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Global cerebellar dysplasia

MedGen UID:
1787651
Concept ID:
C5539789
Finding
HPO: HP:0033744

Definition

A type of cerebellar dysplasia that affects the entire cerebellum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlobal cerebellar dysplasia

Professional guidelines

PubMed

Poretti A, Boltshauser E, Doherty D
Am J Med Genet C Semin Med Genet 2014 Jun;166C(2):211-26. Epub 2014 May 16 doi: 10.1002/ajmg.c.31398. PMID: 24839100

Recent clinical studies

Etiology

Kadali S, Radhika A, Kanaka Durga Devi YR, Sreemanthula JB, Palakonda G, Hussain T, Naushad SM
Clin Nutr ESPEN 2025 Feb;65:126-133. Epub 2024 Nov 26 doi: 10.1016/j.clnesp.2024.11.027. PMID: 39608496
Sokolowski K, Liu J, Delatte MS, Authier S, McMaster O, Bolon B
Toxicol Pathol 2024 Dec;52(8):566-573. Epub 2024 Dec 5 doi: 10.1177/01926233241300065. PMID: 39633285
Liu W, Lin M, Yue Q, Gong Q, Zhou D, Wu X
Seizure 2021 Apr;87:1-6. Epub 2021 Feb 12 doi: 10.1016/j.seizure.2021.02.009. PMID: 33636448
Blondiaux E, Valence S, Friszer S, Rodriguez D, Burglen L, Ducou le Pointe H, Blouet M, Garel C
Fetal Diagn Ther 2019;45(3):197-204. Epub 2017 Jul 5 doi: 10.1159/000475989. PMID: 28675887
Poretti A, Boltshauser E, Doherty D
Am J Med Genet C Semin Med Genet 2014 Jun;166C(2):211-26. Epub 2014 May 16 doi: 10.1002/ajmg.c.31398. PMID: 24839100

Diagnosis

Mattioli F, Voisin N, Preikšaitienė E, Kozlovskaja I, Kučinskas V, Reymond A
Am J Med Genet A 2021 Apr;185(4):1275-1281. Epub 2021 Feb 2 doi: 10.1002/ajmg.a.62098. PMID: 33527719
Abdel Razek AA, Castillo M
J Comput Assist Tomogr 2016 Jan-Feb;40(1):14-25. doi: 10.1097/RCT.0000000000000340. PMID: 26599961
Poretti A, Boltshauser E, Doherty D
Am J Med Genet C Semin Med Genet 2014 Jun;166C(2):211-26. Epub 2014 May 16 doi: 10.1002/ajmg.c.31398. PMID: 24839100
Garel C, Fallet-Bianco C, Guibaud L
J Child Neurol 2011 Dec;26(12):1483-92. Epub 2011 Sep 27 doi: 10.1177/0883073811420148. PMID: 21954430
Kumandas S, Akcakus M, Coskun A, Gumus H
Eur J Neurol 2004 Aug;11(8):505-10. doi: 10.1111/j.1468-1331.2004.00819.x. PMID: 15272893

Therapy

Kadali S, Radhika A, Kanaka Durga Devi YR, Sreemanthula JB, Palakonda G, Hussain T, Naushad SM
Clin Nutr ESPEN 2025 Feb;65:126-133. Epub 2024 Nov 26 doi: 10.1016/j.clnesp.2024.11.027. PMID: 39608496
Shaw CM, Alvord EC Jr
J Child Neurol 1996 Jul;11(4):313-20. doi: 10.1177/088307389601100410. PMID: 8807422

Prognosis

Poretti A, Boltshauser E, Doherty D
Am J Med Genet C Semin Med Genet 2014 Jun;166C(2):211-26. Epub 2014 May 16 doi: 10.1002/ajmg.c.31398. PMID: 24839100
Shaw CM, Alvord EC Jr
J Child Neurol 1996 Jul;11(4):313-20. doi: 10.1177/088307389601100410. PMID: 8807422

Clinical prediction guides

Sokolowski K, Liu J, Delatte MS, Authier S, McMaster O, Bolon B
Toxicol Pathol 2024 Dec;52(8):566-573. Epub 2024 Dec 5 doi: 10.1177/01926233241300065. PMID: 39633285
Chen X, Yin W, Chen S, Zhang W, Li H, Kuang H, Zhou M, Teng Y, Zhang J, Shen G, Liang D, Li Z, Hu B, Wu L
Hum Genet 2021 May;140(5):791-803. Epub 2021 Jan 4 doi: 10.1007/s00439-020-02243-2. PMID: 33392778
Toiviainen-Salo S, Mäkitie O, Mannerkoski M, Hämäläinen J, Valanne L, Autti T
Am J Med Genet A 2008 Jun 15;146A(12):1558-64. doi: 10.1002/ajmg.a.32354. PMID: 18478597
Blatt J, Hamilton RL
Cancer 1998 Apr 15;82(8):1603-8. doi: 10.1002/(sici)1097-0142(19980415)82:8<1603::aid-cncr24>3.0.co;2-7. PMID: 9554540
Shaw CM, Alvord EC Jr
J Child Neurol 1996 Jul;11(4):313-20. doi: 10.1177/088307389601100410. PMID: 8807422

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