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Central Chondrosarcoma, Grade 2

MedGen UID:
1791520
•Concept ID:
C5555079
•
Neoplastic Process

Definition

An intermediate-grade chondrosarcoma arising in the medulla of bone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Chondrosarcoma, Grade 2

Professional guidelines

PubMed

A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma.
Rey V, Tornín J, Alba-Linares JJ, Robledo C, Murillo D, Rodríguez A, Gallego B, Huergo C, Viera C, Braña A, Astudillo A, Heymann D, Szuhai K, Bovée JVMG, Fernández AF, Fraga MF, Alonso J, Rodríguez R
EBioMedicine 2024 Apr;102:105090. Epub 2024 Mar 27 doi: 10.1016/j.ebiom.2024.105090. PMID: 38547578Free PMC Article
Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options.
Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742

Recent clinical studies

Etiology

Twenty-year outcome of prevalence, incidence, mortality and survival rate in patients with malignant bone tumors.
Xu Y, Shi F, Zhang Y, Yin M, Han X, Feng J, Wang G
Int J Cancer 2024 Jan 15;154(2):226-240. Epub 2023 Aug 19 doi: 10.1002/ijc.34694. PMID: 37596989
A pragmatic approach to the imaging and follow-up of solitary central cartilage tumours of the proximal humerus and knee.
Patel A, Davies AM, Botchu R, James S
Clin Radiol 2019 Jul;74(7):517-526. Epub 2019 Mar 1 doi: 10.1016/j.crad.2019.01.025. PMID: 30827492
Asymptomatic grade-2 central chondrosarcoma of the distal femur with non-aggressive radiological features.
Lam YL, Koljonen PA, Ho WY, Ng TP, Shek TW, Wong JS
Hong Kong Med J 2013 Feb;19(1):85-7. PMID: 23378363
Dedifferentiated central chondrosarcoma.
Staals EL, Bacchini P, Bertoni F
Cancer 2006 Jun 15;106(12):2682-91. doi: 10.1002/cncr.21936. PMID: 16691621
Dedifferentiated chondrosarcoma.
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Diagnosis

Twenty-year outcome of prevalence, incidence, mortality and survival rate in patients with malignant bone tumors.
Xu Y, Shi F, Zhang Y, Yin M, Han X, Feng J, Wang G
Int J Cancer 2024 Jan 15;154(2):226-240. Epub 2023 Aug 19 doi: 10.1002/ijc.34694. PMID: 37596989
Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options.
Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
A pragmatic approach to the imaging and follow-up of solitary central cartilage tumours of the proximal humerus and knee.
Patel A, Davies AM, Botchu R, James S
Clin Radiol 2019 Jul;74(7):517-526. Epub 2019 Mar 1 doi: 10.1016/j.crad.2019.01.025. PMID: 30827492
Dedifferentiated central chondrosarcoma.
Staals EL, Bacchini P, Bertoni F
Cancer 2006 Jun 15;106(12):2682-91. doi: 10.1002/cncr.21936. PMID: 16691621
Dedifferentiated chondrosarcoma.
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Therapy

A Systematic Review of Adjuvant Chemotherapy in Localized Dedifferentiated Chondrosarcoma.
Tsukamoto S, Mavrogenis AF, Nitta Y, Righi A, Masunaga T, Honoki K, Fujii H, Kido A, Tanaka Y, Tanaka Y, Errani C
Curr Oncol 2024 Jan 19;31(1):566-578. doi: 10.3390/curroncol31010040. PMID: 38275833Free PMC Article
Intralesional treatment versus wide resection for central low-grade chondrosarcoma of the long bones.
Dierselhuis EF, Goulding KA, Stevens M, Jutte PC
Cochrane Database Syst Rev 2019 Mar 7;3(3):CD010778. doi: 10.1002/14651858.CD010778.pub2. PMID: 30845364Free PMC Article
Synergistic anti-proliferative effects of mTOR and MEK inhibitors in high-grade chondrosarcoma cell line OUMS-27.
Fukumoto S, Kanbara K, Neo M
Acta Histochem 2018 Feb;120(2):142-150. Epub 2018 Feb 3 doi: 10.1016/j.acthis.2018.01.002. PMID: 29397960
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742
New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance.
Monderer D, Luseau A, Bellec A, David E, Ponsolle S, Saiagh S, Bercegeay S, Piloquet P, Denis MG, Lodé L, Rédini F, Biger M, Heymann D, Heymann MF, Le Bot R, Gouin F, Blanchard F
Lab Invest 2013 Oct;93(10):1100-14. Epub 2013 Aug 19 doi: 10.1038/labinvest.2013.101. PMID: 23958880

