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Pleomorphic Leiomyosarcoma

MedGen UID:
1790039
•Concept ID:
C4761201
•
Neoplastic Process

Definition

A leiomyosarcoma characterized by the presence of poorly differentiated areas with pleomorphic appearance, in addition to areas with typical morphologic features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleomorphic Leiomyosarcoma

Professional guidelines

PubMed

Primary and metastatic high-grade pleomorphic sarcoma/malignant fibrous histiocytoma of the gastrointestinal tract: an approach to the differential diagnosis in a series of five cases with emphasis on myofibroblastic differentiation.
Agaimy A, Gaumann A, Schroeder J, Dietmaier W, Hartmann A, Hofstaedter F, Wünsch PH, Mentzel T
Virchows Arch 2007 Nov;451(5):949-57. Epub 2007 Sep 14 doi: 10.1007/s00428-007-0495-3. PMID: 17874130

Recent clinical studies

Etiology

Three uncommon adrenal incidentalomas: a 13-year surgical pathology review.
Kanthan R, Senger JL, Kanthan S
World J Surg Oncol 2012 Apr 27;10:64. doi: 10.1186/1477-7819-10-64. PMID: 22540324Free PMC Article
Global protein-expression analysis of bone and soft tissue sarcomas.
Kawai A, Kondo T, Suehara Y, Kikuta K, Hirohashi S
Clin Orthop Relat Res 2008 Sep;466(9):2099-106. Epub 2008 Jun 6 doi: 10.1007/s11999-008-0330-4. PMID: 18535868Free PMC Article
Comparative fine-needle aspiration and pathologic study of malignant fibrous histiocytoma: cytodiagnostic features of 95 tumors in 71 patients.
Klijanienko J, Caillaud JM, Lagacé R, Vielh P
Diagn Cytopathol 2003 Dec;29(6):320-6. doi: 10.1002/dc.10363. PMID: 14648788
Reassessment and clinicopathological prognostic factors of malignant fibrous histiocytoma of soft parts.
Oda Y, Tamiya S, Oshiro Y, Hachitanda Y, Kinukawa N, Iwamoto Y, Tsuneyoshi M
Pathol Int 2002 Sep;52(9):595-606. doi: 10.1046/j.1440-1827.2002.01399.x. PMID: 12406189
Multifocal cardiac leiomyosarcoma. Diagnosis and surveillance by transoesophageal echocardiography and contrast enhanced cardiovascular magnetic resonance.
Clarke NR, Mohiaddin RH, Westaby S, Banning AP
Postgrad Med J 2002 Aug;78(922):492-3. doi: 10.1136/pmj.78.922.492. PMID: 12185227Free PMC Article

Diagnosis

Pleomorphic Leiomyosarcoma Presenting as a Upper Back Epidermal Inclusion Cyst.
Smith CT, Grider DJ
Am J Dermatopathol 2021 Jun 1;43(6):446-449. doi: 10.1097/DAD.0000000000001896. PMID: 33464746
Adult primary pleomorphic leiomyosarcoma of forearm with axillary lymph node metastasis: a case report and literature review.
Gupta S, Husain N, Kumar A, Sunder S
J Cancer Res Ther 2012 Jul-Sep;8(3):448-50. doi: 10.4103/0973-1482.103532. PMID: 23174734
Primary pancreatic pleomorphic leiomyosarcoma.
Zhang QY, Shen QY, Yan S, Zheng SS
J Int Med Res 2011;39(4):1555-62. doi: 10.1177/147323001103900447. PMID: 21986161
Pleomorphic leiomyosarcoma of the adrenal gland.
Lujan MG, Hoang MP
Arch Pathol Lab Med 2003 Jan;127(1):e32-5. doi: 10.5858/2003-127-e32-PLOTA. PMID: 12562292
Pleomorphic leiomyosarcoma of the soft parts: a reassessment by histology and immunohistochemistry of pleomorphic soft tissue sarcomas.
Yamamoto I, Oshiro Y, Fukuda T, Tsuneyoshi M
Oncol Rep 1999 May-Jun;6(3):533-7. doi: 10.3892/or.6.3.533. PMID: 10203587

Therapy

Favorable control of rapidly progressive retroperitoneal pleomorphic leiomyosarcoma with multimodality therapy: a case report.
Sagara K, Takayoshi K, Kusumoto E, Uchino K, Matsumura T, Kusaba H, Momosaki S, Ikejiri K, Baba E
BMC Res Notes 2014 Jun 19;7:377. doi: 10.1186/1756-0500-7-377. PMID: 24947892Free PMC Article
Adult primary pleomorphic leiomyosarcoma of forearm with axillary lymph node metastasis: a case report and literature review.
Gupta S, Husain N, Kumar A, Sunder S
J Cancer Res Ther 2012 Jul-Sep;8(3):448-50. doi: 10.4103/0973-1482.103532. PMID: 23174734
Pleomorphic leiomyosarcoma of the adrenal gland: case report and review of the literature.
Mohanty SK, Balani JP, Parwani AV
Urology 2007 Sep;70(3):591.e5-7. doi: 10.1016/j.urology.2007.07.029. PMID: 17905130

Prognosis

Uterine pleomorphic leiomyosarcoma with osteoclastic giant cells: Case report with peritoneal washing cytology and cell block study.
Laforga JB, Cortés VA
Rev Esp Patol 2020 Jan-Mar;53(1):61-65. Epub 2018 Jul 26 doi: 10.1016/j.patol.2018.06.002. PMID: 31932012
Pleomorphic leiomyosarcoma with a dedifferentiation-like appearance in the kidney: case report and literature review.
Tajima S, Waki M, Fukuyama M
Med Mol Morphol 2016 Dec;49(4):238-242. Epub 2015 Apr 25 doi: 10.1007/s00795-015-0103-6. PMID: 25910609
Primary pancreatic pleomorphic leiomyosarcoma.
Zhang QY, Shen QY, Yan S, Zheng SS
J Int Med Res 2011;39(4):1555-62. doi: 10.1177/147323001103900447. PMID: 21986161
Pleomorphic leiomyosarcoma: clinicopathologic and immunohistochemical study with special emphasis on its distinction from ordinary leiomyosarcoma and malignant fibrous histiocytoma.
Oda Y, Miyajima K, Kawaguchi K, Tamiya S, Oshiro Y, Hachitanda Y, Oya M, Iwamoto Y, Tsuneyoshi M
Am J Surg Pathol 2001 Aug;25(8):1030-8. doi: 10.1097/00000478-200108000-00007. PMID: 11474287
Sarcomas of the kidney.
Fernández Aceñero MJ, Hernández Gómez MJ, Blanco González J, Suárez Aliaga B
Minerva Urol Nefrol 1997 Sep;49(3):145-9. PMID: 9396222

Clinical prediction guides

Pleomorphic leiomyosarcoma with a dedifferentiation-like appearance in the kidney: case report and literature review.
Tajima S, Waki M, Fukuyama M
Med Mol Morphol 2016 Dec;49(4):238-242. Epub 2015 Apr 25 doi: 10.1007/s00795-015-0103-6. PMID: 25910609
Reassessment and clinicopathological prognostic factors of malignant fibrous histiocytoma of soft parts.
Oda Y, Tamiya S, Oshiro Y, Hachitanda Y, Kinukawa N, Iwamoto Y, Tsuneyoshi M
Pathol Int 2002 Sep;52(9):595-606. doi: 10.1046/j.1440-1827.2002.01399.x. PMID: 12406189
Pleomorphic leiomyosarcoma: clinicopathologic and immunohistochemical study with special emphasis on its distinction from ordinary leiomyosarcoma and malignant fibrous histiocytoma.
Oda Y, Miyajima K, Kawaguchi K, Tamiya S, Oshiro Y, Hachitanda Y, Oya M, Iwamoto Y, Tsuneyoshi M
Am J Surg Pathol 2001 Aug;25(8):1030-8. doi: 10.1097/00000478-200108000-00007. PMID: 11474287
Rhabdoid features in leiomyosarcoma of soft tissue: with special reference to aggressive behavior.
Oshiro Y, Shiratsuchi H, Oda Y, Toyoshima S, Tsuneyoshi M
Mod Pathol 2000 Nov;13(11):1211-8. doi: 10.1038/modpathol.3880225. PMID: 11106079

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