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Distant Metastasis

MedGen UID:
1785231
Concept ID:
C5441917
Pathologic Function
Synonyms: Distant; Distant Cancer

Definition

A biological process that involves the transfer and growth of cancer cells from the site of the primary tumor. Relocation of malignant cells during metastasis can be restricted to movement within a specific tissue/organ or may entail migration to a distal locus within the body. This phenotype is a characteristic of all malignant tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDistant Metastasis

Professional guidelines

PubMed

Li W, Liu JB, Hou LK, Yu F, Zhang J, Wu W, Tang XM, Sun F, Lu HM, Deng J, Bai J, Li J, Wu CY, Lin QL, Lv ZW, Wang GR, Jiang GX, Ma YS, Fu D
Mol Cancer 2022 Jan 20;21(1):25. doi: 10.1186/s12943-022-01505-z. PMID: 35057806Free PMC Article
Wu Z, Li Y, Zhang Y, Hu H, Wu T, Liu S, Chen W, Xie S, Lu Z
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820980426. doi: 10.1177/1533033820980426. PMID: 33353503Free PMC Article
Li H, Wu X, Cheng X
J Gynecol Oncol 2016 Jul;27(4):e43. doi: 10.3802/jgo.2016.27.e43. PMID: 27171673Free PMC Article

Recent clinical studies

Etiology

Naoum GE, Oladeru O, Ababneh H, Shui A, Ly A, Taghian AG
J Clin Oncol 2024 Jan 10;42(2):157-169. Epub 2023 Nov 15 doi: 10.1200/JCO.23.01009. PMID: 37967296
Gupta N, Conomikes A, Murad F, Ruiz ES
J Am Acad Dermatol 2023 Jan;88(1):210-212. Epub 2022 Apr 27 doi: 10.1016/j.jaad.2022.04.039. PMID: 35489550
Eggermont AMM, Kicinski M, Blank CU, Mandala M, Long GV, Atkinson V, Dalle S, Haydon A, Meshcheryakov A, Khattak A, Carlino MS, Sandhu S, Larkin J, Puig S, Ascierto PA, Rutkowski P, Schadendorf D, Boers-Sonderen M, Di Giacomo AM, van den Eertwegh AJM, Grob JJ, Gutzmer R, Jamal R, van Akkooi ACJ, Lorigan P, Grebennik D, Krepler C, Marreaud S, Suciu S, Robert C
NEJM Evid 2022 Nov;1(11):EVIDoa2200214. Epub 2022 Sep 10 doi: 10.1056/EVIDoa2200214. PMID: 38319852
Chen B, Zeng Y, Liu B, Lu G, Xiang Z, Chen J, Yu Y, Zuo Z, Lin Y, Ma J
Front Endocrinol (Lausanne) 2021;12:672024. Epub 2021 Jul 30 doi: 10.3389/fendo.2021.672024. PMID: 34393996Free PMC Article
Oncologist 2021 Feb;26 Suppl 2(Suppl 2):S13-S14. Epub 2021 Jan 5 doi: 10.1002/onco.13666. PMID: 33399243Free PMC Article

Diagnosis

Li F, Xu T, Chen P, Sun R, Li C, Zhao X, Ou J, Li J, Liu T, Zeng M, Zheng W, Lin Y, Yang L, Li Z, Chen H, Zhang Q
Int J Biol Sci 2022;18(15):5858-5872. Epub 2022 Sep 24 doi: 10.7150/ijbs.76162. PMID: 36263165Free PMC Article
Żyluk A, Fliciński F
Pol Przegl Chir 2022 Feb 11;94(5):13-17. doi: 10.5604/01.3001.0015.7341. PMID: 36169589
Chen B, Zeng Y, Liu B, Lu G, Xiang Z, Chen J, Yu Y, Zuo Z, Lin Y, Ma J
Front Endocrinol (Lausanne) 2021;12:672024. Epub 2021 Jul 30 doi: 10.3389/fendo.2021.672024. PMID: 34393996Free PMC Article
Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, Tang LL, Mao YP, He QM, Yang XJ, Zhang Y, Wen X, Zhang J, Wang YQ, Zhang PP, Sun Y, Yun JP, Zeng J, Li L, Liu LZ, Liu N, Ma J
Lancet Oncol 2018 Mar;19(3):382-393. Epub 2018 Feb 7 doi: 10.1016/S1470-2045(18)30080-9. PMID: 29428165
Wang J, Xie X, Wang X, Tang J, Pan Q, Zhang Y, Di M
Surg Oncol 2013 Dec;22(4):247-55. Epub 2013 Oct 12 doi: 10.1016/j.suronc.2013.10.001. PMID: 24144808

