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Elevated circulating 4-methyl-2-oxopentanoic acid concentration

MedGen UID:
1779141
•Concept ID:
C5539590
•
Finding
Synonym: Increased circulating alpha-ketoisocaproic acid concentration
 
HPO: HP:0033437

Definition

The concentration of 4-methyl-2-oxopentanoic acid in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating 4-methyl-2-oxopentanoic acid concentration

Recent clinical studies

Etiology

Branched-chain amino acid and branched-chain ketoacid ingestion increases muscle protein synthesis rates in vivo in older adults: a double-blind, randomized trial.
Fuchs CJ, Hermans WJH, Holwerda AM, Smeets JSJ, Senden JM, van Kranenburg J, Gijsen AP, Wodzig WKHW, Schierbeek H, Verdijk LB, van Loon LJC
Am J Clin Nutr 2019 Oct 1;110(4):862-872. doi: 10.1093/ajcn/nqz120. PMID: 31250889Free PMC Article
Effects of fatty acids on hepatic amino acid catabolism and fibrinogen synthesis in young healthy volunteers.
Freyse EJ, Giessmann T, Petzke KJ, Knospe S, Engel G, Heinke P, Metges CC, Siegmund W
Am J Physiol Endocrinol Metab 2003 Jul;285(1):E54-62. doi: 10.1152/ajpendo.00324.2002. PMID: 12791602

Therapy

Branched-chain amino acid and branched-chain ketoacid ingestion increases muscle protein synthesis rates in vivo in older adults: a double-blind, randomized trial.
Fuchs CJ, Hermans WJH, Holwerda AM, Smeets JSJ, Senden JM, van Kranenburg J, Gijsen AP, Wodzig WKHW, Schierbeek H, Verdijk LB, van Loon LJC
Am J Clin Nutr 2019 Oct 1;110(4):862-872. doi: 10.1093/ajcn/nqz120. PMID: 31250889Free PMC Article
Effects of fatty acids on hepatic amino acid catabolism and fibrinogen synthesis in young healthy volunteers.
Freyse EJ, Giessmann T, Petzke KJ, Knospe S, Engel G, Heinke P, Metges CC, Siegmund W
Am J Physiol Endocrinol Metab 2003 Jul;285(1):E54-62. doi: 10.1152/ajpendo.00324.2002. PMID: 12791602

Clinical prediction guides

Blood and tissue branched-chain amino and alpha-keto acid concentrations: effect of diet, starvation, and disease.
Hutson SM, Harper AE
Am J Clin Nutr 1981 Feb;34(2):173-83. doi: 10.1093/ajcn/34.2.173. PMID: 7211722

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