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Abnormal liver metabolite concentration

MedGen UID:
1841588
Concept ID:
C5826554
Finding
HPO: HP:0034644

Definition

The concentration of a metabolite in the liver is above or below the limits of normal. [from HPO]

Professional guidelines

PubMed

Wang T, Zhou Y, Cao G
Eur J Clin Pharmacol 2021 Aug;77(8):1095-1111. Epub 2021 Jan 29 doi: 10.1007/s00228-021-03088-y. PMID: 33515076
Barić I, Staufner C, Augoustides-Savvopoulou P, Chien YH, Dobbelaere D, Grünert SC, Opladen T, Petković Ramadža D, Rakić B, Wedell A, Blom HJ
J Inherit Metab Dis 2017 Jan;40(1):5-20. Epub 2016 Sep 26 doi: 10.1007/s10545-016-9972-7. PMID: 27671891Free PMC Article
Lee MH, Graham GG, Williams KM, Day RO
Drug Saf 2008;31(8):643-65. doi: 10.2165/00002018-200831080-00002. PMID: 18636784

Recent clinical studies

Etiology

Prescott LF
Br J Clin Pharmacol 2024 Jan;90(1):127-134. Epub 2023 Sep 21 doi: 10.1111/bcp.15903. PMID: 37683599
Zeisel S
Nutrients 2017 Apr 29;9(5) doi: 10.3390/nu9050445. PMID: 28468239Free PMC Article
Chan HL, Fung S, Seto WK, Chuang WL, Chen CY, Kim HJ, Hui AJ, Janssen HL, Chowdhury A, Tsang TY, Mehta R, Gane E, Flaherty JF, Massetto B, Gaggar A, Kitrinos KM, Lin L, Subramanian GM, McHutchison JG, Lim YS, Acharya SK, Agarwal K; GS-US-320-0110 Investigators
Lancet Gastroenterol Hepatol 2016 Nov;1(3):185-195. Epub 2016 Sep 22 doi: 10.1016/S2468-1253(16)30024-3. PMID: 28404091
Lattuada G, Ragogna F, Perseghin G
Curr Diab Rep 2011 Jun;11(3):167-72. doi: 10.1007/s11892-011-0190-2. PMID: 21431854
Mudd SH, Levy HL, Tangerman A, Boujet C, Buist N, Davidson-Mundt A, Hudgins L, Oyanagi K, Nagao M, Wilson WG
Am J Hum Genet 1995 Oct;57(4):882-92. PMID: 7573050Free PMC Article

Diagnosis

Prescott LF
Br J Clin Pharmacol 2024 Jan;90(1):127-134. Epub 2023 Sep 21 doi: 10.1111/bcp.15903. PMID: 37683599
Barić I, Staufner C, Augoustides-Savvopoulou P, Chien YH, Dobbelaere D, Grünert SC, Opladen T, Petković Ramadža D, Rakić B, Wedell A, Blom HJ
J Inherit Metab Dis 2017 Jan;40(1):5-20. Epub 2016 Sep 26 doi: 10.1007/s10545-016-9972-7. PMID: 27671891Free PMC Article
Chan HL, Fung S, Seto WK, Chuang WL, Chen CY, Kim HJ, Hui AJ, Janssen HL, Chowdhury A, Tsang TY, Mehta R, Gane E, Flaherty JF, Massetto B, Gaggar A, Kitrinos KM, Lin L, Subramanian GM, McHutchison JG, Lim YS, Acharya SK, Agarwal K; GS-US-320-0110 Investigators
Lancet Gastroenterol Hepatol 2016 Nov;1(3):185-195. Epub 2016 Sep 22 doi: 10.1016/S2468-1253(16)30024-3. PMID: 28404091
Perman WH, Balci NC, Akduman I
Top Magn Reson Imaging 2009 Apr;20(2):89-97. doi: 10.1097/RMR.0b013e3181c422f1. PMID: 20010063
Mudd SH, Levy HL, Tangerman A, Boujet C, Buist N, Davidson-Mundt A, Hudgins L, Oyanagi K, Nagao M, Wilson WG
Am J Hum Genet 1995 Oct;57(4):882-92. PMID: 7573050Free PMC Article

