000 Dec;9(6):458-65. doi: 10.1007/s005860000167. PMID: 11189913Free PMC Article
Hereditary spherocytosis and elliptocytosis erythrocytes show a normal transbilayer phospholipid distribution.
de Jong K, Larkin SK, Eber S, Franck PF, Roelofsen B, Kuypers FA
Blood 1999 Jul 1;94(1):319-25. PMID: 10381528
Na+ + K+ + 2Cl- cotransport in animal cells--its role in volume regulation.
Geck P, Pfeiffer B
Ann N Y Acad Sci 1985;456:166-82. doi: 10.1111/j.1749-6632.1985.tb14862.x. PMID: 2418724
Enzymatic pattern of glucose metabolic pathways in pyruvate kinase-deficient erythrocytes.
Gumińska M, Wazewska-Czyzewska M
Clin Chim Acta 1975 Oct 15;64(2):165-72. doi: 10.1016/0009-8981(75)90198-9. PMID: 126827

Therapy

Effect of extraluminal ATP application on vascular tone and blood flow in skeletal muscle: implications for exercise hyperemia.
Nyberg M, Al-Khazraji BK, Mortensen SP, Jackson DN, Ellis CG, Hellsten Y
Am J Physiol Regul Integr Comp Physiol 2013 Aug 1;305(3):R281-90. Epub 2013 Jun 12 doi: 10.1152/ajpregu.00189.2013. PMID: 23761642Free PMC Article
LS104, a non-ATP-competitive small-molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2V617F-positive cells.
Lipka DB, Hoffmann LS, Heidel F, Markova B, Blum MC, Breitenbuecher F, Kasper S, Kindler T, Levine RL, Huber C, Fischer T
Mol Cancer Ther 2008 May;7(5):1176-84. doi: 10.1158/1535-7163.MCT-07-2215. PMID: 18483305
A 9-yr evaluation of carrier erythrocyte encapsulated adenosine deaminase (ADA) therapy in a patient with adult-type ADA deficiency.
Bax BE, Bain MD, Fairbanks LD, Webster AD, Ind PW, Hershfield MS, Chalmers RA
Eur J Haematol 2007 Oct;79(4):338-48. Epub 2007 Aug 3 doi: 10.1111/j.1600-0609.2007.00927.x. PMID: 17680812
Effects of oxidative stress on the erythrocyte Na+,K+ ATPase activity in female hyperthyroid patients.
Konukoglu D, Yelke HK, Hatemi H, Sabuncu T
J Toxicol Environ Health A 2001 Jun 22;63(4):289-95. doi: 10.1080/15287390151143677. PMID: 11437061
Postoperative blood salvage and reinfusion in spinal surgery: blood quality, effectiveness and impact on patient blood parameters.
Sebastián C, Romero R, Olalla E, Ferrer C, García-Vallejo JJ, Muñoz M
Eur Spine J 2000 Dec;9(6):458-65. doi: 10.1007/s005860000167. PMID: 11189913Free PMC Article

Prognosis

Erythrocyte pyruvate kinase deficiency. The influence of physiologically important metabolites on the function of normal and defective enzymes.
Lakomek M, Winkler H, Pekrun A, Krüger N, Sander M, Huppke P, Schröter W
Enzyme Protein 1994-1995;48(3):149-63. PMID: 8589802

Clinical prediction guides

Endothelial calcium dynamics elicited by ATP release from red blood cells.
Nayak AK, Das SL, Misbah C
Sci Rep 2024 Jun 12;14(1):13550. doi: 10.1038/s41598-024-63306-2. PMID: 38866785Free PMC Article
Relationship between elevated levels of the alpha 1 acid glycoprotein in chronic myelogenous leukemia in blast crisis and pharmacological resistance to imatinib (Gleevec) in vitro and in vivo.
Larghero J, Leguay T, Mourah S, Madelaine-Chambrin I, Taksin AL, Raffoux E, Bastie JN, Degos L, Berthaud P, Marolleau JP, Calvo F, Chomienne C, Mahon FX, Rousselot P
Biochem Pharmacol 2003 Nov 15;66(10):1907-13. doi: 10.1016/s0006-2952(03)00469-6. PMID: 14599548
Na+ + K+ + 2Cl- cotransport in animal cells--its role in volume regulation.
Geck P, Pfeiffer B
Ann N Y Acad Sci 1985;456:166-82. doi: 10.1111/j.1749-6632.1985.tb14862.x. PMID: 2418724
Observations on the red cell ATP of surgical patients during premortal period.
Kozakowska E, Korta T, Jabłońska-Skwiecińska E
Biomed Biochim Acta 1984;43(6):S103-4. PMID: 6487284
Glycolysis of red cells suspended in solutions of impermeable solutes. Intracellular pH and glycolysis.
Tomoda A, Tsuda-Hirota S, Minakami S
J Biochem 1977 Mar;81(3):697-701. doi: 10.1093/oxfordjournals.jbchem.a131506. PMID: 16876

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