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Primary Choroidal Non-Hodgkin Lymphoma

MedGen UID:
1784001
Concept ID:
C5446545
Neoplastic Process
Synonym: Primary Choroidal Lymphoma

Definition

An indolent, low-grade B-cell non-Hodgkin lymphoma that arises from the choroid. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Lymphoid follicles with germinal centers may be present. In the past these tumors were termed ''reactive lymphoid hyperplasia''. Now they are considered low-grade B-cell lymphomas, most commonly extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Choroidal Non-Hodgkin Lymphoma

Professional guidelines

PubMed

Ahmed AH, Foster CS, Shields CL
JAMA Ophthalmol 2017 Oct 1;135(10):1062-1068. doi: 10.1001/jamaophthalmol.2017.3286. PMID: 28880986Free PMC Article
Tuncer S, Tanyıldız B, Basaran M, Buyukbabani N, Dogan O
Curr Eye Res 2015;40(8):780-5. Epub 2014 Sep 23 doi: 10.3109/02713683.2014.959605. PMID: 25247376

Recent clinical studies

Etiology

Zhang L, Zhang T, Xu G, Zhang C, Qian J, Chang Q, Bi Y, Chen Q
Graefes Arch Clin Exp Ophthalmol 2023 Aug;261(8):2383-2394. Epub 2023 Mar 18 doi: 10.1007/s00417-022-05958-2. PMID: 36933009
Sthapit PR, Saiju R
Cancer Rep (Hoboken) 2021 Aug;4(4):e1347. Epub 2021 Feb 3 doi: 10.1002/cnr2.1347. PMID: 33535273Free PMC Article
Alfaar AS, Saad AM, KhalafAllah MT, Elsherif OE, Osman MH, Strauß O
Graefes Arch Clin Exp Ophthalmol 2021 Feb;259(2):515-526. Epub 2020 Sep 1 doi: 10.1007/s00417-020-04896-1. PMID: 32870371Free PMC Article
Mashayekhi A, Shukla SY, Shields JA, Shields CL
Ophthalmology 2014 Jan;121(1):342-351. Epub 2013 Aug 23 doi: 10.1016/j.ophtha.2013.06.046. PMID: 23978622
Lutz SC, Anderson SF, Wu CY, Townsend JC
Optom Vis Sci 2001 Sep;78(9):639-45. doi: 10.1097/00006324-200109000-00008. PMID: 11587197

Diagnosis

Zhang L, Zhang T, Xu G, Zhang C, Qian J, Chang Q, Bi Y, Chen Q
Graefes Arch Clin Exp Ophthalmol 2023 Aug;261(8):2383-2394. Epub 2023 Mar 18 doi: 10.1007/s00417-022-05958-2. PMID: 36933009
Alfaar AS, Saad AM, KhalafAllah MT, Elsherif OE, Osman MH, Strauß O
Graefes Arch Clin Exp Ophthalmol 2021 Feb;259(2):515-526. Epub 2020 Sep 1 doi: 10.1007/s00417-020-04896-1. PMID: 32870371Free PMC Article
Valenzuela J, Yeaney GA, Hsi ED, Azzato EM, Peereboom DM, Singh AD
Surv Ophthalmol 2020 May-Jun;65(3):361-370. Epub 2019 Oct 30 doi: 10.1016/j.survophthal.2019.10.008. PMID: 31676312
Sebastián C, Vela AC, Figueroa R, Marín MÁ, Alfaro J
Neuroradiol J 2014 Sep;27(4):425-30. Epub 2014 Aug 29 doi: 10.15274/NRJ-2014-10074. PMID: 25196615Free PMC Article
Mashayekhi A, Shukla SY, Shields JA, Shields CL
Ophthalmology 2014 Jan;121(1):342-351. Epub 2013 Aug 23 doi: 10.1016/j.ophtha.2013.06.046. PMID: 23978622

