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Recurrent Metastatic Malignant Neoplasm in the Leptomeninges

MedGen UID:
1756581
•Concept ID:
C5420454
•
Neoplastic Process

Definition

The reemergence of a metastatic malignant neoplasm in the leptomeninges after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Metastatic Malignant Neoplasm in the Leptomeninges

Professional guidelines

PubMed

Multicentric Assessment of Safety and Efficacy of Combinatorial Adjuvant Brain Metastasis Treatment by Intraoperative Radiation Therapy and Immunotherapy.
Layer JP, Shiban E, Brehmer S, Diehl CD, de Castro DG, Hamed M, Dejonckheere CS, Cifarelli DT, Friker LL, Herrlinger U, Hölzel M, Vatter H, Schneider M, Combs SE, Schmeel LC, Cifarelli CP, Giordano FA, Sarria GR, Kahl KH
Int J Radiat Oncol Biol Phys 2024 Apr 1;118(5):1552-1562. Epub 2024 Jan 9 doi: 10.1016/j.ijrobp.2024.01.009. PMID: 38199383
Management of Brain and Leptomeningeal Metastases from Breast Cancer.
Pellerino A, Internò V, Mo F, Franchino F, Soffietti R, Rudà R
Int J Mol Sci 2020 Nov 12;21(22) doi: 10.3390/ijms21228534. PMID: 33198331Free PMC Article
Epidemiology, Treatment, and Complications of Central Nervous System Metastases.
Pruitt AA
Continuum (Minneap Minn) 2017 Dec;23(6, Neuro-oncology):1580-1600. doi: 10.1212/CON.0000000000000551. PMID: 29200112

Recent clinical studies

Etiology

ACTION: a randomized phase 3 study of ONC201 (dordaviprone) in patients with newly diagnosed H3 K27M-mutant diffuse glioma.
Arrillaga-Romany I, Lassman A, McGovern SL, Mueller S, Nabors B, van den Bent M, Vogelbaum MA, Allen JE, Melemed AS, Tarapore RS, Wen PY, Cloughesy T
Neuro Oncol 2024 May 3;26(Supplement_2):S173-S181. doi: 10.1093/neuonc/noae031. PMID: 38445964Free PMC Article
SAFESTEREO: phase II randomized trial to compare stereotactic radiosurgery with fractionated stereotactic radiosurgery for brain metastases.
Crouzen JA, Petoukhova AL, Broekman MLD, Fiocco M, Fisscher UJ, Franssen JH, Gadellaa-van Hooijdonk CGM, Kerkhof M, Kiderlen M, Mast ME, van Rij CM, Nandoe Tewarie R, van de Sande MAE, van der Toorn PPG, Vlasman R, Vos MJ, van der Voort van Zyp NCMG, Wiggenraad RGJ, Wiltink LM, Zindler JD
BMC Cancer 2023 Mar 25;23(1):273. doi: 10.1186/s12885-023-10761-1. PMID: 36964529Free PMC Article
Osimertinib for EGFR-Mutant Non-Small-Cell Lung Cancer Central Nervous System Metastases: Current Evidence and Future Perspectives on Therapeutic Strategies.
Popat S, Ahn MJ, Ekman S, Leighl NB, Ramalingam SS, Reungwetwattana T, Siva S, Tsuboi M, Wu YL, Yang JC
Target Oncol 2023 Jan;18(1):9-24. Epub 2023 Jan 18 doi: 10.1007/s11523-022-00941-7. PMID: 36652172
ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases.
Kumthekar P, Tang SC, Brenner AJ, Kesari S, Piccioni DE, Anders C, Carrillo J, Chalasani P, Kabos P, Puhalla S, Tkaczuk K, Garcia AA, Ahluwalia MS, Wefel JS, Lakhani N, Ibrahim N
Clin Cancer Res 2020 Jun 15;26(12):2789-2799. Epub 2020 Jan 22 doi: 10.1158/1078-0432.CCR-19-3258. PMID: 31969331
Medulloblastoma: From Myth to Molecular.
Ramaswamy V, Taylor MD
J Clin Oncol 2017 Jul 20;35(21):2355-2363. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7842. PMID: 28640708

