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Reduced erythrocyte glutathione concentration

MedGen UID:
1841986
Concept ID:
C5826627
Finding
HPO: HP:0034738

Definition

Concentration of glutathione in red blood cells below the lower limit of normal. Glutathione (GSH) is an important redox active biomolecule critical in the maintenance and regulation of cellular and organismal health. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced erythrocyte glutathione concentration

Professional guidelines

PubMed

Singh A, Mandal UK, Narang RK
Assay Drug Dev Technol 2022 Jan;20(1):22-34. Epub 2021 Nov 15 doi: 10.1089/adt.2021.052. PMID: 34780287
Aubry M, Laughhunn A, Santa Maria F, Lanteri MC, Stassinopoulos A, Musso D
Vox Sang 2018 Apr;113(3):232-241. Epub 2018 Jan 4 doi: 10.1111/vox.12626. PMID: 29314033
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Diabetes Metab 1997 Feb;23(1):58-60. PMID: 9059767

Recent clinical studies

Etiology

Snyder EL, Sekela ME, Welsby IJ, Toyoda Y, Alsammak M, Sodha NR, Beaver TM, Pelletier JPR, Gorham JD, McNeil JS, Sniecinski RM, Pearl RG, Nuttall GA, Sarode R, Reece TB, Kaplan A, Davenport RD, Ipe TS, Benharash P, Lopez-Plaza I, Gammon RR, Sadler P, Pitman JP, Liu K, Bentow S, Corash L, Mufti N, Varrone J, Benjamin RJ; for the ReCePI study group
Trials 2023 Dec 11;24(1):799. doi: 10.1186/s13063-023-07831-x. PMID: 38082326Free PMC Article
Joksimovic Jovic J, Antic S, Nikolic T, Andric K, Petrovic D, Bolevich S, Jakovljevic V
Oxid Med Cell Longev 2022;2022:9598211. Epub 2022 Apr 14 doi: 10.1155/2022/9598211. PMID: 35464768Free PMC Article
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684
Ronquist G, Theodorsson E
Scand J Clin Lab Invest 2007;67(1):105-11. doi: 10.1080/00365510601047910. PMID: 17365988
McLellan AC, Thornalley PJ, Benn J, Sonksen PH
Clin Sci (Lond) 1994 Jul;87(1):21-9. doi: 10.1042/cs0870021. PMID: 8062515

Diagnosis

Snyder EL, Sekela ME, Welsby IJ, Toyoda Y, Alsammak M, Sodha NR, Beaver TM, Pelletier JPR, Gorham JD, McNeil JS, Sniecinski RM, Pearl RG, Nuttall GA, Sarode R, Reece TB, Kaplan A, Davenport RD, Ipe TS, Benharash P, Lopez-Plaza I, Gammon RR, Sadler P, Pitman JP, Liu K, Bentow S, Corash L, Mufti N, Varrone J, Benjamin RJ; for the ReCePI study group
Trials 2023 Dec 11;24(1):799. doi: 10.1186/s13063-023-07831-x. PMID: 38082326Free PMC Article
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684
Song YN, Guo XL, Zheng BB, Liu XY, Dong X, Yu LG, Cheng YN
Toxicol In Vitro 2011 Jun;25(4):937-43. Epub 2011 Mar 21 doi: 10.1016/j.tiv.2011.03.002. PMID: 21402141
Lösler S, Schlief S, Kneifel C, Thiel E, Schrezenmeier H, Rojewski MT
Ann Hematol 2009 Nov;88(11):1047-58. Epub 2009 Mar 21 doi: 10.1007/s00277-009-0736-4. PMID: 19301004
Ronquist G, Theodorsson E
Scand J Clin Lab Invest 2007;67(1):105-11. doi: 10.1080/00365510601047910. PMID: 17365988