Prognosis

Twenty-year outcome of prevalence, incidence, mortality and survival rate in patients with malignant bone tumors.
Xu Y, Shi F, Zhang Y, Yin M, Han X, Feng J, Wang G
Int J Cancer 2024 Jan 15;154(2):226-240. Epub 2023 Aug 19 doi: 10.1002/ijc.34694. PMID: 37596989
Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options.
Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
A pragmatic approach to the imaging and follow-up of solitary central cartilage tumours of the proximal humerus and knee.
Patel A, Davies AM, Botchu R, James S
Clin Radiol 2019 Jul;74(7):517-526. Epub 2019 Mar 1 doi: 10.1016/j.crad.2019.01.025. PMID: 30827492
Dedifferentiated central chondrosarcoma.
Staals EL, Bacchini P, Bertoni F
Cancer 2006 Jun 15;106(12):2682-91. doi: 10.1002/cncr.21936. PMID: 16691621
Dedifferentiated chondrosarcoma.
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Clinical prediction guides

Twenty-year outcome of prevalence, incidence, mortality and survival rate in patients with malignant bone tumors.
Xu Y, Shi F, Zhang Y, Yin M, Han X, Feng J, Wang G
Int J Cancer 2024 Jan 15;154(2):226-240. Epub 2023 Aug 19 doi: 10.1002/ijc.34694. PMID: 37596989
Clinical features and prognostic analysis of patients with chest wall chondrosarcoma.
Gao H, Zhou Y, Wang Z, Zhao R, Qian S
Medicine (Baltimore) 2019 Sep;98(36):e17025. doi: 10.1097/MD.0000000000017025. PMID: 31490388Free PMC Article
Intralesional treatment versus wide resection for central low-grade chondrosarcoma of the long bones.
Dierselhuis EF, Goulding KA, Stevens M, Jutte PC
Cochrane Database Syst Rev 2019 Mar 7;3(3):CD010778. doi: 10.1002/14651858.CD010778.pub2. PMID: 30845364Free PMC Article
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742
Intralesional curettage of central low-grade chondrosarcoma: A midterm follow-up study.
Chen YC, Wu PK, Chen CF, Chen WM
J Chin Med Assoc 2017 Mar;80(3):178-182. Epub 2016 Nov 23 doi: 10.1016/j.jcma.2016.10.002. PMID: 27889461

Recent systematic reviews

Wide surgical margins may be necessary to reduce recurrence and mortality in patients with localized periosteal chondrosarcoma: retrospective analysis of twenty three patients and literature meta-analysis.
Masunaga T, Tsukamoto S, Honoki K, Fujii H, Tanaka Y, Ishida Y, Tanaka Y, Mavrogenis A, Errani C, Kawai A
Int Orthop 2025 Jan;49(1):279-288. Epub 2024 Nov 21 doi: 10.1007/s00264-024-06371-6. PMID: 39570338
A Systematic Review of Adjuvant Chemotherapy in Localized Dedifferentiated Chondrosarcoma.
Tsukamoto S, Mavrogenis AF, Nitta Y, Righi A, Masunaga T, Honoki K, Fujii H, Kido A, Tanaka Y, Tanaka Y, Errani C
Curr Oncol 2024 Jan 19;31(1):566-578. doi: 10.3390/curroncol31010040. PMID: 38275833Free PMC Article
Can MRI differentiate between atypical cartilaginous tumors and high-grade chondrosarcoma? A systematic review.
Deckers C, Steyvers MJ, Hannink G, Schreuder HWB, de Rooy JWJ, Van Der Geest ICM
Acta Orthop 2020 Aug;91(4):471-478. Epub 2020 May 20 doi: 10.1080/17453674.2020.1763717. PMID: 32429792Free PMC Article
Intralesional treatment versus wide resection for central low-grade chondrosarcoma of the long bones.
Dierselhuis EF, Goulding KA, Stevens M, Jutte PC
Cochrane Database Syst Rev 2019 Mar 7;3(3):CD010778. doi: 10.1002/14651858.CD010778.pub2. PMID: 30845364Free PMC Article
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742

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