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Oral Cavity Myeloid Sarcoma

MedGen UID:
1724518
•Concept ID:
C5420235
•
Neoplastic Process

Definition

An extramedullary myeloid tumor that arises from the oral cavity. It occurs de novo or can precede, coincide with, or follow the presentation of acute myeloid leukemia, or can constitute blastic transformation of a myelodysplastic syndrome or myeloproliferative neoplasm. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOral Cavity Myeloid Sarcoma

Recent clinical studies

Etiology

Cancer risk following lymphoid malignancies among HIV-infected people.
Mahale P, Ugoji C, Engels EA, Shiels MS, Peprah S, Morton LM
AIDS 2020 Jul 1;34(8):1237-1245. doi: 10.1097/QAD.0000000000002528. PMID: 32287068Free PMC Article
Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults.
Keegan TH, Ries LA, Barr RD, Geiger AM, Dahlke DV, Pollock BH, Bleyer WA; National Cancer Institute Next Steps for Adolescent and Young Adult Oncology Epidemiology Working Group
Cancer 2016 Apr 1;122(7):1009-16. Epub 2016 Feb 5 doi: 10.1002/cncr.29869. PMID: 26848927
Risk of second cancer after lymphohematopoietic neoplasm.
Royle JS, Baade P, Joske D, Fritschi L
Int J Cancer 2011 Aug 15;129(4):910-9. Epub 2010 Nov 28 doi: 10.1002/ijc.25706. PMID: 20886600
Extramedullary infiltration at diagnosis and prognosis in children with acute myelogenous leukemia.
Kobayashi R, Tawa A, Hanada R, Horibe K, Tsuchida M, Tsukimoto I; Japanese childhood AML cooperative study group
Pediatr Blood Cancer 2007 Apr;48(4):393-8. doi: 10.1002/pbc.20824. PMID: 16550530
Granulocytic sarcoma: an atypical presentation in the oral cavity.
Stoopler ET, Pinto A, Alawi F, Raghavendra S, Boyce R Jr, Porter D, Sollecito TP
Spec Care Dentist 2004 Mar-Apr;24(2):65-9. doi: 10.1111/j.1754-4505.2004.tb01681.x. PMID: 15200230

Diagnosis

Leukaemic infiltration in the oral and maxillofacial region: An update.
de Sena ACVP, de Arruda JAA, Costa FPD, Lemos APV, Kakehasi FM, Travassos DV, Abreu LG, Fonseca FP, Mesquita RA, Silva TA
J Oral Pathol Med 2021 Jul;50(6):558-564. Epub 2021 Jun 28 doi: 10.1111/jop.13206. PMID: 34101926
A case of myeloid sarcoma of the mandibular gingiva as extramedullary relapse of acute myeloid leukemia.
Ishikawa S, Kato Y, Kabasawa T, Yoshioka C, Kitabatake K, Yamakawa M, Ishizawa K, Iino M
Oral Maxillofac Surg 2020 Mar;24(1):121-126. Epub 2019 Dec 1 doi: 10.1007/s10006-019-00812-y. PMID: 31788742
How Rare Is an Oral Presentation of Myeloid Sarcoma in the Infant?
Gaal A, Chisholm KM, Egbert M
J Oral Maxillofac Surg 2018 Mar;76(3):561-568. Epub 2017 Sep 21 doi: 10.1016/j.joms.2017.08.034. PMID: 28943463
Oral myeloid sarcoma: two case reports.
Yap M, Hewson I, McLean C, Ciciulla J
Aust Dent J 2014 Dec;59(4):511-5. Epub 2014 Sep 16 doi: 10.1111/adj.12220. PMID: 25159834
Myeloid sarcoma of the head and neck region.
Zhou J, Bell D, Medeiros LJ
Arch Pathol Lab Med 2013 Nov;137(11):1560-8. Epub 2013 Mar 26 doi: 10.5858/arpa.2012-0537-OA. PMID: 23530613

