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Fibrinolysis Shutdown

MedGen UID:
1774231
Concept ID:
C5420384
Disease or Syndrome

Definition

Acute impairment of breaking down fibrin clots leading to venous thromboembolism, stroke, and renal failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibrinolysis Shutdown

Professional guidelines

PubMed

Pluta J, Cieniewicz A, Trzebicki J
Anaesthesiol Intensive Ther 2021;53(2):153-161. doi: 10.5114/ait.2021.105783. PMID: 34006056Free PMC Article
Napolitano LM
Expert Rev Hematol 2021 Feb;14(2):219-239. Epub 2021 Jan 6 doi: 10.1080/17474086.2021.1858788. PMID: 33267678
Lampridou M, Sokou R, Tsantes AG, Theodoraki M, Konstantinidi A, Ioakeimidis G, Bonovas S, Politou M, Valsami S, Iliodromiti Z, Boutsikou T, Iacovidou N, Nikolopoulos G, Tsantes AE
Thromb Res 2020 Aug;192:103-108. Epub 2020 May 20 doi: 10.1016/j.thromres.2020.05.028. PMID: 32464452

Recent clinical studies

Etiology

Kartiko S, Koizumi N, Yamane D, Sarani B, Siddique AB, Levine AR, Jackson AM, Wieruszewski PM, Smischney NJ, Khanna AK, Chow JH; CRUSH COVID Investigators
J Intensive Care Med 2023 May;38(5):449-456. Epub 2022 Nov 29 doi: 10.1177/08850666221142265. PMID: 36448250Free PMC Article
Nakae R, Murai Y, Wada T, Fujiki Y, Kanaya T, Takayama Y, Suzuki G, Naoe Y, Yokota H, Yokobori S
Sci Rep 2022 Nov 9;12(1):19107. doi: 10.1038/s41598-022-23912-4. PMID: 36352256Free PMC Article
Duque P, Gonzalez-Zarco L, Martínez R, Gago S, Varela JA
Rev Esp Anestesiol Reanim (Engl Ed) 2021 May;68(5):301-303. Epub 2021 May 5 doi: 10.1016/j.redare.2020.06.016. PMID: 34140128
Fletcher-Sandersjöö A, Thelin EP, Maegele M, Svensson M, Bellander BM
Neurocrit Care 2021 Apr;34(2):635-656. doi: 10.1007/s12028-020-01037-8. PMID: 32607969Free PMC Article
Stettler GR, Moore EE, Nunns GR, Moore HB, Huebner BR, Silliman CC, Banerjee A, Sauaia A
Eur J Trauma Emerg Surg 2021 Dec;47(6):1827-1835. Epub 2020 Mar 10 doi: 10.1007/s00068-020-01328-x. PMID: 32157340Free PMC Article

Diagnosis

Kartiko S, Koizumi N, Yamane D, Sarani B, Siddique AB, Levine AR, Jackson AM, Wieruszewski PM, Smischney NJ, Khanna AK, Chow JH; CRUSH COVID Investigators
J Intensive Care Med 2023 May;38(5):449-456. Epub 2022 Nov 29 doi: 10.1177/08850666221142265. PMID: 36448250Free PMC Article
Creel-Bulos C, Auld SC, Caridi-Scheible M, Barker NA, Friend S, Gaddh M, Kempton CL, Maier CL, Nahab F, Sniecinski R
Shock 2021 Mar 1;55(3):316-320. doi: 10.1097/SHK.0000000000001635. PMID: 32769822Free PMC Article
Moore HB, Moore EE, Neal MD, Sheppard FR, Kornblith LZ, Draxler DF, Walsh M, Medcalf RL, Cohen MJ, Cotton BA, Thomas SG, Leeper CM, Gaines BA, Sauaia A
Anesth Analg 2019 Sep;129(3):762-773. doi: 10.1213/ANE.0000000000004234. PMID: 31425218Free PMC Article
Madurska MJ, Sachse KA, Jansen JO, Rasmussen TE, Morrison JJ
Eur J Trauma Emerg Surg 2018 Feb;44(1):35-44. Epub 2017 Sep 16 doi: 10.1007/s00068-017-0833-3. PMID: 28918481
Ramirez RJ, Spinella PC, Bochicchio GV
Crit Care Clin 2017 Jan;33(1):85-99. doi: 10.1016/j.ccc.2016.08.004. PMID: 27894501

