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Advanced Non-Hodgkin Lymphoma

MedGen UID:
1750455
•Concept ID:
C5419617
•
Neoplastic Process

Definition

Non-Hodgkin lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Who does not receive treatment for cancer?
Ward MM, Ullrich F, Matthews K, Rushton G, Goldstein MA, Bajorin DF, Hanley A, Lynch CF
J Oncol Pract 2013 Jan;9(1):20-6. doi: 10.1200/JOP.2012.000829. PMID: 23633967Free PMC Article

Recent clinical studies

Etiology

Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells.
Kebriaei P, Singh H, Huls MH, Figliola MJ, Bassett R, Olivares S, Jena B, Dawson MJ, Kumaresan PR, Su S, Maiti S, Dai J, Moriarity B, Forget MA, Senyukov V, Orozco A, Liu T, McCarty J, Jackson RN, Moyes JS, Rondon G, Qazilbash M, Ciurea S, Alousi A, Nieto Y, Rezvani K, Marin D, Popat U, Hosing C, Shpall EJ, Kantarjian H, Keating M, Wierda W, Do KA, Largaespada DA, Lee DA, Hackett PB, Champlin RE, Cooper LJ
J Clin Invest 2016 Sep 1;126(9):3363-76. Epub 2016 Aug 2 doi: 10.1172/JCI86721. PMID: 27482888Free PMC Article
Radioimmunotherapy with yttrium-90-ibritumomab tiuxetan as part of a reduced- intensity conditioning regimen for allogeneic hematopoietic cell transplantation in patients with advanced non-Hodgkin lymphoma: results of a phase 2 study.
Bethge WA, Lange T, Meisner C, von Harsdorf S, Bornhaeuser M, Federmann B, Stadler M, Uharek L, Stelljes M, Knop S, Wulf G, Trenschel R, Vucinic V, Dittmann H, Faul C, Vogel W, Kanz L, Bunjes D
Blood 2010 Sep 9;116(10):1795-802. Epub 2010 Jun 7 doi: 10.1182/blood-2010-02-270538. PMID: 20530284
Comorbidities, not age, impact outcomes in autologous stem cell transplant for relapsed non-Hodgkin lymphoma.
Wildes TM, Augustin KM, Sempek D, Zhang QJ, Vij R, Dipersio JF, Devine SM
Biol Blood Marrow Transplant 2008 Jul;14(7):840-6. doi: 10.1016/j.bbmt.2008.05.002. PMID: 18541205
[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography for early evaluation of treatment efficacy in advanced non-Hodgkin lymphoma of uterine corpus: a case report.
Imperiale A, Blondet C, Fohrer C, Cimarelli S, Herbrecht R, Constantinesco A
Clin Lymphoma Myeloma 2007 May;7(6):421-4. doi: 10.3816/CLM.2007.n.021. PMID: 17621408
Long-term results of low dose total body irradiation for advanced non-Hodgkin lymphoma.
Lybeert ML, Meerwaldt JH, Deneve W
Int J Radiat Oncol Biol Phys 1987 Aug;13(8):1167-72. doi: 10.1016/0360-3016(87)90190-8. PMID: 3301759

Diagnosis

Bloodstream infection due to Mycoplasma arginini in an immunocompromised patient.
Watanabe M, Hitomi S, Goto M, Hasegawa Y
J Clin Microbiol 2012 Sep;50(9):3133-5. Epub 2012 Jul 11 doi: 10.1128/JCM.00736-12. PMID: 22785195Free PMC Article
Radioimmunotherapy with yttrium-90-ibritumomab tiuxetan as part of a reduced- intensity conditioning regimen for allogeneic hematopoietic cell transplantation in patients with advanced non-Hodgkin lymphoma: results of a phase 2 study.
Bethge WA, Lange T, Meisner C, von Harsdorf S, Bornhaeuser M, Federmann B, Stadler M, Uharek L, Stelljes M, Knop S, Wulf G, Trenschel R, Vucinic V, Dittmann H, Faul C, Vogel W, Kanz L, Bunjes D
Blood 2010 Sep 9;116(10):1795-802. Epub 2010 Jun 7 doi: 10.1182/blood-2010-02-270538. PMID: 20530284
Second-line age-adjusted International Prognostic Index in patients with advanced non-Hodgkin lymphoma after T-cell depleted allogeneic hematopoietic SCT.
Perales MA, Jenq R, Goldberg JD, Wilton AS, Lee SS, Castro-Malaspina HR, Hsu K, Papadopoulos EB, van den Brink MR, Boulad F, Kernan NA, Small TN, Wolden S, Collins NH, Chiu M, Heller G, O'Reilly RJ, Kewalramani T, Young JW, Jakubowski AA
Bone Marrow Transplant 2010 Sep;45(9):1408-16. Epub 2010 Jan 11 doi: 10.1038/bmt.2009.371. PMID: 20062091Free PMC Article
A new protocol (MiCEP) for the treatment of intermediate or high-grade non-Hodgkin's lymphoma in the elderly.
Bellesi G, Rigacci L, Alterini R, Bernardi F, Stefanacci S, Innocenti F, Fusco II, Longo G, Di Lollo S, Ferrini PR
Leuk Lymphoma 1996 Feb;20(5-6):475-80. doi: 10.3109/10428199609052432. PMID: 8833406
Primary chemotherapy for obstructive jaundice caused by intermediate-grade non-Hodgkin lymphoma.
Dudgeon DJ, Brower M
Cancer 1993 May 1;71(9):2813-6. doi: 10.1002/1097-0142(19930501)71:9<2813::aid-cncr2820710921>3.0.co;2-d. PMID: 7682150