Therapy

Clinical characteristics and management of primary granulocytic sarcoma of the oral cavity: A case report and literature review.
Hu YG, Deng XH, Lei W, Li XL
Medicine (Baltimore) 2020 Oct 23;99(43):e22820. doi: 10.1097/MD.0000000000022820. PMID: 33120806Free PMC Article
Myeloid sarcoma of the nasal cavity in a 15-month-old child: A case report.
Liu R, Du J, Gao L, Liu Y, Liu S
Medicine (Baltimore) 2020 Jul 2;99(27):e21119. doi: 10.1097/MD.0000000000021119. PMID: 32629746Free PMC Article
Acute myeloid leukaemia diagnosed by intra-oral myeloid sarcoma. A case report.
Papamanthos MK, Kolokotronis AE, Skulakis HE, Fericean AM, Zorba MT, Matiakis AT
Head Neck Pathol 2010 Jun;4(2):132-5. Epub 2010 Jan 26 doi: 10.1007/s12105-010-0163-9. PMID: 20512638Free PMC Article
Granulocytic sarcoma of the lips: report of an unusual case.
Srinivasan B, Ethunandan M, Anand R, Hussein K, Ilankovan V
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008 Jan;105(1):e34-6. doi: 10.1016/j.tripleo.2007.07.020. PMID: 18155599
Intraoral granulocytic sarcoma presenting as multiple maxillary and mandibular masses: a case report and literature review.
Xie Z, Zhang F, Song E, Ge W, Zhu F, Hu J
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Jun;103(6):e44-8. Epub 2007 Apr 11 doi: 10.1016/j.tripleo.2006.12.028. PMID: 17428693

Prognosis

Oral myeloid sarcoma as an uncommon manifestation of acute myeloid leukemia: A case series and review of the literature.
Wang D, He K, Sroussi H, Treister N, Luskin M, Villa A, Woo SB, Shazib MA
J Am Dent Assoc 2021 May;152(5):393-400.e8. doi: 10.1016/j.adaj.2021.01.017. PMID: 33926625
Myeloid sarcoma of the nasal cavity in a 15-month-old child: A case report.
Liu R, Du J, Gao L, Liu Y, Liu S
Medicine (Baltimore) 2020 Jul 2;99(27):e21119. doi: 10.1097/MD.0000000000021119. PMID: 32629746Free PMC Article
Cancer risk following lymphoid malignancies among HIV-infected people.
Mahale P, Ugoji C, Engels EA, Shiels MS, Peprah S, Morton LM
AIDS 2020 Jul 1;34(8):1237-1245. doi: 10.1097/QAD.0000000000002528. PMID: 32287068Free PMC Article
A case of myeloid sarcoma of the mandibular gingiva as extramedullary relapse of acute myeloid leukemia.
Ishikawa S, Kato Y, Kabasawa T, Yoshioka C, Kitabatake K, Yamakawa M, Ishizawa K, Iino M
Oral Maxillofac Surg 2020 Mar;24(1):121-126. Epub 2019 Dec 1 doi: 10.1007/s10006-019-00812-y. PMID: 31788742
Oral myeloid sarcoma: two case reports.
Yap M, Hewson I, McLean C, Ciciulla J
Aust Dent J 2014 Dec;59(4):511-5. Epub 2014 Sep 16 doi: 10.1111/adj.12220. PMID: 25159834

Clinical prediction guides

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review.
Jo S, Shim HK, Kim JY, Bae SK, Kim MR
Biomed Res Int 2019;2019:9869406. Epub 2019 Nov 22 doi: 10.1155/2019/9869406. PMID: 31886274Free PMC Article
Myeloid sarcoma of the Gingiva with myelodysplastic syndrome: A Case Report.
Jin SH, Park G, Ko Y, Park JB
Medicine (Baltimore) 2016 Jun;95(24):e3897. doi: 10.1097/MD.0000000000003897. PMID: 27310987Free PMC Article
Oral myeloid sarcoma: two case reports.
Yap M, Hewson I, McLean C, Ciciulla J
Aust Dent J 2014 Dec;59(4):511-5. Epub 2014 Sep 16 doi: 10.1111/adj.12220. PMID: 25159834
The risk of developing second cancers among survivors of childhood soft tissue sarcoma.
Cohen RJ, Curtis RE, Inskip PD, Fraumeni JF Jr
Cancer 2005 Jun 1;103(11):2391-6. doi: 10.1002/cncr.21040. PMID: 15852362
Granulocytic sarcoma (chloroma) of the oral cavity: a case with aleukemic presentation.
Ficarra G, Silverman S Jr, Quivey JM, Hansen LS, Giannotti K
Oral Surg Oral Med Oral Pathol 1987 Jun;63(6):709-14. doi: 10.1016/0030-4220(87)90375-6. PMID: 3473396

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