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Probst bundles

MedGen UID:
1814227
•Concept ID:
C5676654
•
Finding
HPO: HP:0034054

Definition

Probst bundles (also known as longitudinal callosal fascicles) are neuroanatomical homologues to the corpus callosum and can occur in association with callosal agenesis. Probst bundles are white matter fibers that normally cross the corpus callosum but (because of the agenesis of the corpus callosum) fail to cross the midline, such that when they reach the corticoseptal boundary, they turn and run parallel to the interhemispheric fissure within the septal leaves, indenting the medial walls of the lateral ventricles. [from HPO]

Conditions with this feature

Chromosome 6q24-q25 deletion syndrome
MedGen UID:
461565
•Concept ID:
C3150215
•
Disease or Syndrome
6q25 microdeletion syndrome is a recently described syndrome characterized by developmental delay, facial dysmorphism and hearing loss.
See: Condition Record
Macrocephaly, acquired, with impaired intellectual development
MedGen UID:
1648471
•Concept ID:
C4748993
•
Disease or Syndrome
See: Condition Record
Chromosome 6q24-q25 deletion syndrome
Macrocephaly, acquired, with impaired intellectual development

Professional guidelines

PubMed

Multicenter implementation of a severe sepsis and septic shock treatment bundle.
Miller RR 3rd, Dong L, Nelson NC, Brown SM, Kuttler KG, Probst DR, Allen TL, Clemmer TP; Intermountain Healthcare Intensive Medicine Clinical Program
Am J Respir Crit Care Med 2013 Jul 1;188(1):77-82. doi: 10.1164/rccm.201212-2199OC. PMID: 23631750Free PMC Article
Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients.
Smits JP, Eckardt L, Probst V, Bezzina CR, Schott JJ, Remme CA, Haverkamp W, Breithardt G, Escande D, Schulze-Bahr E, LeMarec H, Wilde AA
J Am Coll Cardiol 2002 Jul 17;40(2):350-6. doi: 10.1016/s0735-1097(02)01962-9. PMID: 12106943

Recent clinical studies

Etiology

Quantitative fetal MRI with diffusion tensor imaging in cases with 'short' corpus callosum.
Corroenne R, Grevent D, Mahallati H, Millischer AE, Gauchard G, Bussieres L, Kasprian G, Ville Y, Salomon LJ
Ultrasound Obstet Gynecol 2024 Mar;63(3):385-391. Epub 2024 Feb 7 doi: 10.1002/uog.27473. PMID: 37676105
Feasibility and Added Value of Fetal DTI Tractography in the Evaluation of an Isolated Short Corpus Callosum: Preliminary Results.
Millischer AE, Grevent D, Sonigo P, Bahi-Buisson N, Desguerre I, Mahallati H, Bault JP, Quibel T, Couderc S, Moutard ML, Julien E, Dangouloff V, Bessieres B, Malan V, Attie T, Salomon LJ, Boddaert N
AJNR Am J Neuroradiol 2022 Jan;43(1):132-138. Epub 2021 Dec 23 doi: 10.3174/ajnr.A7383. PMID: 34949593Free PMC Article
Structural Connectivity Analysis in Children with Segmental Callosal Agenesis.
Severino M, Tortora D, Toselli B, Uccella S, Traverso M, Morana G, Capra V, Veneselli E, Fato MM, Rossi A
AJNR Am J Neuroradiol 2017 Mar;38(3):639-647. Epub 2017 Jan 19 doi: 10.3174/ajnr.A5043. PMID: 28104634Free PMC Article
The middle interhemispheric variant of holoprosencephaly: magnetic resonance and diffusion tensor imaging findings.
Bulakbasi N, Cancuri O, Kocaoğlu M
Br J Radiol 2016 Jul;89(1063):20160115. Epub 2016 Apr 19 doi: 10.1259/bjr.20160115. PMID: 27089898Free PMC Article
Corpus callosum abnormalities: neuroradiological and clinical correlations.
Al-Hashim AH, Blaser S, Raybaud C, MacGregor D
Dev Med Child Neurol 2016 May;58(5):475-84. Epub 2015 Dec 9 doi: 10.1111/dmcn.12978. PMID: 26661037

Diagnosis

Feasibility and Added Value of Fetal DTI Tractography in the Evaluation of an Isolated Short Corpus Callosum: Preliminary Results.
Millischer AE, Grevent D, Sonigo P, Bahi-Buisson N, Desguerre I, Mahallati H, Bault JP, Quibel T, Couderc S, Moutard ML, Julien E, Dangouloff V, Bessieres B, Malan V, Attie T, Salomon LJ, Boddaert N
AJNR Am J Neuroradiol 2022 Jan;43(1):132-138. Epub 2021 Dec 23 doi: 10.3174/ajnr.A7383. PMID: 34949593Free PMC Article
Buffalo horn ventricles: case illustration.
Jackson EM, Cohen AR
J Neurosurg Pediatr 2018 May;21(5):496-497. Epub 2018 Mar 2 doi: 10.3171/2018.1.PEDS17667. PMID: 29498606
Corpus callosum abnormalities: neuroradiological and clinical correlations.
Al-Hashim AH, Blaser S, Raybaud C, MacGregor D
Dev Med Child Neurol 2016 May;58(5):475-84. Epub 2015 Dec 9 doi: 10.1111/dmcn.12978. PMID: 26661037
Morphometric variability of neuroimaging features in children with agenesis of the corpus callosum.
Neal JB, Filippi CG, Mayeux R
BMC Neurol 2015 Jul 25;15:116. doi: 10.1186/s12883-015-0382-5. PMID: 26209096Free PMC Article
Novel proximal 14q deletion: clinical and diffusion tensor imaging tractography findings in a patient with lissencephaly, agenesis of the corpus callosum, and septo-optic dysplasia.
Bravo EK, White ML, Olney AH, McAllister JL, Zhang YD
AJNR Am J Neuroradiol 2012 Feb;33(2):E16-8. Epub 2011 Dec 22 doi: 10.3174/ajnr.A2745. PMID: 22194387Free PMC Article