Therapy

Prescott LF
Br J Clin Pharmacol 2024 Jan;90(1):127-134. Epub 2023 Sep 21 doi: 10.1111/bcp.15903. PMID: 37683599
Wang T, Zhou Y, Cao G
Eur J Clin Pharmacol 2021 Aug;77(8):1095-1111. Epub 2021 Jan 29 doi: 10.1007/s00228-021-03088-y. PMID: 33515076
Chan HL, Fung S, Seto WK, Chuang WL, Chen CY, Kim HJ, Hui AJ, Janssen HL, Chowdhury A, Tsang TY, Mehta R, Gane E, Flaherty JF, Massetto B, Gaggar A, Kitrinos KM, Lin L, Subramanian GM, McHutchison JG, Lim YS, Acharya SK, Agarwal K; GS-US-320-0110 Investigators
Lancet Gastroenterol Hepatol 2016 Nov;1(3):185-195. Epub 2016 Sep 22 doi: 10.1016/S2468-1253(16)30024-3. PMID: 28404091
Wilson RG, Davis RE
Adv Clin Chem 1983;23:1-68. doi: 10.1016/s0065-2423(08)60397-2. PMID: 6398613
Poppers PJ
Anaesthesist 1980 Feb;29(2):55-8. PMID: 6990824

Prognosis

Prescott LF
Br J Clin Pharmacol 2024 Jan;90(1):127-134. Epub 2023 Sep 21 doi: 10.1111/bcp.15903. PMID: 37683599
Lv S, Wang Y, Zhang W, Shang H
Heart 2022 May 25;108(12):917-922. doi: 10.1136/heartjnl-2021-320054. PMID: 34611047
Chan HL, Fung S, Seto WK, Chuang WL, Chen CY, Kim HJ, Hui AJ, Janssen HL, Chowdhury A, Tsang TY, Mehta R, Gane E, Flaherty JF, Massetto B, Gaggar A, Kitrinos KM, Lin L, Subramanian GM, McHutchison JG, Lim YS, Acharya SK, Agarwal K; GS-US-320-0110 Investigators
Lancet Gastroenterol Hepatol 2016 Nov;1(3):185-195. Epub 2016 Sep 22 doi: 10.1016/S2468-1253(16)30024-3. PMID: 28404091
Lattuada G, Ragogna F, Perseghin G
Curr Diab Rep 2011 Jun;11(3):167-72. doi: 10.1007/s11892-011-0190-2. PMID: 21431854
Mudd SH, Levy HL, Tangerman A, Boujet C, Buist N, Davidson-Mundt A, Hudgins L, Oyanagi K, Nagao M, Wilson WG
Am J Hum Genet 1995 Oct;57(4):882-92. PMID: 7573050Free PMC Article

Clinical prediction guides

Prescott LF
Br J Clin Pharmacol 2024 Jan;90(1):127-134. Epub 2023 Sep 21 doi: 10.1111/bcp.15903. PMID: 37683599
Córdoba-Jover B, Ribera J, Portolés I, Lecue E, Rodriguez-Vita J, Pérez-Sisqués L, Mannara F, Solsona-Vilarrasa E, García-Ruiz C, Fernández-Checa JC, Casals G, Rodríguez-Revenga L, Álvarez-Mora MI, Arteche-López A, Díaz de Bustamante A, Calvo R, Pujol A, Azkargorta M, Elortza F, Malagelada C, Pinyol R, Huguet-Pradell J, Melgar-Lesmes P, Jiménez W, Morales-Ruiz M
Liver Int 2023 Aug;43(8):1822-1836. Epub 2023 Jun 14 doi: 10.1111/liv.15640. PMID: 37312667
Schwasinger-Schmidt TE, Macaluso M
Handb Exp Pharmacol 2019;250:325-355. doi: 10.1007/164_2018_167. PMID: 30194544
Mudd SH, Levy HL, Tangerman A, Boujet C, Buist N, Davidson-Mundt A, Hudgins L, Oyanagi K, Nagao M, Wilson WG
Am J Hum Genet 1995 Oct;57(4):882-92. PMID: 7573050Free PMC Article
Kumar R
Physiol Rev 1984 Apr;64(2):478-504. doi: 10.1152/physrev.1984.64.2.478. PMID: 6324253

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