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Hyponatremia with Hypoosmolality

MedGen UID:
1789288
•Concept ID:
C0494356
•
Finding
Synonym: Hyponatremia with Hypo-osmolality

Definition

Abnormally low serum sodium levels in the setting of electrolyte/fluid imbalance. This condition may be the result of excessive intake or retention of water and/or excretion of salt. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyponatremia with Hypoosmolality

Professional guidelines

PubMed

Hyponatremia in cirrhosis: pathogenesis, clinical significance, and management.
Ginès P, Guevara M
Hepatology 2008 Sep;48(3):1002-10. doi: 10.1002/hep.22418. PMID: 18671303
Evaluation and management of hypo-osmolality in hospitalized patients.
Janicic N, Verbalis JG
Endocrinol Metab Clin North Am 2003 Jun;32(2):459-81, vii. doi: 10.1016/s0889-8529(03)00004-5. PMID: 12800541
Drug-induced syndrome of inappropriate antidiuretic hormone secretion. Causes, diagnosis and management.
Chan TY
Drugs Aging 1997 Jul;11(1):27-44. doi: 10.2165/00002512-199711010-00004. PMID: 9237039

Recent clinical studies

Etiology

Arginine vasopressin receptor signaling and functional outcomes in heart failure.
Wasilewski MA, Myers VD, Recchia FA, Feldman AM, Tilley DG
Cell Signal 2016 Mar;28(3):224-233. Epub 2015 Jul 30 doi: 10.1016/j.cellsig.2015.07.021. PMID: 26232615Free PMC Article
The neurological manifestations of acute liver failure.
Shawcross DL, Wendon JA
Neurochem Int 2012 Jun;60(7):662-71. Epub 2011 Nov 2 doi: 10.1016/j.neuint.2011.10.006. PMID: 22067133
Hyponatremia in cirrhosis: pathogenesis, clinical significance, and management.
Ginès P, Guevara M
Hepatology 2008 Sep;48(3):1002-10. doi: 10.1002/hep.22418. PMID: 18671303
Therapeutic approach to hyponatremia.
Han DS, Cho BS
Nephron 2002;92 Suppl 1:9-13. doi: 10.1159/000065371. PMID: 12401932
Citalopram-associated SIADH.
Barclay TS, Lee AJ
Ann Pharmacother 2002 Oct;36(10):1558-63. doi: 10.1345/aph.1C071. PMID: 12243606

Diagnosis

Neurochemistry of hyponatremic encephalopathy evaluated by MR spectroscopy.
Asaki Y, Murofushi Y, Yasukawa K, Hara M, Takanashi JI
Brain Dev 2020 Nov;42(10):767-770. Epub 2020 Jul 25 doi: 10.1016/j.braindev.2020.07.005. PMID: 32718672
Hyponatremia and Glucocorticoid Deficiency.
Garrahy A, Thompson CJ
Front Horm Res 2019;52:80-92. Epub 2019 Jan 15 doi: 10.1159/000493239. PMID: 32097946
Citalopram-associated SIADH.
Barclay TS, Lee AJ
Ann Pharmacother 2002 Oct;36(10):1558-63. doi: 10.1345/aph.1C071. PMID: 12243606
Hyponatremia.
DiBartola SP
Vet Clin North Am Small Anim Pract 1998 May;28(3):515-32. doi: 10.1016/s0195-5616(98)50053-8. PMID: 9597712
Inappropriate antidiuresis and hyponatremia with suppressible vasopressin in Guillain-Barré syndrome.
Cooke CR, Latif KA, Huch KM, Wall BM
Am J Nephrol 1998;18(1):71-6. doi: 10.1159/000013309. PMID: 9481444