Therapy

Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells.
Kebriaei P, Singh H, Huls MH, Figliola MJ, Bassett R, Olivares S, Jena B, Dawson MJ, Kumaresan PR, Su S, Maiti S, Dai J, Moriarity B, Forget MA, Senyukov V, Orozco A, Liu T, McCarty J, Jackson RN, Moyes JS, Rondon G, Qazilbash M, Ciurea S, Alousi A, Nieto Y, Rezvani K, Marin D, Popat U, Hosing C, Shpall EJ, Kantarjian H, Keating M, Wierda W, Do KA, Largaespada DA, Lee DA, Hackett PB, Champlin RE, Cooper LJ
J Clin Invest 2016 Sep 1;126(9):3363-76. Epub 2016 Aug 2 doi: 10.1172/JCI86721. PMID: 27482888Free PMC Article
Phase II study of vincristine sulfate liposome injection (Marqibo) and rituximab for patients with relapsed and refractory diffuse large B-Cell lymphoma or mantle cell lymphoma in need of palliative therapy.
Kaplan LD, Deitcher SR, Silverman JA, Morgan G
Clin Lymphoma Myeloma Leuk 2014 Feb;14(1):37-42. Epub 2013 Oct 1 doi: 10.1016/j.clml.2013.09.009. PMID: 24252360
[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography for early evaluation of treatment efficacy in advanced non-Hodgkin lymphoma of uterine corpus: a case report.
Imperiale A, Blondet C, Fohrer C, Cimarelli S, Herbrecht R, Constantinesco A
Clin Lymphoma Myeloma 2007 May;7(6):421-4. doi: 10.3816/CLM.2007.n.021. PMID: 17621408
Pediatric primary leptomeningeal lymphoma treated without cranial radiotherapy.
Taga T, Sakaue Y, Anzai Y, Takeuchi Y, Ohta S
Pediatr Blood Cancer 2007 Apr;48(4):477-8. doi: 10.1002/pbc.20704. PMID: 16411209
High-dose methotrexate with folinic acid in the treatment of advanced non-Hodgkin lymphoma including CNS involvement.
Skarin AT, Zuckerman KS, Pitman SW, Rosenthal DS, Moloney W, Frei E 3rd, Canellos GP
Blood 1977 Dec;50(6):1039-47. PMID: 303529