Therapy

Duque P, Gonzalez-Zarco L, Martínez R, Gago S, Varela JA
Rev Esp Anestesiol Reanim (Engl Ed) 2021 May;68(5):301-303. Epub 2021 May 5 doi: 10.1016/j.redare.2020.06.016. PMID: 34140128
Moore HB, Moore BA, Sauaia A, Moore EE
ANZ J Surg 2020 Apr;90(4):413-414. Epub 2019 Sep 19 doi: 10.1111/ans.15426. PMID: 31535453
Moore HB, Moore EE, Neal MD, Sheppard FR, Kornblith LZ, Draxler DF, Walsh M, Medcalf RL, Cohen MJ, Cotton BA, Thomas SG, Leeper CM, Gaines BA, Sauaia A
Anesth Analg 2019 Sep;129(3):762-773. doi: 10.1213/ANE.0000000000004234. PMID: 31425218Free PMC Article
Madurska MJ, Sachse KA, Jansen JO, Rasmussen TE, Morrison JJ
Eur J Trauma Emerg Surg 2018 Feb;44(1):35-44. Epub 2017 Sep 16 doi: 10.1007/s00068-017-0833-3. PMID: 28918481
Ramirez RJ, Spinella PC, Bochicchio GV
Crit Care Clin 2017 Jan;33(1):85-99. doi: 10.1016/j.ccc.2016.08.004. PMID: 27894501

Prognosis

Nakae R, Murai Y, Wada T, Fujiki Y, Kanaya T, Takayama Y, Suzuki G, Naoe Y, Yokota H, Yokobori S
Sci Rep 2022 Nov 9;12(1):19107. doi: 10.1038/s41598-022-23912-4. PMID: 36352256Free PMC Article
Lawson MA, Holle LA, Dow NE, Hennig G, de Laat B, Moore HB, Moore EE, Cohen MJ, Bouchard BA, Freeman K, Wolberg AS
J Trauma Acute Care Surg 2022 Nov 1;93(5):579-587. Epub 2022 Jun 10 doi: 10.1097/TA.0000000000003723. PMID: 35687811Free PMC Article
Duque P, Chasco-Ganuza M, Burgos-Santamaria A, Terradillos E
Blood Coagul Fibrinolysis 2021 Jun 1;32(4):298-301. doi: 10.1097/MBC.0000000000001017. PMID: 33491994
Creel-Bulos C, Auld SC, Caridi-Scheible M, Barker NA, Friend S, Gaddh M, Kempton CL, Maier CL, Nahab F, Sniecinski R
Shock 2021 Mar 1;55(3):316-320. doi: 10.1097/SHK.0000000000001635. PMID: 32769822Free PMC Article
Fletcher-Sandersjöö A, Thelin EP, Maegele M, Svensson M, Bellander BM
Neurocrit Care 2021 Apr;34(2):635-656. doi: 10.1007/s12028-020-01037-8. PMID: 32607969Free PMC Article

Clinical prediction guides

Liu B, Yang C, Deng Y, Duan Z, Wang K, Li J, Ding W
Injury 2023 May;54(5):1265-1270. Epub 2023 Feb 7 doi: 10.1016/j.injury.2023.02.013. PMID: 36774266
Calvet L, Thouy F, Mascle O, Sapin AF, Grapin K, Liteaudon JM, Evrard B, Bonnet B, Adda M, Souweine B, Dupuis C
PLoS One 2022;17(11):e0277544. Epub 2022 Nov 23 doi: 10.1371/journal.pone.0277544. PMID: 36417476Free PMC Article
Lawson MA, Holle LA, Dow NE, Hennig G, de Laat B, Moore HB, Moore EE, Cohen MJ, Bouchard BA, Freeman K, Wolberg AS
J Trauma Acute Care Surg 2022 Nov 1;93(5):579-587. Epub 2022 Jun 10 doi: 10.1097/TA.0000000000003723. PMID: 35687811Free PMC Article
Duque P, Chasco-Ganuza M, Burgos-Santamaria A, Terradillos E
Blood Coagul Fibrinolysis 2021 Jun 1;32(4):298-301. doi: 10.1097/MBC.0000000000001017. PMID: 33491994
Creel-Bulos C, Auld SC, Caridi-Scheible M, Barker NA, Friend S, Gaddh M, Kempton CL, Maier CL, Nahab F, Sniecinski R
Shock 2021 Mar 1;55(3):316-320. doi: 10.1097/SHK.0000000000001635. PMID: 32769822Free PMC Article

Recent systematic reviews

Słomka A, Kowalewski M, Żekanowska E
Thromb Haemost 2021 Sep;121(9):1181-1192. Epub 2021 Mar 3 doi: 10.1055/a-1346-3178. [Epub ahead of print] PMID: 33401332
Fletcher-Sandersjöö A, Thelin EP, Maegele M, Svensson M, Bellander BM
Neurocrit Care 2021 Apr;34(2):635-656. doi: 10.1007/s12028-020-01037-8. PMID: 32607969Free PMC Article

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