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Skip Metastasis

MedGen UID:
1792208
•Concept ID:
C5555767
•
Neoplastic Process

Definition

A metastatic lesion that arises in an uninvolved contiguous area next to a cancer. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkip Metastasis

Professional guidelines

PubMed

Supraomohyoid neck dissection in the management of oral squamous cell carcinoma: special consideration for skip metastases at level IV or V.
Feng Z, Li JN, Niu LX, Guo CB
J Oral Maxillofac Surg 2014 Jun;72(6):1203-11. Epub 2013 Dec 25 doi: 10.1016/j.joms.2013.12.008. PMID: 24480771
Clinical applications of sentinel lymph-node biopsy for the staging and treatment of solid neoplasms.
Gipponi M
Minerva Chir 2005 Aug;60(4):217-33. PMID: 16166921
Guidelines for sentinel node biopsy and lymphatic mapping of patients with breast cancer.
Cox CE, Pendas S, Cox JM, Joseph E, Shons AR, Yeatman T, Ku NN, Lyman GH, Berman C, Haddad F, Reintgen DS
Ann Surg 1998 May;227(5):645-51; discussion 651-3. doi: 10.1097/00000658-199805000-00005. PMID: 9605656Free PMC Article

Recent clinical studies

Etiology

Incidence and impact of skip metastasis in the neck in early oral cancer: Reality or a myth?
Gurmeet Singh A, Sathe P, Roy S, Thiagrajan S, Chaukar D, Chaturvedi P
Oral Oncol 2022 Dec;135:106201. Epub 2022 Oct 12 doi: 10.1016/j.oraloncology.2022.106201. PMID: 36242909
The Prognosis of Skip Metastasis in Papillary Thyroid Microcarcinoma Is Better Than That of Continuous Metastasis.
Weng HY, Yan T, Qiu WW, Fan YB, Yang ZL
J Clin Endocrinol Metab 2022 May 17;107(6):1589-1598. doi: 10.1210/clinem/dgac107. PMID: 35213704
Altered lymphatic structure and function in pleural anthracosis: negative role in skip N2 metastasis.
Takeda A, Ueda K, Aoki M, Nagata T, Kamimura G, Umehara T, Tokunaga T, Tabata K, Tanimoto A, Sato M
Eur J Cardiothorac Surg 2022 Aug 3;62(3) doi: 10.1093/ejcts/ezac123. PMID: 35211750
New revisions and current issues in the eighth edition of the TNM classification for non-small cell lung cancer.
Hattori A, Takamochi K, Oh S, Suzuki K
Jpn J Clin Oncol 2019 Jan 1;49(1):3-11. doi: 10.1093/jjco/hyy142. PMID: 30277521
Skip mediastinal lymph node metastasis and lung cancer: a particular N2 subgroup with a better prognosis.
Riquet M, Assouad J, Bagan P, Foucault C, Le Pimpec Barthes F, Dujon A, Danel C
Ann Thorac Surg 2005 Jan;79(1):225-33. doi: 10.1016/j.athoracsur.2004.06.081. PMID: 15620948

Diagnosis

Comparative Analysis of Skip Metastasis in Pediatric Osteosarcoma: Clinical Features and Outcomes.
Halalsheh H, Amer S, Omari Z, Shawagfeh M, Boheisi M, Sultan I
J Pediatr Hematol Oncol 2024 Apr 1;46(3):154-158. Epub 2024 Feb 19 doi: 10.1097/MPH.0000000000002831. PMID: 38408127Free PMC Article
Risk factors for skip metastasis in patients with papillary thyroid microcarcinoma.
Wu X, Li B, Zheng C, He X
Cancer Med 2023 Mar;12(6):7560-7566. Epub 2022 Dec 8 doi: 10.1002/cam4.5507. PMID: 36479912Free PMC Article
A Novel and Effective Model to Predict Skip Metastasis in Papillary Thyroid Carcinoma Based on a Support Vector Machine.
Zhu S, Wang Q, Zheng D, Zhu L, Zhou Z, Xu S, Shi B, Jin C, Zheng G, Cai Y
Front Endocrinol (Lausanne) 2022;13:916121. Epub 2022 Jul 5 doi: 10.3389/fendo.2022.916121. PMID: 35865315Free PMC Article
Central lymph node metastasis: is it a reliable indicator of lateral node involvement in papillary thyroid carcinoma?
Xiao GZ, Gao L
World J Surg 2010 Feb;34(2):237-41. doi: 10.1007/s00268-009-0347-1. PMID: 20041247
Intracranial skip metastasis from parotid and facial skin tumors: mechanism, diagnosis, and treatment.
Kumar PP, Patil AA, Ogren FP, Johansson SL, Reeves MA
J Natl Med Assoc 1993 May;85(5):369-74. PMID: 8388480Free PMC Article