Prognosis

Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells.
Kebriaei P, Singh H, Huls MH, Figliola MJ, Bassett R, Olivares S, Jena B, Dawson MJ, Kumaresan PR, Su S, Maiti S, Dai J, Moriarity B, Forget MA, Senyukov V, Orozco A, Liu T, McCarty J, Jackson RN, Moyes JS, Rondon G, Qazilbash M, Ciurea S, Alousi A, Nieto Y, Rezvani K, Marin D, Popat U, Hosing C, Shpall EJ, Kantarjian H, Keating M, Wierda W, Do KA, Largaespada DA, Lee DA, Hackett PB, Champlin RE, Cooper LJ
J Clin Invest 2016 Sep 1;126(9):3363-76. Epub 2016 Aug 2 doi: 10.1172/JCI86721. PMID: 27482888Free PMC Article
Phase II study of vincristine sulfate liposome injection (Marqibo) and rituximab for patients with relapsed and refractory diffuse large B-Cell lymphoma or mantle cell lymphoma in need of palliative therapy.
Kaplan LD, Deitcher SR, Silverman JA, Morgan G
Clin Lymphoma Myeloma Leuk 2014 Feb;14(1):37-42. Epub 2013 Oct 1 doi: 10.1016/j.clml.2013.09.009. PMID: 24252360
A new protocol (MiCEP) for the treatment of intermediate or high-grade non-Hodgkin's lymphoma in the elderly.
Bellesi G, Rigacci L, Alterini R, Bernardi F, Stefanacci S, Innocenti F, Fusco II, Longo G, Di Lollo S, Ferrini PR
Leuk Lymphoma 1996 Feb;20(5-6):475-80. doi: 10.3109/10428199609052432. PMID: 8833406
Long-term results of low dose total body irradiation for advanced non-Hodgkin lymphoma.
Lybeert ML, Meerwaldt JH, Deneve W
Int J Radiat Oncol Biol Phys 1987 Aug;13(8):1167-72. doi: 10.1016/0360-3016(87)90190-8. PMID: 3301759
Combination chemotherapy of advanced non-Hodgkin lymphoma with bleomycin, adriamycin, cyclophosphamide, vincristine, and prednisone (BACOP).
Skarin AT, Rosenthal DS, Moloney WC, Frei E 3rd
Blood 1977 May;49(5):759-70. PMID: 66957

Clinical prediction guides

Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells.
Kebriaei P, Singh H, Huls MH, Figliola MJ, Bassett R, Olivares S, Jena B, Dawson MJ, Kumaresan PR, Su S, Maiti S, Dai J, Moriarity B, Forget MA, Senyukov V, Orozco A, Liu T, McCarty J, Jackson RN, Moyes JS, Rondon G, Qazilbash M, Ciurea S, Alousi A, Nieto Y, Rezvani K, Marin D, Popat U, Hosing C, Shpall EJ, Kantarjian H, Keating M, Wierda W, Do KA, Largaespada DA, Lee DA, Hackett PB, Champlin RE, Cooper LJ
J Clin Invest 2016 Sep 1;126(9):3363-76. Epub 2016 Aug 2 doi: 10.1172/JCI86721. PMID: 27482888Free PMC Article
Phase II study of vincristine sulfate liposome injection (Marqibo) and rituximab for patients with relapsed and refractory diffuse large B-Cell lymphoma or mantle cell lymphoma in need of palliative therapy.
Kaplan LD, Deitcher SR, Silverman JA, Morgan G
Clin Lymphoma Myeloma Leuk 2014 Feb;14(1):37-42. Epub 2013 Oct 1 doi: 10.1016/j.clml.2013.09.009. PMID: 24252360
Radioimmunotherapy with yttrium-90-ibritumomab tiuxetan as part of a reduced- intensity conditioning regimen for allogeneic hematopoietic cell transplantation in patients with advanced non-Hodgkin lymphoma: results of a phase 2 study.
Bethge WA, Lange T, Meisner C, von Harsdorf S, Bornhaeuser M, Federmann B, Stadler M, Uharek L, Stelljes M, Knop S, Wulf G, Trenschel R, Vucinic V, Dittmann H, Faul C, Vogel W, Kanz L, Bunjes D
Blood 2010 Sep 9;116(10):1795-802. Epub 2010 Jun 7 doi: 10.1182/blood-2010-02-270538. PMID: 20530284
Second-line age-adjusted International Prognostic Index in patients with advanced non-Hodgkin lymphoma after T-cell depleted allogeneic hematopoietic SCT.
Perales MA, Jenq R, Goldberg JD, Wilton AS, Lee SS, Castro-Malaspina HR, Hsu K, Papadopoulos EB, van den Brink MR, Boulad F, Kernan NA, Small TN, Wolden S, Collins NH, Chiu M, Heller G, O'Reilly RJ, Kewalramani T, Young JW, Jakubowski AA
Bone Marrow Transplant 2010 Sep;45(9):1408-16. Epub 2010 Jan 11 doi: 10.1038/bmt.2009.371. PMID: 20062091Free PMC Article
Comorbidities, not age, impact outcomes in autologous stem cell transplant for relapsed non-Hodgkin lymphoma.
Wildes TM, Augustin KM, Sempek D, Zhang QJ, Vij R, Dipersio JF, Devine SM
Biol Blood Marrow Transplant 2008 Jul;14(7):840-6. doi: 10.1016/j.bbmt.2008.05.002. PMID: 18541205

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