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Metastatic Glioblastoma

MedGen UID:
1762790
•Concept ID:
C5418922
•
Neoplastic Process

Definition

Glioblastoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Glioblastoma

Professional guidelines

PubMed

The evolving role of reirradiation in the management of recurrent brain tumors.
De Pietro R, Zaccaro L, Marampon F, Tini P, De Felice F, Minniti G
J Neurooncol 2023 Sep;164(2):271-286. Epub 2023 Aug 25 doi: 10.1007/s11060-023-04407-2. PMID: 37624529Free PMC Article
Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook.
Garcia J, Hurwitz HI, Sandler AB, Miles D, Coleman RL, Deurloo R, Chinot OL
Cancer Treat Rev 2020 Jun;86:102017. Epub 2020 Mar 26 doi: 10.1016/j.ctrv.2020.102017. PMID: 32335505
Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.
Gholamin S, Mitra SS, Feroze AH, Liu J, Kahn SA, Zhang M, Esparza R, Richard C, Ramaswamy V, Remke M, Volkmer AK, Willingham S, Ponnuswami A, McCarty A, Lovelace P, Storm TA, Schubert S, Hutter G, Narayanan C, Chu P, Raabe EH, Harsh G 4th, Taylor MD, Monje M, Cho YJ, Majeti R, Volkmer JP, Fisher PG, Grant G, Steinberg GK, Vogel H, Edwards M, Weissman IL, Cheshier SH
Sci Transl Med 2017 Mar 15;9(381) doi: 10.1126/scitranslmed.aaf2968. PMID: 28298418

Recent clinical studies

Etiology

Metastatic glioblastoma to the lungs: a case report and literature review.
Yuen CA, Pekmezci M, Bao S, Kong XT
CNS Oncol 2024 Jun 6;13(1):2351789. Epub 2024 Jun 12 doi: 10.1080/20450907.2024.2351789. PMID: 38864820Free PMC Article
Extracranial metastasis of brain glioblastoma outside CNS: Pathogenesis revisited.
Kurdi M, Baeesa S, Okal F, Bamaga AK, Faizo E, Fathaddin AA, Alkhotani A, Karami MM, Bahakeem B
Cancer Rep (Hoboken) 2023 Dec;6(12):e1905. Epub 2023 Oct 9 doi: 10.1002/cnr2.1905. PMID: 37814403Free PMC Article
Evaluation of prognostic integrin α2β1 PET tracer and concurrent targeting delivery using focused ultrasound for brain glioma detection.
Chung YH, Hsu PH, Huang CW, Hsieh WC, Huang FT, Chang WC, Chiu H, Hsu ST, Yen TC
Mol Pharm 2014 Nov 3;11(11):3904-14. Epub 2014 Aug 25 doi: 10.1021/mp500296n. PMID: 25153169
Extraneural metastatic glioblastoma after interstitial brachytherapy.
Houston SC, Crocker IR, Brat DJ, Olson JJ
Int J Radiat Oncol Biol Phys 2000 Oct 1;48(3):831-6. doi: 10.1016/s0360-3016(00)00662-3. PMID: 11020581

Diagnosis

Extracranial metastasis of brain glioblastoma outside CNS: Pathogenesis revisited.
Kurdi M, Baeesa S, Okal F, Bamaga AK, Faizo E, Fathaddin AA, Alkhotani A, Karami MM, Bahakeem B
Cancer Rep (Hoboken) 2023 Dec;6(12):e1905. Epub 2023 Oct 9 doi: 10.1002/cnr2.1905. PMID: 37814403Free PMC Article
Primary and metastatic glioblastoma of the spine in the pediatric population: a systematic review.
Yang R, Isaacs AM, Cadieux M, Hirmer TJ, CreveCoeur TS, Lapointe AP, Opoku-Darko M, Premji Z, Riva-Cambrin J, Gallagher CN
Childs Nerv Syst 2021 Jun;37(6):1849-1858. Epub 2021 Mar 6 doi: 10.1007/s00381-021-05098-8. PMID: 33675391
Genetic and histologic spatiotemporal evolution of recurrent, multifocal, multicentric and metastatic glioblastoma.
Georgescu MM, Olar A
Acta Neuropathol Commun 2020 Feb 3;8(1):10. doi: 10.1186/s40478-020-0889-x. PMID: 32014051Free PMC Article
Widely metastatic glioblastoma with BRCA1 and ARID1A mutations: a case report.
Umphlett M, Shea S, Tome-Garcia J, Zhang Y, Hormigo A, Fowkes M, Tsankova NM, Yong RL
BMC Cancer 2020 Jan 20;20(1):47. doi: 10.1186/s12885-020-6540-1. PMID: 31959133Free PMC Article
Metastatic glioblastoma: case presentations and a review of the literature.
Kalokhe G, Grimm SA, Chandler JP, Helenowski I, Rademaker A, Raizer JJ
J Neurooncol 2012 Mar;107(1):21-7. Epub 2011 Oct 2 doi: 10.1007/s11060-011-0731-1. PMID: 21964740

