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Solitary angiokeratoma

MedGen UID:
1841647
•Concept ID:
C5826378
•
Neoplastic Process
HPO: HP:0034408

Definition

A dark, keratotic papule about 2-10 mm in diameter, usually occurring on the lower extremeities. Usually the lesions begin as bright, soft, and nonkeratotic paules which grow larger and change to a firm, blue to black and keratotic stage. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSolitary angiokeratoma

Professional guidelines

PubMed

Topical sirolimus for treatment of a solitary angiokeratoma.
Camacho I, Scott J, DeKlotz C
Dermatol Ther 2020 Nov;33(6):e13907. Epub 2020 Jul 17 doi: 10.1111/dth.13907. PMID: 32594609

Recent clinical studies

Etiology

Angiokeratomas Scroti Associated with Angiokeratomas of the Eyelids: Coincidence or One Entity? A Case Report and Review of the Literature.
Buehler S, Itin P
Dermatology 2015;231(3):213-6. Epub 2015 Jul 24 doi: 10.1159/000435810. PMID: 26228617
Expression of lymphatic markers in angiokeratomas.
Wang L, Yuan W, Geng S, Xiong Y, Zhang D, Zhao X, Li S, Bi X, Gao T, Wang G
J Cutan Pathol 2014 Jul;41(7):576-81. Epub 2014 May 6 doi: 10.1111/cup.12349. PMID: 24666194
Solitary angiokeratoma on palms and soles: a clinicopathological analysis of 21 cases.
Wang L, Gao T, Wang G
J Dermatol 2013 Aug;40(8):653-6. Epub 2013 Jun 5 doi: 10.1111/1346-8138.12192. PMID: 23734792
Solitary angiokeratoma of the tongue in an adult patient treated with intensity modulated radiation therapy.
Erkal EY, Karabey MS, Vural Ç, Mutlu F, Aksu G, Sarper B, Akansel G
Am J Otolaryngol 2013 Sep-Oct;34(5):582-5. Epub 2013 Feb 11 doi: 10.1016/j.amjoto.2013.01.011. PMID: 23410904
A case of solitary angiokeratoma circumscriptum of the tongue.
Yildirim M, Kilinç N, Oktay MF, Topçu I
Kulak Burun Bogaz Ihtis Derg 2007;17(6):333-5. PMID: 18187999

Diagnosis

Solitary angiokeratoma on palms and soles: a clinicopathological analysis of 21 cases.
Wang L, Gao T, Wang G
J Dermatol 2013 Aug;40(8):653-6. Epub 2013 Jun 5 doi: 10.1111/1346-8138.12192. PMID: 23734792
Large, solitary angiokeratoma in the posterior third and base of the tongue: case report.
Dutta M, Ghatak S, Biswas G, Sinha R
J Laryngol Otol 2011 Oct;125(10):1083-6. Epub 2011 Jun 21 doi: 10.1017/S0022215111001277. PMID: 21729432
Solitary angiokeratoma of the tongue in adults.
Fernández-Aceñero MJ, Rey Biel J, Renedo G
Rom J Morphol Embryol 2010;51(4):771-3. PMID: 21103640
Angiokeratoma presenting as plantar verruca: a case study.
Dunnihoo ME, Kitterman RT, Tran D
J Am Podiatr Med Assoc 2010 Nov-Dec;100(6):502-4. doi: 10.7547/1000502. PMID: 21084538
Angiokeratomas: an update.
Schiller PI, Itin PH
Dermatology 1996;193(4):275-82. doi: 10.1159/000246270. PMID: 8993949

Therapy

A case of solitary angiokeratoma successfully treated with a 1064-nm long-pulsed Nd:YAG laser.
Kutlubay Z, Gökler G, Küçüktaş M, Engın B, Serdaroglu S
J Cosmet Laser Ther 2015 Apr;17(2):93-5. Epub 2014 Oct 16 doi: 10.3109/14764172.2014.968585. PMID: 25260142
Expression of lymphatic markers in angiokeratomas.
Wang L, Yuan W, Geng S, Xiong Y, Zhang D, Zhao X, Li S, Bi X, Gao T, Wang G
J Cutan Pathol 2014 Jul;41(7):576-81. Epub 2014 May 6 doi: 10.1111/cup.12349. PMID: 24666194
Solitary angiokeratoma of the tongue treated with diode laser.
Ergun S, Mete O, Yeşil S, Tanyeri H
Lasers Med Sci 2009 Jan;24(1):123-5. Epub 2007 Dec 5 doi: 10.1007/s10103-007-0525-z. PMID: 18057978

Prognosis

Solitary angiokeratoma of the tongue in an adult patient treated with intensity modulated radiation therapy.
Erkal EY, Karabey MS, Vural Ç, Mutlu F, Aksu G, Sarper B, Akansel G
Am J Otolaryngol 2013 Sep-Oct;34(5):582-5. Epub 2013 Feb 11 doi: 10.1016/j.amjoto.2013.01.011. PMID: 23410904
Angiokeratomas: an update.
Schiller PI, Itin PH
Dermatology 1996;193(4):275-82. doi: 10.1159/000246270. PMID: 8993949

Clinical prediction guides

A case of solitary angiokeratoma successfully treated with a 1064-nm long-pulsed Nd:YAG laser.
Kutlubay Z, Gökler G, Küçüktaş M, Engın B, Serdaroglu S
J Cosmet Laser Ther 2015 Apr;17(2):93-5. Epub 2014 Oct 16 doi: 10.3109/14764172.2014.968585. PMID: 25260142
Solitary angiokeratoma of the tongue.
Sion-Vardy N, Manor E, Puterman M, Bodner L
Med Oral Patol Oral Cir Bucal 2008 Jan 1;13(1):E12-4. PMID: 18167473

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