T/NK-Cell Lymphoproliferative Disorder

MedGen UID:: 1791872
•Concept ID:: C5555431
•: Disease or Syndrome

Synonym:

T-Cell Lymphoproliferative Disorder

Definition

A non-neoplastic or neoplastic proliferation of T-lymphocytes and/or NK-cells. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVT/NK-Cell Lymphoproliferative Disorder

Pathological process
- Disease
  - Disorder by Site
    - Hematopoietic and Lymphatic System Disorder
      - Hematologic disorder
        Lymphoproliferative disorder
        T/NK-Cell Lymphoproliferative Disorder
        Indolent T-Lymphoblastic Proliferation
        Monomorphic T/NK-Cell Post-Transplant Lymphoproliferative Disorder
        Severe Mosquito Bite Allergy
        T-cell and NK-cell neoplasm
        Neoplasm of mature T-cells or NK-cells
        Aggressive NK-cell leukemia
        Chronic lymphoproliferative disorder of NK-cells
        Cutaneous Mature T-Cell and NK-Cell Neoplasm
        EBV-positive T-cell lymphoproliferative disorder of childhood
        Mature T-cell and NK-cell non-Hodgkin lymphoma
        Recurrent Mature T-Cell and NK-Cell Neoplasm
        Refractory Mature T-Cell and NK-Cell Neoplasm
        T-cell large granular lymphocyte leukemia
        T-Cell Proliferation of Uncertain Malignant Potential
        T-cell prolymphocytic leukemia
        Precursor T-lymphoblastic lymphoma/leukemia
        Childhood precursor T-lymphoblastic lymphoma/leukemia
        Cutaneous T Lymphoblastic Leukemia/Lymphoma
        Mediastinal T Lymphoblastic Leukemia/Lymphoma
        Recurrent T Lymphoblastic Leukemia/Lymphoma
        Refractory precursor T-lymphoblastic lymphoma/leukemia
        Stage I T Lymphoblastic Leukemia/Lymphoma
        Stage II T Lymphoblastic Leukemia/Lymphoma
        Stage III T Lymphoblastic Leukemia/Lymphoma
        Stage IV T Lymphoblastic Leukemia/Lymphoma
        T-cell acute lymphoblastic leukemia
        T-lymphoblastic lymphoma
        T-cell lymphoma
        Aggressive T-Cell Non-Hodgkin Lymphoma
        Anaplastic large cell lymphoma
        Angioimmunoblastic T-cell lymphoma
        Breast T-Cell Non-Hodgkin Lymphoma
        CD4+/CD56+ hematodermic neoplasm
        Central Nervous System T-Cell Non-Hodgkin Lymphoma
        Enteropathy-associated T-cell lymphoma
        Extranodal NK-T-Cell Lymphoma
        Gastric T-Cell Non-Hodgkin Lymphoma
        Hepatosplenic T-cell lymphoma
        Hydroa vacciniforme-like lymphoma
        Peripheral T-cell lymphoma
        Post-transplant lymphoproliferative disease
        Primary cutaneous T-cell lymphoma
        Recurrent T-Cell Non-Hodgkin Lymphoma
        Refractory T-Cell Non-Hodgkin Lymphoma
        Small Intestinal T-Cell Non-Hodgkin Lymphoma
        Subcutaneous panniculitis-like T-cell lymphoma
        Systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood
        T-cell lymphoma/leukemia
        T-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage

Professional guidelines

PubMed

Treatment of extranodal NK/T-cell lymphoma: From past to future.

Yan Z, Yao S, Wang Z, Zhou W, Yao Z, Liu Y
Front Immunol 2023;14:1088685. Epub 2023 Feb 7 doi: 10.3389/fimmu.2023.1088685. PMID: 36825002 Free PMC Article

Epstein - Barr virus positive T and NK-cell lymphoproliferations: Morphological features and differential diagnosis.

Montes-Mojarro IA, Kim WY, Fend F, Quintanilla-Martinez L
Semin Diagn Pathol 2020 Jan;37(1):32-46. Epub 2019 Dec 17 doi: 10.1053/j.semdp.2019.12.004. PMID: 31889602

Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies.

Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188 Free PMC Article

See all (17)

Recent clinical studies

Diagnosis

Extranodal NK/T-cell lymphoma of the nasal cavity developed in a patient with intestinal Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder.

Furuya G, Abe H, Shinozaki-Ushiku A, Yamashita A, Ihara S, Hirata Y, Chiba A, Fujioka Y, Kurokawa M, Koike K, Fukayama M
Pathol Res Pract 2018 Jul;214(7):1051-1055. Epub 2018 May 22 doi: 10.1016/j.prp.2018.05.022. PMID: 29843925

A distinct subtype of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder: adult patients with chronic active Epstein-Barr virus infection-like features.

Kawamoto K, Miyoshi H, Suzuki T, Kozai Y, Kato K, Miyahara M, Yujiri T, Choi I, Fujimaki K, Muta T, Kume M, Moriguchi S, Tamura S, Kato T, Tagawa H, Makiyama J, Kanisawa Y, Sasaki Y, Kurita D, Yamada K, Shimono J, Sone H, Takizawa J, Seto M, Kimura H, Ohshima K
Haematologica 2018 Jun;103(6):1018-1028. Epub 2017 Dec 14 doi: 10.3324/haematol.2017.174177. PMID: 29242302 Free PMC Article

Clinicopathological categorization of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disease: an analysis of 42 cases with an emphasis on prognostic implications.

Paik JH, Choe JY, Kim H, Lee JO, Kang HJ, Shin HY, Lee DS, Heo DS, Kim CW, Cho KH, Kim TM, Jeon YK
Leuk Lymphoma 2017 Jan;58(1):53-63. Epub 2016 May 9 doi: 10.1080/10428194.2016.1179297. PMID: 27157296

An adult case of systemic Epstein-Barr virus-positive T-cell lymphoproliferative disorder with severe hepatic dysfunction and megalosplenia.

Liu X, Li J, Yao W, Zhang W, Shen K, Cui X, Wu H
Rev Esp Enferm Dig 2015 Jun;107(6):384-8. PMID: 26031871

Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: a case report.

Kato S, Miyata T, Takata K, Shimada S, Ito Y, Tomita A, Elsayed AA, Takahashi E, Asano N, Kinoshita T, Kimura H, Nakamura S
Hum Pathol 2013 Dec;44(12):2849-52. Epub 2013 Sep 3 doi: 10.1016/j.humpath.2013.05.025. PMID: 24012167

See all (5)