Therapy

Snyder EL, Sekela ME, Welsby IJ, Toyoda Y, Alsammak M, Sodha NR, Beaver TM, Pelletier JPR, Gorham JD, McNeil JS, Sniecinski RM, Pearl RG, Nuttall GA, Sarode R, Reece TB, Kaplan A, Davenport RD, Ipe TS, Benharash P, Lopez-Plaza I, Gammon RR, Sadler P, Pitman JP, Liu K, Bentow S, Corash L, Mufti N, Varrone J, Benjamin RJ; for the ReCePI study group
Trials 2023 Dec 11;24(1):799. doi: 10.1186/s13063-023-07831-x. PMID: 38082326Free PMC Article
Joksimovic Jovic J, Antic S, Nikolic T, Andric K, Petrovic D, Bolevich S, Jakovljevic V
Oxid Med Cell Longev 2022;2022:9598211. Epub 2022 Apr 14 doi: 10.1155/2022/9598211. PMID: 35464768Free PMC Article
Ścibior A, Pietrzyk Ł, Plewa Z, Skiba A
J Trace Elem Med Biol 2020 Sep;61:126508. Epub 2020 Apr 12 doi: 10.1016/j.jtemb.2020.126508. PMID: 32305626Free PMC Article
Amen F, Machin A, Touriño C, Rodríguez I, Denicola A, Thomson L
Arch Biochem Biophys 2017 May 1;621:31-37. Epub 2017 Apr 6 doi: 10.1016/j.abb.2017.02.012. PMID: 28392212
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684

Prognosis

Kosenko EA, Alilova GA, Tikhonova LA
Biochemistry (Mosc) 2023 Sep;88(9):1404-1415. doi: 10.1134/S0006297923090195. PMID: 37770406
Horecka A, Biernacka J, Hordyjewska A, Dąbrowski W, Terlecki P, Zubilewicz T, Musik I, Kurzepa J
Phlebology 2018 Aug;33(7):464-469. Epub 2017 Jul 14 doi: 10.1177/0268355517721055. PMID: 28705052
Toaldo IM, Cruz FA, da Silva EL, Bordignon-Luiz MT
Nutr Res 2016 Aug;36(8):808-17. Epub 2016 Apr 29 doi: 10.1016/j.nutres.2016.04.010. PMID: 27440535
Varamenti EI, Kyparos A, Veskoukis AS, Bakou M, Kalaboka S, Jamurtas AZ, Koutedakis Y, Kouretas D
Food Chem Toxicol 2013 Nov;61:3-8. Epub 2012 Dec 29 doi: 10.1016/j.fct.2012.12.001. PMID: 23279843
Nwose EU, Jelinek HF, Richards RS, Kerr PG
Redox Rep 2006;11(3):99-104. doi: 10.1179/135100006X116583. PMID: 16805963

Clinical prediction guides

Tozoni SS, Dias GF, Bohnen G, Grobe N, Pecoits-Filho R, Kotanko P, Moreno-Amaral AN
Cell Physiol Biochem 2019;53:794-804. doi: 10.33594/000000173. PMID: 31661199
Vives i Corrons JL
Baillieres Best Pract Res Clin Haematol 2000 Mar;13(1):103-18. doi: 10.1053/beha.1999.0060. PMID: 10916681
Searcy DG, Lee SH
J Exp Zool 1998 Oct 15;282(3):310-22. doi: 10.1002/(sici)1097-010x(19981015)282:3<310::aid-jez4>3.0.co;2-p. PMID: 9755482
Aaseth J, Alexander J, Norseth T
Acta Pharmacol Toxicol (Copenh) 1982 Apr;50(4):310-5. doi: 10.1111/j.1600-0773.1982.tb00979.x. PMID: 7102348
Bellomo G, Nicotera PL, Fratino P
Boll Soc Ital Biol Sper 1981 Aug 30;57(16):1660-5. PMID: 7030365

Recent systematic reviews

Rambabu L, Megson IL, Eddleston M
Clin Toxicol (Phila) 2020 Jun;58(6):437-452. Epub 2019 Dec 6 doi: 10.1080/15563650.2019.1693589. PMID: 31810386

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