Diagnosis

ACTION: a randomized phase 3 study of ONC201 (dordaviprone) in patients with newly diagnosed H3 K27M-mutant diffuse glioma.
Arrillaga-Romany I, Lassman A, McGovern SL, Mueller S, Nabors B, van den Bent M, Vogelbaum MA, Allen JE, Melemed AS, Tarapore RS, Wen PY, Cloughesy T
Neuro Oncol 2024 May 3;26(Supplement_2):S173-S181. doi: 10.1093/neuonc/noae031. PMID: 38445964Free PMC Article
Establishment and Comprehensive Characterization of a Novel Preclinical Platform of Metastatic Retinoblastoma for Therapeutic Developments.
Zugbi S, Aschero R, Ganiewich D, Cancela MB, Winter U, Ottaviani D, Sampor C, Dinardi M, Torbidoni AV, Mena M, Balaguer-Lluna L, Lamas G, Sgroi M, Lagomarsino E, Lubieniecki F, Fandiño A, Radvanyi F, Abramson DH, Podhajcer O, Llera AS, Cafferata EG, Chantada G, Carcaboso AM, Schaiquevich P
Invest Ophthalmol Vis Sci 2023 Dec 1;64(15):27. doi: 10.1167/iovs.64.15.27. PMID: 38117242Free PMC Article
Leptomeningeal dissemination in pediatric brain tumors.
Cocito C, Martin B, Giantini-Larsen AM, Valcarce-Aspegren M, Souweidane MM, Szalontay L, Dahmane N, Greenfield JP
Neoplasia 2023 May;39:100898. Epub 2023 Apr 1 doi: 10.1016/j.neo.2023.100898. PMID: 37011459Free PMC Article
Phase 1 study of intraventricular (131)I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies.
Kramer K, Pandit-Taskar N, Kushner BH, Zanzonico P, Humm JL, Tomlinson U, Donzelli M, Wolden SL, Haque S, Dunkel I, Souweidane MM, Greenfield JP, Tickoo S, Lewis JS, Lyashchenko SK, Carrasquillo JA, Chu B, Horan C, Larson SM, Cheung NV, Modak S
J Hematol Oncol 2022 Nov 12;15(1):165. doi: 10.1186/s13045-022-01383-4. PMID: 36371226Free PMC Article
Spinal meningioma causing diffuse leptomeningeal enhancement.
Lucey BP, Tihan T, Pomper MG, Olivi A, Laterra J
Neurology 2003 Jan 28;60(2):350-1. doi: 10.1212/01.wnl.0000044052.79677.a9. PMID: 12552066

Therapy

ACTION: a randomized phase 3 study of ONC201 (dordaviprone) in patients with newly diagnosed H3 K27M-mutant diffuse glioma.
Arrillaga-Romany I, Lassman A, McGovern SL, Mueller S, Nabors B, van den Bent M, Vogelbaum MA, Allen JE, Melemed AS, Tarapore RS, Wen PY, Cloughesy T
Neuro Oncol 2024 May 3;26(Supplement_2):S173-S181. doi: 10.1093/neuonc/noae031. PMID: 38445964Free PMC Article
SAFESTEREO: phase II randomized trial to compare stereotactic radiosurgery with fractionated stereotactic radiosurgery for brain metastases.
Crouzen JA, Petoukhova AL, Broekman MLD, Fiocco M, Fisscher UJ, Franssen JH, Gadellaa-van Hooijdonk CGM, Kerkhof M, Kiderlen M, Mast ME, van Rij CM, Nandoe Tewarie R, van de Sande MAE, van der Toorn PPG, Vlasman R, Vos MJ, van der Voort van Zyp NCMG, Wiggenraad RGJ, Wiltink LM, Zindler JD
BMC Cancer 2023 Mar 25;23(1):273. doi: 10.1186/s12885-023-10761-1. PMID: 36964529Free PMC Article
Osimertinib for EGFR-Mutant Non-Small-Cell Lung Cancer Central Nervous System Metastases: Current Evidence and Future Perspectives on Therapeutic Strategies.
Popat S, Ahn MJ, Ekman S, Leighl NB, Ramalingam SS, Reungwetwattana T, Siva S, Tsuboi M, Wu YL, Yang JC
Target Oncol 2023 Jan;18(1):9-24. Epub 2023 Jan 18 doi: 10.1007/s11523-022-00941-7. PMID: 36652172
Recent Advances and Applications of Radiation Therapy for Brain Metastases.
Mathis NJ, Wijetunga NA, Imber BS, Pike LRG, Yang JT
Curr Oncol Rep 2022 Mar;24(3):335-342. Epub 2022 Feb 8 doi: 10.1007/s11912-022-01209-z. PMID: 35133614
ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases.
Kumthekar P, Tang SC, Brenner AJ, Kesari S, Piccioni DE, Anders C, Carrillo J, Chalasani P, Kabos P, Puhalla S, Tkaczuk K, Garcia AA, Ahluwalia MS, Wefel JS, Lakhani N, Ibrahim N
Clin Cancer Res 2020 Jun 15;26(12):2789-2799. Epub 2020 Jan 22 doi: 10.1158/1078-0432.CCR-19-3258. PMID: 31969331