Therapy

Quantitative fetal MRI with diffusion tensor imaging in cases with 'short' corpus callosum.
Corroenne R, Grevent D, Mahallati H, Millischer AE, Gauchard G, Bussieres L, Kasprian G, Ville Y, Salomon LJ
Ultrasound Obstet Gynecol 2024 Mar;63(3):385-391. Epub 2024 Feb 7 doi: 10.1002/uog.27473. PMID: 37676105
Electrophysiological Correlates of Morphological Neuroplasticity in Human Callosal Dysgenesis.
Lazarev VV, de Carvalho Monteiro M, Vianna-Barbosa R, deAzevedo LC, Lent R, Tovar-Moll F
PLoS One 2016;11(4):e0152668. Epub 2016 Apr 7 doi: 10.1371/journal.pone.0152668. PMID: 27055255Free PMC Article

Prognosis

Feasibility and Added Value of Fetal DTI Tractography in the Evaluation of an Isolated Short Corpus Callosum: Preliminary Results.
Millischer AE, Grevent D, Sonigo P, Bahi-Buisson N, Desguerre I, Mahallati H, Bault JP, Quibel T, Couderc S, Moutard ML, Julien E, Dangouloff V, Bessieres B, Malan V, Attie T, Salomon LJ, Boddaert N
AJNR Am J Neuroradiol 2022 Jan;43(1):132-138. Epub 2021 Dec 23 doi: 10.3174/ajnr.A7383. PMID: 34949593Free PMC Article
Transient Probst Bundle Diffusion Restriction: An Acute Encephalopathy Equivalent to Clinically Mild Encephalopathy with a Reversible Splenial Lesion.
Ohashi E, Hayakawa I, Abe Y, Tsutsumi Y, Kubota M
Intern Med 2021 Aug 15;60(16):2667-2670. Epub 2021 Mar 1 doi: 10.2169/internalmedicine.6840-20. PMID: 33642486Free PMC Article
The middle interhemispheric variant of holoprosencephaly: magnetic resonance and diffusion tensor imaging findings.
Bulakbasi N, Cancuri O, Kocaoğlu M
Br J Radiol 2016 Jul;89(1063):20160115. Epub 2016 Apr 19 doi: 10.1259/bjr.20160115. PMID: 27089898Free PMC Article
Corpus callosum abnormalities: neuroradiological and clinical correlations.
Al-Hashim AH, Blaser S, Raybaud C, MacGregor D
Dev Med Child Neurol 2016 May;58(5):475-84. Epub 2015 Dec 9 doi: 10.1111/dmcn.12978. PMID: 26661037
The structural connectome of the human brain in agenesis of the corpus callosum.
Owen JP, Li YO, Ziv E, Strominger Z, Gold J, Bukhpun P, Wakahiro M, Friedman EJ, Sherr EH, Mukherjee P
Neuroimage 2013 Apr 15;70:340-55. Epub 2012 Dec 23 doi: 10.1016/j.neuroimage.2012.12.031. PMID: 23268782Free PMC Article

Clinical prediction guides

Electrophysiological Correlates of Morphological Neuroplasticity in Human Callosal Dysgenesis.
Lazarev VV, de Carvalho Monteiro M, Vianna-Barbosa R, deAzevedo LC, Lent R, Tovar-Moll F
PLoS One 2016;11(4):e0152668. Epub 2016 Apr 7 doi: 10.1371/journal.pone.0152668. PMID: 27055255Free PMC Article
Corpus callosum abnormalities: neuroradiological and clinical correlations.
Al-Hashim AH, Blaser S, Raybaud C, MacGregor D
Dev Med Child Neurol 2016 May;58(5):475-84. Epub 2015 Dec 9 doi: 10.1111/dmcn.12978. PMID: 26661037
Organising white matter in a brain without corpus callosum fibres.
Bénézit A, Hertz-Pannier L, Dehaene-Lambertz G, Monzalvo K, Germanaud D, Duclap D, Guevara P, Mangin JF, Poupon C, Moutard ML, Dubois J
Cortex 2015 Feb;63:155-71. Epub 2014 Sep 11 doi: 10.1016/j.cortex.2014.08.022. PMID: 25282054
The structural connectome of the human brain in agenesis of the corpus callosum.
Owen JP, Li YO, Ziv E, Strominger Z, Gold J, Bukhpun P, Wakahiro M, Friedman EJ, Sherr EH, Mukherjee P
Neuroimage 2013 Apr 15;70:340-55. Epub 2012 Dec 23 doi: 10.1016/j.neuroimage.2012.12.031. PMID: 23268782Free PMC Article

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