Therapy

Hernández-Pons A, Gómez-Beltrán E, Fernández-Zarzoso M, Albert-Fort M, Martínez-Costa L
Eur J Ophthalmol 2021 Mar;31(2):NP97-NP101. Epub 2020 Mar 13 doi: 10.1177/1120672120911333. PMID: 32164465
Simonett JM, Ambady P, Neuwelt EA, Skalet AH, Lin P
Ophthalmic Surg Lasers Imaging Retina 2020 May 1;51(5):S5-S12. doi: 10.3928/23258160-20200108-01. PMID: 32484895
Ramasubramanian A, Shields CL, Longmire M, Hunt DJ
J AAPOS 2011 Feb;15(1):94-5. doi: 10.1016/j.jaapos.2010.12.004. PMID: 21397815
Grimm SA, Pulido JS, Jahnke K, Schiff D, Hall AJ, Shenkier TN, Siegal T, Doolittle ND, Batchelor T, Herrlinger U, Neuwelt EA, Laperriere N, Chamberlain MC, Blay JY, Ferreri AJ, Omuro AM, Thiel E, Abrey LE
Ann Oncol 2007 Nov;18(11):1851-5. Epub 2007 Sep 5 doi: 10.1093/annonc/mdm340. PMID: 17804469
Lutz SC, Anderson SF, Wu CY, Townsend JC
Optom Vis Sci 2001 Sep;78(9):639-45. doi: 10.1097/00006324-200109000-00008. PMID: 11587197

Prognosis

Wang Z, Liu Y, Mo J, Cao X, Xu X, Shen L, Wang H, Wei W
BMC Ophthalmol 2022 Sep 19;22(1):371. doi: 10.1186/s12886-022-02598-2. PMID: 36123589Free PMC Article
Simonett JM, Ambady P, Neuwelt EA, Skalet AH, Lin P
Ophthalmic Surg Lasers Imaging Retina 2020 May 1;51(5):S5-S12. doi: 10.3928/23258160-20200108-01. PMID: 32484895
Valenzuela J, Yeaney GA, Hsi ED, Azzato EM, Peereboom DM, Singh AD
Surv Ophthalmol 2020 May-Jun;65(3):361-370. Epub 2019 Oct 30 doi: 10.1016/j.survophthal.2019.10.008. PMID: 31676312
Grimm SA, Pulido JS, Jahnke K, Schiff D, Hall AJ, Shenkier TN, Siegal T, Doolittle ND, Batchelor T, Herrlinger U, Neuwelt EA, Laperriere N, Chamberlain MC, Blay JY, Ferreri AJ, Omuro AM, Thiel E, Abrey LE
Ann Oncol 2007 Nov;18(11):1851-5. Epub 2007 Sep 5 doi: 10.1093/annonc/mdm340. PMID: 17804469
Lutz SC, Anderson SF, Wu CY, Townsend JC
Optom Vis Sci 2001 Sep;78(9):639-45. doi: 10.1097/00006324-200109000-00008. PMID: 11587197

Clinical prediction guides

Wang Z, Liu Y, Mo J, Cao X, Xu X, Shen L, Wang H, Wei W
BMC Ophthalmol 2022 Sep 19;22(1):371. doi: 10.1186/s12886-022-02598-2. PMID: 36123589Free PMC Article
Valenzuela J, Yeaney GA, Hsi ED, Azzato EM, Peereboom DM, Singh AD
Surv Ophthalmol 2020 May-Jun;65(3):361-370. Epub 2019 Oct 30 doi: 10.1016/j.survophthal.2019.10.008. PMID: 31676312
Mashayekhi A, Shukla SY, Shields JA, Shields CL
Ophthalmology 2014 Jan;121(1):342-351. Epub 2013 Aug 23 doi: 10.1016/j.ophtha.2013.06.046. PMID: 23978622
Coupland SE, Dodson A, Liu H, Du MQ, Angi M, Damato BE
Graefes Arch Clin Exp Ophthalmol 2013 May;251(5):1383-8. Epub 2012 Dec 12 doi: 10.1007/s00417-012-2216-0. PMID: 23232651
Schanzer MC, Font RL, O'Malley RE
Ophthalmology 1991 Jan;98(1):88-91. doi: 10.1016/s0161-6420(91)32335-2. PMID: 2023740

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