Prognosis

ACTION: a randomized phase 3 study of ONC201 (dordaviprone) in patients with newly diagnosed H3 K27M-mutant diffuse glioma.
Arrillaga-Romany I, Lassman A, McGovern SL, Mueller S, Nabors B, van den Bent M, Vogelbaum MA, Allen JE, Melemed AS, Tarapore RS, Wen PY, Cloughesy T
Neuro Oncol 2024 May 3;26(Supplement_2):S173-S181. doi: 10.1093/neuonc/noae031. PMID: 38445964Free PMC Article
Lymphomas of Central Nervous System.
Yokogami K, Azuma M, Takeshima H, Hirai T
Adv Exp Med Biol 2023;1405:527-543. doi: 10.1007/978-3-031-23705-8_20. PMID: 37452952
Osimertinib for EGFR-Mutant Non-Small-Cell Lung Cancer Central Nervous System Metastases: Current Evidence and Future Perspectives on Therapeutic Strategies.
Popat S, Ahn MJ, Ekman S, Leighl NB, Ramalingam SS, Reungwetwattana T, Siva S, Tsuboi M, Wu YL, Yang JC
Target Oncol 2023 Jan;18(1):9-24. Epub 2023 Jan 18 doi: 10.1007/s11523-022-00941-7. PMID: 36652172
ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases.
Kumthekar P, Tang SC, Brenner AJ, Kesari S, Piccioni DE, Anders C, Carrillo J, Chalasani P, Kabos P, Puhalla S, Tkaczuk K, Garcia AA, Ahluwalia MS, Wefel JS, Lakhani N, Ibrahim N
Clin Cancer Res 2020 Jun 15;26(12):2789-2799. Epub 2020 Jan 22 doi: 10.1158/1078-0432.CCR-19-3258. PMID: 31969331
Medulloblastoma: From Myth to Molecular.
Ramaswamy V, Taylor MD
J Clin Oncol 2017 Jul 20;35(21):2355-2363. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7842. PMID: 28640708

Clinical prediction guides

Establishment and Comprehensive Characterization of a Novel Preclinical Platform of Metastatic Retinoblastoma for Therapeutic Developments.
Zugbi S, Aschero R, Ganiewich D, Cancela MB, Winter U, Ottaviani D, Sampor C, Dinardi M, Torbidoni AV, Mena M, Balaguer-Lluna L, Lamas G, Sgroi M, Lagomarsino E, Lubieniecki F, Fandiño A, Radvanyi F, Abramson DH, Podhajcer O, Llera AS, Cafferata EG, Chantada G, Carcaboso AM, Schaiquevich P
Invest Ophthalmol Vis Sci 2023 Dec 1;64(15):27. doi: 10.1167/iovs.64.15.27. PMID: 38117242Free PMC Article
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Surgery in the Management of Adults With Metastatic Brain Tumors.
Nahed BV, Alvarez-Breckenridge C, Brastianos PK, Shih H, Sloan A, Ammirati M, Kuo JS, Ryken TC, Kalkanis SN, Olson JJ
Neurosurgery 2019 Mar 1;84(3):E152-E155. doi: 10.1093/neuros/nyy542. PMID: 30629227
Central Nervous System Prophylaxis Strategies in Diffuse Large B Cell Lymphoma.
Kansara R
Curr Treat Options Oncol 2018 Sep 10;19(11):52. doi: 10.1007/s11864-018-0569-2. PMID: 30203318
Epidemiology, Treatment, and Complications of Central Nervous System Metastases.
Pruitt AA
Continuum (Minneap Minn) 2017 Dec;23(6, Neuro-oncology):1580-1600. doi: 10.1212/CON.0000000000000551. PMID: 29200112
Prevention of CNS relapse in diffuse large B-cell lymphoma.
Kridel R, Dietrich PY
Lancet Oncol 2011 Dec;12(13):1258-66. Epub 2011 Sep 18 doi: 10.1016/S1470-2045(11)70140-1. PMID: 21933751

Recent systematic reviews

Preoperative versus postoperative stereotactic radiosurgery for brain metastases: a systematic review and meta-analysis of comparative studies.
Maroufi SF, Fallahi MS, Maroufi SP, Kassaeyan V, Palmisciano P, Sheehan JP
Neurosurg Rev 2025 Jan 2;48(1):16. doi: 10.1007/s10143-024-03166-6. PMID: 39743641
Intrathecal chemotherapy for leptomeningeal disease in high-grade gliomas: a systematic review.
Singh E, Gurses ME, Costello MC, Berke C, Lu VM, Daggubati L, Komotar RJ, Ivan ME, Shah AH
J Neurooncol 2024 Mar;167(1):39-47. Epub 2024 Jan 31 doi: 10.1007/s11060-024-04582-w. PMID: 38294637
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Surgery in the Management of Adults With Metastatic Brain Tumors.
Nahed BV, Alvarez-Breckenridge C, Brastianos PK, Shih H, Sloan A, Ammirati M, Kuo JS, Ryken TC, Kalkanis SN, Olson JJ
Neurosurgery 2019 Mar 1;84(3):E152-E155. doi: 10.1093/neuros/nyy542. PMID: 30629227
Stereotactic radiosurgery versus whole-brain radiotherapy after intracranial metastasis resection: a systematic review and meta-analysis.
Lamba N, Muskens IS, DiRisio AC, Meijer L, Briceno V, Edrees H, Aslam B, Minhas S, Verhoeff JJC, Kleynen CE, Smith TR, Mekary RA, Broekman ML
Radiat Oncol 2017 Jun 24;12(1):106. doi: 10.1186/s13014-017-0840-x. PMID: 28646895Free PMC Article

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