Therapy

Inappropriate antidiuresis and hyponatremia with suppressible vasopressin in Guillain-Barré syndrome.
Cooke CR, Latif KA, Huch KM, Wall BM
Am J Nephrol 1998;18(1):71-6. doi: 10.1159/000013309. PMID: 9481444
Posthysteroscopic hyponatremia.
Gonzales R, Brensilver JM, Rovinsky JJ
Am J Kidney Dis 1994 May;23(5):735-8. doi: 10.1016/s0272-6386(12)70286-x. PMID: 8172218
Beer drinkers' hyponatremia: a hypoosmolality syndrome.
Kessler RK, Channick BJ, Kessler WB, Metzger WD
Del Med J 1984 Oct;56(10):625-8. PMID: 6500106
Is "cerebral hyponatraemia" iatrogenic?
Bouzarth WF, Shenkin HA
Lancet 1982 May 8;1(8280):1061-2. doi: 10.1016/s0140-6736(82)92111-0. PMID: 6122862
The effect of thyroid therapy on the hyponatremia and hypoosmolality of myxedema.
Marieb NJ, Ragaza EP, al-Sadĭr J
Conn Med 1970 Jan;34(1):29-31. PMID: 5414953

Prognosis

The neurological manifestations of acute liver failure.
Shawcross DL, Wendon JA
Neurochem Int 2012 Jun;60(7):662-71. Epub 2011 Nov 2 doi: 10.1016/j.neuint.2011.10.006. PMID: 22067133
Effects of dilutional hyponatremia on brain organic osmolytes and water content in patients with cirrhosis.
Restuccia T, Gómez-Ansón B, Guevara M, Alessandria C, Torre A, Alayrach ME, Terra C, Martín M, Castellví M, Rami L, Sainz A, Ginès P, Arroyo V
Hepatology 2004 Jun;39(6):1613-22. doi: 10.1002/hep.20237. PMID: 15185302
SIADH: a case review.
Shirland L
Neonatal Netw 2001 Feb;20(1):25-9. doi: 10.1891/0730-0832.20.1.29. PMID: 12143836
Syndrome of inappropriate antidiuretic hormone secretion associated with head neck cancers: review of the literature.
Ferlito A, Rinaldo A, Devaney KO
Ann Otol Rhinol Laryngol 1997 Oct;106(10 Pt 1):878-83. doi: 10.1177/000348949710601014. PMID: 9342988
Hyponatremia and osmoregulation of thirst and vasopressin secretion in patients with adrenal insufficiency.
Kamoi K, Tamura T, Tanaka K, Ishibashi M, Yamaji T
J Clin Endocrinol Metab 1993 Dec;77(6):1584-8. doi: 10.1210/jcem.77.6.8263145. PMID: 8263145

Clinical prediction guides

Duloxetine and Angiotensin II Receptor Blocker Combination Potentially Induce Severe Hyponatremia in an Elderly Woman.
Takayama A, Nagamine T, Matsumoto Y, Nakamura M
Intern Med 2019 Jun 15;58(12):1791-1794. Epub 2019 Feb 25 doi: 10.2169/internalmedicine.2059-18. PMID: 30799349Free PMC Article
The neurological manifestations of acute liver failure.
Shawcross DL, Wendon JA
Neurochem Int 2012 Jun;60(7):662-71. Epub 2011 Nov 2 doi: 10.1016/j.neuint.2011.10.006. PMID: 22067133
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignant disease.
Sørensen JB, Andersen MK, Hansen HH
J Intern Med 1995 Aug;238(2):97-110. doi: 10.1111/j.1365-2796.1995.tb00907.x. PMID: 7629492
Is "cerebral hyponatraemia" iatrogenic?
Bouzarth WF, Shenkin HA
Lancet 1982 May 8;1(8280):1061-2. doi: 10.1016/s0140-6736(82)92111-0. PMID: 6122862
Heat oedema: a clinical study.
Sitprija V
Postgrad Med J 1979 Oct;55(648):728-9. doi: 10.1136/pgmj.55.648.728. PMID: 537961Free PMC Article

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