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Metastatic Low Grade Astrocytoma

MedGen UID:
1791573
•Concept ID:
C5555132
•
Neoplastic Process

Definition

Low grade astrocytoma that has spread from its primary site to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Low Grade Astrocytoma

Professional guidelines

PubMed

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Is chemotherapy alone an option as initial treatment for low-grade oligodendrogliomas?
Rudà R, Touat M, Soffietti R
Curr Opin Neurol 2020 Dec;33(6):707-715. doi: 10.1097/WCO.0000000000000866. PMID: 33027142
Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas.
Chen R, Ravindra VM, Cohen AL, Jensen RL, Salzman KL, Prescot AP, Colman H
Neurosurg Focus 2015 Mar;38(3):E2. doi: 10.3171/2015.1.FOCUS14745. PMID: 25727224

Recent clinical studies

Etiology

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
A Molecular Update and Review of Current Trials in Paediatric Low-Grade Gliomas.
Al-Jilaihawi S, Lowis S
Pediatr Neurosurg 2023;58(5):290-298. Epub 2023 Aug 21 doi: 10.1159/000533703. PMID: 37604126
Recurrence- and Malignant Progression-Associated Biomarkers in Low-Grade Gliomas and Their Roles in Immunotherapy.
Teng C, Zhu Y, Li Y, Dai L, Pan Z, Wanggou S, Li X
Front Immunol 2022;13:899710. Epub 2022 May 23 doi: 10.3389/fimmu.2022.899710. PMID: 35677036Free PMC Article
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article
Partial seizures triggering infantile spasms in the presence of a basal ganglia glioma.
RamachandranNair R, Ochi A, Akiyama T, Buckley DJ, Soman TB, Weiss SK, Otsubo H
Epileptic Disord 2005 Dec;7(4):378-82. PMID: 16338683

Diagnosis

Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1).
Fisher MJ, Jones DTW, Li Y, Guo X, Sonawane PS, Waanders AJ, Phillips JJ, Weiss WA, Resnick AC, Gosline S, Banerjee J, Guinney J, Gnekow A, Kandels D, Foreman NK, Korshunov A, Ryzhova M, Massimi L, Gururangan S, Kieran MW, Wang Z, Fouladi M, Sato M, Øra I, Holm S, Markham SJ, Beck P, Jäger N, Wittmann A, Sommerkamp AC, Sahm F, Pfister SM, Gutmann DH
Acta Neuropathol 2021 Apr;141(4):605-617. Epub 2021 Feb 14 doi: 10.1007/s00401-021-02276-5. PMID: 33585982
The Multifaceted Metabolism of Glioblastoma.
Quinones A, Le A
Adv Exp Med Biol 2018;1063:59-72. doi: 10.1007/978-3-319-77736-8_4. PMID: 29946775
The definition of primary and secondary glioblastoma.
Ohgaki H, Kleihues P
Clin Cancer Res 2013 Feb 15;19(4):764-72. Epub 2012 Dec 3 doi: 10.1158/1078-0432.CCR-12-3002. PMID: 23209033
Partial seizures triggering infantile spasms in the presence of a basal ganglia glioma.
RamachandranNair R, Ochi A, Akiyama T, Buckley DJ, Soman TB, Weiss SK, Otsubo H
Epileptic Disord 2005 Dec;7(4):378-82. PMID: 16338683
Levels of enolase and other enzymes in the cerebrospinal fluid as indices of pathological change.
Royds JA, Timperley WR, Taylor CB
J Neurol Neurosurg Psychiatry 1981 Dec;44(12):1129-35. doi: 10.1136/jnnp.44.12.1129. PMID: 7334408Free PMC Article

Therapy

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor.
Hu H, Mu Q, Bao Z, Chen Y, Liu Y, Chen J, Wang K, Wang Z, Nam Y, Jiang B, Sa JK, Cho HJ, Her NG, Zhang C, Zhao Z, Zhang Y, Zeng F, Wu F, Kang X, Liu Y, Qian Z, Wang Z, Huang R, Wang Q, Zhang W, Qiu X, Li W, Nam DH, Fan X, Wang J, Jiang T
Cell 2018 Nov 29;175(6):1665-1678.e18. Epub 2018 Oct 18 doi: 10.1016/j.cell.2018.09.038. PMID: 30343896
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article
Low grade astrocytoma presenting with visual loss.
Groves MD, Katz RL
J Neurooncol 2008 Aug;89(1):49-50. Epub 2008 Apr 9 doi: 10.1007/s11060-008-9584-7. PMID: 18398571
Partial seizures triggering infantile spasms in the presence of a basal ganglia glioma.
RamachandranNair R, Ochi A, Akiyama T, Buckley DJ, Soman TB, Weiss SK, Otsubo H
Epileptic Disord 2005 Dec;7(4):378-82. PMID: 16338683

