Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Metastatic Primary Malignant Brain Neoplasm

MedGen UID:: 1788110
•Concept ID:: C5446614
•: Neoplastic Process

Definition

A malignant neoplasm that arises from the brain and has spread from its original site of growth to other sites. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMetastatic Primary Malignant Brain Neoplasm

Disorder of nervous system
- Disorder of the central nervous system
  - Neoplasm of the central nervous system
    - Intracranial Neoplasm
      - Malignant Intracranial Neoplasm
        Malignant neoplasm of brain
        Metastatic Primary Malignant Brain Neoplasm
        Advanced Primary Malignant Brain Neoplasm
        Locally Advanced Primary Malignant Brain Neoplasm
        Metastatic Medulloblastoma
        Medulloblastoma with Leptomeningeal Spread

Professional guidelines

PubMed

European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022.

Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Höller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:236-255. Epub 2022 May 12 doi: 10.1016/j.ejca.2022.03.008. PMID: 35570085

Ependymoma: Evaluation and Management Updates.

Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591 Free PMC Article

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.

Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393

See all (803)

Recent clinical studies

Etiology

Cerebral metastases.

Ganz JC
Prog Brain Res 2022;268(1):229-258. Epub 2022 Jan 13 doi: 10.1016/bs.pbr.2021.10.034. PMID: 35074082

Molecular and cellular mechanisms underlying brain metastasis of breast cancer.

Hosonaga M, Saya H, Arima Y
Cancer Metastasis Rev 2020 Sep;39(3):711-720. doi: 10.1007/s10555-020-09881-y. PMID: 32399646 Free PMC Article

ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases.

Kumthekar P, Tang SC, Brenner AJ, Kesari S, Piccioni DE, Anders C, Carrillo J, Chalasani P, Kabos P, Puhalla S, Tkaczuk K, Garcia AA, Ahluwalia MS, Wefel JS, Lakhani N, Ibrahim N
Clin Cancer Res 2020 Jun 15;26(12):2789-2799. Epub 2020 Jan 22 doi: 10.1158/1078-0432.CCR-19-3258. PMID: 31969331

Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.

Gholamin S, Mitra SS, Feroze AH, Liu J, Kahn SA, Zhang M, Esparza R, Richard C, Ramaswamy V, Remke M, Volkmer AK, Willingham S, Ponnuswami A, McCarty A, Lovelace P, Storm TA, Schubert S, Hutter G, Narayanan C, Chu P, Raabe EH, Harsh G 4th, Taylor MD, Monje M, Cho YJ, Majeti R, Volkmer JP, Fisher PG, Grant G, Steinberg GK, Vogel H, Edwards M, Weissman IL, Cheshier SH
Sci Transl Med 2017 Mar 15;9(381) doi: 10.1126/scitranslmed.aaf2968. PMID: 28298418

Brain tumor rehabilitation.

Vargo M
Am J Phys Med Rehabil 2011 May;90(5 Suppl 1):S50-62. doi: 10.1097/PHM.0b013e31820be31f. PMID: 21765264

See all (4440)

Diagnosis

Brain metastasis.

Boire A, Brastianos PK, Garzia L, Valiente M
Nat Rev Cancer 2020 Jan;20(1):4-11. Epub 2019 Nov 28 doi: 10.1038/s41568-019-0220-y. PMID: 31780784

Brain malignancies: Glioblastoma and brain metastases.

Lah TT, Novak M, Breznik B
Semin Cancer Biol 2020 Feb;60:262-273. Epub 2019 Oct 22 doi: 10.1016/j.semcancer.2019.10.010. PMID: 31654711

Brain metastases: neuroimaging.

Pope WB
Handb Clin Neurol 2018;149:89-112. doi: 10.1016/B978-0-12-811161-1.00007-4. PMID: 29307364 Free PMC Article

Metastasis in Adult Brain Tumors.

Barajas RF Jr, Cha S
Neuroimaging Clin N Am 2016 Nov;26(4):601-620. Epub 2016 Sep 2 doi: 10.1016/j.nic.2016.06.008. PMID: 27712796 Free PMC Article

Brain metastases.

Gállego Pérez-Larraya J, Hildebrand J
Handb Clin Neurol 2014;121:1143-57. doi: 10.1016/B978-0-7020-4088-7.00077-8. PMID: 24365409

See all (4794)

Therapy

Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases: Updated Exploratory Analysis of the HER2CLIMB Randomized Clinical Trial.

Lin NU, Murthy RK, Abramson V, Anders C, Bachelot T, Bedard PL, Borges V, Cameron D, Carey LA, Chien AJ, Curigliano G, DiGiovanna MP, Gelmon K, Hortobagyi G, Hurvitz SA, Krop I, Loi S, Loibl S, Mueller V, Oliveira M, Paplomata E, Pegram M, Slamon D, Zelnak A, Ramos J, Feng W, Winer E
JAMA Oncol 2023 Feb 1;9(2):197-205. doi: 10.1001/jamaoncol.2022.5610. PMID: 36454580 Free PMC Article

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.

ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases.

Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial.

Brown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, Laack NNI, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D
Lancet Oncol 2017 Aug;18(8):1049-1060. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30441-2. PMID: 28687377 Free PMC Article

Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial.

Brown PD, Jaeckle K, Ballman KV, Farace E, Cerhan JH, Anderson SK, Carrero XW, Barker FG 2nd, Deming R, Burri SH, Ménard C, Chung C, Stieber VW, Pollock BE, Galanis E, Buckner JC, Asher AL
JAMA 2016 Jul 26;316(4):401-409. doi: 10.1001/jama.2016.9839. PMID: 27458945 Free PMC Article

See all (3334)

Prognosis

Brain metastases: the role of clinical imaging.

Derks SHAE, van der Veldt AAM, Smits M
Br J Radiol 2022 Feb 1;95(1130):20210944. Epub 2021 Dec 14 doi: 10.1259/bjr.20210944. PMID: 34808072 Free PMC Article

ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases.

Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial.

Brain metastases.

Gállego Pérez-Larraya J, Hildebrand J
Handb Clin Neurol 2014;121:1143-57. doi: 10.1016/B978-0-7020-4088-7.00077-8. PMID: 24365409

Epidemiology of brain metastases.

Nayak L, Lee EQ, Wen PY
Curr Oncol Rep 2012 Feb;14(1):48-54. doi: 10.1007/s11912-011-0203-y. PMID: 22012633

See all (4504)

Clinical prediction guides

Metabolism in the progression and metastasis of brain tumors.

Tyagi A, Wu SY, Watabe K
Cancer Lett 2022 Jul 28;539:215713. Epub 2022 May 2 doi: 10.1016/j.canlet.2022.215713. PMID: 35513201 Free PMC Article

Brain metastases: neuroimaging.

Pope WB
Handb Clin Neurol 2018;149:89-112. doi: 10.1016/B978-0-12-811161-1.00007-4. PMID: 29307364 Free PMC Article

Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial.

Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G
Lancet Oncol 2017 Aug;18(8):1040-1048. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30414-X. PMID: 28687375 Free PMC Article

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.

Brastianos PK, Carter SL, Santagata S, Cahill DP, Taylor-Weiner A, Jones RT, Van Allen EM, Lawrence MS, Horowitz PM, Cibulskis K, Ligon KL, Tabernero J, Seoane J, Martinez-Saez E, Curry WT, Dunn IF, Paek SH, Park SH, McKenna A, Chevalier A, Rosenberg M, Barker FG 2nd, Gill CM, Van Hummelen P, Thorner AR, Johnson BE, Hoang MP, Choueiri TK, Signoretti S, Sougnez C, Rabin MS, Lin NU, Winer EP, Stemmer-Rachamimov A, Meyerson M, Garraway L, Gabriel S, Lander ES, Beroukhim R, Batchelor TT, Baselga J, Louis DN, Getz G, Hahn WC
Cancer Discov 2015 Nov;5(11):1164-1177. Epub 2015 Sep 26 doi: 10.1158/2159-8290.CD-15-0369. PMID: 26410082 Free PMC Article

Advanced magnetic resonance imaging biomarkers of cerebral metastases.

Mills SJ, Thompson G, Jackson A
Cancer Imaging 2012 Aug 10;12(1):245-52. doi: 10.1102/1470-7330.2012.0012. PMID: 22935843 Free PMC Article

See all (2958)

Recent systematic reviews

A Systematic Review Informing the Management of Symptomatic Brain Radiation Necrosis After Stereotactic Radiosurgery and International Stereotactic Radiosurgery Society Recommendations.

Vellayappan B, Lim-Fat MJ, Kotecha R, De Salles A, Fariselli L, Levivier M, Ma L, Paddick I, Pollock BE, Regis J, Sheehan JP, Suh JH, Yomo S, Sahgal A
Int J Radiat Oncol Biol Phys 2024 Jan 1;118(1):14-28. Epub 2023 Jul 22 doi: 10.1016/j.ijrobp.2023.07.015. PMID: 37482137

Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline.

Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020

Stereotactic radiosurgery versus whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer: a systematic review and meta-analysis.

Gaebe K, Li AY, Park A, Parmar A, Lok BH, Sahgal A, Chan KKW, Erickson AW, Das S
Lancet Oncol 2022 Jul;23(7):931-939. Epub 2022 May 26 doi: 10.1016/S1470-2045(22)00271-6. PMID: 35644163

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.

Defining oligometastatic disease from a radiation oncology perspective: An ESTRO-ASTRO consensus document.

Lievens Y, Guckenberger M, Gomez D, Hoyer M, Iyengar P, Kindts I, Méndez Romero A, Nevens D, Palma D, Park C, Ricardi U, Scorsetti M, Yu J, Woodward WA
Radiother Oncol 2020 Jul;148:157-166. Epub 2020 Apr 22 doi: 10.1016/j.radonc.2020.04.003. PMID: 32388150

See all (187)

MedGen

National Center for Biotechnology Information

Send to:

Metastatic Primary Malignant Brain Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity