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Vaginal Smooth Muscle Tumor of Uncertain Malignant Potential

MedGen UID:: 1793822
•Concept ID:: C5557381
•: Neoplastic Process

Synonyms:

Vaginal Smooth Muscle Neoplasm of Uncertain Malignant Potential; Vaginal STUMP

Definition

A smooth muscle neoplasm that arises from the vagina and cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVVaginal Smooth Muscle Tumor of Uncertain Malignant Potential

Disorder by Site
- Disorder of the genitourinary system
  - Reproductive system disorder
    - Female reproductive system disorder
      - Female reproductive system neoplasm
        Female Reproductive System Smooth Muscle Tumor of Uncertain Malignant Potential
        Vaginal Smooth Muscle Tumor of Uncertain Malignant Potential

Professional guidelines

PubMed

Functional outcome of the anterior vaginal wall in a pelvic surgery injury rat model after treatment with stem cell-derived progenitors of smooth muscle cells.

Wang Y, Wen Y, Kim K, Wu H, Zhang J, Dobberfuhl AD, Chen B
Stem Cell Res Ther 2024 Sep 11;15(1):291. doi: 10.1186/s13287-024-03900-3. PMID: 39256865 Free PMC Article

Criteria for risk stratification of vulvar and vaginal smooth muscle tumors: a follow-up study with application to leiomyoma variants, smooth muscle tumors of uncertain malignant potential, and leiomyosarcomas.

Swanson AA, Howitt BE, Schoolmeester JK
Hum Pathol 2020 Sep;103:83-94. Epub 2020 Jul 17 doi: 10.1016/j.humpath.2020.06.008. PMID: 32687944

Criteria for Risk Stratification of Vulvar and Vaginal Smooth Muscle Tumors: An Evaluation of 71 Cases Comparing Proposed Classification Systems.

Sayeed S, Xing D, Jenkins SM, Weisman PS, Buehler D, Warmke L, Uram-Tuculescu C, Bakkum-Gamez JN, Howitt BE, Cortese C, Park KJ, Schoolmeester JK
Am J Surg Pathol 2018 Jan;42(1):84-94. doi: 10.1097/PAS.0000000000000920. PMID: 28786880 Free PMC Article

See all (4)

Recent clinical studies

Etiology

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.

Richtarova A, Boudova B, Dundr P, Lisa Z, Hlinecka K, Zizka Z, Fruhauf F, Kuzel D, Slama J, Mara M
Int J Gynecol Cancer 2023 May 1;33(5):701-706. doi: 10.1136/ijgc-2022-004038. PMID: 36898699 Free PMC Article

Vaginal Leiomyoma: A Case Report.

Shah M, Saha R, Kc N
JNMA J Nepal Med Assoc 2021 May 25;59(237):504-505. doi: 10.31729/jnma.6180. PMID: 34508428 Free PMC Article

Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.

Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612

MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors.

Markowski DN, Huhle S, Nimzyk R, Stenman G, Löning T, Bullerdiek J
Genes Chromosomes Cancer 2013 Mar;52(3):297-304. Epub 2012 Dec 8 doi: 10.1002/gcc.22029. PMID: 23225304

Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature.

Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW
Am J Surg Pathol 2005 Dec;29(12):1558-75. doi: 10.1097/01.pas.0000173232.22117.37. PMID: 16327428

See all (32)

Diagnosis

Atypical Polypoid Adenomyoma (APAM).

Javed L, Ashraf N, Sabqat M, Zareen A
J Coll Physicians Surg Pak 2021 Jun;31(6):719-721. doi: 10.29271/jcpsp.2021.06.719. PMID: 34102788

Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.

Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612

Gynecological Sarcomas: Molecular Characteristics, Behavior, and Histology-Driven Therapy.

Libertini M, Hallin M, Thway K, Noujaim J, Benson C, van der Graaf W, Jones RL
Int J Surg Pathol 2021 Feb;29(1):4-20. Epub 2020 Sep 10 doi: 10.1177/1066896920958120. PMID: 32909482

Smooth Muscle Tumors of the Female Genital Tract.