Therapy

Lymph Node Dissection for Papillary Thyroid Carcinoma.
Lo CY
Methods Mol Biol 2022;2534:57-78. doi: 10.1007/978-1-0716-2505-7_5. PMID: 35670968
Assessment of the Rate of Skip Metastasis to Neck Level IV in Patients With Clinically Node-Negative Neck Oral Cavity Squamous Cell Carcinoma: A Systematic Review and Meta-analysis.
Warshavsky A, Rosen R, Nard-Carmel N, Abu-Ghanem S, Oestreicher-Kedem Y, Abergel A, Fliss DM, Horowitz G
JAMA Otolaryngol Head Neck Surg 2019 Jun 1;145(6):542-548. doi: 10.1001/jamaoto.2019.0784. PMID: 31070693Free PMC Article
Sentinel Node Navigation in Gastric Cancer: Where Do We Stand?
Lianos GD, Bali CD, Hasemaki N, Glantzounis GK, Mitsis M, Rausei S
J Gastrointest Cancer 2019 Jun;50(2):201-206. doi: 10.1007/s12029-019-00217-w. PMID: 30815770
Biopsy of the sentinel node in lung cancer.
Uribe-Etxebarria Lugariza-Aresti N, Barceló Galíndez R, Pac Ferrer J, Méndez Martín J, Genollá Subirats J, Casanova Viudez J
Med Clin (Barc) 2017 Mar 22;148(6):257-259. Epub 2016 Dec 16 doi: 10.1016/j.medcli.2016.10.034. PMID: 27993403
Skip metastases in osteosarcoma: recent experience.
Malawer MM, Dunham WK
J Surg Oncol 1983 Apr;22(4):236-45. doi: 10.1002/jso.2930220406. PMID: 6572771

Prognosis

Incidence and impact of skip metastasis in the neck in early oral cancer: Reality or a myth?
Gurmeet Singh A, Sathe P, Roy S, Thiagrajan S, Chaukar D, Chaturvedi P
Oral Oncol 2022 Dec;135:106201. Epub 2022 Oct 12 doi: 10.1016/j.oraloncology.2022.106201. PMID: 36242909
Prognostic value of node skip metastasis on esophageal cancer: A systematic review and meta-analysis.
A-Lai GH, Xu ZJ, Yao P, Zhong X, Wang YC, Lin YD
Asian J Surg 2022 Dec;45(12):2601-2607. Epub 2022 Feb 24 doi: 10.1016/j.asjsur.2021.12.071. PMID: 35221181
The Prognosis of Skip Metastasis in Papillary Thyroid Microcarcinoma Is Better Than That of Continuous Metastasis.
Weng HY, Yan T, Qiu WW, Fan YB, Yang ZL
J Clin Endocrinol Metab 2022 May 17;107(6):1589-1598. doi: 10.1210/clinem/dgac107. PMID: 35213704
New revisions and current issues in the eighth edition of the TNM classification for non-small cell lung cancer.
Hattori A, Takamochi K, Oh S, Suzuki K
Jpn J Clin Oncol 2019 Jan 1;49(1):3-11. doi: 10.1093/jjco/hyy142. PMID: 30277521
Prognosis of osteosarcoma with "skip" metastasis.
Wuisman P, Enneking WF
Chir Organi Mov 1990;75(1 Suppl):60-4. PMID: 2249561

