U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Irreversible airflow obstruction

MedGen UID:
1787242
•Concept ID:
C5539669
•
Finding
Synonym: Irreversible pulmonary obstruction
 
HPO: HP:0033541

Definition

Airflow obstruction without significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIrreversible airflow obstruction

Professional guidelines

PubMed

Vitamin D for the management of chronic obstructive pulmonary disease.
Williamson A, Martineau AR, Jolliffe D, Sheikh A, Janssens W, Sluyter J, Rafiq R, de Jongh R, Griffiths CJ
Cochrane Database Syst Rev 2024 Sep 27;9(9):CD013284. doi: 10.1002/14651858.CD013284.pub2. PMID: 39329240Free PMC Article
Combination therapy of inhaled corticosteroids and long-acting beta2-adrenergics in management of patients with chronic obstructive pulmonary disease.
Sin DD, Johnson M, Gan WQ, Man SF
Curr Pharm Des 2004;10(28):3547-60. doi: 10.2174/1381612043382990. PMID: 15579052
Present and future treatment of asthma in infants and young children.
Martinez FD
J Allergy Clin Immunol 1999 Oct;104(4 Pt 2):169-74. doi: 10.1016/s0091-6749(99)70058-8. PMID: 10518843

Recent clinical studies

Etiology

Deciphering Respiratory-Virus-Associated Interferon Signaling in COPD Airway Epithelium.
Guo-Parke H, Linden D, Weldon S, Kidney JC, Taggart CC
Medicina (Kaunas) 2022 Jan 13;58(1) doi: 10.3390/medicina58010121. PMID: 35056429Free PMC Article
Clinical and biological factors associated with irreversible airway obstruction in adult asthma.
Graff S, Bricmont N, Moermans C, Henket M, Paulus V, Guissard F, Louis R, Schleich F
Respir Med 2020 Dec;175:106202. Epub 2020 Nov 10 doi: 10.1016/j.rmed.2020.106202. PMID: 33202369
The roles of microRNAs in the pathogenesis of chronic obstructive pulmonary disease.
Huang X, Zhu Z, Guo X, Kong X
Int Immunopharmacol 2019 Feb;67:335-347. Epub 2018 Dec 19 doi: 10.1016/j.intimp.2018.12.013. PMID: 30578969
Bronchiolitis obliterans: an update.
Chan A, Allen R
Curr Opin Pulm Med 2004 Mar;10(2):133-41. doi: 10.1097/00063198-200403000-00008. PMID: 15021183
Asthma remission: does it exist?
van den Toorn LM, Overbeek SE, Prins JB, Hoogsteden HC, de Jongste JC
Curr Opin Pulm Med 2003 Jan;9(1):15-20. doi: 10.1097/00063198-200301000-00003. PMID: 12476079

Diagnosis

The roles of microRNAs in the pathogenesis of chronic obstructive pulmonary disease.
Huang X, Zhu Z, Guo X, Kong X
Int Immunopharmacol 2019 Feb;67:335-347. Epub 2018 Dec 19 doi: 10.1016/j.intimp.2018.12.013. PMID: 30578969
State-of-the-art testing for alpha-1 antitrypsin deficiency.
Kueppers F, Sanders C
Allergy Asthma Proc 2017 Mar 24;38(2):108-114. Epub 2017 Jan 24 doi: 10.2500/aap.2017.38.4031. PMID: 28120746
Bronchiolitis.
Garibaldi BT, Illei P, Danoff SK
Immunol Allergy Clin North Am 2012 Nov;32(4):601-19. Epub 2012 Sep 14 doi: 10.1016/j.iac.2012.08.002. PMID: 23102068
Bronchodilator reversibility in COPD.
Hanania NA, Celli BR, Donohue JF, Martin UJ
Chest 2011 Oct;140(4):1055-1063. doi: 10.1378/chest.10-2974. PMID: 21972384
Difficult asthma.
Strek ME
Proc Am Thorac Soc 2006;3(1):116-23. doi: 10.1513/pats.200510-115JH. PMID: 16493159

Therapy

SIRT1 as a Potential Therapeutic Target for Chronic Obstructive Pulmonary Disease.
Li S, Huang Q, He B
Lung 2023 Apr;201(2):201-215. Epub 2023 Feb 15 doi: 10.1007/s00408-023-00607-9. PMID: 36790647
Biologics and airway remodeling in severe asthma.
Varricchi G, Ferri S, Pepys J, Poto R, Spadaro G, Nappi E, Paoletti G, Virchow JC, Heffler E, Canonica WG
Allergy 2022 Dec;77(12):3538-3552. Epub 2022 Aug 23 doi: 10.1111/all.15473. PMID: 35950646Free PMC Article
Bronchodilator reversibility in COPD.
Hanania NA, Celli BR, Donohue JF, Martin UJ
Chest 2011 Oct;140(4):1055-1063. doi: 10.1378/chest.10-2974. PMID: 21972384
Eosinophilic airway inflammation in COPD.
Saha S, Brightling CE
Int J Chron Obstruct Pulmon Dis 2006;1(1):39-47. doi: 10.2147/copd.2006.1.1.39. PMID: 18046901Free PMC Article
Difficult asthma.
Strek ME
Proc Am Thorac Soc 2006;3(1):116-23. doi: 10.1513/pats.200510-115JH. PMID: 16493159

Prognosis

Nutritional State and COPD: Effects on Dyspnoea and Exercise Tolerance.
Tramontano A, Palange P
Nutrients 2023 Apr 6;15(7) doi: 10.3390/nu15071786. PMID: 37049625Free PMC Article
Clinical and biological factors associated with irreversible airway obstruction in adult asthma.
Graff S, Bricmont N, Moermans C, Henket M, Paulus V, Guissard F, Louis R, Schleich F
Respir Med 2020 Dec;175:106202. Epub 2020 Nov 10 doi: 10.1016/j.rmed.2020.106202. PMID: 33202369
Bronchodilator reversibility in COPD.
Hanania NA, Celli BR, Donohue JF, Martin UJ
Chest 2011 Oct;140(4):1055-1063. doi: 10.1378/chest.10-2974. PMID: 21972384
Difficult asthma.
Strek ME
Proc Am Thorac Soc 2006;3(1):116-23. doi: 10.1513/pats.200510-115JH. PMID: 16493159
Asthma remission: does it exist?
van den Toorn LM, Overbeek SE, Prins JB, Hoogsteden HC, de Jongste JC
Curr Opin Pulm Med 2003 Jan;9(1):15-20. doi: 10.1097/00063198-200301000-00003. PMID: 12476079

Clinical prediction guides

Clinical and biological factors associated with irreversible airway obstruction in adult asthma.
Graff S, Bricmont N, Moermans C, Henket M, Paulus V, Guissard F, Louis R, Schleich F
Respir Med 2020 Dec;175:106202. Epub 2020 Nov 10 doi: 10.1016/j.rmed.2020.106202. PMID: 33202369
Bronchodilator reversibility in COPD.
Hanania NA, Celli BR, Donohue JF, Martin UJ
Chest 2011 Oct;140(4):1055-1063. doi: 10.1378/chest.10-2974. PMID: 21972384
Airway remodeling in asthma.
Sumi Y, Hamid Q
Allergol Int 2007 Dec;56(4):341-8. Epub 2007 Nov 1 doi: 10.2332/allergolint.R-07-153. PMID: 17965577
Eosinophilic airway inflammation in COPD.
Saha S, Brightling CE
Int J Chron Obstruct Pulmon Dis 2006;1(1):39-47. doi: 10.2147/copd.2006.1.1.39. PMID: 18046901Free PMC Article
Airway remodeling and persistent airway obstruction in asthma.
Fish JE, Peters SP
J Allergy Clin Immunol 1999 Sep;104(3 Pt 1):509-16. doi: 10.1016/s0091-6749(99)70315-5. PMID: 10482819

Recent systematic reviews

Vitamin D for the management of chronic obstructive pulmonary disease.
Williamson A, Martineau AR, Jolliffe D, Sheikh A, Janssens W, Sluyter J, Rafiq R, de Jongh R, Griffiths CJ
Cochrane Database Syst Rev 2024 Sep 27;9(9):CD013284. doi: 10.1002/14651858.CD013284.pub2. PMID: 39329240Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...