Therapy

Latifyan S, Haanen JB
Med 2024 Apr 12;5(4):288-290. doi: 10.1016/j.medj.2024.03.004. PMID: 38614074
Reijers ILM, Menzies AM, van Akkooi ACJ, Versluis JM, van den Heuvel NMJ, Saw RPM, Pennington TE, Kapiteijn E, van der Veldt AAM, Suijkerbuijk KPM, Hospers GAP, Rozeman EA, Klop WMC, van Houdt WJ, Sikorska K, van der Hage JA, Grünhagen DJ, Wouters MW, Witkamp AJ, Zuur CL, Lijnsvelt JM, Torres Acosta A, Grijpink-Ongering LG, Gonzalez M, Jóźwiak K, Bierman C, Shannon KF, Ch'ng S, Colebatch AJ, Spillane AJ, Haanen JBAG, Rawson RV, van de Wiel BA, van de Poll-Franse LV, Scolyer RA, Boekhout AH, Long GV, Blank CU
Nat Med 2022 Jun;28(6):1178-1188. Epub 2022 Jun 5 doi: 10.1038/s41591-022-01851-x. PMID: 35661157
Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, Kurata T, Chiappori A, Lee KH, de Wit M, Cho BC, Bourhaba M, Quantin X, Tokito T, Mekhail T, Planchard D, Kim YC, Karapetis CS, Hiret S, Ostoros G, Kubota K, Gray JE, Paz-Ares L, de Castro Carpeño J, Faivre-Finn C, Reck M, Vansteenkiste J, Spigel DR, Wadsworth C, Melillo G, Taboada M, Dennis PA, Özgüroğlu M; PACIFIC Investigators
N Engl J Med 2018 Dec 13;379(24):2342-2350. Epub 2018 Sep 25 doi: 10.1056/NEJMoa1809697. PMID: 30280658
Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S
Lancet 2018 Sep 15;392(10151):971-984. doi: 10.1016/S0140-6736(18)31559-9. PMID: 30238891
Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, Yokoi T, Chiappori A, Lee KH, de Wit M, Cho BC, Bourhaba M, Quantin X, Tokito T, Mekhail T, Planchard D, Kim YC, Karapetis CS, Hiret S, Ostoros G, Kubota K, Gray JE, Paz-Ares L, de Castro Carpeño J, Wadsworth C, Melillo G, Jiang H, Huang Y, Dennis PA, Özgüroğlu M; PACIFIC Investigators
N Engl J Med 2017 Nov 16;377(20):1919-1929. Epub 2017 Sep 8 doi: 10.1056/NEJMoa1709937. PMID: 28885881

Prognosis

Zheng Y, Jiang P, Tu Y, Huang Y, Wang J, Gou S, Tian C, Yuan R
Int J Gynaecol Obstet 2024 May;165(2):655-665. Epub 2023 Nov 27 doi: 10.1002/ijgo.15264. PMID: 38010285
Kishan AU, Cook RR, Ciezki JP, Ross AE, Pomerantz MM, Nguyen PL, Shaikh T, Tran PT, Sandler KA, Stock RG, Merrick GS, Demanes DJ, Spratt DE, Abu-Isa EI, Wedde TB, Lilleby W, Krauss DJ, Shaw GK, Alam R, Reddy CA, Stephenson AJ, Klein EA, Song DY, Tosoian JJ, Hegde JV, Yoo SM, Fiano R, D'Amico AV, Nickols NG, Aronson WJ, Sadeghi A, Greco S, Deville C, McNutt T, DeWeese TL, Reiter RE, Said JW, Steinberg ML, Horwitz EM, Kupelian PA, King CR
JAMA 2018 Mar 6;319(9):896-905. doi: 10.1001/jama.2018.0587. PMID: 29509865Free PMC Article
Hartwig MF, Bulut O, Niebuhr M, Thind P, Steven K, Bülow S
Pol Przegl Chir 2016 Mar 1;88(2):99-105. doi: 10.1515/pjs-2016-0034. PMID: 27213256
Han G, Wang Z, Guo X, Wang M, Wu H, Liu D
J Oral Maxillofac Surg 2012 Oct;70(10):2347-51. Epub 2012 Feb 11 doi: 10.1016/j.joms.2011.10.034. PMID: 22330330
Akiyoshi T, Fujimoto Y, Konishi T, Kuroyanagi H, Ueno M, Oya M, Miyata S, Yamaguchi T
Am J Surg 2011 Jun;201(6):726-33. Epub 2010 Sep 23 doi: 10.1016/j.amjsurg.2010.03.003. PMID: 20864084

Clinical prediction guides

Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501
Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, Tang LL, Mao YP, He QM, Yang XJ, Zhang Y, Wen X, Zhang J, Wang YQ, Zhang PP, Sun Y, Yun JP, Zeng J, Li L, Liu LZ, Liu N, Ma J
Lancet Oncol 2018 Mar;19(3):382-393. Epub 2018 Feb 7 doi: 10.1016/S1470-2045(18)30080-9. PMID: 29428165
Tsubokawa N, Harada H, Taniyama D, Uemura T, Kuraoka K, Yamashita Y
Asian Cardiovasc Thorac Ann 2016 Oct;24(8):814-817. Epub 2016 Aug 4 doi: 10.1177/0218492316664672. PMID: 27493191
Ito Y, Hirokawa M, Miyauchi A, Masuoka H, Yabuta T, Fukushima M, Kihara M, Higashiyama T, Kobayashi K, Miya A
Endocr J 2016 Oct 29;63(10):913-917. Epub 2016 Jul 16 doi: 10.1507/endocrj.EJ16-0277. PMID: 27432822
Eubank WB
Radiol Clin North Am 2007 Jul;45(4):659-67, vi. doi: 10.1016/j.rcl.2007.05.005. PMID: 17706530

Recent systematic reviews

Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501
Wei X, Wang X, Xiong J, Li C, Liao Y, Zhu Y, Mao J
Biomed Res Int 2022;2022:9959649. Epub 2022 May 18 doi: 10.1155/2022/9959649. PMID: 35647194Free PMC Article
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Baretta Z, Mocellin S, Goldin E, Olopade OI, Huo D
Medicine (Baltimore) 2016 Oct;95(40):e4975. doi: 10.1097/MD.0000000000004975. PMID: 27749552Free PMC Article

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