Therapy

Solitary vertebral metastatic glioblastoma in the absence of primary brain tumor relapse: a case report and literature review.
Li ZG, Zheng MY, Zhao Q, Liu K, Du JX, Zhang SW
BMC Med Imaging 2020 Jul 31;20(1):89. doi: 10.1186/s12880-020-00488-x. PMID: 32736607Free PMC Article
Widely metastatic glioblastoma with BRCA1 and ARID1A mutations: a case report.
Umphlett M, Shea S, Tome-Garcia J, Zhang Y, Hormigo A, Fowkes M, Tsankova NM, Yong RL
BMC Cancer 2020 Jan 20;20(1):47. doi: 10.1186/s12885-020-6540-1. PMID: 31959133Free PMC Article
Cytological diagnosis of metastatic glioblastoma in the pleural effusion of a lung transplant patient.
Nauen DW, Li QK
Diagn Cytopathol 2014 Jul;42(7):619-23. Epub 2013 Apr 3 doi: 10.1002/dc.22993. PMID: 23554289
Radiotherapy and bevacizumab for intramedullary and leptomenigeal metastatic glioblastoma: a case report and review of the literature.
Fiorentino A, Caivano R, Chiumento C, Cozzolino M, Fusco V
Int J Neurosci 2012 Nov;122(11):691-4. Epub 2012 Aug 8 doi: 10.3109/00207454.2012.704456. PMID: 22720749
Transmission of metastatic glioblastoma multiforme from donor to lung transplant recipient.
Fatt MA, Horton KM, Fishman EK
J Comput Assist Tomogr 2008 May-Jun;32(3):407-9. doi: 10.1097/RCT.0b013e318076b472. PMID: 18520546

Prognosis

Extracranial metastasis of brain glioblastoma outside CNS: Pathogenesis revisited.
Kurdi M, Baeesa S, Okal F, Bamaga AK, Faizo E, Fathaddin AA, Alkhotani A, Karami MM, Bahakeem B
Cancer Rep (Hoboken) 2023 Dec;6(12):e1905. Epub 2023 Oct 9 doi: 10.1002/cnr2.1905. PMID: 37814403Free PMC Article
Primary and metastatic glioblastoma of the spine in the pediatric population: a systematic review.
Yang R, Isaacs AM, Cadieux M, Hirmer TJ, CreveCoeur TS, Lapointe AP, Opoku-Darko M, Premji Z, Riva-Cambrin J, Gallagher CN
Childs Nerv Syst 2021 Jun;37(6):1849-1858. Epub 2021 Mar 6 doi: 10.1007/s00381-021-05098-8. PMID: 33675391
Solitary vertebral metastatic glioblastoma in the absence of primary brain tumor relapse: a case report and literature review.
Li ZG, Zheng MY, Zhao Q, Liu K, Du JX, Zhang SW
BMC Med Imaging 2020 Jul 31;20(1):89. doi: 10.1186/s12880-020-00488-x. PMID: 32736607Free PMC Article
Subcutaneous tissue metastasis from glioblastoma multiforme: A case report and review of the literature.
Frade Porto N, Delgado Fernández J, García Pallero MLÁ, Penanes Cuesta JR, Pulido Rivas P, Gil Simoes R
Neurocirugia (Astur : Engl Ed) 2019 May-Jun;30(3):149-154. Epub 2018 May 16 doi: 10.1016/j.neucir.2018.03.005. PMID: 29778285
Radiotherapy and bevacizumab for intramedullary and leptomenigeal metastatic glioblastoma: a case report and review of the literature.
Fiorentino A, Caivano R, Chiumento C, Cozzolino M, Fusco V
Int J Neurosci 2012 Nov;122(11):691-4. Epub 2012 Aug 8 doi: 10.3109/00207454.2012.704456. PMID: 22720749

Clinical prediction guides

Metastatic glioblastoma to the lungs: a case report and literature review.
Yuen CA, Pekmezci M, Bao S, Kong XT
CNS Oncol 2024 Jun 6;13(1):2351789. Epub 2024 Jun 12 doi: 10.1080/20450907.2024.2351789. PMID: 38864820Free PMC Article
Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis.
Rennert RC, Hoshide RR, Signorelli JW, Amaro D, Sack JA, Brennan CW, Chen CC
J Neurosurg 2017 May;126(5):1472-1478. Epub 2016 Jul 22 doi: 10.3171/2016.4.JNS153052. PMID: 27447440
Malignant melanoma mimicking giant cell variant of glioblastoma multiforme: a case report and review of literature.
Arcega R, Yong WH, Xu H
Int J Clin Exp Pathol 2015;8(5):5929-33. Epub 2015 May 1 PMID: 26191321Free PMC Article
Systemic metastasis in glioblastoma may represent the emergence of neoplastic subclones.
Park CC, Hartmann C, Folkerth R, Loeffler JS, Wen PY, Fine HA, Black PM, Shafman T, Louis DN
J Neuropathol Exp Neurol 2000 Dec;59(12):1044-50. doi: 10.1093/jnen/59.12.1044. PMID: 11138924
High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma.
Forsyth PA, Laing TD, Gibson AW, Rewcastle NB, Brasher P, Sutherland G, Johnston RN, Edwards DR
J Neurooncol 1998 Jan;36(1):21-9. doi: 10.1023/a:1005879027267. PMID: 9525822

Recent systematic reviews

Bone metastasis from glioblastoma: a systematic review.
Strong MJ, Koduri S, Allison JA, Pesavento CM, Ogunsola S, Ogunsola O, Yee TJ, Khalsa SSS, Saadeh YS, Joseph JR, Kashlan ON, Park P, Oppenlander ME, Szerlip NJ
J Neurooncol 2022 Jul;158(3):379-392. Epub 2022 May 17 doi: 10.1007/s11060-022-04025-4. PMID: 35578056
Primary and metastatic glioblastoma of the spine in the pediatric population: a systematic review.
Yang R, Isaacs AM, Cadieux M, Hirmer TJ, CreveCoeur TS, Lapointe AP, Opoku-Darko M, Premji Z, Riva-Cambrin J, Gallagher CN
Childs Nerv Syst 2021 Jun;37(6):1849-1858. Epub 2021 Mar 6 doi: 10.1007/s00381-021-05098-8. PMID: 33675391

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