Clinical prediction guides

Comparative Analysis of Skip Metastasis in Pediatric Osteosarcoma: Clinical Features and Outcomes.
Halalsheh H, Amer S, Omari Z, Shawagfeh M, Boheisi M, Sultan I
J Pediatr Hematol Oncol 2024 Apr 1;46(3):154-158. Epub 2024 Feb 19 doi: 10.1097/MPH.0000000000002831. PMID: 38408127Free PMC Article
Incidence and impact of skip metastasis in the neck in early oral cancer: Reality or a myth?
Gurmeet Singh A, Sathe P, Roy S, Thiagrajan S, Chaukar D, Chaturvedi P
Oral Oncol 2022 Dec;135:106201. Epub 2022 Oct 12 doi: 10.1016/j.oraloncology.2022.106201. PMID: 36242909
The Prognosis of Skip Metastasis in Papillary Thyroid Microcarcinoma Is Better Than That of Continuous Metastasis.
Weng HY, Yan T, Qiu WW, Fan YB, Yang ZL
J Clin Endocrinol Metab 2022 May 17;107(6):1589-1598. doi: 10.1210/clinem/dgac107. PMID: 35213704
Altered lymphatic structure and function in pleural anthracosis: negative role in skip N2 metastasis.
Takeda A, Ueda K, Aoki M, Nagata T, Kamimura G, Umehara T, Tokunaga T, Tabata K, Tanimoto A, Sato M
Eur J Cardiothorac Surg 2022 Aug 3;62(3) doi: 10.1093/ejcts/ezac123. PMID: 35211750
Detection of alternative subpleural lymph flow pathways using indocyanine green fluorescence.
Takeda AH, Watanabe Y, Nagata T, Aoki M, Umehara T, Suzuki S, Kamimura G, Wakida K, Otsuka T, Yokomakura N, Kariatsumari K, Sakasegawa K, Nakamura Y, Sato M
Surg Today 2018 Jun;48(6):640-648. Epub 2018 Jan 30 doi: 10.1007/s00595-018-1631-1. PMID: 29383594

Recent systematic reviews

The Prognostic Value of Nodal Skip Metastasis in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis.
Li X, Shang Q, Yang Y, Zhou J, Fang P, Luan S, Xiao X, Yuan Y
World J Surg 2023 Feb;47(2):489-499. Epub 2022 Oct 28 doi: 10.1007/s00268-022-06796-3. PMID: 36305953
Prognostic value of node skip metastasis on esophageal cancer: A systematic review and meta-analysis.
A-Lai GH, Xu ZJ, Yao P, Zhong X, Wang YC, Lin YD
Asian J Surg 2022 Dec;45(12):2601-2607. Epub 2022 Feb 24 doi: 10.1016/j.asjsur.2021.12.071. PMID: 35221181
D3-lymphadenectomy enhances oncological clearance in patients with right colon cancer. Results of a meta-analysis.
Balciscueta Z, Balciscueta I, Uribe N, Pellino G, Frasson M, García-Granero E, García-Granero Á
Eur J Surg Oncol 2021 Jul;47(7):1541-1551. Epub 2021 Feb 26 doi: 10.1016/j.ejso.2021.02.020. PMID: 33676793
Skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review.
Attard A, Paladino NC, Lo Monte AI, Falco N, Melfa G, Rotolo G, Rizzuto S, Gulotta E, Salamone G, Bonventre S, Scerrino G, Cocorullo G
BMC Surg 2019 Apr 24;18(Suppl 1):112. doi: 10.1186/s12893-018-0435-y. PMID: 31074393Free PMC Article
Assessment of the Rate of Skip Metastasis to Neck Level IV in Patients With Clinically Node-Negative Neck Oral Cavity Squamous Cell Carcinoma: A Systematic Review and Meta-analysis.
Warshavsky A, Rosen R, Nard-Carmel N, Abu-Ghanem S, Oestreicher-Kedem Y, Abergel A, Fliss DM, Horowitz G
JAMA Otolaryngol Head Neck Surg 2019 Jun 1;145(6):542-548. doi: 10.1001/jamaoto.2019.0784. PMID: 31070693Free PMC Article

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