Prognosis

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor.
Hu H, Mu Q, Bao Z, Chen Y, Liu Y, Chen J, Wang K, Wang Z, Nam Y, Jiang B, Sa JK, Cho HJ, Her NG, Zhang C, Zhao Z, Zhang Y, Zeng F, Wu F, Kang X, Liu Y, Qian Z, Wang Z, Huang R, Wang Q, Zhang W, Qiu X, Li W, Nam DH, Fan X, Wang J, Jiang T
Cell 2018 Nov 29;175(6):1665-1678.e18. Epub 2018 Oct 18 doi: 10.1016/j.cell.2018.09.038. PMID: 30343896
The Multifaceted Metabolism of Glioblastoma.
Quinones A, Le A
Adv Exp Med Biol 2018;1063:59-72. doi: 10.1007/978-3-319-77736-8_4. PMID: 29946775
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article
The definition of primary and secondary glioblastoma.
Ohgaki H, Kleihues P
Clin Cancer Res 2013 Feb 15;19(4):764-72. Epub 2012 Dec 3 doi: 10.1158/1078-0432.CCR-12-3002. PMID: 23209033

Clinical prediction guides

Recurrence- and Malignant Progression-Associated Biomarkers in Low-Grade Gliomas and Their Roles in Immunotherapy.
Teng C, Zhu Y, Li Y, Dai L, Pan Z, Wanggou S, Li X
Front Immunol 2022;13:899710. Epub 2022 May 23 doi: 10.3389/fimmu.2022.899710. PMID: 35677036Free PMC Article
Molecular landscape of IDH-mutant primary astrocytoma Grade IV/glioblastomas.
Wong QH, Li KK, Wang WW, Malta TM, Noushmehr H, Grabovska Y, Jones C, Chan AK, Kwan JS, Huang QJ, Wong GC, Li WC, Liu XZ, Chen H, Chan DT, Mao Y, Zhang ZY, Shi ZF, Ng HK
Mod Pathol 2021 Jul;34(7):1245-1260. Epub 2021 Mar 10 doi: 10.1038/s41379-021-00778-x. PMID: 33692446
Structure and evolution of double minutes in diagnosis and relapse brain tumors.
Xu K, Ding L, Chang TC, Shao Y, Chiang J, Mulder H, Wang S, Shaw TI, Wen J, Hover L, McLeod C, Wang YD, Easton J, Rusch M, Dalton J, Downing JR, Ellison DW, Zhang J, Baker SJ, Wu G
Acta Neuropathol 2019 Jan;137(1):123-137. Epub 2018 Sep 28 doi: 10.1007/s00401-018-1912-1. PMID: 30267146Free PMC Article
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article
Biomarker-driven diagnosis of diffuse gliomas.
Appin CL, Brat DJ
Mol Aspects Med 2015 Nov;45:87-96. Epub 2015 May 21 doi: 10.1016/j.mam.2015.05.002. PMID: 26004297

Recent systematic reviews

Application of Machine Learning for Classification of Brain Tumors: A Systematic Review and Meta-Analysis.
Silva Santana L, Borges Camargo Diniz J, Mothé Glioche Gasparri L, Buccaran Canto A, Batista Dos Reis S, Santana Neville Ribeiro I, Gadelha Figueiredo E, Paulo Mota Telles J
World Neurosurg 2024 Jun;186:204-218.e2. Epub 2024 Apr 3 doi: 10.1016/j.wneu.2024.03.152. PMID: 38580093
Laser Interstitial Thermal Therapy for the Treatment of Primary and Metastatic Brain Tumors: A Systematic Review and Meta-Analysis.
Alkazemi M, Lo YT, Hussein H, Mammi M, Saleh S, Araujo-Lama L, Mommsen S, Pisano A, Lamba N, Bunevicius A, Mekary RA
World Neurosurg 2023 Mar;171:e654-e671. Epub 2022 Dec 19 doi: 10.1016/j.wneu.2022.12.079. PMID: 36549438
External beam radiation dose escalation for high grade glioma.
Khan L, Soliman H, Sahgal A, Perry J, Xu W, Tsao MN
Cochrane Database Syst Rev 2020 May 21;5(5):CD011475. doi: 10.1002/14651858.CD011475.pub3. PMID: 32437039Free PMC Article
A systematic review of outcome in intramedullary ependymoma and astrocytoma.
Hamilton KR, Lee SS, Urquhart JC, Jonker BP
J Clin Neurosci 2019 May;63:168-175. Epub 2019 Mar 2 doi: 10.1016/j.jocn.2019.02.001. PMID: 30833131
A systematic literature review of magnetic resonance spectroscopy for the characterization of brain tumors.
Hollingworth W, Medina LS, Lenkinski RE, Shibata DK, Bernal B, Zurakowski D, Comstock B, Jarvik JG
AJNR Am J Neuroradiol 2006 Aug;27(7):1404-11. PMID: 16908548Free PMC Article

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