Devereaux KA, Schoolmeester JK
Surg Pathol Clin 2019 Jun;12(2):397-455. doi: 10.1016/j.path.2019.02.004. PMID: 31097110

Paraurethral leiomyoma.

Pastor Navarro H, Martínez Ruiz J, Martínez Sanchíz C, Perán Teruel M, Segura Martín M, Pastor Guzman JM, Virseda Rodríguez J
Arch Esp Urol 2013 Oct;66(8):820-3. PMID: 24136487

See all (103)

Therapy

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.

Hydrosalpinx in a premenarcheal 14-year-old girl with the proliferation of smooth muscle cells in the isthmus of the fallopian tube: A case report.

Kamo N, Takahashi T, Soeda S, Jimbo M, Yoshida-Komiya H, Fujimori K
J Obstet Gynaecol Res 2023 Feb;49(2):769-774. Epub 2022 Oct 28 doi: 10.1111/jog.15481. PMID: 36305392

Safety of Manual Morcellation After Vaginal or Laparoscopic-assisted Vaginal Hysterectomy.

Balgobin S, Maldonado PA, Chin K, Schaffer JI, Hamid CA
J Minim Invasive Gynecol 2016 May-Jun;23(4):542-7. Epub 2016 Jan 21 doi: 10.1016/j.jmig.2016.01.014. PMID: 26802908

Atypical smooth muscle tumor of the vagina--a pediatric case report and review of the literature.

Crowley HM, Mohamed A, Baker P, Jayanthi VR, Ranalli M, Aldrink JH
J Pediatr Surg 2013 May;48(5):1118-22. doi: 10.1016/j.jpedsurg.2013.03.046. PMID: 23701791

Uterine smooth-muscle tumors with unusual growth patterns.

Vaquero ME, Magrina JF, Leslie KO
J Minim Invasive Gynecol 2009 May-Jun;16(3):263-8. doi: 10.1016/j.jmig.2009.01.013. PMID: 19423058

See all (12)

Prognosis

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.

Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.

Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612

Gynecological Sarcomas: Molecular Characteristics, Behavior, and Histology-Driven Therapy.

Libertini M, Hallin M, Thway K, Noujaim J, Benson C, van der Graaf W, Jones RL
Int J Surg Pathol 2021 Feb;29(1):4-20. Epub 2020 Sep 10 doi: 10.1177/1066896920958120. PMID: 32909482

Smooth Muscle Tumors of the Female Genital Tract.

Devereaux KA, Schoolmeester JK
Surg Pathol Clin 2019 Jun;12(2):397-455. doi: 10.1016/j.path.2019.02.004. PMID: 31097110

Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature.

Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW
Am J Surg Pathol 2005 Dec;29(12):1558-75. doi: 10.1097/01.pas.0000173232.22117.37. PMID: 16327428

See all (41)

Clinical prediction guides

Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.

Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.

Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612

Gynecological Sarcomas: Molecular Characteristics, Behavior, and Histology-Driven Therapy.

Libertini M, Hallin M, Thway K, Noujaim J, Benson C, van der Graaf W, Jones RL
Int J Surg Pathol 2021 Feb;29(1):4-20. Epub 2020 Sep 10 doi: 10.1177/1066896920958120. PMID: 32909482

Uterine adenomyoma: a clinicopathologic review of 26 cases and a review of the literature.

Tahlan A, Nanda A, Mohan H
Int J Gynecol Pathol 2006 Oct;25(4):361-5. doi: 10.1097/01.pgp.0000209570.08716.b3. PMID: 16990713

Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature.

Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW
Am J Surg Pathol 2005 Dec;29(12):1558-75. doi: 10.1097/01.pas.0000173232.22117.37. PMID: 16327428

See all (21)

MedGen

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Vaginal Smooth Muscle Tumor of Uncertain Malignant Potential

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

Related information

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